C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCJ4_LEIBR

TriTrypDb:

LbrM.22.1450 , LBRM2903_220021300

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	40	42	PF00675	0.334
CLV_NRD_NRD_1	538	540	PF00675	0.390
CLV_PCSK_KEX2_1	40	42	PF00082	0.344
CLV_PCSK_SKI1_1	10	14	PF00082	0.718
CLV_PCSK_SKI1_1	133	137	PF00082	0.446
CLV_PCSK_SKI1_1	334	338	PF00082	0.529
CLV_PCSK_SKI1_1	41	45	PF00082	0.354
CLV_PCSK_SKI1_1	66	70	PF00082	0.498
DEG_APCC_DBOX_1	462	470	PF00400	0.584
DEG_APCC_DBOX_1	550	558	PF00400	0.370
DEG_SPOP_SBC_1	312	316	PF00917	0.490
DOC_CYCLIN_RxL_1	36	47	PF00134	0.291
DOC_MAPK_FxFP_2	210	213	PF00069	0.312
DOC_MAPK_gen_1	129	138	PF00069	0.517
DOC_MAPK_gen_1	373	381	PF00069	0.465
DOC_MAPK_HePTP_8	103	115	PF00069	0.462
DOC_MAPK_MEF2A_6	106	115	PF00069	0.470
DOC_MAPK_MEF2A_6	132	140	PF00069	0.505
DOC_MAPK_MEF2A_6	186	193	PF00069	0.421
DOC_MAPK_MEF2A_6	285	293	PF00069	0.380
DOC_MAPK_MEF2A_6	298	307	PF00069	0.403
DOC_MAPK_MEF2A_6	364	371	PF00069	0.623
DOC_MAPK_MEF2A_6	382	390	PF00069	0.549
DOC_MAPK_NFAT4_5	133	141	PF00069	0.499
DOC_PP1_RVXF_1	267	273	PF00149	0.367
DOC_PP4_FxxP_1	210	213	PF00568	0.312
DOC_PP4_FxxP_1	89	92	PF00568	0.574
DOC_USP7_MATH_1	246	250	PF00917	0.505
DOC_USP7_MATH_1	3	7	PF00917	0.774
DOC_USP7_MATH_1	312	316	PF00917	0.466
DOC_USP7_MATH_1	459	463	PF00917	0.676
DOC_USP7_MATH_1	526	530	PF00917	0.435
DOC_USP7_MATH_1	92	96	PF00917	0.657
DOC_USP7_UBL2_3	32	36	PF12436	0.386
DOC_WW_Pin1_4	12	17	PF00397	0.554
DOC_WW_Pin1_4	185	190	PF00397	0.571
DOC_WW_Pin1_4	191	196	PF00397	0.513
DOC_WW_Pin1_4	494	499	PF00397	0.444
DOC_WW_Pin1_4	562	567	PF00397	0.455
DOC_WW_Pin1_4	80	85	PF00397	0.326
LIG_14-3-3_CanoR_1	10	19	PF00244	0.533
LIG_14-3-3_CanoR_1	204	209	PF00244	0.311
LIG_14-3-3_CanoR_1	248	254	PF00244	0.324
LIG_14-3-3_CanoR_1	269	278	PF00244	0.376
LIG_14-3-3_CanoR_1	457	467	PF00244	0.402
LIG_14-3-3_CanoR_1	551	559	PF00244	0.418
LIG_14-3-3_CanoR_1	579	588	PF00244	0.444
LIG_Actin_WH2_2	116	131	PF00022	0.414
LIG_Actin_WH2_2	171	188	PF00022	0.266
LIG_Actin_WH2_2	233	250	PF00022	0.255
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_BRCT_BRCA1_1	496	500	PF00533	0.438
LIG_BRCT_BRCA1_1	545	549	PF00533	0.478
LIG_BRCT_BRCA1_1	586	590	PF00533	0.473
LIG_BRCT_BRCA1_1	72	76	PF00533	0.550
LIG_Clathr_ClatBox_1	42	46	PF01394	0.360
LIG_EH_1	457	461	PF12763	0.665
LIG_FHA_1	141	147	PF00498	0.316
LIG_FHA_1	155	161	PF00498	0.493
LIG_FHA_1	169	175	PF00498	0.311
LIG_FHA_1	200	206	PF00498	0.430
LIG_FHA_1	273	279	PF00498	0.347
LIG_FHA_1	32	38	PF00498	0.378
LIG_FHA_1	326	332	PF00498	0.370
LIG_FHA_1	475	481	PF00498	0.386
LIG_FHA_1	491	497	PF00498	0.540
LIG_FHA_1	593	599	PF00498	0.437
LIG_FHA_2	192	198	PF00498	0.524
