Farnesyl pyrophosphate synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

farnesyl pyrophosphate synthase

Species:

Leishmania braziliensis

UniProt:

A4HCH8_LEIBR

TriTrypDb:

LbrM.22.1240 , LBRM2903_220019000

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Expansion

Sequence features

A4HCH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCH8

PDB structure(s): 4jzb_A , 4jzb_B , 4jzx_A , 4jzx_B , 4k10_A , 4k10_B , 4k10_C , 4k10_D , 6vjc_A , 6vjc_B , 6w7i_A , 6w7i_B , 6ww1_A , 6ww1_B

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006720	isoprenoid metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008299	isoprenoid biosynthetic process	4	11
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006644	phospholipid metabolic process	4	1
GO:0006721	terpenoid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0016114	terpenoid biosynthetic process	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0045337	farnesyl diphosphate biosynthetic process	6	1
GO:0045338	farnesyl diphosphate metabolic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004161	dimethylallyltranstransferase activity	5	6
GO:0004337	geranyltranstransferase activity	5	7
GO:0004659	prenyltransferase activity	4	8
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.434
CLV_C14_Caspase3-7	99	103	PF00656	0.225
CLV_NRD_NRD_1	107	109	PF00675	0.329
CLV_NRD_NRD_1	201	203	PF00675	0.434
CLV_NRD_NRD_1	31	33	PF00675	0.430
CLV_NRD_NRD_1	359	361	PF00675	0.404
CLV_PCSK_KEX2_1	107	109	PF00082	0.329
CLV_PCSK_KEX2_1	201	203	PF00082	0.302
CLV_PCSK_KEX2_1	24	26	PF00082	0.532
CLV_PCSK_KEX2_1	33	35	PF00082	0.284
CLV_PCSK_KEX2_1	359	361	PF00082	0.391
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.532
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.434
CLV_PCSK_SKI1_1	146	150	PF00082	0.302
CLV_PCSK_SKI1_1	232	236	PF00082	0.438
CLV_PCSK_SKI1_1	34	38	PF00082	0.280
CLV_Separin_Metazoa	151	155	PF03568	0.434
DEG_APCC_DBOX_1	145	153	PF00400	0.302
DOC_MAPK_gen_1	24	30	PF00069	0.466
DOC_MAPK_gen_1	48	58	PF00069	0.302
DOC_MAPK_MEF2A_6	273	281	PF00069	0.320
DOC_PP1_RVXF_1	349	355	PF00149	0.478
DOC_PP4_FxxP_1	256	259	PF00568	0.302
DOC_USP7_MATH_1	272	276	PF00917	0.329
DOC_USP7_UBL2_3	33	37	PF12436	0.434
DOC_WW_Pin1_4	193	198	PF00397	0.453
DOC_WW_Pin1_4	255	260	PF00397	0.303
LIG_APCC_ABBA_1	153	158	PF00400	0.434
LIG_EH1_1	168	176	PF00400	0.434
LIG_eIF4E_1	312	318	PF01652	0.426
LIG_FHA_1	118	124	PF00498	0.434
LIG_FHA_1	160	166	PF00498	0.412
LIG_FHA_1	170	176	PF00498	0.404
LIG_FHA_1	188	194	PF00498	0.374
LIG_FHA_1	210	216	PF00498	0.316
LIG_FHA_1	233	239	PF00498	0.345
LIG_FHA_1	40	46	PF00498	0.302
LIG_FHA_2	255	261	PF00498	0.302
LIG_FHA_2	265	271	PF00498	0.302
LIG_FHA_2	74	80	PF00498	0.468
LIG_LIR_Apic_2	212	216	PF02991	0.302
LIG_LIR_Apic_2	254	259	PF02991	0.302
LIG_LIR_Gen_1	275	284	PF02991	0.320
LIG_LIR_Gen_1	5	14	PF02991	0.402
LIG_LIR_Nem_3	189	195	PF02991	0.302
LIG_LIR_Nem_3	208	213	PF02991	0.320
LIG_LIR_Nem_3	244	248	PF02991	0.310
LIG_LIR_Nem_3	275	279	PF02991	0.320
LIG_LIR_Nem_3	280	284	PF02991	0.320
LIG_LIR_Nem_3	5	10	PF02991	0.380
LIG_NRP_CendR_1	359	362	PF00754	0.321
LIG_Pex14_1	354	358	PF04695	0.398
LIG_Rb_pABgroove_1	163	171	PF01858	0.327
LIG_SH2_NCK_1	11	15	PF00017	0.368
LIG_SH2_SRC	11	14	PF00017	0.373
LIG_SH2_SRC	114	117	PF00017	0.458
LIG_SH2_STAP1	211	215	PF00017	0.302
LIG_SH2_STAT3	312	315	PF00017	0.374
LIG_SH2_STAT3	358	361	PF00017	0.465
LIG_SH2_STAT5	114	117	PF00017	0.434
LIG_SH2_STAT5	142	145	PF00017	0.322
LIG_SH2_STAT5	192	195	PF00017	0.421
LIG_SH2_STAT5	211	214	PF00017	0.187
LIG_SH2_STAT5	245	248	PF00017	0.320
LIG_SH2_STAT5	35	38	PF00017	0.306
