Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCH4_LEIBR

TriTrypDb:

LbrM.22.1210 , LBRM2903_220018600

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.574
CLV_C14_Caspase3-7	250	254	PF00656	0.587
CLV_C14_Caspase3-7	35	39	PF00656	0.735
CLV_C14_Caspase3-7	394	398	PF00656	0.617
CLV_C14_Caspase3-7	561	565	PF00656	0.783
CLV_C14_Caspase3-7	576	580	PF00656	0.598
CLV_NRD_NRD_1	105	107	PF00675	0.683
CLV_NRD_NRD_1	176	178	PF00675	0.515
CLV_NRD_NRD_1	26	28	PF00675	0.659
CLV_NRD_NRD_1	274	276	PF00675	0.515
CLV_NRD_NRD_1	390	392	PF00675	0.476
CLV_NRD_NRD_1	407	409	PF00675	0.394
CLV_NRD_NRD_1	608	610	PF00675	0.570
CLV_PCSK_KEX2_1	176	178	PF00082	0.515
CLV_PCSK_KEX2_1	26	28	PF00082	0.659
CLV_PCSK_KEX2_1	274	276	PF00082	0.515
CLV_PCSK_KEX2_1	390	392	PF00082	0.501
CLV_PCSK_KEX2_1	406	408	PF00082	0.385
CLV_PCSK_KEX2_1	608	610	PF00082	0.509
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.556
CLV_PCSK_SKI1_1	143	147	PF00082	0.570
CLV_PCSK_SKI1_1	19	23	PF00082	0.617
CLV_PCSK_SKI1_1	317	321	PF00082	0.553
CLV_PCSK_SKI1_1	544	548	PF00082	0.567
CLV_PCSK_SKI1_1	594	598	PF00082	0.569
CLV_PCSK_SKI1_1	611	615	PF00082	0.360
CLV_Separin_Metazoa	140	144	PF03568	0.617
CLV_Separin_Metazoa	330	334	PF03568	0.607
CLV_Separin_Metazoa	541	545	PF03568	0.675
DEG_APCC_DBOX_1	543	551	PF00400	0.615
DOC_ANK_TNKS_1	105	112	PF00023	0.713
DOC_MAPK_gen_1	150	158	PF00069	0.587
DOC_MAPK_gen_1	353	362	PF00069	0.569
DOC_MAPK_gen_1	479	489	PF00069	0.612
DOC_MAPK_gen_1	533	542	PF00069	0.603
DOC_MAPK_MEF2A_6	152	160	PF00069	0.588
DOC_MAPK_MEF2A_6	356	364	PF00069	0.502
DOC_MAPK_MEF2A_6	544	551	PF00069	0.686
DOC_MAPK_NFAT4_5	544	552	PF00069	0.691
DOC_USP7_MATH_1	265	269	PF00917	0.456
DOC_USP7_MATH_1	319	323	PF00917	0.612
DOC_USP7_MATH_1	334	338	PF00917	0.323
DOC_USP7_MATH_1	367	371	PF00917	0.434
DOC_USP7_MATH_1	381	385	PF00917	0.386
DOC_USP7_MATH_1	440	444	PF00917	0.579
DOC_USP7_MATH_1	56	60	PF00917	0.634
DOC_USP7_MATH_1	635	639	PF00917	0.618
DOC_WW_Pin1_4	694	699	PF00397	0.638
LIG_14-3-3_CanoR_1	143	153	PF00244	0.588
LIG_14-3-3_CanoR_1	26	36	PF00244	0.698
LIG_14-3-3_CanoR_1	333	343	PF00244	0.558
LIG_14-3-3_CanoR_1	407	411	PF00244	0.443
LIG_14-3-3_CanoR_1	416	424	PF00244	0.377
LIG_14-3-3_CanoR_1	646	651	PF00244	0.543
LIG_14-3-3_CanoR_1	694	698	PF00244	0.743
LIG_Actin_WH2_2	581	596	PF00022	0.603
