Putative Serine-threonin protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Serine-threonin protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HCJ2_LEIBR

TriTrypDb:

LbrM.22.1390 , LBRM2903_220020500

Length:

361

Annotations

LeishMANIAdb annotations

A metalloenzyme with the catalytic domain facing outwards. Related to plant Shewanella-like protein phosphatases. Kinetoplastids have multiple copies of these genes but probably from a very ancient gene duplication.. The cluster might merge two separate, very distantly related groups.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 4
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HCJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCJ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0016787	hydrolase activity	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.591
CLV_C14_Caspase3-7	72	76	PF00656	0.341
CLV_NRD_NRD_1	237	239	PF00675	0.345
CLV_NRD_NRD_1	31	33	PF00675	0.538
CLV_PCSK_SKI1_1	131	135	PF00082	0.340
CLV_PCSK_SKI1_1	216	220	PF00082	0.302
DEG_APCC_DBOX_1	92	100	PF00400	0.334
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DEG_SCF_FBW7_1	266	273	PF00400	0.279
DOC_MAPK_gen_1	162	171	PF00069	0.156
DOC_MAPK_gen_1	7	17	PF00069	0.452
DOC_MAPK_MEF2A_6	10	19	PF00069	0.526
DOC_MAPK_MEF2A_6	298	306	PF00069	0.465
DOC_USP7_MATH_1	270	274	PF00917	0.403
DOC_WW_Pin1_4	266	271	PF00397	0.271
DOC_WW_Pin1_4	343	348	PF00397	0.664
DOC_WW_Pin1_4	73	78	PF00397	0.168
LIG_14-3-3_CanoR_1	10	19	PF00244	0.477
LIG_14-3-3_CanoR_1	225	229	PF00244	0.455
LIG_14-3-3_CanoR_1	79	87	PF00244	0.444
LIG_14-3-3_CanoR_1	93	97	PF00244	0.308
LIG_APCC_ABBA_1	26	31	PF00400	0.325
LIG_BRCT_BRCA1_1	317	321	PF00533	0.471
LIG_FHA_1	110	116	PF00498	0.309
LIG_FHA_1	308	314	PF00498	0.317
LIG_FHA_1	92	98	PF00498	0.313
LIG_FHA_2	267	273	PF00498	0.378
LIG_FHA_2	334	340	PF00498	0.624
LIG_FHA_2	355	361	PF00498	0.526
LIG_LIR_Gen_1	18	27	PF02991	0.457
LIG_LIR_Gen_1	356	361	PF02991	0.723
LIG_LIR_Gen_1	51	60	PF02991	0.395
LIG_LIR_Nem_3	172	178	PF02991	0.281
LIG_LIR_Nem_3	18	22	PF02991	0.462
LIG_LIR_Nem_3	303	309	PF02991	0.448
LIG_LIR_Nem_3	356	361	PF02991	0.694
LIG_LIR_Nem_3	51	56	PF02991	0.328
LIG_PDZ_Class_3	356	361	PF00595	0.662
LIG_Pex14_2	224	228	PF04695	0.270
LIG_SH2_CRK	12	16	PF00017	0.624
LIG_SH2_CRK	148	152	PF00017	0.365
LIG_SH2_GRB2like	150	153	PF00017	0.407
LIG_SH2_NCK_1	335	339	PF00017	0.385
LIG_SH2_STAP1	12	16	PF00017	0.600
LIG_SH2_STAP1	296	300	PF00017	0.487
LIG_SH2_STAP1	309	313	PF00017	0.506
LIG_SH2_STAT5	150	153	PF00017	0.301
LIG_SH2_STAT5	178	181	PF00017	0.287
LIG_SH2_STAT5	279	282	PF00017	0.326
LIG_SH2_STAT5	309	312	PF00017	0.362
LIG_SH2_STAT5	335	338	PF00017	0.387
LIG_SH2_STAT5	4	7	PF00017	0.492
LIG_SH3_3	21	27	PF00018	0.475
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.297
LIG_SUMO_SIM_anti_2	20	25	PF11976	0.472
LIG_SUMO_SIM_par_1	20	25	PF11976	0.480
LIG_SUMO_SIM_par_1	283	288	PF11976	0.252
LIG_SUMO_SIM_par_1	39	45	PF11976	0.304
LIG_TRAF2_1	118	121	PF00917	0.407
LIG_TRAF2_1	269	272	PF00917	0.404
LIG_WRC_WIRS_1	16	21	PF05994	0.599
