MORN repeat family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCH7_LEIBR

TriTrypDb:

LbrM.22.1280 , LBRM2903_220019400

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0005815	microtubule organizing center	2	1
GO:0005816	spindle pole body	3	1
GO:0036064	ciliary basal body	3	1
GO:0044732	mitotic spindle pole body	4	1
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HCH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCH7

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.250
CLV_NRD_NRD_1	118	120	PF00675	0.393
CLV_NRD_NRD_1	381	383	PF00675	0.544
CLV_NRD_NRD_1	52	54	PF00675	0.486
CLV_PCSK_KEX2_1	118	120	PF00082	0.332
CLV_PCSK_KEX2_1	325	327	PF00082	0.331
CLV_PCSK_KEX2_1	52	54	PF00082	0.486
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.331
CLV_PCSK_SKI1_1	9	13	PF00082	0.694
DEG_APCC_DBOX_1	78	86	PF00400	0.638
DEG_APCC_DBOX_1	8	16	PF00400	0.681
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.669
DOC_MAPK_FxFP_2	93	96	PF00069	0.557
DOC_PP4_FxxP_1	93	96	PF00568	0.557
DOC_USP7_MATH_1	285	289	PF00917	0.335
DOC_USP7_MATH_1	62	66	PF00917	0.563
DOC_USP7_UBL2_3	159	163	PF12436	0.409
LIG_14-3-3_CanoR_1	81	86	PF00244	0.603
LIG_BIR_II_1	1	5	PF00653	0.720
LIG_BIR_III_1	1	5	PF00653	0.425
LIG_BIR_III_3	1	5	PF00653	0.425
LIG_deltaCOP1_diTrp_1	293	299	PF00928	0.397
LIG_FHA_1	199	205	PF00498	0.283
LIG_FHA_1	302	308	PF00498	0.436
LIG_FHA_1	397	403	PF00498	0.619
LIG_Integrin_RGDW_4	197	200	PF00362	0.393
LIG_LIR_Apic_2	210	214	PF02991	0.397
LIG_LIR_Apic_2	304	308	PF02991	0.489
LIG_LIR_Apic_2	92	96	PF02991	0.558
LIG_LIR_Gen_1	144	151	PF02991	0.508
LIG_LIR_Gen_1	68	78	PF02991	0.319
LIG_LIR_Gen_1	88	96	PF02991	0.484
LIG_LIR_Nem_3	144	150	PF02991	0.475
LIG_LIR_Nem_3	270	276	PF02991	0.331
LIG_LIR_Nem_3	68	74	PF02991	0.582
LIG_LIR_Nem_3	88	93	PF02991	0.470
LIG_SH2_CRK	147	151	PF00017	0.519
LIG_SH2_CRK	273	277	PF00017	0.411
LIG_SH2_GRB2like	321	324	PF00017	0.470
LIG_SH2_SRC	211	214	PF00017	0.386
LIG_SH2_SRC	321	324	PF00017	0.250
LIG_SH2_STAT5	173	176	PF00017	0.294
LIG_SH2_STAT5	188	191	PF00017	0.371
LIG_SH2_STAT5	211	214	PF00017	0.287
LIG_SH2_STAT5	242	245	PF00017	0.312
LIG_SH2_STAT5	317	320	PF00017	0.371
LIG_SH2_STAT5	332	335	PF00017	0.353
LIG_SH2_STAT5	377	380	PF00017	0.523
LIG_SH2_STAT6	89	93	PF00017	0.555
LIG_WRC_WIRS_1	90	95	PF05994	0.535
MOD_CK1_1	256	262	PF00069	0.438
MOD_CK1_1	335	341	PF00069	0.436
MOD_CK1_1	57	63	PF00069	0.416
MOD_CK1_1	65	71	PF00069	0.341
MOD_CK2_1	25	31	PF00069	0.517
MOD_Cter_Amidation	323	326	PF01082	0.352
MOD_GlcNHglycan	143	146	PF01048	0.481
MOD_GlcNHglycan	214	217	PF01048	0.327
MOD_GlcNHglycan	59	62	PF01048	0.599
MOD_GlcNHglycan	66	70	PF01048	0.561
