Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 11, putative

Species:

Leishmania braziliensis

UniProt:

A4HCH5_LEIBR

TriTrypDb:

LbrM.22.1230 , LBRM2903_220018900

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0005783	endoplasmic reticulum	5	3
GO:0005794	Golgi apparatus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3

Expansion

Sequence features

A4HCH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCH5

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	3
GO:0006605	protein targeting	5	3
GO:0006612	protein targeting to membrane	5	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0006810	transport	3	3
GO:0006886	intracellular protein transport	4	3
GO:0006897	endocytosis	5	3
GO:0008104	protein localization	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016192	vesicle-mediated transport	4	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018198	peptidyl-cysteine modification	6	3
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	3
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	3
GO:0018345	protein palmitoylation	6	3
GO:0019538	protein metabolic process	3	3
GO:0033036	macromolecule localization	2	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0043543	protein acylation	5	3
GO:0044238	primary metabolic process	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046907	intracellular transport	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0051668	localization within membrane	3	3
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071704	organic substance metabolic process	2	3
GO:0071705	nitrogen compound transport	4	3
GO:0072657	protein localization to membrane	4	3
GO:0090150	establishment of protein localization to membrane	4	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016409	palmitoyltransferase activity	5	14
GO:0016417	S-acyltransferase activity	5	14
GO:0016740	transferase activity	2	14
GO:0016746	acyltransferase activity	3	14
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	14
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	14
GO:0019707	protein-cysteine S-acyltransferase activity	3	14
GO:0140096	catalytic activity, acting on a protein	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.262
CLV_NRD_NRD_1	257	259	PF00675	0.389
CLV_NRD_NRD_1	26	28	PF00675	0.319
CLV_NRD_NRD_1	268	270	PF00675	0.443
CLV_NRD_NRD_1	285	287	PF00675	0.414
CLV_NRD_NRD_1	288	290	PF00675	0.407
CLV_NRD_NRD_1	370	372	PF00675	0.541
CLV_PCSK_FUR_1	24	28	PF00082	0.321
CLV_PCSK_FUR_1	286	290	PF00082	0.434
CLV_PCSK_KEX2_1	125	127	PF00082	0.263
CLV_PCSK_KEX2_1	197	199	PF00082	0.483
CLV_PCSK_KEX2_1	256	258	PF00082	0.375
CLV_PCSK_KEX2_1	26	28	PF00082	0.319
CLV_PCSK_KEX2_1	261	263	PF00082	0.389
CLV_PCSK_KEX2_1	268	270	PF00082	0.458
CLV_PCSK_KEX2_1	287	289	PF00082	0.411
CLV_PCSK_KEX2_1	369	371	PF00082	0.546
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.533
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.370
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.381
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.418
