Autophagy-related protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATG12/APG12, putative

Species:

Leishmania braziliensis

UniProt:

A4HCG9_LEIBR

TriTrypDb:

LbrM.22.1180 , LBRM2903_220017700

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HCG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCG9

Function

Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	8
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	8
GO:0009987	cellular process	1	8
GO:0044237	cellular metabolic process	2	8
GO:0044248	cellular catabolic process	3	8
GO:0061919	process utilizing autophagic mechanism	2	8
GO:0006950	response to stress	2	1
GO:0006995	cellular response to nitrogen starvation	5	1
GO:0007154	cell communication	2	1
GO:0009267	cellular response to starvation	4	1
GO:0009605	response to external stimulus	2	1
GO:0009991	response to extracellular stimulus	3	1
GO:0031667	response to nutrient levels	4	1
GO:0031668	cellular response to extracellular stimulus	3	1
GO:0031669	cellular response to nutrient levels	4	1
GO:0033554	cellular response to stress	3	1
GO:0042594	response to starvation	3	1
GO:0043562	cellular response to nitrogen levels	5	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071496	cellular response to external stimulus	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	35	37	PF00675	0.309
CLV_PCSK_KEX2_1	35	37	PF00082	0.309
CLV_PCSK_SKI1_1	115	119	PF00082	0.401
CLV_PCSK_SKI1_1	134	138	PF00082	0.286
CLV_PCSK_SKI1_1	27	31	PF00082	0.402
CLV_PCSK_SKI1_1	84	88	PF00082	0.492
DEG_SPOP_SBC_1	67	71	PF00917	0.515
DOC_CYCLIN_RxL_1	81	90	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	9	12	PF00134	0.424
DOC_MAPK_MEF2A_6	122	131	PF00069	0.339
DOC_PP2B_LxvP_1	56	59	PF13499	0.538
DOC_PP2B_LxvP_1	9	12	PF13499	0.424
DOC_PP4_FxxP_1	105	108	PF00568	0.643
DOC_USP7_MATH_1	136	140	PF00917	0.487
DOC_USP7_MATH_1	155	159	PF00917	0.339
DOC_USP7_MATH_1	49	53	PF00917	0.502
DOC_USP7_MATH_1	67	71	PF00917	0.647
DOC_USP7_MATH_1	92	96	PF00917	0.471
DOC_USP7_UBL2_3	111	115	PF12436	0.455
DOC_WW_Pin1_4	104	109	PF00397	0.707
DOC_WW_Pin1_4	54	59	PF00397	0.745
LIG_14-3-3_CanoR_1	189	197	PF00244	0.493
LIG_14-3-3_CanoR_1	27	37	PF00244	0.292
LIG_Actin_WH2_2	40	57	PF00022	0.474
LIG_EVH1_1	10	14	PF00568	0.407
LIG_FHA_1	40	46	PF00498	0.406
LIG_FHA_2	189	195	PF00498	0.432
LIG_LIR_Apic_2	103	108	PF02991	0.646
LIG_LIR_Apic_2	165	170	PF02991	0.313
LIG_LIR_Gen_1	142	152	PF02991	0.462
LIG_LIR_Gen_1	16	24	PF02991	0.498
LIG_LIR_Gen_1	171	180	PF02991	0.285
LIG_LIR_Gen_1	50	61	PF02991	0.469
LIG_LIR_Nem_3	142	147	PF02991	0.462
LIG_LIR_Nem_3	16	20	PF02991	0.366
LIG_LIR_Nem_3	162	167	PF02991	0.171
LIG_LIR_Nem_3	171	176	PF02991	0.292
LIG_LIR_Nem_3	50	56	PF02991	0.452
LIG_MYND_1	7	11	PF01753	0.493
LIG_NRBOX	175	181	PF00104	0.339
LIG_PCNA_yPIPBox_3	157	168	PF02747	0.339
LIG_PDZ_Class_2	194	199	PF00595	0.445
LIG_SH2_STAT5	175	178	PF00017	0.362
LIG_SH2_STAT5	53	56	PF00017	0.452
LIG_SH3_3	1	7	PF00018	0.639
LIG_SH3_3	149	155	PF00018	0.345
LIG_SH3_3	57	63	PF00018	0.689
LIG_SH3_3	8	14	PF00018	0.578
LIG_SUMO_SIM_par_1	42	48	PF11976	0.384
LIG_TRAF2_1	191	194	PF00917	0.426
LIG_WRC_WIRS_1	21	26	PF05994	0.490
LIG_WW_3	12	16	PF00397	0.504
MOD_CDK_SPxxK_3	104	111	PF00069	0.576
MOD_CDK_SPxxK_3	59	66	PF00069	0.489
MOD_CK1_1	100	106	PF00069	0.557
MOD_CK1_1	107	113	PF00069	0.427
MOD_CK1_1	139	145	PF00069	0.355
MOD_CK1_1	62	68	PF00069	0.628
MOD_CK1_1	70	76	PF00069	0.681
MOD_CK2_1	120	126	PF00069	0.372
MOD_CK2_1	143	149	PF00069	0.409
MOD_CK2_1	187	193	PF00069	0.431
MOD_GlcNHglycan	102	105	PF01048	0.508
MOD_GSK3_1	100	107	PF00069	0.512
MOD_GSK3_1	139	146	PF00069	0.353
MOD_GSK3_1	62	69	PF00069	0.650
MOD_GSK3_1	92	99	PF00069	0.563
MOD_LATS_1	64	70	PF00433	0.511
MOD_N-GLC_1	92	97	PF02516	0.555
MOD_NEK2_1	143	148	PF00069	0.372
MOD_NEK2_1	180	185	PF00069	0.313
MOD_NEK2_1	29	34	PF00069	0.275
MOD_PKA_2	188	194	PF00069	0.450
MOD_Plk_1	180	186	PF00069	0.328
MOD_Plk_1	92	98	PF00069	0.470
MOD_Plk_4	139	145	PF00069	0.339
MOD_Plk_4	155	161	PF00069	0.188
MOD_Plk_4	49	55	PF00069	0.483
MOD_ProDKin_1	104	110	PF00069	0.700
MOD_ProDKin_1	54	60	PF00069	0.747
TRG_DiLeu_BaEn_1	149	154	PF01217	0.339
TRG_DiLeu_BaEn_1	25	30	PF01217	0.409
TRG_DiLeu_BaEn_3	193	199	PF01217	0.441
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.436
TRG_ENDOCYTIC_2	18	21	PF00928	0.441
TRG_ENDOCYTIC_2	53	56	PF00928	0.483
TRG_ER_diArg_1	131	134	PF00400	0.285
TRG_ER_diArg_1	34	36	PF00400	0.311
TRG_NES_CRM1_1	126	138	PF08389	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NTH8	Trypanosomatidae	31%	100%
A0A3S7WX93	Leishmania donovani	80%	100%
A0A422MXH5	Trypanosoma rangeli	26%	100%
E9AH00	Leishmania infantum	81%	100%
E9AVW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QBL7	Leishmania major	81%	100%