Intraflagellar transport protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCH3_LEIBR

TriTrypDb:

LbrM.22.1250 , LBRM2903_220019100

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0030992	intraciliary transport particle B	2	11
GO:0031514	motile cilium	5	9
GO:0032991	protein-containing complex	1	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	4	1
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3	1
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Expansion

Sequence features

A4HCH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCH3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006996	organelle organization	4	10
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0030030	cell projection organization	4	10
GO:0030031	cell projection assembly	5	10
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0042073	intraciliary transport	3	11
GO:0044782	cilium organization	5	10
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0060271	cilium assembly	6	10
GO:0070925	organelle assembly	5	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0099111	microtubule-based transport	4	11
GO:0120031	plasma membrane bounded cell projection assembly	6	10
GO:0120036	plasma membrane bounded cell projection organization	5	10
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006754	ATP biosynthetic process	8	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009141	nucleoside triphosphate metabolic process	5	1
GO:0009142	nucleoside triphosphate biosynthetic process	6	1
GO:0009144	purine nucleoside triphosphate metabolic process	6	1
GO:0009145	purine nucleoside triphosphate biosynthetic process	7	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009199	ribonucleoside triphosphate metabolic process	6	1
GO:0009201	ribonucleoside triphosphate biosynthetic process	7	1
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	1
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	8	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0015986	proton motive force-driven ATP synthesis	9	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046034	ATP metabolic process	7	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0048487	beta-tubulin binding	5	11
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.524
CLV_NRD_NRD_1	110	112	PF00675	0.373
CLV_NRD_NRD_1	144	146	PF00675	0.425
CLV_NRD_NRD_1	208	210	PF00675	0.426
CLV_NRD_NRD_1	211	213	PF00675	0.421
CLV_NRD_NRD_1	373	375	PF00675	0.443
CLV_NRD_NRD_1	453	455	PF00675	0.411
CLV_PCSK_FUR_1	209	213	PF00082	0.516
CLV_PCSK_KEX2_1	112	114	PF00082	0.390
CLV_PCSK_KEX2_1	144	146	PF00082	0.424
CLV_PCSK_KEX2_1	198	200	PF00082	0.403
CLV_PCSK_KEX2_1	210	212	PF00082	0.367
CLV_PCSK_KEX2_1	353	355	PF00082	0.518
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.392
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.403
