Protein arginine methyltransferase NDUFAF7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative S-adenosyl-L-methionine-dependent methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HCH2_LEIBR

TriTrypDb:

LbrM.22.1220 , LBRM2903_220018800

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HCH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCH2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008170	N-methyltransferase activity	5	11
GO:0008276	protein methyltransferase activity	3	11
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016273	arginine N-methyltransferase activity	6	11
GO:0016274	protein-arginine N-methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0004175	endopeptidase activity	4	1
GO:0004190	aspartic-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0070001	aspartic-type peptidase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.339
CLV_NRD_NRD_1	108	110	PF00675	0.392
CLV_NRD_NRD_1	254	256	PF00675	0.272
CLV_NRD_NRD_1	343	345	PF00675	0.405
CLV_NRD_NRD_1	426	428	PF00675	0.270
CLV_NRD_NRD_1	61	63	PF00675	0.452
CLV_PCSK_KEX2_1	253	255	PF00082	0.274
CLV_PCSK_KEX2_1	342	344	PF00082	0.407
CLV_PCSK_KEX2_1	426	428	PF00082	0.197
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.405
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.222
CLV_PCSK_PC7_1	249	255	PF00082	0.315
CLV_PCSK_SKI1_1	136	140	PF00082	0.392
CLV_PCSK_SKI1_1	402	406	PF00082	0.305
CLV_PCSK_SKI1_1	418	422	PF00082	0.210
CLV_PCSK_SKI1_1	480	484	PF00082	0.396
CLV_PCSK_SKI1_1	62	66	PF00082	0.475
DEG_APCC_DBOX_1	401	409	PF00400	0.342
DEG_MDM2_SWIB_1	394	401	PF02201	0.272
DOC_CKS1_1	148	153	PF01111	0.413
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	425	431	PF00134	0.339
DOC_MAPK_gen_1	253	261	PF00069	0.274
DOC_MAPK_gen_1	416	425	PF00069	0.291
DOC_MAPK_gen_1	60	70	PF00069	0.491
DOC_MAPK_HePTP_8	251	263	PF00069	0.315
DOC_MAPK_MEF2A_6	253	261	PF00069	0.293
DOC_MAPK_RevD_3	413	427	PF00069	0.328
DOC_PP1_RVXF_1	311	318	PF00149	0.291
DOC_PP2B_LxvP_1	338	341	PF13499	0.405
DOC_PP4_FxxP_1	148	151	PF00568	0.421
DOC_USP7_MATH_1	124	128	PF00917	0.344
DOC_USP7_MATH_1	278	282	PF00917	0.445
DOC_USP7_UBL2_3	106	110	PF12436	0.367
DOC_WW_Pin1_4	142	147	PF00397	0.367
DOC_WW_Pin1_4	363	368	PF00397	0.291
DOC_WW_Pin1_4	505	510	PF00397	0.493
LIG_14-3-3_CanoR_1	112	122	PF00244	0.423
LIG_BIR_III_2	15	19	PF00653	0.468
LIG_CSL_BTD_1	371	374	PF09270	0.272
LIG_deltaCOP1_diTrp_1	282	287	PF00928	0.272
LIG_FHA_1	188	194	PF00498	0.291
LIG_FHA_1	352	358	PF00498	0.347
LIG_FHA_1	368	374	PF00498	0.192
LIG_FHA_1	82	88	PF00498	0.434
LIG_FHA_2	293	299	PF00498	0.287
LIG_FHA_2	443	449	PF00498	0.272
LIG_GBD_Chelix_1	259	267	PF00786	0.405
LIG_LIR_Apic_2	116	122	PF02991	0.427
LIG_LIR_Apic_2	145	151	PF02991	0.424
LIG_LIR_Gen_1	211	221	PF02991	0.280
LIG_LIR_Gen_1	320	331	PF02991	0.272
LIG_LIR_Gen_1	355	365	PF02991	0.193
LIG_LIR_Gen_1	397	406	PF02991	0.315
LIG_LIR_Gen_1	445	454	PF02991	0.272
LIG_LIR_Gen_1	90	97	PF02991	0.327
LIG_LIR_Nem_3	117	123	PF02991	0.422
LIG_LIR_Nem_3	133	137	PF02991	0.314
LIG_LIR_Nem_3	152	158	PF02991	0.319
LIG_LIR_Nem_3	203	208	PF02991	0.273
LIG_LIR_Nem_3	211	217	PF02991	0.274
LIG_LIR_Nem_3	281	287	PF02991	0.275
LIG_LIR_Nem_3	298	303	PF02991	0.258
LIG_LIR_Nem_3	320	326	PF02991	0.272
LIG_LIR_Nem_3	397	401	PF02991	0.272
LIG_LIR_Nem_3	445	450	PF02991	0.272
LIG_LIR_Nem_3	451	457	PF02991	0.272
LIG_LIR_Nem_3	488	493	PF02991	0.343
LIG_LIR_Nem_3	495	500	PF02991	0.343