LIG_Actin_WH2_2	84	102	PF00022	0.731
LIG_Clathr_ClatBox_1	63	67	PF01394	0.717
LIG_deltaCOP1_diTrp_1	199	202	PF00928	0.560
LIG_FHA_1	349	355	PF00498	0.415
LIG_FHA_1	421	427	PF00498	0.583
LIG_FHA_1	472	478	PF00498	0.491
LIG_FHA_1	484	490	PF00498	0.611
LIG_FHA_1	512	518	PF00498	0.600
LIG_FHA_1	573	579	PF00498	0.720
LIG_FHA_2	160	166	PF00498	0.557
LIG_FHA_2	187	193	PF00498	0.546
LIG_FHA_2	248	254	PF00498	0.569
LIG_FHA_2	33	39	PF00498	0.732
LIG_FHA_2	498	504	PF00498	0.617
LIG_GBD_Chelix_1	437	445	PF00786	0.583
LIG_Integrin_RGD_1	625	627	PF01839	0.629
LIG_LIR_Apic_2	263	267	PF02991	0.558
LIG_LIR_Apic_2	686	691	PF02991	0.739
LIG_LIR_Gen_1	198	206	PF02991	0.474
LIG_LIR_Gen_1	268	277	PF02991	0.498
LIG_LIR_LC3C_4	102	105	PF02991	0.720
LIG_LIR_Nem_3	198	203	PF02991	0.470
LIG_LIR_Nem_3	268	273	PF02991	0.389
LIG_NRBOX	359	365	PF00104	0.573
LIG_Pex14_2	266	270	PF04695	0.461
LIG_RPA_C_Fungi	159	171	PF08784	0.607
LIG_RPA_C_Plants	306	317	PF08784	0.594
LIG_SH2_NCK_1	688	692	PF00017	0.751
LIG_SH2_STAP1	315	319	PF00017	0.612
LIG_SH2_STAP1	473	477	PF00017	0.459
LIG_SH2_STAP1	650	654	PF00017	0.617
LIG_SH2_STAP1	95	99	PF00017	0.675
LIG_SH2_STAT3	315	318	PF00017	0.613
LIG_SH2_STAT3	650	653	PF00017	0.618
LIG_SH2_STAT3	95	98	PF00017	0.727
LIG_SH2_STAT5	235	238	PF00017	0.589
LIG_SH2_STAT5	473	476	PF00017	0.492
LIG_SH2_STAT5	587	590	PF00017	0.660
LIG_SH3_4	184	191	PF00018	0.562
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.503
LIG_SUMO_SIM_anti_2	59	65	PF11976	0.718
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.737
LIG_SUMO_SIM_par_1	361	366	PF11976	0.511
LIG_SUMO_SIM_par_1	485	490	PF11976	0.555
LIG_SUMO_SIM_par_1	513	518	PF11976	0.620
LIG_SUMO_SIM_par_1	62	67	PF11976	0.716
LIG_TRAF2_1	166	169	PF00917	0.597
LIG_TRAF2_1	380	383	PF00917	0.473
LIG_TRAF2_1	589	592	PF00917	0.654
LIG_TRAF2_1	631	634	PF00917	0.586
LIG_UBA3_1	272	281	PF00899	0.598
MOD_CK1_1	144	150	PF00069	0.586
MOD_CK1_1	322	328	PF00069	0.610
MOD_CK1_1	443	449	PF00069	0.550
MOD_CK1_1	692	698	PF00069	0.676
MOD_CK2_1	132	138	PF00069	0.579
MOD_CK2_1	159	165	PF00069	0.596
MOD_CK2_1	186	192	PF00069	0.503
MOD_CK2_1	202	208	PF00069	0.374
MOD_CK2_1	343	349	PF00069	0.530
MOD_CK2_1	367	373	PF00069	0.451
MOD_CK2_1	381	387	PF00069	0.474
MOD_CK2_1	416	422	PF00069	0.497
MOD_CK2_1	497	503	PF00069	0.568
MOD_CK2_1	599	605	PF00069	0.535
MOD_CK2_1	628	634	PF00069	0.585
