LeishMANIAdb
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Putative 40S ribosomal protein L14

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 40S ribosomal protein L14
Gene product:
60S ribosomal protein L14, putative
Species:
Leishmania braziliensis
UniProt:
A4HCJ1_LEIBR
TriTrypDb:
LbrM.22.1460 , LBRM2903_220021400
Length:
175

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 14
GO:0032991 protein-containing complex 1 15
GO:0043226 organelle 2 15
GO:0043228 non-membrane-bounded organelle 3 15
GO:0043229 intracellular organelle 3 15
GO:0043232 intracellular non-membrane-bounded organelle 4 15
GO:0110165 cellular anatomical entity 1 15
GO:1990904 ribonucleoprotein complex 2 15
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0015934 large ribosomal subunit 4 1
GO:0022625 cytosolic large ribosomal subunit 5 1
GO:0044391 ribosomal subunit 3 1

Expansion

Sequence features

A4HCJ1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCJ1

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 15
GO:0006518 peptide metabolic process 4 15
GO:0006807 nitrogen compound metabolic process 2 15
GO:0008152 metabolic process 1 15
GO:0009058 biosynthetic process 2 15
GO:0009059 macromolecule biosynthetic process 4 15
GO:0009987 cellular process 1 15
GO:0019538 protein metabolic process 3 15
GO:0034641 cellular nitrogen compound metabolic process 3 15
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 15
GO:0043043 peptide biosynthetic process 5 15
GO:0043170 macromolecule metabolic process 3 15
GO:0043603 amide metabolic process 3 15
GO:0043604 amide biosynthetic process 4 15
GO:0044237 cellular metabolic process 2 15
GO:0044238 primary metabolic process 2 15
GO:0044249 cellular biosynthetic process 3 15
GO:0044260 obsolete cellular macromolecule metabolic process 3 15
GO:0044271 cellular nitrogen compound biosynthetic process 4 15
GO:0071704 organic substance metabolic process 2 15
GO:1901564 organonitrogen compound metabolic process 3 15
GO:1901566 organonitrogen compound biosynthetic process 4 15
GO:1901576 organic substance biosynthetic process 3 15
GO:0022613 ribonucleoprotein complex biogenesis 4 1
GO:0042273 ribosomal large subunit biogenesis 5 1
GO:0044085 cellular component biogenesis 3 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 15
GO:0003723 RNA binding 4 15
GO:0003735 structural constituent of ribosome 2 15
GO:0005198 structural molecule activity 1 15
GO:0005488 binding 1 15
GO:0097159 organic cyclic compound binding 2 15
GO:1901363 heterocyclic compound binding 2 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 129 133 PF00656 0.582
CLV_C14_Caspase3-7 152 156 PF00656 0.428
CLV_C14_Caspase3-7 29 33 PF00656 0.419
CLV_C14_Caspase3-7 76 80 PF00656 0.245
CLV_NRD_NRD_1 117 119 PF00675 0.396
CLV_NRD_NRD_1 124 126 PF00675 0.373
CLV_NRD_NRD_1 162 164 PF00675 0.563
CLV_NRD_NRD_1 170 172 PF00675 0.476
CLV_PCSK_KEX2_1 117 119 PF00082 0.343
CLV_PCSK_KEX2_1 145 147 PF00082 0.536
CLV_PCSK_KEX2_1 161 163 PF00082 0.508
CLV_PCSK_PC1ET2_1 145 147 PF00082 0.536
CLV_PCSK_PC1ET2_1 161 163 PF00082 0.508
CLV_PCSK_SKI1_1 125 129 PF00082 0.547
CLV_PCSK_SKI1_1 131 135 PF00082 0.452
CLV_PCSK_SKI1_1 141 145 PF00082 0.466
CLV_PCSK_SKI1_1 171 175 PF00082 0.567
CLV_PCSK_SKI1_1 72 76 PF00082 0.361
CLV_PCSK_SKI1_1 86 90 PF00082 0.313
DOC_MAPK_gen_1 17 26 PF00069 0.408
DOC_MAPK_MEF2A_6 20 28 PF00069 0.392
DOC_USP7_MATH_1 116 120 PF00917 0.343
DOC_USP7_MATH_1 77 81 PF00917 0.414
DOC_USP7_UBL2_3 141 145 PF12436 0.468
DOC_USP7_UBL2_3 149 153 PF12436 0.497
DOC_USP7_UBL2_3 82 86 PF12436 0.335
DOC_WW_Pin1_4 132 137 PF00397 0.589
LIG_14-3-3_CanoR_1 67 74 PF00244 0.353
LIG_BRCT_BRCA1_1 104 108 PF00533 0.335
LIG_FHA_2 104 110 PF00498 0.346
LIG_LIR_Gen_1 138 147 PF02991 0.471
LIG_LIR_Nem_3 105 111 PF02991 0.326
LIG_LIR_Nem_3 138 142 PF02991 0.455
LIG_SH2_STAT5 6 9 PF00017 0.425
LIG_SH2_STAT5 61 64 PF00017 0.470
LIG_SH3_3 35 41 PF00018 0.392
LIG_SUMO_SIM_par_1 26 32 PF11976 0.402
MOD_CK2_1 103 109 PF00069 0.335
MOD_GlcNHglycan 69 72 PF01048 0.483
MOD_GSK3_1 149 156 PF00069 0.418
MOD_N-GLC_1 67 72 PF02516 0.357
MOD_NEK2_1 1 6 PF00069 0.625
MOD_NEK2_1 78 83 PF00069 0.462
MOD_PKA_1 149 155 PF00069 0.417
MOD_PKA_2 116 122 PF00069 0.457
MOD_ProDKin_1 132 138 PF00069 0.585
MOD_SUMO_rev_2 129 136 PF00179 0.451
MOD_SUMO_rev_2 39 46 PF00179 0.415
TRG_ER_diArg_1 117 120 PF00400 0.469
TRG_ER_diArg_1 162 164 PF00400 0.658
TRG_NLS_Bipartite_1 145 165 PF00514 0.591
TRG_NLS_MonoExtC_3 170 175 PF00514 0.666
TRG_Pf-PMV_PEXEL_1 35 39 PF00026 0.386

