DUF4101 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCH6_LEIBR

TriTrypDb:

LbrM.22.1270 , LBRM2903_220019300

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.589
CLV_PCSK_SKI1_1	150	154	PF00082	0.334
CLV_PCSK_SKI1_1	167	171	PF00082	0.461
CLV_PCSK_SKI1_1	206	210	PF00082	0.389
CLV_PCSK_SKI1_1	221	225	PF00082	0.379
CLV_PCSK_SKI1_1	238	242	PF00082	0.402
CLV_Separin_Metazoa	10	14	PF03568	0.623
DEG_APCC_DBOX_1	237	245	PF00400	0.293
DOC_MAPK_MEF2A_6	206	215	PF00069	0.345
DOC_USP7_MATH_1	45	49	PF00917	0.758
DOC_USP7_MATH_1	50	54	PF00917	0.751
DOC_USP7_UBL2_3	91	95	PF12436	0.499
DOC_WW_Pin1_4	257	262	PF00397	0.409
DOC_WW_Pin1_4	35	40	PF00397	0.536
LIG_14-3-3_CanoR_1	150	155	PF00244	0.333
LIG_14-3-3_CanoR_1	167	173	PF00244	0.406
LIG_14-3-3_CanoR_1	17	22	PF00244	0.581
LIG_14-3-3_CanoR_1	193	197	PF00244	0.368
LIG_14-3-3_CanoR_1	221	229	PF00244	0.399
LIG_14-3-3_CanoR_1	29	39	PF00244	0.635
LIG_APCC_ABBA_1	154	159	PF00400	0.579
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_BIR_III_4	234	238	PF00653	0.498
LIG_FHA_1	169	175	PF00498	0.471
LIG_FHA_1	210	216	PF00498	0.356
LIG_FHA_1	222	228	PF00498	0.387
LIG_LIR_Nem_3	234	239	PF02991	0.517
LIG_PDZ_Class_3	262	267	PF00595	0.712
LIG_REV1ctd_RIR_1	90	99	PF16727	0.405
LIG_SH2_STAP1	88	92	PF00017	0.395
LIG_SH2_STAT5	144	147	PF00017	0.537
LIG_SH2_STAT5	157	160	PF00017	0.332
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.422
LIG_SUMO_SIM_par_1	207	212	PF11976	0.422
LIG_UBA3_1	208	216	PF00899	0.526
LIG_WRC_WIRS_1	18	23	PF05994	0.679
MOD_CK1_1	20	26	PF00069	0.660
MOD_CK1_1	204	210	PF00069	0.486
MOD_CK2_1	4	10	PF00069	0.643
MOD_CK2_1	45	51	PF00069	0.697
MOD_Cter_Amidation	76	79	PF01082	0.428
MOD_GlcNHglycan	202	206	PF01048	0.425
MOD_GlcNHglycan	23	26	PF01048	0.670
MOD_GlcNHglycan	231	234	PF01048	0.421
MOD_GlcNHglycan	33	36	PF01048	0.510
MOD_GlcNHglycan	51	55	PF01048	0.733
MOD_GSK3_1	13	20	PF00069	0.602
MOD_GSK3_1	200	207	PF00069	0.484
MOD_GSK3_1	257	264	PF00069	0.574
MOD_GSK3_1	31	38	PF00069	0.629
MOD_GSK3_1	45	52	PF00069	0.712
MOD_N-GLC_1	117	122	PF02516	0.407
MOD_NEK2_1	192	197	PF00069	0.521
MOD_NEK2_1	209	214	PF00069	0.333
MOD_NEK2_1	21	26	PF00069	0.650
MOD_PKA_2	185	191	PF00069	0.598
MOD_PKA_2	192	198	PF00069	0.484
MOD_Plk_1	136	142	PF00069	0.364
MOD_Plk_1	4	10	PF00069	0.447
MOD_Plk_1	54	60	PF00069	0.653
MOD_Plk_4	192	198	PF00069	0.512
MOD_ProDKin_1	257	263	PF00069	0.408
MOD_ProDKin_1	35	41	PF00069	0.536
MOD_SUMO_rev_2	183	192	PF00179	0.602
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J7D9	Bodo saltans	44%	79%
A0A1X0NU43	Trypanosomatidae	41%	74%
A0A422N2C4	Trypanosoma rangeli	40%	77%
C9ZSQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	70%
E9AH07	Leishmania infantum	78%	100%
E9AVX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QBK8	Leishmania major	74%	97%
V5D4J4	Trypanosoma cruzi	38%	78%