LIG_SUMO_SIM_anti_2	127	133	PF11976	0.434
LIG_SUMO_SIM_par_1	333	340	PF11976	0.397
LIG_SUMO_SIM_par_1	54	60	PF11976	0.381
MOD_CDC14_SPxK_1	258	261	PF00782	0.222
MOD_CDK_SPxK_1	255	261	PF00069	0.222
MOD_CK2_1	17	23	PF00069	0.321
MOD_CK2_1	254	260	PF00069	0.302
MOD_CK2_1	264	270	PF00069	0.302
MOD_GlcNHglycan	176	179	PF01048	0.455
MOD_GlcNHglycan	223	226	PF01048	0.381
MOD_GlcNHglycan	298	301	PF01048	0.514
MOD_GSK3_1	170	177	PF00069	0.302
MOD_GSK3_1	205	212	PF00069	0.302
MOD_GSK3_1	232	239	PF00069	0.449
MOD_N-GLC_1	187	192	PF02516	0.374
MOD_NEK2_1	101	106	PF00069	0.302
MOD_NEK2_1	161	166	PF00069	0.449
MOD_NEK2_1	174	179	PF00069	0.302
MOD_NEK2_1	221	226	PF00069	0.363
MOD_NEK2_1	277	282	PF00069	0.302
MOD_NEK2_1	346	351	PF00069	0.359
MOD_NEK2_1	39	44	PF00069	0.306
MOD_NEK2_1	73	78	PF00069	0.445
MOD_PIKK_1	118	124	PF00454	0.320
MOD_PIKK_1	133	139	PF00454	0.329
MOD_Plk_1	169	175	PF00069	0.302
MOD_Plk_1	40	46	PF00069	0.302
MOD_Plk_1	73	79	PF00069	0.222
MOD_Plk_2-3	170	176	PF00069	0.302
MOD_Plk_4	170	176	PF00069	0.345
MOD_Plk_4	209	215	PF00069	0.319
MOD_Plk_4	236	242	PF00069	0.222
MOD_Plk_4	272	278	PF00069	0.302
MOD_ProDKin_1	193	199	PF00069	0.453
MOD_ProDKin_1	255	261	PF00069	0.303
MOD_SUMO_rev_2	268	275	PF00179	0.302
MOD_SUMO_rev_2	288	295	PF00179	0.175
TRG_DiLeu_BaEn_1	331	336	PF01217	0.396
TRG_DiLeu_BaEn_3	12	18	PF01217	0.425
TRG_ENDOCYTIC_2	11	14	PF00928	0.354
TRG_ENDOCYTIC_2	195	198	PF00928	0.318
TRG_ENDOCYTIC_2	245	248	PF00928	0.331
TRG_ER_diArg_1	107	110	PF00400	0.356
TRG_ER_diArg_1	201	203	PF00400	0.434
TRG_ER_diArg_1	32	35	PF00400	0.311
TRG_ER_diArg_1	358	360	PF00400	0.296
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT48	Leptomonas seymouri	82%	100%
A0A1D8PH78	Candida albicans (strain SC5314 / ATCC MYA-2876)	34%	100%
A0A1X0NV51	Trypanosomatidae	65%	100%
A0A343W969	Murgantia histrionica	24%	94%
A0A343W970	Murgantia histrionica	33%	89%
A0A386JV86	Nezara viridula	27%	96%
A0A386JVA3	Nezara viridula	35%	90%
A0A3Q8IEB9	Leishmania donovani	91%	100%
A0A3R7K303	Trypanosoma rangeli	62%	100%
B4YA15	Ganoderma lucidum	33%	100%
C9ZSP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	99%
D7PHZ5	Penicillium aethiopicum	34%	100%
E9AH04	Leishmania infantum	91%	100%
E9AVW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O14230	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
O24241	Parthenium argentatum	40%	100%
O24242	Parthenium argentatum	40%	100%
O59703	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
O64905	Helianthus annuus	40%	100%
P05369	Rattus norvegicus	37%	100%
P08524	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P08836	Gallus gallus	36%	99%
P0C565	Tanacetum cinerariifolium	35%	92%
P14324	Homo sapiens	38%	86%
P49349	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	35%	100%
P49350	Artemisia annua	40%	100%
P49351	Lupinus albus	41%	100%
P49352	Lupinus albus	40%	100%
P49353	Zea mays	43%	100%
Q09152	Arabidopsis thaliana	40%	94%
Q43315	Arabidopsis thaliana	41%	100%
Q4JHN6	Panax ginseng	40%	100%
Q4QBL1	Leishmania major	91%	100%
Q4WEB8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	34%	100%
Q54XP1	Dictyostelium discoideum	33%	100%
Q55EU7	Dictyostelium discoideum	26%	92%
Q58GE8	Ips pini	26%	87%
Q7XYS8	Artemisia spiciformis	35%	92%
Q7XYS9	Artemisia spiciformis	40%	100%
Q7XYT0	Artemisia spiciformis	40%	100%
Q8WMY2	Bos taurus	35%	100%
Q920E5	Mus musculus	39%	100%
Q92235	Gibberella fujikuroi	35%	100%
Q92250	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
Q9NH03	Dictyostelium discoideum	37%	95%
V5BDA5	Trypanosoma cruzi	62%	100%
V6RG22	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	34%	100%