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.367
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.513
CLV_PCSK_SKI1_1	144	148	PF00082	0.508
CLV_PCSK_SKI1_1	205	209	PF00082	0.424
CLV_PCSK_SKI1_1	369	373	PF00082	0.443
CLV_PCSK_SKI1_1	386	390	PF00082	0.525
CLV_PCSK_SKI1_1	423	427	PF00082	0.408
CLV_PCSK_SKI1_1	75	79	PF00082	0.335
CLV_Separin_Metazoa	202	206	PF03568	0.409
DEG_APCC_DBOX_1	303	311	PF00400	0.515
DEG_Nend_UBRbox_1	1	4	PF02207	0.551
DOC_CYCLIN_RxL_1	364	373	PF00134	0.437
DOC_MAPK_gen_1	111	119	PF00069	0.372
DOC_MAPK_gen_1	127	134	PF00069	0.376
DOC_MAPK_gen_1	237	245	PF00069	0.370
DOC_MAPK_gen_1	288	296	PF00069	0.309
DOC_MAPK_MEF2A_6	112	121	PF00069	0.388
DOC_MAPK_MEF2A_6	288	296	PF00069	0.309
DOC_MAPK_MEF2A_6	506	515	PF00069	0.436
DOC_PP1_SILK_1	205	210	PF00149	0.459
DOC_USP7_MATH_1	238	242	PF00917	0.445
DOC_USP7_MATH_1	262	266	PF00917	0.544
DOC_USP7_MATH_1	4	8	PF00917	0.543
LIG_14-3-3_CanoR_1	261	271	PF00244	0.476
LIG_14-3-3_CanoR_1	323	330	PF00244	0.465
LIG_14-3-3_CanoR_1	408	415	PF00244	0.461
LIG_14-3-3_CanoR_1	52	57	PF00244	0.533
LIG_APCC_ABBA_1	292	297	PF00400	0.310
LIG_EH1_1	163	171	PF00400	0.440
LIG_FHA_1	129	135	PF00498	0.452
LIG_FHA_1	420	426	PF00498	0.463
LIG_FHA_1	458	464	PF00498	0.324
LIG_FHA_1	479	485	PF00498	0.500
LIG_FHA_1	493	499	PF00498	0.435
LIG_FHA_1	524	530	PF00498	0.659
LIG_FHA_2	254	260	PF00498	0.548
LIG_FHA_2	346	352	PF00498	0.598
LIG_FHA_2	498	504	PF00498	0.468
LIG_LIR_Gen_1	115	126	PF02991	0.420
LIG_LIR_Gen_1	155	164	PF02991	0.277
LIG_LIR_Gen_1	407	417	PF02991	0.536
LIG_LIR_Gen_1	462	471	PF02991	0.525
LIG_LIR_Gen_1	485	494	PF02991	0.386
LIG_LIR_Nem_3	115	121	PF02991	0.426
LIG_LIR_Nem_3	152	156	PF02991	0.370
LIG_LIR_Nem_3	23	28	PF02991	0.400
LIG_LIR_Nem_3	407	412	PF02991	0.547
LIG_LIR_Nem_3	462	467	PF02991	0.506
LIG_LIR_Nem_3	485	490	PF02991	0.388
LIG_PCNA_yPIPBox_3	309	321	PF02747	0.346
LIG_Pex14_1	478	482	PF04695	0.499
LIG_SH2_CRK	156	160	PF00017	0.482
LIG_SH2_CRK	433	437	PF00017	0.458
LIG_SH2_PTP2	25	28	PF00017	0.389
LIG_SH2_PTP2	487	490	PF00017	0.457
LIG_SH2_STAT5	156	159	PF00017	0.275
LIG_SH2_STAT5	25	28	PF00017	0.389
LIG_SH2_STAT5	433	436	PF00017	0.518
LIG_SH2_STAT5	487	490	PF00017	0.448
LIG_SH2_STAT5	497	500	PF00017	0.354
LIG_SUMO_SIM_anti_2	241	247	PF11976	0.373
LIG_TRAF2_1	256	259	PF00917	0.529
LIG_TRAF2_1	266	269	PF00917	0.478
LIG_TRAF2_1	281	284	PF00917	0.345
LIG_TRAF2_1	468	471	PF00917	0.453
LIG_UBA3_1	203	210	PF00899	0.461
LIG_UBA3_1	232	237	PF00899	0.512
LIG_Vh1_VBS_1	117	135	PF01044	0.445
MOD_CK1_1	219	225	PF00069	0.416
MOD_CK1_1	322	328	PF00069	0.513
MOD_CK1_1	339	345	PF00069	0.664
MOD_CK1_1	393	399	PF00069	0.481
MOD_CK1_1	480	486	PF00069	0.430
MOD_CK1_1	55	61	PF00069	0.474
MOD_CK2_1	221	227	PF00069	0.399
MOD_CK2_1	238	244	PF00069	0.368
MOD_CK2_1	253	259	PF00069	0.367
MOD_CK2_1	262	268	PF00069	0.415