MOD_GSK3_1	230	237	PF00069	0.384
MOD_GSK3_1	253	260	PF00069	0.317
MOD_GSK3_1	331	338	PF00069	0.431
MOD_GSK3_1	373	380	PF00069	0.319
MOD_N-GLC_1	207	212	PF02516	0.422
MOD_N-GLC_1	285	290	PF02516	0.331
MOD_NEK2_1	117	122	PF00069	0.403
MOD_NEK2_1	25	30	PF00069	0.588
MOD_NEK2_1	257	262	PF00069	0.573
MOD_PIKK_1	403	409	PF00454	0.348
MOD_PIKK_1	54	60	PF00454	0.415
MOD_PKA_2	117	123	PF00069	0.401
MOD_PKA_2	230	236	PF00069	0.332
MOD_PKA_2	265	271	PF00069	0.522
MOD_PKA_2	301	307	PF00069	0.436
MOD_PKA_2	315	321	PF00069	0.341
MOD_PKA_2	80	86	PF00069	0.571
MOD_PKB_1	79	87	PF00069	0.631
MOD_Plk_1	178	184	PF00069	0.403
MOD_Plk_1	5	11	PF00069	0.675
MOD_Plk_1	65	71	PF00069	0.500
MOD_Plk_4	151	157	PF00069	0.362
MOD_Plk_4	207	213	PF00069	0.323
MOD_Plk_4	358	364	PF00069	0.550
MOD_Plk_4	373	379	PF00069	0.332
MOD_Plk_4	89	95	PF00069	0.342
MOD_SUMO_for_1	217	220	PF00179	0.430
MOD_SUMO_rev_2	125	132	PF00179	0.351
MOD_SUMO_rev_2	154	160	PF00179	0.370
TRG_DiLeu_BaEn_2	127	133	PF01217	0.272
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.564
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.684
TRG_ENDOCYTIC_2	147	150	PF00928	0.491
TRG_ENDOCYTIC_2	273	276	PF00928	0.436
TRG_ENDOCYTIC_2	90	93	PF00928	0.481
TRG_ER_diArg_1	117	119	PF00400	0.393
TRG_ER_diArg_1	224	227	PF00400	0.484
TRG_ER_diArg_1	296	299	PF00400	0.431
TRG_LysEnd_GGAAcLL_1	411	417	PF00790	0.494
TRG_NES_CRM1_1	66	80	PF08389	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIF6	Leptomonas seymouri	79%	73%
A0A0N1IIK8	Leptomonas seymouri	37%	100%
A0A0S4J443	Bodo saltans	26%	94%
A0A0S4JES9	Bodo saltans	30%	82%
A0A0S4KIY0	Bodo saltans	37%	100%
A0A0S4KKM9	Bodo saltans	30%	78%
A0A1X0NTG8	Trypanosomatidae	44%	95%
A0A1X0P1A5	Trypanosomatidae	38%	100%
A0A1X0P3N0	Trypanosomatidae	24%	100%
A0A1X0P769	Trypanosomatidae	31%	74%
A0A3R7M394	Trypanosoma rangeli	24%	100%
A0A3R7NAK8	Trypanosoma rangeli	44%	100%
A0A3S7WXA1	Leishmania donovani	87%	79%
A0A3S7X3U7	Leishmania donovani	37%	100%
A0A3S7XBA2	Leishmania donovani	24%	100%
A0A422P0W0	Trypanosoma rangeli	38%	100%
A4HIR9	Leishmania braziliensis	35%	100%
A4HPP6	Leishmania braziliensis	24%	100%
A4HZZ9	Leishmania infantum	87%	79%
A4I615	Leishmania infantum	37%	100%
A4ID18	Leishmania infantum	24%	100%
C9ZRE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZSQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	95%
E9ATG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AVX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B1A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4Q137	Leishmania major	24%	100%
Q4Q6V8	Leishmania major	37%	100%
Q4QBK7	Leishmania major	87%	100%
V5BGR9	Trypanosoma cruzi	31%	75%