CLV_PCSK_PC7_1	257	263	PF00082	0.438
CLV_PCSK_SKI1_1	261	265	PF00082	0.422
CLV_PCSK_SKI1_1	277	281	PF00082	0.480
CLV_PCSK_SKI1_1	289	293	PF00082	0.478
CLV_PCSK_SKI1_1	83	87	PF00082	0.314
DEG_APCC_DBOX_1	97	105	PF00400	0.535
DEG_Nend_Nbox_1	1	3	PF02207	0.634
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.215
DOC_PP1_RVXF_1	233	240	PF00149	0.359
DOC_PP2B_LxvP_1	55	58	PF13499	0.220
DOC_USP7_MATH_1	114	118	PF00917	0.607
DOC_USP7_MATH_1	25	29	PF00917	0.543
DOC_USP7_UBL2_3	256	260	PF12436	0.519
DOC_WW_Pin1_4	204	209	PF00397	0.280
DOC_WW_Pin1_4	313	318	PF00397	0.818
DOC_WW_Pin1_4	363	368	PF00397	0.668
LIG_14-3-3_CanoR_1	103	111	PF00244	0.458
LIG_14-3-3_CanoR_1	162	168	PF00244	0.480
LIG_14-3-3_CanoR_1	198	208	PF00244	0.257
LIG_14-3-3_CanoR_1	7	15	PF00244	0.632
LIG_Actin_WH2_2	178	193	PF00022	0.184
LIG_APCC_ABBA_1	239	244	PF00400	0.480
LIG_CaM_IQ_9	183	199	PF13499	0.410
LIG_EH1_1	183	191	PF00400	0.337
LIG_EVH1_2	208	212	PF00568	0.218
LIG_FHA_1	164	170	PF00498	0.351
LIG_FHA_2	103	109	PF00498	0.601
LIG_IRF3_LxIS_1	65	72	PF10401	0.457
LIG_LIR_Apic_2	17	22	PF02991	0.542
LIG_LIR_Apic_2	202	208	PF02991	0.280
LIG_LIR_Apic_2	28	33	PF02991	0.491
LIG_LIR_Gen_1	166	175	PF02991	0.316
LIG_LIR_Gen_1	249	255	PF02991	0.461
LIG_LIR_Gen_1	40	50	PF02991	0.430
LIG_LIR_Nem_3	12	18	PF02991	0.556
LIG_LIR_Nem_3	166	170	PF02991	0.396
LIG_LIR_Nem_3	249	254	PF02991	0.513
LIG_LIR_Nem_3	394	400	PF02991	0.812
LIG_LIR_Nem_3	40	45	PF02991	0.401
LIG_Pex14_1	15	19	PF04695	0.540
LIG_Pex14_2	123	127	PF04695	0.440
LIG_SH2_CRK	205	209	PF00017	0.280
LIG_SH2_NCK_1	397	401	PF00017	0.597
LIG_SH2_SRC	242	245	PF00017	0.544
LIG_SH2_SRC	251	254	PF00017	0.503
LIG_SH2_SRC	397	400	PF00017	0.595
LIG_SH2_STAP1	251	255	PF00017	0.472
LIG_SH2_STAT3	184	187	PF00017	0.410
LIG_SH2_STAT3	267	270	PF00017	0.668
LIG_SH2_STAT3	53	56	PF00017	0.290
LIG_SH2_STAT3	89	92	PF00017	0.523
LIG_SH2_STAT5	184	187	PF00017	0.309
LIG_SH2_STAT5	242	245	PF00017	0.475
LIG_SH2_STAT5	373	376	PF00017	0.696
LIG_SH3_1	19	25	PF00018	0.535
LIG_SH3_2	22	27	PF14604	0.515
LIG_SH3_3	19	25	PF00018	0.531
LIG_SH3_3	314	320	PF00018	0.819
LIG_SH3_3	393	399	PF00018	0.598
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.363
LIG_SUMO_SIM_par_1	67	73	PF11976	0.301
LIG_TRAF2_1	379	382	PF00917	0.601
LIG_WRC_WIRS_1	164	169	PF05994	0.403
MOD_CDC14_SPxK_1	366	369	PF00782	0.595
MOD_CDK_SPxK_1	363	369	PF00069	0.597
MOD_CDK_SPxxK_3	363	370	PF00069	0.598
MOD_CK1_1	329	335	PF00069	0.791
MOD_CK1_1	339	345	PF00069	0.793
MOD_CK1_1	351	357	PF00069	0.720
MOD_CK1_1	391	397	PF00069	0.651
MOD_CK1_1	40	46	PF00069	0.184
MOD_CK2_1	102	108	PF00069	0.567
MOD_CK2_1	246	252	PF00069	0.497
MOD_CK2_1	25	31	PF00069	0.498
MOD_CK2_1	278	284	PF00069	0.544
MOD_CK2_1	351	357	PF00069	0.767
MOD_CK2_1	376	382	PF00069	0.601
MOD_GlcNHglycan	112	115	PF01048	0.438
MOD_GlcNHglycan	27	30	PF01048	0.309
MOD_GlcNHglycan	270	273	PF01048	0.461
MOD_GlcNHglycan	294	297	PF01048	0.477
MOD_GlcNHglycan	337	341	PF01048	0.591
MOD_GlcNHglycan	361	364	PF01048	0.467
MOD_GlcNHglycan	378	381	PF01048	0.467
