P22

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

P22

Gene product:

Mitochondrial glycoprotein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCI6_LEIBR

TriTrypDb:

LbrM.22.1360 , LBRM2903_220020200

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 19
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	21
GO:0031974	membrane-enclosed lumen	2	21
GO:0043233	organelle lumen	3	21
GO:0070013	intracellular organelle lumen	4	21
GO:0110165	cellular anatomical entity	1	21

Expansion

Sequence features

A4HCI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCI6

PDB structure(s): 1yqf_A , 1yqf_B , 1yqf_C , 1yqf_D , 1yqf_E , 1yqf_F

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.345
CLV_NRD_NRD_1	186	188	PF00675	0.265
CLV_NRD_NRD_1	243	245	PF00675	0.359
CLV_NRD_NRD_1	29	31	PF00675	0.554
CLV_PCSK_FUR_1	123	127	PF00082	0.247
CLV_PCSK_FUR_1	184	188	PF00082	0.246
CLV_PCSK_KEX2_1	125	127	PF00082	0.369
CLV_PCSK_KEX2_1	184	186	PF00082	0.306
CLV_PCSK_KEX2_1	29	31	PF00082	0.554
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.247
CLV_PCSK_PC7_1	25	31	PF00082	0.643
CLV_PCSK_SKI1_1	48	52	PF00082	0.493
CLV_PCSK_SKI1_1	54	58	PF00082	0.430
DOC_PP1_RVXF_1	3	9	PF00149	0.441
DOC_PP4_FxxP_1	50	53	PF00568	0.484
DOC_USP7_MATH_1	23	27	PF00917	0.727
LIG_14-3-3_CanoR_1	5	9	PF00244	0.560
LIG_14-3-3_CterR_2	244	248	PF00244	0.531
LIG_BIR_II_1	1	5	PF00653	0.440
LIG_BRCT_BRCA1_1	68	72	PF00533	0.435
LIG_eIF4E_1	115	121	PF01652	0.491
LIG_FHA_1	127	133	PF00498	0.449
LIG_FHA_2	135	141	PF00498	0.484
LIG_FHA_2	36	42	PF00498	0.461
LIG_FHA_2	90	96	PF00498	0.495
LIG_LIR_Apic_2	189	194	PF02991	0.483
LIG_LIR_Apic_2	49	53	PF02991	0.488
LIG_LIR_Gen_1	112	122	PF02991	0.466
LIG_LIR_Gen_1	69	80	PF02991	0.399
LIG_LIR_Nem_3	112	118	PF02991	0.494
LIG_LIR_Nem_3	69	75	PF02991	0.543
LIG_Pex14_2	4	8	PF04695	0.620
LIG_SH2_CRK	191	195	PF00017	0.502
LIG_SH2_GRB2like	115	118	PF00017	0.559
LIG_SH2_GRB2like	236	239	PF00017	0.491
LIG_SH2_NCK_1	168	172	PF00017	0.582
LIG_SH2_STAP1	168	172	PF00017	0.528
LIG_SH2_STAT3	230	233	PF00017	0.487
LIG_SH2_STAT5	115	118	PF00017	0.487
LIG_SH2_STAT5	168	171	PF00017	0.581
LIG_SH2_STAT5	210	213	PF00017	0.450
LIG_SH2_STAT5	230	233	PF00017	0.492
LIG_SH2_STAT5	236	239	PF00017	0.479
LIG_SH3_3	49	55	PF00018	0.462
LIG_SUMO_SIM_anti_2	140	146	PF11976	0.467
LIG_SUMO_SIM_par_1	89	96	PF11976	0.421
LIG_TRAF2_1	152	155	PF00917	0.559
LIG_UBA3_1	56	62	PF00899	0.456
LIG_UBA3_1	90	97	PF00899	0.289
LIG_WW_3	51	55	PF00397	0.378
MOD_CK1_1	135	141	PF00069	0.433
MOD_CK2_1	35	41	PF00069	0.456
MOD_CK2_1	4	10	PF00069	0.623
MOD_CK2_1	89	95	PF00069	0.439
MOD_GlcNHglycan	1	4	PF01048	0.651
MOD_GlcNHglycan	179	182	PF01048	0.368
MOD_GlcNHglycan	66	69	PF01048	0.574
MOD_GSK3_1	146	153	PF00069	0.564
MOD_GSK3_1	4	11	PF00069	0.580
MOD_GSK3_1	89	96	PF00069	0.526
MOD_N-GLC_1	166	171	PF02516	0.287
MOD_NEK2_1	132	137	PF00069	0.485
MOD_NEK2_1	4	9	PF00069	0.625
MOD_NEK2_2	35	40	PF00069	0.564
MOD_PKA_1	186	192	PF00069	0.377
MOD_PKA_2	186	192	PF00069	0.444
MOD_PKA_2	4	10	PF00069	0.641
MOD_PKB_1	184	192	PF00069	0.419
MOD_Plk_1	132	138	PF00069	0.529
MOD_Plk_2-3	201	207	PF00069	0.491
TRG_DiLeu_BaEn_4	111	117	PF01217	0.559
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.491
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.507
TRG_ENDOCYTIC_2	115	118	PF00928	0.486
TRG_ER_diArg_1	184	187	PF00400	0.486
TRG_ER_diArg_1	28	30	PF00400	0.566
TRG_NES_CRM1_1	140	154	PF08389	0.530
TRG_NLS_MonoCore_2	122	127	PF00514	0.467
TRG_NLS_MonoExtC_3	123	128	PF00514	0.467
TRG_NLS_MonoExtN_4	123	128	PF00514	0.467
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P990	Leptomonas seymouri	27%	100%
A0A0N1HS24	Leptomonas seymouri	72%	97%
A0A0S4ITN8	Bodo saltans	30%	100%
A0A1X0NTH7	Trypanosomatidae	65%	95%
A0A1X0P207	Trypanosomatidae	30%	100%
A0A3Q8IBW7	Leishmania donovani	28%	100%
A0A3Q8IFM4	Leishmania donovani	85%	97%
A0A422P4Z7	Trypanosoma rangeli	28%	100%
A4HI52	Leishmania braziliensis	28%	100%
A4I007	Leishmania infantum	85%	97%
A4I5C8	Leishmania infantum	28%	100%
C9ZQR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZSQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	95%
C9ZU92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	67%
E9AVY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9B0M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q7K6	Leishmania major	28%	86%
Q4QBJ9	Leishmania major	83%	100%
V5BDB3	Trypanosoma cruzi	64%	95%