LIG_FHA_2	45	51	PF00498	0.424
LIG_FHA_2	503	509	PF00498	0.388
LIG_LIR_Apic_2	207	213	PF02991	0.318
LIG_LIR_Gen_1	179	189	PF02991	0.357
LIG_LIR_Gen_1	235	245	PF02991	0.414
LIG_LIR_Gen_1	546	557	PF02991	0.429
LIG_LIR_Gen_1	597	607	PF02991	0.475
LIG_LIR_Nem_3	179	184	PF02991	0.316
LIG_LIR_Nem_3	190	196	PF02991	0.465
LIG_LIR_Nem_3	197	203	PF02991	0.348
LIG_LIR_Nem_3	209	215	PF02991	0.278
LIG_LIR_Nem_3	235	240	PF02991	0.427
LIG_LIR_Nem_3	33	38	PF02991	0.380
LIG_LIR_Nem_3	546	552	PF02991	0.440
LIG_LIR_Nem_3	587	593	PF02991	0.398
LIG_LIR_Nem_3	594	599	PF02991	0.451
LIG_LIR_Nem_3	99	103	PF02991	0.515
LIG_Pex14_2	272	276	PF04695	0.307
LIG_PTAP_UEV_1	298	303	PF05743	0.418
LIG_PTB_Apo_2	425	432	PF02174	0.457
LIG_SH2_CRK	181	185	PF00017	0.275
LIG_SH2_CRK	200	204	PF00017	0.504
LIG_SH2_CRK	352	356	PF00017	0.560
LIG_SH2_CRK	599	603	PF00017	0.453
LIG_SH2_STAP1	181	185	PF00017	0.275
LIG_SH2_STAT5	153	156	PF00017	0.392
LIG_SH2_STAT5	223	226	PF00017	0.386
LIG_SH2_STAT5	253	256	PF00017	0.357
LIG_SH2_STAT5	271	274	PF00017	0.323
LIG_SH2_STAT5	581	584	PF00017	0.492
LIG_SH2_STAT5	591	594	PF00017	0.392
LIG_SH3_3	296	302	PF00018	0.421
LIG_SH3_3	453	459	PF00018	0.653
LIG_SUMO_SIM_anti_2	503	508	PF11976	0.416
LIG_SUMO_SIM_par_1	116	124	PF11976	0.378
LIG_SUMO_SIM_par_1	41	47	PF11976	0.479
LIG_SUMO_SIM_par_1	570	576	PF11976	0.453
LIG_TRAF2_1	338	341	PF00917	0.567
LIG_UBA3_1	466	472	PF00899	0.552
LIG_WRC_WIRS_1	212	217	PF05994	0.357
MOD_CDK_SPK_2	80	85	PF00069	0.415
MOD_CK1_1	145	151	PF00069	0.426
MOD_CK1_1	15	21	PF00069	0.562
MOD_CK1_1	249	255	PF00069	0.485
MOD_CK1_1	315	321	PF00069	0.535
MOD_CK1_1	470	476	PF00069	0.451
MOD_CK1_1	522	528	PF00069	0.460
MOD_CK1_1	573	579	PF00069	0.477
MOD_CK1_1	603	609	PF00069	0.350
MOD_CK2_1	191	197	PF00069	0.536
MOD_CK2_1	421	427	PF00069	0.655
MOD_CK2_1	98	104	PF00069	0.586
MOD_Cter_Amidation	130	133	PF01082	0.479
MOD_GlcNHglycan	1	4	PF01048	0.686
MOD_GlcNHglycan	100	103	PF01048	0.472
MOD_GlcNHglycan	249	252	PF01048	0.516
MOD_GlcNHglycan	272	275	PF01048	0.401
MOD_GlcNHglycan	299	302	PF01048	0.430
MOD_GlcNHglycan	357	360	PF01048	0.614
MOD_GlcNHglycan	415	418	PF01048	0.675
MOD_GlcNHglycan	524	527	PF01048	0.448
MOD_GlcNHglycan	6	9	PF01048	0.623
MOD_GSK3_1	163	170	PF00069	0.324
MOD_GSK3_1	199	206	PF00069	0.342
MOD_GSK3_1	211	218	PF00069	0.303
MOD_GSK3_1	232	239	PF00069	0.454
MOD_GSK3_1	249	256	PF00069	0.453
MOD_GSK3_1	272	279	PF00069	0.399
MOD_GSK3_1	289	296	PF00069	0.415
MOD_GSK3_1	311	318	PF00069	0.365
MOD_GSK3_1	325	332	PF00069	0.360
MOD_GSK3_1	4	11	PF00069	0.661
MOD_GSK3_1	409	416	PF00069	0.669
MOD_GSK3_1	470	477	PF00069	0.420
MOD_GSK3_1	490	497	PF00069	0.494
MOD_GSK3_1	522	529	PF00069	0.425