MOD_GlcNHglycan	384	387	PF01048	0.504
MOD_GlcNHglycan	39	42	PF01048	0.325
MOD_GlcNHglycan	9	12	PF01048	0.483
MOD_GSK3_1	110	117	PF00069	0.679
MOD_GSK3_1	243	250	PF00069	0.440
MOD_GSK3_1	292	299	PF00069	0.580
MOD_GSK3_1	326	333	PF00069	0.725
MOD_GSK3_1	335	342	PF00069	0.748
MOD_GSK3_1	359	366	PF00069	0.602
MOD_GSK3_1	382	389	PF00069	0.783
MOD_N-GLC_1	296	301	PF02516	0.432
MOD_N-GLC_2	153	155	PF02516	0.270
MOD_NEK2_1	163	168	PF00069	0.339
MOD_NEK2_1	243	248	PF00069	0.464
MOD_NEK2_1	359	364	PF00069	0.603
MOD_NEK2_1	37	42	PF00069	0.509
MOD_NEK2_1	388	393	PF00069	0.699
MOD_NEK2_1	69	74	PF00069	0.355
MOD_NEK2_2	179	184	PF00069	0.184
MOD_NEK2_2	278	283	PF00069	0.632
MOD_OFUCOSY	149	155	PF10250	0.254
MOD_PIKK_1	102	108	PF00454	0.553
MOD_PIKK_1	318	324	PF00454	0.698
MOD_PK_1	133	139	PF00069	0.497
MOD_PKA_1	268	274	PF00069	0.585
MOD_PKA_1	292	298	PF00069	0.671
MOD_PKA_2	102	108	PF00069	0.459
MOD_PKA_2	190	196	PF00069	0.293
MOD_PKA_2	25	31	PF00069	0.515
MOD_PKA_2	268	274	PF00069	0.556
MOD_Plk_1	326	332	PF00069	0.610
MOD_Plk_1	348	354	PF00069	0.689
MOD_Plk_4	163	169	PF00069	0.424
MOD_Plk_4	46	52	PF00069	0.339
MOD_Plk_4	70	76	PF00069	0.383
MOD_ProDKin_1	204	210	PF00069	0.280
MOD_ProDKin_1	313	319	PF00069	0.817
MOD_ProDKin_1	363	369	PF00069	0.669
MOD_SUMO_rev_2	271	279	PF00179	0.645
TRG_ENDOCYTIC_2	161	164	PF00928	0.470
TRG_ENDOCYTIC_2	242	245	PF00928	0.505
TRG_ENDOCYTIC_2	251	254	PF00928	0.437
TRG_ENDOCYTIC_2	373	376	PF00928	0.725
TRG_ENDOCYTIC_2	397	400	PF00928	0.595
TRG_ER_diArg_1	125	127	PF00400	0.470
TRG_ER_diArg_1	23	26	PF00400	0.525
TRG_ER_diArg_1	267	269	PF00400	0.615
TRG_ER_diArg_1	285	288	PF00400	0.619
TRG_ER_diArg_1	369	371	PF00400	0.739
TRG_NLS_Bipartite_1	268	290	PF00514	0.568
TRG_NLS_MonoCore_2	285	290	PF00514	0.704
TRG_NLS_MonoExtN_4	286	291	PF00514	0.686
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T7	Leptomonas seymouri	61%	99%
A0A1X0NUX2	Trypanosomatidae	48%	100%
A0A3Q8IIC8	Leishmania donovani	26%	100%
A0A3R7RC91	Trypanosoma rangeli	44%	100%
A0A3S5H6J6	Leishmania donovani	31%	100%
A0A3S7WX91	Leishmania donovani	74%	100%
A4HG63	Leishmania braziliensis	24%	100%
A4IBG8	Leishmania infantum	26%	100%
C9ZSP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E7EZI4	Danio rerio	26%	93%
E9AF82	Leishmania major	26%	100%
E9AH03	Leishmania infantum	74%	100%
E9AVW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9AXW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B6D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
J9VJ99	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	22%	88%
O80685	Arabidopsis thaliana	26%	98%
P0C7U3	Homo sapiens	24%	100%
P0CS68	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	21%	87%
P0CS69	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	21%	87%
Q14AK4	Mus musculus	29%	100%
Q4QBL2	Leishmania major	73%	97%
Q4QGX1	Leishmania major	31%	100%
Q4QGX2	Leishmania major	32%	77%
Q6DR03	Arabidopsis thaliana	27%	71%
Q8R0N9	Mus musculus	28%	83%
Q8WTX9	Homo sapiens	27%	83%
Q9H8X9	Homo sapiens	26%	97%
V5B8P9	Trypanosoma cruzi	47%	100%