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P212 Leptomonas seymouri 87% 100%
A0A0S4IV19 Bodo saltans 61% 70%
A0A1X0NR58 Trypanosomatidae 74% 97%
A0A1X0NTL1 Trypanosomatidae 74% 97%
A0A3Q8ICC3 Leishmania donovani 95% 100%
A0A3R7RDB6 Trypanosoma rangeli 70% 98%
A0A422NG13 Trypanosoma rangeli 70% 98%
A1XQU3 Sus scrofa 29% 82%
A4I011 Leishmania infantum 95% 75%
C9ZQ81 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 76% 93%
D0A8Y5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 77% 93%
E9AVY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
P36105 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
P38754 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
P50914 Homo sapiens 28% 81%
P55841 Drosophila melanogaster 29% 100%
P55842 Trypanosoma brucei brucei 76% 93%
P55843 Trypanosoma congolense 74% 95%
P55844 Pisum sativum 31% 100%
Q24C27 Tetrahymena thermophila (strain SB210) 28% 100%
Q25278 Leishmania donovani 95% 100%
Q3T0U2 Bos taurus 29% 82%
Q4QBJ1 Leishmania major 94% 100%
Q54Z09 Dictyostelium discoideum 32% 100%
Q63507 Rattus norvegicus 28% 82%
Q7XYA7 Griffithsia japonica 30% 100%
Q95ZE8 Drosophila virilis 29% 100%
Q9CR57 Mus musculus 28% 81%
Q9SIM4 Arabidopsis thaliana 30% 100%
Q9T043 Arabidopsis thaliana 29% 100%
V5D9P7 Trypanosoma cruzi 70% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS