TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCI5_LEIBR

TriTrypDb:

LbrM.22.1350 , LBRM2903_220020100

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCI5

PDB structure(s): 7am2_BQ

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.687
CLV_C14_Caspase3-7	273	277	PF00656	0.486
CLV_C14_Caspase3-7	97	101	PF00656	0.397
CLV_MEL_PAP_1	425	431	PF00089	0.388
CLV_NRD_NRD_1	114	116	PF00675	0.345
CLV_NRD_NRD_1	184	186	PF00675	0.364
CLV_NRD_NRD_1	313	315	PF00675	0.614
CLV_NRD_NRD_1	4	6	PF00675	0.626
CLV_NRD_NRD_1	427	429	PF00675	0.419
CLV_PCSK_KEX2_1	114	116	PF00082	0.345
CLV_PCSK_KEX2_1	184	186	PF00082	0.364
CLV_PCSK_KEX2_1	3	5	PF00082	0.564
CLV_PCSK_KEX2_1	427	429	PF00082	0.419
CLV_PCSK_SKI1_1	152	156	PF00082	0.413
CLV_PCSK_SKI1_1	188	192	PF00082	0.486
CLV_PCSK_SKI1_1	241	245	PF00082	0.467
CLV_PCSK_SKI1_1	387	391	PF00082	0.500
CLV_PCSK_SKI1_1	5	9	PF00082	0.457
CLV_Separin_Metazoa	111	115	PF03568	0.330
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DEG_SPOP_SBC_1	228	232	PF00917	0.333
DOC_CYCLIN_RxL_1	339	350	PF00134	0.283
DOC_CYCLIN_RxL_1	382	393	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	61	67	PF00134	0.290
DOC_MAPK_gen_1	137	146	PF00069	0.266
DOC_MAPK_gen_1	184	191	PF00069	0.523
DOC_MAPK_gen_1	3	9	PF00069	0.604
DOC_MAPK_MEF2A_6	137	146	PF00069	0.289
DOC_PP1_RVXF_1	186	192	PF00149	0.440
DOC_PP2B_LxvP_1	195	198	PF13499	0.532
DOC_PP4_FxxP_1	131	134	PF00568	0.483
DOC_PP4_FxxP_1	37	40	PF00568	0.365
DOC_USP7_MATH_1	154	158	PF00917	0.367
DOC_USP7_MATH_1	198	202	PF00917	0.532
DOC_USP7_MATH_1	221	225	PF00917	0.634
DOC_USP7_MATH_1	228	232	PF00917	0.586
DOC_USP7_MATH_1	310	314	PF00917	0.640
DOC_USP7_MATH_1	367	371	PF00917	0.560
DOC_WW_Pin1_4	178	183	PF00397	0.356
DOC_WW_Pin1_4	224	229	PF00397	0.464
DOC_WW_Pin1_4	369	374	PF00397	0.545
LIG_14-3-3_CanoR_1	241	247	PF00244	0.445
LIG_14-3-3_CanoR_1	4	10	PF00244	0.494
LIG_14-3-3_CanoR_1	66	74	PF00244	0.287
LIG_Actin_WH2_2	139	154	PF00022	0.282
LIG_APCC_ABBA_1	345	350	PF00400	0.507
LIG_deltaCOP1_diTrp_1	400	406	PF00928	0.365
LIG_deltaCOP1_diTrp_1	84	90	PF00928	0.392
LIG_FHA_1	100	106	PF00498	0.500
LIG_FHA_1	283	289	PF00498	0.382
LIG_FHA_1	29	35	PF00498	0.377
LIG_FHA_1	374	380	PF00498	0.669
LIG_FHA_2	215	221	PF00498	0.525
LIG_FHA_2	230	236	PF00498	0.358
LIG_FHA_2	243	249	PF00498	0.380
LIG_FHA_2	57	63	PF00498	0.341
LIG_IBAR_NPY_1	93	95	PF08397	0.424
LIG_LIR_Apic_2	129	134	PF02991	0.502
LIG_LIR_Apic_2	224	228	PF02991	0.598
LIG_LIR_Gen_1	400	411	PF02991	0.375
LIG_LIR_Nem_3	118	124	PF02991	0.474
LIG_LIR_Nem_3	400	406	PF02991	0.416
LIG_LIR_Nem_3	424	429	PF02991	0.398
LIG_NRBOX	238	244	PF00104	0.347
LIG_NRBOX	262	268	PF00104	0.250
LIG_PDZ_Class_3	440	445	PF00595	0.465
LIG_Pex14_1	86	90	PF04695	0.376
LIG_Pex14_2	397	401	PF04695	0.374
LIG_PTB_Apo_2	405	412	PF02174	0.381
LIG_PTB_Phospho_1	405	411	PF10480	0.385
LIG_SH2_PTP2	225	228	PF00017	0.474
LIG_SH2_STAP1	256	260	PF00017	0.394
LIG_SH2_STAP1	95	99	PF00017	0.263
LIG_SH2_STAT3	74	77	PF00017	0.508
LIG_SH2_STAT5	108	111	PF00017	0.481
LIG_SH2_STAT5	225	228	PF00017	0.474
LIG_SH2_STAT5	321	324	PF00017	0.453
LIG_SH2_STAT5	33	36	PF00017	0.375
LIG_SH2_STAT5	46	49	PF00017	0.338
