Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCJ6_LEIBR

TriTrypDb:

LbrM.22.1480 , LBRM2903_220021600

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.465
CLV_NRD_NRD_1	152	154	PF00675	0.568
CLV_NRD_NRD_1	194	196	PF00675	0.741
CLV_NRD_NRD_1	65	67	PF00675	0.682
CLV_PCSK_FUR_1	150	154	PF00082	0.568
CLV_PCSK_KEX2_1	152	154	PF00082	0.571
CLV_PCSK_KEX2_1	194	196	PF00082	0.744
CLV_PCSK_KEX2_1	65	67	PF00082	0.728
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.725
CLV_PCSK_SKI1_1	130	134	PF00082	0.445
CLV_PCSK_SKI1_1	152	156	PF00082	0.582
CLV_PCSK_SKI1_1	24	28	PF00082	0.470
CLV_PCSK_SKI1_1	270	274	PF00082	0.580
DEG_Nend_UBRbox_1	1	4	PF02207	0.545
DEG_SPOP_SBC_1	309	313	PF00917	0.631
DEG_SPOP_SBC_1	58	62	PF00917	0.614
DEG_SPOP_SBC_1	72	76	PF00917	0.483
DEG_SPOP_SBC_1	85	89	PF00917	0.480
DOC_CYCLIN_RxL_1	146	159	PF00134	0.493
DOC_CYCLIN_RxL_1	28	42	PF00134	0.676
DOC_CYCLIN_yCln2_LP_2	27	33	PF00134	0.428
DOC_MAPK_gen_1	129	136	PF00069	0.500
DOC_PP2B_LxvP_1	277	280	PF13499	0.590
DOC_USP7_MATH_1	268	272	PF00917	0.621
DOC_USP7_MATH_1	338	342	PF00917	0.578
DOC_USP7_MATH_1	49	53	PF00917	0.644
DOC_USP7_MATH_1	72	76	PF00917	0.612
DOC_USP7_MATH_1	84	88	PF00917	0.616
DOC_USP7_UBL2_3	65	69	PF12436	0.722
DOC_WW_Pin1_4	26	31	PF00397	0.693
DOC_WW_Pin1_4	54	59	PF00397	0.573
DOC_WW_Pin1_4	68	73	PF00397	0.638
DOC_WW_Pin1_4	76	81	PF00397	0.687
LIG_14-3-3_CanoR_1	194	198	PF00244	0.722
LIG_14-3-3_CanoR_1	2	8	PF00244	0.467
LIG_14-3-3_CanoR_1	292	299	PF00244	0.522
LIG_14-3-3_CanoR_1	324	334	PF00244	0.742
LIG_APCC_ABBA_1	362	367	PF00400	0.450
LIG_FHA_1	16	22	PF00498	0.559
LIG_FHA_1	315	321	PF00498	0.541
LIG_FHA_1	359	365	PF00498	0.451
LIG_FHA_2	104	110	PF00498	0.613
LIG_FHA_2	327	333	PF00498	0.588
LIG_IBAR_NPY_1	186	188	PF08397	0.524
LIG_LIR_Gen_1	240	246	PF02991	0.586
LIG_LIR_Nem_3	120	125	PF02991	0.523
LIG_LIR_Nem_3	202	208	PF02991	0.428
LIG_LIR_Nem_3	240	245	PF02991	0.587
LIG_LIR_Nem_3	8	14	PF02991	0.434
LIG_PDZ_Class_2	370	375	PF00595	0.647
LIG_SH2_STAP1	242	246	PF00017	0.639
LIG_SH2_STAP1	360	364	PF00017	0.633
LIG_SH2_STAT5	360	363	PF00017	0.622
LIG_SUMO_SIM_par_1	359	368	PF11976	0.537
LIG_TRAF2_1	142	145	PF00917	0.543
LIG_TRAF2_1	294	297	PF00917	0.442
LIG_TRAF2_1	88	91	PF00917	0.612
LIG_TRAF2_1	99	102	PF00917	0.545
LIG_UBA3_1	176	185	PF00899	0.579
LIG_WRC_WIRS_1	242	247	PF05994	0.640
MOD_CDK_SPK_2	76	81	PF00069	0.623
MOD_CK1_1	120	126	PF00069	0.550
MOD_CK1_1	193	199	PF00069	0.599
