RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCI4_LEIBR

TriTrypDb:

LbrM.22.1320 , LBRM2903_220019800

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCI4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.391
CLV_C14_Caspase3-7	221	225	PF00656	0.367
CLV_NRD_NRD_1	279	281	PF00675	0.513
CLV_NRD_NRD_1	308	310	PF00675	0.611
CLV_PCSK_KEX2_1	279	281	PF00082	0.513
CLV_PCSK_KEX2_1	308	310	PF00082	0.611
CLV_PCSK_KEX2_1	331	333	PF00082	0.600
CLV_PCSK_KEX2_1	4	6	PF00082	0.460
CLV_PCSK_KEX2_1	49	51	PF00082	0.498
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.585
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.427
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.496
CLV_PCSK_SKI1_1	272	276	PF00082	0.560
CLV_PCSK_SKI1_1	331	335	PF00082	0.560
CLV_PCSK_SKI1_1	339	343	PF00082	0.469
CLV_PCSK_SKI1_1	4	8	PF00082	0.595
CLV_PCSK_SKI1_1	423	427	PF00082	0.697
CLV_PCSK_SKI1_1	49	53	PF00082	0.502
DEG_APCC_DBOX_1	195	203	PF00400	0.363
DEG_APCC_DBOX_1	271	279	PF00400	0.365
DEG_Nend_Nbox_1	1	3	PF02207	0.637
DOC_CKS1_1	155	160	PF01111	0.367
DOC_MAPK_DCC_7	196	204	PF00069	0.367
DOC_MAPK_MEF2A_6	196	204	PF00069	0.378
DOC_MAPK_MEF2A_6	381	388	PF00069	0.290
DOC_PP1_RVXF_1	337	343	PF00149	0.345
DOC_USP7_MATH_1	301	305	PF00917	0.378
DOC_USP7_MATH_1	361	365	PF00917	0.402
DOC_USP7_MATH_1	44	48	PF00917	0.685
DOC_USP7_MATH_1	452	456	PF00917	0.495
DOC_USP7_UBL2_3	356	360	PF12436	0.301
DOC_WW_Pin1_4	154	159	PF00397	0.363
DOC_WW_Pin1_4	237	242	PF00397	0.420
DOC_WW_Pin1_4	30	35	PF00397	0.689
LIG_14-3-3_CanoR_1	160	165	PF00244	0.421
LIG_14-3-3_CanoR_1	196	200	PF00244	0.376
LIG_14-3-3_CanoR_1	201	205	PF00244	0.377
LIG_14-3-3_CanoR_1	22	28	PF00244	0.731
LIG_Actin_RPEL_3	484	503	PF02755	0.412
LIG_APCC_ABBAyCdc20_2	414	420	PF00400	0.423
LIG_BRCT_BRCA1_1	133	137	PF00533	0.517
LIG_BRCT_BRCA1_1	389	393	PF00533	0.451
LIG_BRCT_BRCA1_1	86	90	PF00533	0.508
LIG_Clathr_ClatBox_1	302	306	PF01394	0.331
LIG_deltaCOP1_diTrp_1	169	178	PF00928	0.389
LIG_FHA_1	279	285	PF00498	0.351
LIG_FHA_1	297	303	PF00498	0.336
LIG_FHA_1	381	387	PF00498	0.368
LIG_FHA_1	398	404	PF00498	0.497
LIG_FHA_1	424	430	PF00498	0.442
LIG_FHA_1	67	73	PF00498	0.376
LIG_FHA_1	79	85	PF00498	0.343
LIG_FHA_2	164	170	PF00498	0.482
LIG_FHA_2	321	327	PF00498	0.375
LIG_FHA_2	464	470	PF00498	0.517
LIG_FHA_2	9	15	PF00498	0.735
LIG_FXI_DFP_1	128	132	PF00024	0.597
LIG_IBAR_NPY_1	498	500	PF08397	0.445
LIG_LIR_Apic_2	240	245	PF02991	0.389
LIG_LIR_Apic_2	349	355	PF02991	0.354
LIG_LIR_Apic_2	479	485	PF02991	0.413
LIG_LIR_Gen_1	169	180	PF02991	0.387
LIG_LIR_Nem_3	169	175	PF02991	0.390
LIG_LIR_Nem_3	469	473	PF02991	0.512
LIG_PDZ_Class_2	499	504	PF00595	0.421
LIG_Pex14_1	172	176	PF04695	0.377
LIG_PTAP_UEV_1	388	393	PF05743	0.374
LIG_PTB_Apo_2	289	296	PF02174	0.305
LIG_PTB_Apo_2	95	102	PF02174	0.401
LIG_PTB_Phospho_1	95	101	PF10480	0.401
LIG_SH2_CRK	482	486	PF00017	0.485
LIG_SH2_CRK	500	504	PF00017	0.346