LIG_SH3_3	141	147	PF00018	0.474
LIG_SH3_3	37	43	PF00018	0.364
LIG_SH3_3	88	94	PF00018	0.421
LIG_SUMO_SIM_anti_2	257	265	PF11976	0.526
LIG_SUMO_SIM_par_1	79	85	PF11976	0.376
LIG_TRAF2_1	329	332	PF00917	0.461
LIG_TRAF2_1	94	97	PF00917	0.400
LIG_WRC_WIRS_1	128	133	PF05994	0.504
LIG_WRC_WIRS_1	243	248	PF05994	0.377
LIG_WRC_WIRS_1	266	271	PF05994	0.510
MOD_CDK_SPK_2	224	229	PF00069	0.387
MOD_CDK_SPxK_1	178	184	PF00069	0.356
MOD_CDK_SPxxK_3	178	185	PF00069	0.345
MOD_CK1_1	123	129	PF00069	0.545
MOD_CK1_1	201	207	PF00069	0.450
MOD_CK1_1	224	230	PF00069	0.558
MOD_CK1_1	258	264	PF00069	0.447
MOD_CK1_1	265	271	PF00069	0.413
MOD_CK1_1	281	287	PF00069	0.369
MOD_CK1_1	313	319	PF00069	0.593
MOD_CK1_1	369	375	PF00069	0.636
MOD_CK1_1	393	399	PF00069	0.461
MOD_CK2_1	156	162	PF00069	0.300
MOD_CK2_1	214	220	PF00069	0.542
MOD_CK2_1	230	236	PF00069	0.409
MOD_CK2_1	242	248	PF00069	0.297
MOD_CK2_1	415	421	PF00069	0.414
MOD_CK2_1	56	62	PF00069	0.331
MOD_GlcNHglycan	125	128	PF01048	0.565
MOD_GlcNHglycan	156	159	PF01048	0.300
MOD_GlcNHglycan	200	203	PF01048	0.448
MOD_GlcNHglycan	257	260	PF01048	0.406
MOD_GlcNHglycan	315	318	PF01048	0.477
MOD_GlcNHglycan	362	365	PF01048	0.531
MOD_GlcNHglycan	369	372	PF01048	0.639
MOD_GlcNHglycan	392	395	PF01048	0.443
MOD_GlcNHglycan	440	443	PF01048	0.380
MOD_GSK3_1	123	130	PF00069	0.541
MOD_GSK3_1	173	180	PF00069	0.454
MOD_GSK3_1	193	200	PF00069	0.521
MOD_GSK3_1	212	219	PF00069	0.537
MOD_GSK3_1	224	231	PF00069	0.445
MOD_GSK3_1	24	31	PF00069	0.397
MOD_GSK3_1	258	265	PF00069	0.387
MOD_GSK3_1	278	285	PF00069	0.333
MOD_GSK3_1	309	316	PF00069	0.569
MOD_GSK3_1	369	376	PF00069	0.536
MOD_GSK3_1	434	441	PF00069	0.434
MOD_LATS_1	22	28	PF00433	0.409
MOD_N-GLC_1	281	286	PF02516	0.429
MOD_N-GLC_1	5	10	PF02516	0.390
MOD_NEK2_1	177	182	PF00069	0.277
MOD_NEK2_1	242	247	PF00069	0.306
MOD_NEK2_1	262	267	PF00069	0.460
MOD_NEK2_1	323	328	PF00069	0.435
MOD_NEK2_1	366	371	PF00069	0.505
MOD_NEK2_1	390	395	PF00069	0.398
MOD_NEK2_2	156	161	PF00069	0.274
MOD_PKA_2	171	177	PF00069	0.278
MOD_PKA_2	198	204	PF00069	0.657
MOD_PKA_2	313	319	PF00069	0.579
MOD_PKA_2	65	71	PF00069	0.392
MOD_PKB_1	3	11	PF00069	0.392
MOD_Plk_1	5	11	PF00069	0.382
MOD_Plk_4	221	227	PF00069	0.473
MOD_Plk_4	258	264	PF00069	0.255
MOD_Plk_4	28	34	PF00069	0.423
MOD_Plk_4	421	427	PF00069	0.411
MOD_ProDKin_1	178	184	PF00069	0.356
MOD_ProDKin_1	224	230	PF00069	0.463
MOD_ProDKin_1	369	375	PF00069	0.545
MOD_SUMO_for_1	136	139	PF00179	0.416
MOD_SUMO_rev_2	230	240	PF00179	0.376
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.463
TRG_ENDOCYTIC_2	121	124	PF00928	0.433
TRG_ENDOCYTIC_2	95	98	PF00928	0.552
TRG_ER_diArg_1	113	115	PF00400	0.449
TRG_ER_diArg_1	184	186	PF00400	0.364
TRG_ER_diArg_1	2	5	PF00400	0.638
TRG_ER_diArg_1	426	428	PF00400	0.420
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGW5	Leptomonas seymouri	69%	100%
A0A1X0NU50	Trypanosomatidae	53%	99%
A0A3R7M6E1	Trypanosoma rangeli	51%	100%
A0A3S7WXB0	Leishmania donovani	84%	100%
A4I006	Leishmania infantum	84%	100%
C9ZSQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
E9AVX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QBK0	Leishmania major	84%	100%
V5B8Q9	Trypanosoma cruzi	50%	98%