LIG_LIR_Nem_3	90	94	PF02991	0.326
LIG_LIR_Nem_3	99	104	PF02991	0.392
LIG_LYPXL_yS_3	104	107	PF13949	0.334
LIG_Pex14_2	368	372	PF04695	0.315
LIG_Pex14_2	394	398	PF04695	0.272
LIG_Pex14_2	443	447	PF04695	0.272
LIG_SH2_CRK	111	115	PF00017	0.412
LIG_SH2_CRK	454	458	PF00017	0.291
LIG_SH2_CRK	490	494	PF00017	0.384
LIG_SH2_GRB2like	314	317	PF00017	0.405
LIG_SH2_SRC	184	187	PF00017	0.315
LIG_SH2_STAP1	134	138	PF00017	0.360
LIG_SH2_STAT3	301	304	PF00017	0.339
LIG_SH2_STAT5	119	122	PF00017	0.428
LIG_SH2_STAT5	166	169	PF00017	0.291
LIG_SH2_STAT5	200	203	PF00017	0.291
LIG_SH2_STAT5	311	314	PF00017	0.306
LIG_SH2_STAT5	32	35	PF00017	0.541
LIG_SH2_STAT5	363	366	PF00017	0.339
LIG_SH2_STAT5	387	390	PF00017	0.315
LIG_SH2_STAT5	424	427	PF00017	0.272
LIG_SH2_STAT5	454	457	PF00017	0.193
LIG_SH3_1	174	180	PF00018	0.272
LIG_SH3_3	174	180	PF00018	0.272
LIG_SH3_3	405	411	PF00018	0.291
LIG_SUMO_SIM_par_1	179	185	PF11976	0.273
LIG_SUMO_SIM_par_1	257	262	PF11976	0.405
LIG_SUMO_SIM_par_1	47	55	PF11976	0.521
LIG_TYR_ITSM	450	457	PF00017	0.284
MOD_CK1_1	505	511	PF00069	0.517
MOD_CK1_1	81	87	PF00069	0.425
MOD_CK2_1	292	298	PF00069	0.287
MOD_GlcNHglycan	264	267	PF01048	0.281
MOD_GlcNHglycan	27	30	PF01048	0.602
MOD_GlcNHglycan	487	490	PF01048	0.368
MOD_GSK3_1	348	355	PF00069	0.336
MOD_GSK3_1	363	370	PF00069	0.275
MOD_GSK3_1	448	455	PF00069	0.193
MOD_GSK3_1	478	485	PF00069	0.383
MOD_GSK3_1	501	508	PF00069	0.391
MOD_GSK3_1	74	81	PF00069	0.644
MOD_N-GLC_1	348	353	PF02516	0.193
MOD_NEK2_1	114	119	PF00069	0.454
MOD_NEK2_1	141	146	PF00069	0.498
MOD_NEK2_1	167	172	PF00069	0.405
MOD_NEK2_1	193	198	PF00069	0.291
MOD_NEK2_1	350	355	PF00069	0.427
MOD_NEK2_1	380	385	PF00069	0.210
MOD_NEK2_1	472	477	PF00069	0.347
MOD_NEK2_1	483	488	PF00069	0.363
MOD_NEK2_1	82	87	PF00069	0.481
MOD_NEK2_1	96	101	PF00069	0.411
MOD_NEK2_2	124	129	PF00069	0.350
MOD_PIKK_1	149	155	PF00454	0.321
MOD_PIKK_1	33	39	PF00454	0.721
MOD_PK_1	342	348	PF00069	0.251
MOD_PKA_1	342	348	PF00069	0.251
MOD_PKA_2	334	340	PF00069	0.367
MOD_PKA_2	342	348	PF00069	0.328
MOD_Plk_1	319	325	PF00069	0.272
MOD_Plk_1	396	402	PF00069	0.315
MOD_Plk_1	478	484	PF00069	0.422
MOD_Plk_4	193	199	PF00069	0.291
MOD_Plk_4	241	247	PF00069	0.351
MOD_Plk_4	449	455	PF00069	0.349
MOD_Plk_4	82	88	PF00069	0.455
MOD_ProDKin_1	142	148	PF00069	0.367
MOD_ProDKin_1	363	369	PF00069	0.291
MOD_ProDKin_1	505	511	PF00069	0.517
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.405
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.210
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.336
TRG_ENDOCYTIC_2	104	107	PF00928	0.334
TRG_ENDOCYTIC_2	111	114	PF00928	0.404
TRG_ENDOCYTIC_2	159	162	PF00928	0.291
TRG_ENDOCYTIC_2	214	217	PF00928	0.280
TRG_ENDOCYTIC_2	235	238	PF00928	0.291
TRG_ENDOCYTIC_2	300	303	PF00928	0.291
TRG_ENDOCYTIC_2	454	457	PF00928	0.272
TRG_ENDOCYTIC_2	490	493	PF00928	0.380
TRG_ER_diArg_1	227	230	PF00400	0.197
TRG_ER_diArg_1	425	427	PF00400	0.197
TRG_NLS_MonoExtC_3	341	347	PF00514	0.222
TRG_NLS_MonoExtN_4	106	113	PF00514	0.399
TRG_NLS_MonoExtN_4	341	346	PF00514	0.222

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E5	Leptomonas seymouri	84%	83%
A0A0S4JG91	Bodo saltans	62%	99%
A0A1X0NTX7	Trypanosomatidae	68%	85%
A0A3S7WXD7	Leishmania donovani	94%	100%
C9ZSP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	86%
E9AH02	Leishmania infantum	93%	100%
E9AVW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBL3	Leishmania major	93%	100%
V5D4I8	Trypanosoma cruzi	74%	85%