Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 11, putative

Species:

Leishmania braziliensis

UniProt:

A4HCH5_LEIBR

TriTrypDb:

LbrM.22.1230 , LBRM2903_220018900

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	3
GO:0005794	Golgi apparatus	5	3
GO:0016020	membrane	2	14
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	14

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Expansion

Sequence features

A4HCH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCH5

Function

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Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	3
GO:0006605	protein targeting	5	3
GO:0006612	protein targeting to membrane	5	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0006810	transport	3	3
GO:0006886	intracellular protein transport	4	3
GO:0006897	endocytosis	5	3
GO:0008104	protein localization	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016409	palmitoyltransferase activity	5	14
GO:0016417	S-acyltransferase activity	5	14
GO:0016740	transferase activity	2	14
GO:0016746	acyltransferase activity	3	14
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	14
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	14
GO:0019707	protein-cysteine S-acyltransferase activity	3	14
GO:0140096	catalytic activity, acting on a protein	2	14

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.262
CLV_NRD_NRD_1	257	259	PF00675	0.389
CLV_NRD_NRD_1	26	28	PF00675	0.319
CLV_NRD_NRD_1	268	270	PF00675	0.443
CLV_NRD_NRD_1	285	287	PF00675	0.414
CLV_NRD_NRD_1	288	290	PF00675	0.407
CLV_NRD_NRD_1	370	372	PF00675	0.541
CLV_PCSK_FUR_1	24	28	PF00082	0.321
CLV_PCSK_FUR_1	286	290	PF00082	0.434
CLV_PCSK_KEX2_1	125	127	PF00082	0.263

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T7	Leptomonas seymouri	61%	99%
A0A1X0NUX2	Trypanosomatidae	48%	100%
A0A3Q8IIC8	Leishmania donovani	26%	100%
A0A3R7RC91	Trypanosoma rangeli	44%	100%
A0A3S5H6J6	Leishmania donovani	31%	100%
A0A3S7WX91	Leishmania donovani	74%	100%
A4HG63	Leishmania braziliensis	24%	100%
A4IBG8	Leishmania infantum	26%	100%
C9ZSP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E7EZI4	Danio rerio	26%	93%

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