Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fk506-binding protein 1-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCI1_LEIBR

TriTrypDb:

LbrM.22.1310 , LBRM2903_220019700

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HCI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCI1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	3
GO:0003824	catalytic activity	1	3
GO:0016853	isomerase activity	2	3
GO:0016859	cis-trans isomerase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	41	43	PF00675	0.532
CLV_PCSK_KEX2_1	41	43	PF00082	0.485
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.485
DEG_Nend_UBRbox_3	1	3	PF02207	0.420
DOC_AGCK_PIF_1	21	26	PF00069	0.413
DOC_CKS1_1	28	33	PF01111	0.418
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.207
DOC_CYCLIN_yCln2_LP_2	172	175	PF00134	0.177
DOC_MAPK_gen_1	41	49	PF00069	0.468
DOC_MAPK_gen_1	60	68	PF00069	0.518
DOC_PP1_RVXF_1	44	50	PF00149	0.457
DOC_PP2B_LxvP_1	156	159	PF13499	0.207
DOC_PP2B_LxvP_1	172	175	PF13499	0.177
DOC_USP7_MATH_1	33	37	PF00917	0.452
DOC_WW_Pin1_4	27	32	PF00397	0.415
DOC_WW_Pin1_4	67	72	PF00397	0.503
LIG_14-3-3_CanoR_1	153	159	PF00244	0.207
LIG_14-3-3_CanoR_1	65	71	PF00244	0.461
LIG_BRCT_BRCA1_1	9	13	PF00533	0.519
LIG_FHA_2	182	188	PF00498	0.207
LIG_FHA_2	72	78	PF00498	0.443
LIG_LIR_Gen_1	25	33	PF02991	0.435
LIG_LIR_Nem_3	10	16	PF02991	0.471
LIG_LIR_Nem_3	105	111	PF02991	0.275
LIG_LIR_Nem_3	167	172	PF02991	0.247
LIG_LIR_Nem_3	25	29	PF02991	0.480
LIG_MYND_1	170	174	PF01753	0.207
LIG_PDZ_Class_3	184	189	PF00595	0.266
LIG_SH2_STAT5	108	111	PF00017	0.207
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.306
LIG_SUMO_SIM_par_1	102	107	PF11976	0.207
LIG_WRC_WIRS_1	23	28	PF05994	0.508
MOD_CK1_1	102	108	PF00069	0.348
MOD_CK1_1	154	160	PF00069	0.207
MOD_CK1_1	36	42	PF00069	0.474
MOD_CK2_1	117	123	PF00069	0.207
MOD_CK2_1	146	152	PF00069	0.207
MOD_Cter_Amidation	39	42	PF01082	0.480
MOD_GSK3_1	113	120	PF00069	0.232
MOD_GSK3_1	154	161	PF00069	0.207
MOD_GSK3_1	67	74	PF00069	0.475
MOD_N-GLC_1	175	180	PF02516	0.272
MOD_NEK2_1	181	186	PF00069	0.214
MOD_NEK2_1	51	56	PF00069	0.477
MOD_NEK2_1	66	71	PF00069	0.434
MOD_NEK2_1	7	12	PF00069	0.423
MOD_PK_1	99	105	PF00069	0.207
MOD_PKA_2	66	72	PF00069	0.465
MOD_Plk_1	118	124	PF00069	0.369
MOD_Plk_1	175	181	PF00069	0.269
MOD_Plk_4	175	181	PF00069	0.269
MOD_Plk_4	99	105	PF00069	0.250
MOD_ProDKin_1	27	33	PF00069	0.418
MOD_ProDKin_1	67	73	PF00069	0.503
MOD_SUMO_rev_2	87	97	PF00179	0.317
TRG_ER_diArg_1	65	68	PF00400	0.578
TRG_NLS_MonoExtN_4	38	45	PF00514	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AN99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
O46638	Oryctolagus cuniculus	32%	84%
P26884	Bos taurus	37%	84%
P51752	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	32%	82%
Q00688	Homo sapiens	37%	84%
Q8K943	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	30%	75%