MOD_CK2_1	465	471	PF00069	0.425
MOD_CK2_1	497	503	PF00069	0.507
MOD_GlcNHglycan	11	14	PF01048	0.538
MOD_GlcNHglycan	264	267	PF01048	0.480
MOD_GlcNHglycan	274	277	PF01048	0.369
MOD_GlcNHglycan	337	341	PF01048	0.577
MOD_GlcNHglycan	35	39	PF01048	0.543
MOD_GlcNHglycan	395	398	PF01048	0.473
MOD_GlcNHglycan	530	533	PF01048	0.590
MOD_GlcNHglycan	6	9	PF01048	0.588
MOD_GlcNHglycan	98	102	PF01048	0.530
MOD_GSK3_1	121	128	PF00069	0.447
MOD_GSK3_1	253	260	PF00069	0.517
MOD_GSK3_1	4	11	PF00069	0.659
MOD_GSK3_1	462	469	PF00069	0.523
MOD_GSK3_1	492	499	PF00069	0.389
MOD_GSK3_1	51	58	PF00069	0.495
MOD_GSK3_1	528	535	PF00069	0.594
MOD_N-GLC_1	272	277	PF02516	0.497
MOD_N-GLC_1	52	57	PF02516	0.408
MOD_N-GLC_1	86	91	PF02516	0.538
MOD_NEK2_1	257	262	PF00069	0.402
MOD_NEK2_1	477	482	PF00069	0.389
MOD_NEK2_1	530	535	PF00069	0.572
MOD_NEK2_2	221	226	PF00069	0.534
MOD_PIKK_1	216	222	PF00454	0.506
MOD_PIKK_1	322	328	PF00454	0.410
MOD_PIKK_1	345	351	PF00454	0.620
MOD_PIKK_1	466	472	PF00454	0.457
MOD_PIKK_1	492	498	PF00454	0.548
MOD_PIKK_1	55	61	PF00454	0.465
MOD_PK_1	52	58	PF00069	0.407
MOD_PKA_2	253	259	PF00069	0.541
MOD_PKA_2	262	268	PF00069	0.548
MOD_PKA_2	322	328	PF00069	0.424
MOD_PKA_2	407	413	PF00069	0.407
MOD_PKA_2	51	57	PF00069	0.565
MOD_PKB_1	435	443	PF00069	0.514
MOD_Plk_1	20	26	PF00069	0.418
MOD_Plk_1	52	58	PF00069	0.407
MOD_Plk_4	52	58	PF00069	0.415
MOD_SUMO_for_1	225	228	PF00179	0.478
MOD_SUMO_for_1	388	391	PF00179	0.463
MOD_SUMO_for_1	96	99	PF00179	0.523
MOD_SUMO_rev_2	123	128	PF00179	0.489
MOD_SUMO_rev_2	194	200	PF00179	0.429
MOD_SUMO_rev_2	265	274	PF00179	0.438
MOD_SUMO_rev_2	355	363	PF00179	0.533
MOD_SUMO_rev_2	368	376	PF00179	0.339
MOD_SUMO_rev_2	379	388	PF00179	0.387
MOD_SUMO_rev_2	396	404	PF00179	0.398
TRG_AP2beta_CARGO_1	407	416	PF09066	0.538
TRG_DiLeu_BaEn_1	228	233	PF01217	0.424
TRG_DiLeu_BaEn_1	45	50	PF01217	0.389
TRG_DiLeu_BaEn_2	290	296	PF01217	0.391
TRG_DiLeu_BaEn_4	137	143	PF01217	0.359
TRG_ENDOCYTIC_2	156	159	PF00928	0.488
TRG_ENDOCYTIC_2	25	28	PF00928	0.389
TRG_ENDOCYTIC_2	433	436	PF00928	0.459
TRG_ENDOCYTIC_2	487	490	PF00928	0.531
TRG_ER_diArg_1	111	114	PF00400	0.395
TRG_ER_diArg_1	144	146	PF00400	0.425
TRG_ER_diArg_1	208	211	PF00400	0.404
TRG_ER_diArg_1	473	476	PF00400	0.509
TRG_NES_CRM1_1	319	333	PF08389	0.516
TRG_NES_CRM1_1	503	516	PF08389	0.468
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E7	Leptomonas seymouri	78%	90%
A0A1X0NTR4	Trypanosomatidae	58%	89%
A0A3R7KQW5	Trypanosoma rangeli	57%	90%
A0A3S7WX98	Leishmania donovani	92%	90%
C9ZSP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	90%
E9AH05	Leishmania infantum	92%	100%
E9AVW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBL0	Leishmania major	92%	100%
Q6RCE1	Chlamydomonas reinhardtii	23%	84%
Q8BKE9	Mus musculus	24%	89%
Q96LB3	Homo sapiens	25%	89%
V5B464	Trypanosoma cruzi	58%	90%