MOD_CK1_1	311	317	PF00069	0.674
MOD_CK1_1	51	57	PF00069	0.636
MOD_CK1_1	6	12	PF00069	0.612
MOD_CK1_1	60	66	PF00069	0.719
MOD_CK1_1	68	74	PF00069	0.587
MOD_CK1_1	79	85	PF00069	0.648
MOD_CK1_1	93	99	PF00069	0.555
MOD_CK2_1	241	247	PF00069	0.686
MOD_CK2_1	254	260	PF00069	0.446
MOD_CK2_1	291	297	PF00069	0.609
MOD_CK2_1	85	91	PF00069	0.697
MOD_GlcNHglycan	201	204	PF01048	0.429
MOD_GlcNHglycan	213	216	PF01048	0.514
MOD_GlcNHglycan	220	223	PF01048	0.722
MOD_GlcNHglycan	237	240	PF01048	0.476
MOD_GlcNHglycan	270	273	PF01048	0.547
MOD_GlcNHglycan	303	307	PF01048	0.579
MOD_GlcNHglycan	91	95	PF01048	0.488
MOD_GSK3_1	113	120	PF00069	0.513
MOD_GSK3_1	15	22	PF00069	0.551
MOD_GSK3_1	189	196	PF00069	0.685
MOD_GSK3_1	233	240	PF00069	0.656
MOD_GSK3_1	246	253	PF00069	0.660
MOD_GSK3_1	304	311	PF00069	0.594
MOD_GSK3_1	32	39	PF00069	0.579
MOD_GSK3_1	48	55	PF00069	0.487
MOD_GSK3_1	68	75	PF00069	0.668
MOD_GSK3_1	86	93	PF00069	0.631
MOD_LATS_1	32	38	PF00433	0.555
MOD_NEK2_1	213	218	PF00069	0.619
MOD_NEK2_1	325	330	PF00069	0.560
MOD_NEK2_1	36	41	PF00069	0.640
MOD_NEK2_2	280	285	PF00069	0.600
MOD_PIKK_1	19	25	PF00454	0.523
MOD_PIKK_1	213	219	PF00454	0.639
MOD_PIKK_1	86	92	PF00454	0.461
MOD_PKA_1	65	71	PF00069	0.496
MOD_PKA_2	193	199	PF00069	0.647
MOD_PKA_2	291	297	PF00069	0.482
MOD_PKA_2	52	58	PF00069	0.665
MOD_PKA_2	65	71	PF00069	0.593
MOD_Plk_1	15	21	PF00069	0.429
MOD_Plk_1	158	164	PF00069	0.553
MOD_Plk_1	280	286	PF00069	0.467
MOD_Plk_1	358	364	PF00069	0.586
MOD_Plk_2-3	241	247	PF00069	0.619
MOD_Plk_4	241	247	PF00069	0.642
MOD_Plk_4	280	286	PF00069	0.564
MOD_Plk_4	93	99	PF00069	0.496
MOD_ProDKin_1	26	32	PF00069	0.695
MOD_ProDKin_1	54	60	PF00069	0.573
MOD_ProDKin_1	68	74	PF00069	0.639
MOD_ProDKin_1	76	82	PF00069	0.687
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.639
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.679
TRG_ENDOCYTIC_2	242	245	PF00928	0.586
TRG_ER_diArg_1	150	153	PF00400	0.526
TRG_NLS_MonoExtC_3	64	69	PF00514	0.741
TRG_NLS_MonoExtN_4	65	70	PF00514	0.750
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4X3	Leptomonas seymouri	36%	100%
A0A1X0NTI1	Trypanosomatidae	31%	100%
A0A3Q8IAT9	Leishmania donovani	74%	100%
A0A422N4X5	Trypanosoma rangeli	28%	100%
A4I016	Leishmania infantum	74%	100%
C9ZQ77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AVY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QBJ0	Leishmania major	71%	99%
V5ARZ4	Trypanosoma cruzi	29%	100%