MOD_GSK3_1	92	99	PF00069	0.680
MOD_N-GLC_1	191	196	PF02516	0.570
MOD_N-GLC_1	232	237	PF02516	0.347
MOD_N-GLC_1	276	281	PF02516	0.522
MOD_N-GLC_1	293	298	PF02516	0.449
MOD_N-GLC_1	326	331	PF02516	0.380
MOD_N-GLC_1	445	450	PF02516	0.626
MOD_N-GLC_1	467	472	PF02516	0.495
MOD_N-GLC_1	552	557	PF02516	0.396
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	215	220	PF00069	0.425
MOD_NEK2_1	247	252	PF00069	0.472
MOD_NEK2_1	272	277	PF00069	0.315
MOD_NEK2_1	289	294	PF00069	0.372
MOD_NEK2_1	413	418	PF00069	0.654
MOD_NEK2_1	467	472	PF00069	0.499
MOD_NEK2_1	500	505	PF00069	0.340
MOD_NEK2_1	52	57	PF00069	0.512
MOD_NEK2_1	602	607	PF00069	0.432
MOD_NEK2_1	68	73	PF00069	0.415
MOD_NEK2_2	526	531	PF00069	0.463
MOD_PIKK_1	140	146	PF00454	0.561
MOD_PIKK_1	256	262	PF00454	0.464
MOD_PIKK_1	293	299	PF00454	0.433
MOD_PIKK_1	336	342	PF00454	0.448
MOD_PIKK_1	467	473	PF00454	0.489
MOD_PIKK_1	543	549	PF00454	0.529
MOD_PIKK_1	579	585	PF00454	0.459
MOD_PIKK_1	92	98	PF00454	0.554
MOD_PKA_2	105	111	PF00069	0.416
MOD_PKA_2	203	209	PF00069	0.309
MOD_PKA_2	247	253	PF00069	0.277
MOD_Plk_1	167	173	PF00069	0.313
MOD_Plk_1	235	241	PF00069	0.371
MOD_Plk_1	326	332	PF00069	0.382
MOD_Plk_1	445	451	PF00069	0.610
MOD_Plk_2-3	594	600	PF00069	0.439
MOD_Plk_4	142	148	PF00069	0.461
MOD_Plk_4	180	186	PF00069	0.457
MOD_Plk_4	211	217	PF00069	0.340
MOD_Plk_4	249	255	PF00069	0.500
MOD_Plk_4	445	451	PF00069	0.575
MOD_Plk_4	502	508	PF00069	0.495
MOD_Plk_4	594	600	PF00069	0.439
MOD_Plk_4	603	609	PF00069	0.398
MOD_ProDKin_1	12	18	PF00069	0.555
MOD_ProDKin_1	185	191	PF00069	0.572
MOD_ProDKin_1	494	500	PF00069	0.432
MOD_ProDKin_1	562	568	PF00069	0.447
MOD_ProDKin_1	80	86	PF00069	0.333
TRG_DiLeu_BaEn_1	33	38	PF01217	0.418
TRG_DiLeu_BaEn_2	426	432	PF01217	0.455
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.466
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.610
TRG_ENDOCYTIC_2	153	156	PF00928	0.439
TRG_ENDOCYTIC_2	181	184	PF00928	0.417
TRG_ENDOCYTIC_2	200	203	PF00928	0.504
TRG_ENDOCYTIC_2	212	215	PF00928	0.494
TRG_ENDOCYTIC_2	352	355	PF00928	0.560
TRG_ENDOCYTIC_2	599	602	PF00928	0.443
TRG_ER_diArg_1	39	41	PF00400	0.345
TRG_ER_diArg_1	557	560	PF00400	0.475
TRG_ER_FFAT_2	518	529	PF00635	0.542
TRG_NES_CRM1_1	222	236	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRF1	Leptomonas seymouri	77%	100%
A0A0S4J7N2	Bodo saltans	30%	74%
A0A1X0NTT4	Trypanosomatidae	51%	100%
A0A3Q8ICD1	Leishmania donovani	88%	100%
A0A3R7K4C8	Trypanosoma rangeli	54%	100%
A4I014	Leishmania infantum	88%	100%
C9ZQ83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AVY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QBJ2	Leishmania major	86%	99%
V5BGJ4	Trypanosoma cruzi	51%	100%