LIG_WW_3	76	80	PF00397	0.290
MOD_CDC14_SPxK_1	76	79	PF00782	0.156
MOD_CDK_SPK_2	343	348	PF00069	0.702
MOD_CDK_SPxK_1	73	79	PF00069	0.156
MOD_CK1_1	316	322	PF00069	0.458
MOD_CK1_1	68	74	PF00069	0.246
MOD_CK1_1	85	91	PF00069	0.174
MOD_CK2_1	115	121	PF00069	0.365
MOD_CK2_1	266	272	PF00069	0.452
MOD_CK2_1	333	339	PF00069	0.618
MOD_GlcNHglycan	12	15	PF01048	0.647
MOD_GlcNHglycan	125	128	PF01048	0.426
MOD_GlcNHglycan	216	219	PF01048	0.361
MOD_GlcNHglycan	231	234	PF01048	0.344
MOD_GlcNHglycan	272	275	PF01048	0.418
MOD_GlcNHglycan	330	333	PF01048	0.564
MOD_GlcNHglycan	64	68	PF01048	0.411
MOD_GSK3_1	224	231	PF00069	0.360
MOD_GSK3_1	266	273	PF00069	0.289
MOD_GSK3_1	307	314	PF00069	0.454
MOD_GSK3_1	317	324	PF00069	0.464
MOD_GSK3_1	81	88	PF00069	0.345
MOD_N-GLC_1	259	264	PF02516	0.372
MOD_NEK2_1	15	20	PF00069	0.518
MOD_NEK2_1	169	174	PF00069	0.394
MOD_NEK2_1	22	27	PF00069	0.526
MOD_NEK2_1	224	229	PF00069	0.319
MOD_NEK2_1	259	264	PF00069	0.319
MOD_NEK2_1	313	318	PF00069	0.442
MOD_NEK2_1	333	338	PF00069	0.605
MOD_PIKK_1	125	131	PF00454	0.395
MOD_PIKK_1	82	88	PF00454	0.156
MOD_PKA_2	224	230	PF00069	0.445
MOD_PKA_2	92	98	PF00069	0.303
MOD_Plk_1	259	265	PF00069	0.363
MOD_Plk_1	88	94	PF00069	0.241
MOD_Plk_2-3	243	249	PF00069	0.208
MOD_Plk_2-3	354	360	PF00069	0.450
MOD_Plk_4	224	230	PF00069	0.308
MOD_Plk_4	317	323	PF00069	0.391
MOD_Plk_4	92	98	PF00069	0.300
MOD_ProDKin_1	266	272	PF00069	0.271
MOD_ProDKin_1	343	349	PF00069	0.669
MOD_ProDKin_1	73	79	PF00069	0.168
MOD_SUMO_rev_2	25	35	PF00179	0.428
TRG_DiLeu_BaEn_2	189	195	PF01217	0.397
TRG_ENDOCYTIC_2	12	15	PF00928	0.603
TRG_ENDOCYTIC_2	148	151	PF00928	0.346
TRG_ENDOCYTIC_2	335	338	PF00928	0.387
TRG_ENDOCYTIC_2	358	361	PF00928	0.641
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3V2	Leptomonas seymouri	29%	97%
A0A0N1P9R1	Leptomonas seymouri	56%	100%
A0A0S4JBT9	Bodo saltans	37%	93%
A0A0S4JMN0	Bodo saltans	31%	89%
A0A0S4KJG1	Bodo saltans	26%	97%
A0A1X0NU01	Trypanosomatidae	42%	97%
A0A1X0NZX7	Trypanosomatidae	32%	81%
A0A1X0P2G6	Trypanosomatidae	28%	97%
A0A3Q8IBB4	Leishmania donovani	78%	100%
A0A3Q8IIK0	Leishmania donovani	29%	95%
A0A3R7NTC0	Trypanosoma rangeli	29%	98%
A0A3S5IRW3	Trypanosoma rangeli	30%	87%
A0A3S7X3U9	Leishmania donovani	28%	97%
A4HH45	Leishmania braziliensis	28%	95%
A4HIR7	Leishmania braziliensis	28%	86%
A4I008	Leishmania infantum	78%	100%
A4I498	Leishmania infantum	29%	95%
A4I612	Leishmania infantum	28%	97%
C9ZQ86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
C9ZRD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	81%
E9ADP5	Leishmania major	30%	100%
E9AM35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	95%
E9AVY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9B1A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
O74480	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q4Q6W1	Leishmania major	28%	100%
Q4QBJ8	Leishmania major	79%	100%
Q8L774	Arabidopsis thaliana	25%	93%
Q944L7	Arabidopsis thaliana	26%	92%
V5ARZ9	Trypanosoma cruzi	46%	96%
V5BPY7	Trypanosoma cruzi	30%	82%
V5BX32	Trypanosoma cruzi	28%	98%