I/6 autoantigen-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

i/6 autoantigen-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCI3_LEIBR

TriTrypDb:

LbrM.22.1340 , LBRM2903_220020000

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCI3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005509	calcium ion binding	5	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.441
CLV_NRD_NRD_1	162	164	PF00675	0.489
CLV_NRD_NRD_1	202	204	PF00675	0.510
CLV_PCSK_KEX2_1	11	13	PF00082	0.447
CLV_PCSK_KEX2_1	152	154	PF00082	0.480
CLV_PCSK_KEX2_1	161	163	PF00082	0.526
CLV_PCSK_KEX2_1	201	203	PF00082	0.516
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.447
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.622
CLV_PCSK_SKI1_1	12	16	PF00082	0.428
CLV_PCSK_SKI1_1	206	210	PF00082	0.552
DEG_APCC_DBOX_1	93	101	PF00400	0.546
DEG_Nend_Nbox_1	1	3	PF02207	0.502
DOC_USP7_MATH_1	157	161	PF00917	0.389
DOC_USP7_MATH_1	86	90	PF00917	0.571
DOC_USP7_UBL2_3	103	107	PF12436	0.682
DOC_USP7_UBL2_3	189	193	PF12436	0.720
DOC_WW_Pin1_4	1	6	PF00397	0.625
DOC_WW_Pin1_4	38	43	PF00397	0.530
LIG_14-3-3_CanoR_1	180	185	PF00244	0.512
LIG_14-3-3_CanoR_1	25	31	PF00244	0.384
LIG_14-3-3_CanoR_1	68	74	PF00244	0.446
LIG_FAT_LD_1	97	105	PF03623	0.426
LIG_FHA_1	131	137	PF00498	0.369
LIG_FHA_2	119	125	PF00498	0.492
LIG_FHA_2	13	19	PF00498	0.518
LIG_FHA_2	41	47	PF00498	0.452
LIG_FHA_2	56	62	PF00498	0.333
LIG_LIR_Gen_1	117	124	PF02991	0.477
LIG_LIR_Gen_1	61	67	PF02991	0.397
LIG_LIR_Nem_3	117	123	PF02991	0.480
LIG_LIR_Nem_3	61	65	PF02991	0.473
LIG_SH2_PTP2	82	85	PF00017	0.337
LIG_SH2_STAT3	53	56	PF00017	0.559
LIG_SH2_STAT5	37	40	PF00017	0.517
LIG_SH2_STAT5	82	85	PF00017	0.337
LIG_SH3_3	82	88	PF00018	0.462
LIG_SUMO_SIM_anti_2	17	24	PF11976	0.476
LIG_TRAF2_1	75	78	PF00917	0.515
LIG_TRAF2_1	96	99	PF00917	0.471
LIG_UBA3_1	100	107	PF00899	0.455
LIG_UBA3_1	119	128	PF00899	0.477
LIG_UBA3_1	136	143	PF00899	0.312
MOD_CK1_1	72	78	PF00069	0.462
MOD_CK2_1	191	197	PF00069	0.803
MOD_CK2_1	40	46	PF00069	0.439
MOD_CK2_1	55	61	PF00069	0.379
MOD_CK2_1	72	78	PF00069	0.397
MOD_CK2_1	93	99	PF00069	0.467
MOD_GlcNHglycan	74	77	PF01048	0.534
MOD_GlcNHglycan	88	91	PF01048	0.626
MOD_GSK3_1	118	125	PF00069	0.453
MOD_GSK3_1	191	198	PF00069	0.700
MOD_GSK3_1	68	75	PF00069	0.547
MOD_GSK3_1	86	93	PF00069	0.354
MOD_N-GLC_1	68	73	PF02516	0.557
MOD_PIKK_1	175	181	PF00454	0.473
MOD_PKA_2	67	73	PF00069	0.457
MOD_PKA_2	93	99	PF00069	0.467
MOD_Plk_1	68	74	PF00069	0.508
MOD_Plk_4	69	75	PF00069	0.526
MOD_ProDKin_1	1	7	PF00069	0.627
MOD_ProDKin_1	38	44	PF00069	0.525
MOD_SUMO_rev_2	178	187	PF00179	0.593
MOD_SUMO_rev_2	199	209	PF00179	0.703
TRG_ENDOCYTIC_2	82	85	PF00928	0.337
TRG_ER_diArg_1	152	154	PF00400	0.395
TRG_ER_diArg_1	201	203	PF00400	0.516
TRG_ER_FFAT_2	67	78	PF00635	0.390
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S4	Leptomonas seymouri	66%	94%
A0A1X0NTK1	Trypanosomatidae	42%	96%
A0A3Q8IAT1	Leishmania donovani	69%	100%
A0A422N4A4	Trypanosoma rangeli	42%	100%
A4I005	Leishmania infantum	69%	100%
C9ZSQ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	87%
C9ZSQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AVX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
Q26768	Trypanosoma brucei brucei	35%	87%
Q4QBK1	Leishmania major	58%	95%