MOD_CK2_1	635	641	PF00069	0.518
MOD_CK2_1	683	689	PF00069	0.638
MOD_DYRK1A_RPxSP_1	694	698	PF00069	0.743
MOD_GlcNHglycan	143	146	PF01048	0.594
MOD_GlcNHglycan	267	270	PF01048	0.498
MOD_GlcNHglycan	336	339	PF01048	0.544
MOD_GlcNHglycan	400	403	PF01048	0.594
MOD_GlcNHglycan	442	445	PF01048	0.558
MOD_GlcNHglycan	453	456	PF01048	0.405
MOD_GlcNHglycan	527	530	PF01048	0.663
MOD_GlcNHglycan	560	564	PF01048	0.754
MOD_GlcNHglycan	575	578	PF01048	0.569
MOD_GSK3_1	198	205	PF00069	0.555
MOD_GSK3_1	318	325	PF00069	0.614
MOD_GSK3_1	416	423	PF00069	0.506
MOD_GSK3_1	439	446	PF00069	0.560
MOD_GSK3_1	483	490	PF00069	0.573
MOD_GSK3_1	689	696	PF00069	0.684
MOD_N-GLC_1	684	689	PF02516	0.728
MOD_NEK2_1	186	191	PF00069	0.482
MOD_NEK2_1	487	492	PF00069	0.541
MOD_NEK2_1	495	500	PF00069	0.546
MOD_NEK2_1	578	583	PF00069	0.714
MOD_NEK2_1	99	104	PF00069	0.721
MOD_NEK2_2	132	137	PF00069	0.675
MOD_NEK2_2	32	37	PF00069	0.727
MOD_NEK2_2	381	386	PF00069	0.583
MOD_PIKK_1	416	422	PF00454	0.524
MOD_PIKK_1	495	501	PF00454	0.617
MOD_PIKK_1	506	512	PF00454	0.432
MOD_PIKK_1	649	655	PF00454	0.532
MOD_PKA_1	26	32	PF00069	0.683
MOD_PKA_1	406	412	PF00069	0.591
MOD_PKA_2	26	32	PF00069	0.683
MOD_PKA_2	367	373	PF00069	0.451
MOD_PKA_2	406	412	PF00069	0.465
MOD_PKA_2	511	517	PF00069	0.636
MOD_PKA_2	693	699	PF00069	0.747
MOD_PKA_2	99	105	PF00069	0.719
MOD_Plk_1	198	204	PF00069	0.522
MOD_Plk_1	381	387	PF00069	0.555
MOD_Plk_1	420	426	PF00069	0.582
MOD_Plk_1	578	584	PF00069	0.713
MOD_Plk_1	684	690	PF00069	0.731
MOD_Plk_2-3	247	253	PF00069	0.524
MOD_Plk_4	497	503	PF00069	0.620
MOD_Plk_4	635	641	PF00069	0.619
MOD_Plk_4	71	77	PF00069	0.734
MOD_Plk_4	99	105	PF00069	0.719
MOD_ProDKin_1	694	700	PF00069	0.688
MOD_SUMO_rev_2	178	186	PF00179	0.589
MOD_SUMO_rev_2	322	329	PF00179	0.548
MOD_SUMO_rev_2	463	471	PF00179	0.479
MOD_SUMO_rev_2	671	680	PF00179	0.681
TRG_DiLeu_BaEn_1	359	364	PF01217	0.416
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.676
TRG_DiLeu_LyEn_5	545	550	PF01217	0.683
TRG_ER_diArg_1	213	216	PF00400	0.469
TRG_ER_diArg_1	273	275	PF00400	0.510
TRG_ER_diArg_1	607	609	PF00400	0.631
TRG_ER_diArg_1	645	648	PF00400	0.498
TRG_NES_CRM1_1	352	366	PF08389	0.500
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRC1	Leptomonas seymouri	42%	87%
A0A1X0NTF5	Trypanosomatidae	27%	100%
A0A422MXI7	Trypanosoma rangeli	25%	100%