LIG_SH2_NCK_1	106	110	PF00017	0.547
LIG_SH2_NCK_1	482	486	PF00017	0.551
LIG_SH2_STAP1	101	105	PF00017	0.406
LIG_SH2_STAP1	500	504	PF00017	0.466
LIG_SH2_STAT5	164	167	PF00017	0.485
LIG_SH2_STAT5	500	503	PF00017	0.386
LIG_SH3_3	383	389	PF00018	0.365
LIG_SUMO_SIM_anti_2	55	60	PF11976	0.374
LIG_SUMO_SIM_par_1	301	306	PF11976	0.331
LIG_SUMO_SIM_par_1	382	387	PF11976	0.360
LIG_TRAF2_1	413	416	PF00917	0.480
LIG_TRAF2_1	455	458	PF00917	0.524
LIG_TRFH_1	495	499	PF08558	0.449
LIG_WRC_WIRS_1	175	180	PF05994	0.384
MOD_CDK_SPxK_1	154	160	PF00069	0.366
MOD_CK1_1	104	110	PF00069	0.608
MOD_CK1_1	153	159	PF00069	0.532
MOD_CK1_1	364	370	PF00069	0.414
MOD_CK1_1	431	437	PF00069	0.536
MOD_CK1_1	439	445	PF00069	0.489
MOD_CK1_1	77	83	PF00069	0.497
MOD_CK2_1	163	169	PF00069	0.426
MOD_CK2_1	452	458	PF00069	0.533
MOD_CK2_1	463	469	PF00069	0.537
MOD_CK2_1	8	14	PF00069	0.733
MOD_GlcNHglycan	107	110	PF01048	0.755
MOD_GlcNHglycan	389	392	PF01048	0.591
MOD_GlcNHglycan	430	433	PF01048	0.726
MOD_GlcNHglycan	438	441	PF01048	0.659
MOD_GSK3_1	100	107	PF00069	0.579
MOD_GSK3_1	118	125	PF00069	0.441
MOD_GSK3_1	146	153	PF00069	0.411
MOD_GSK3_1	434	441	PF00069	0.569
MOD_GSK3_1	476	483	PF00069	0.388
MOD_GSK3_1	74	81	PF00069	0.488
MOD_N-GLC_1	295	300	PF02516	0.638
MOD_N-GLC_1	8	13	PF02516	0.522
MOD_N-GLC_1	99	104	PF02516	0.712
MOD_N-GLC_2	260	262	PF02516	0.611
MOD_NEK2_1	195	200	PF00069	0.352
MOD_NEK2_1	278	283	PF00069	0.380
MOD_NEK2_1	290	295	PF00069	0.289
MOD_NEK2_1	341	346	PF00069	0.448
MOD_NEK2_1	421	426	PF00069	0.478
MOD_NEK2_1	428	433	PF00069	0.505
MOD_NEK2_1	436	441	PF00069	0.455
MOD_PIKK_1	150	156	PF00454	0.512
MOD_PIKK_1	310	316	PF00454	0.470
MOD_PIKK_1	431	437	PF00454	0.498
MOD_PKA_1	308	314	PF00069	0.426
MOD_PKA_2	195	201	PF00069	0.373
MOD_PKA_2	278	284	PF00069	0.358
MOD_PKA_2	308	314	PF00069	0.493
MOD_PKA_2	380	386	PF00069	0.417
MOD_PKA_2	45	51	PF00069	0.695
MOD_PKA_2	92	98	PF00069	0.576
MOD_Plk_1	326	332	PF00069	0.373
MOD_Plk_1	364	370	PF00069	0.414
MOD_Plk_1	54	60	PF00069	0.517
MOD_Plk_1	8	14	PF00069	0.724
MOD_Plk_4	101	107	PF00069	0.562
MOD_Plk_4	124	130	PF00069	0.532
MOD_Plk_4	160	166	PF00069	0.484
MOD_Plk_4	290	296	PF00069	0.265
MOD_Plk_4	380	386	PF00069	0.365
MOD_Plk_4	498	504	PF00069	0.469
MOD_Plk_4	74	80	PF00069	0.580
MOD_Plk_4	8	14	PF00069	0.741
MOD_ProDKin_1	154	160	PF00069	0.366
MOD_ProDKin_1	237	243	PF00069	0.418
MOD_ProDKin_1	30	36	PF00069	0.691
MOD_SUMO_for_1	96	99	PF00179	0.511
TRG_DiLeu_BaEn_1	349	354	PF01217	0.359
TRG_DiLeu_BaEn_1	55	60	PF01217	0.300
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.398
TRG_ENDOCYTIC_2	500	503	PF00928	0.472
TRG_ER_diArg_1	278	280	PF00400	0.306
TRG_ER_diArg_1	90	93	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J803	Bodo saltans	34%	97%
A0A1X0NV61	Trypanosomatidae	40%	100%
A0A3Q8ICC1	Leishmania donovani	84%	99%
A4I003	Leishmania infantum	84%	99%
E9AVX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QBK3	Leishmania major	84%	100%