MORN repeat-containing protein 5

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCG8_LEIBR

TriTrypDb:

LbrM.22.1150 , LBRM2903_220017300

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.598
CLV_NRD_NRD_1	17	19	PF00675	0.529
CLV_NRD_NRD_1	173	175	PF00675	0.688
CLV_NRD_NRD_1	185	187	PF00675	0.429
CLV_NRD_NRD_1	213	215	PF00675	0.614
CLV_NRD_NRD_1	288	290	PF00675	0.651
CLV_NRD_NRD_1	305	307	PF00675	0.819
CLV_PCSK_KEX2_1	17	19	PF00082	0.529
CLV_PCSK_KEX2_1	172	174	PF00082	0.730
CLV_PCSK_KEX2_1	185	187	PF00082	0.443
CLV_PCSK_KEX2_1	288	290	PF00082	0.699
CLV_PCSK_KEX2_1	305	307	PF00082	0.786
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.753
DEG_Nend_UBRbox_2	1	3	PF02207	0.641
DOC_PP4_FxxP_1	50	53	PF00568	0.569
DOC_PP4_FxxP_1	97	100	PF00568	0.677
DOC_USP7_MATH_1	163	167	PF00917	0.558
DOC_USP7_MATH_1	229	233	PF00917	0.762
DOC_USP7_MATH_1	300	304	PF00917	0.814
DOC_WW_Pin1_4	111	116	PF00397	0.687
DOC_WW_Pin1_4	296	301	PF00397	0.729
DOC_WW_Pin1_4	49	54	PF00397	0.696
DOC_WW_Pin1_4	61	66	PF00397	0.674
DOC_WW_Pin1_4	69	74	PF00397	0.518
DOC_WW_Pin1_4	96	101	PF00397	0.534
LIG_14-3-3_CanoR_1	173	177	PF00244	0.481
LIG_14-3-3_CanoR_1	24	28	PF00244	0.405
LIG_FHA_1	322	328	PF00498	0.601
LIG_FHA_1	339	345	PF00498	0.690
LIG_FHA_2	233	239	PF00498	0.643
LIG_LIR_Gen_1	120	125	PF02991	0.725
LIG_LIR_Nem_3	120	124	PF02991	0.668
LIG_PCNA_yPIPBox_3	387	401	PF02747	0.730
LIG_REV1ctd_RIR_1	47	52	PF16727	0.511
LIG_SH2_STAT3	149	152	PF00017	0.392
LIG_SH2_STAT3	8	11	PF00017	0.545
LIG_SH2_STAT5	149	152	PF00017	0.411
LIG_SH2_STAT5	179	182	PF00017	0.593
LIG_SH2_STAT5	191	194	PF00017	0.602
LIG_SH2_STAT5	25	28	PF00017	0.297
LIG_SH2_STAT5	33	36	PF00017	0.332
LIG_SH2_STAT5	8	11	PF00017	0.502
LIG_SH3_2	75	80	PF14604	0.578
LIG_SH3_3	194	200	PF00018	0.608
LIG_SH3_3	262	268	PF00018	0.546
LIG_SH3_3	373	379	PF00018	0.723
LIG_SH3_3	67	73	PF00018	0.672
LIG_SUMO_SIM_par_1	392	398	PF11976	0.717
LIG_TRAF2_1	279	282	PF00917	0.439
MOD_CDC14_SPxK_1	299	302	PF00782	0.556
MOD_CDK_SPK_2	69	74	PF00069	0.578
MOD_CDK_SPxK_1	296	302	PF00069	0.535
MOD_CK1_1	159	165	PF00069	0.732
MOD_CK1_1	232	238	PF00069	0.692
MOD_CK1_1	320	326	PF00069	0.604
MOD_CK1_1	61	67	PF00069	0.597
MOD_CK1_1	82	88	PF00069	0.783
MOD_CK2_1	221	227	PF00069	0.783
MOD_CK2_1	232	238	PF00069	0.681
MOD_CK2_1	284	290	PF00069	0.502
MOD_Cter_Amidation	15	18	PF01082	0.597
MOD_GlcNHglycan	12	15	PF01048	0.628
MOD_GlcNHglycan	126	129	PF01048	0.737
MOD_GlcNHglycan	159	162	PF01048	0.711
MOD_GlcNHglycan	164	168	PF01048	0.745
MOD_GlcNHglycan	60	63	PF01048	0.737
MOD_GSK3_1	159	166	PF00069	0.619
MOD_GSK3_1	223	230	PF00069	0.783
MOD_GSK3_1	296	303	PF00069	0.783
MOD_GSK3_1	305	312	PF00069	0.756
MOD_GSK3_1	317	324	PF00069	0.642
MOD_GSK3_1	57	64	PF00069	0.595
MOD_GSK3_1	65	72	PF00069	0.584
MOD_GSK3_1	79	86	PF00069	0.573
MOD_GSK3_1	96	103	PF00069	0.669
MOD_N-GLC_1	386	391	PF02516	0.578
MOD_NEK2_1	1	6	PF00069	0.518
MOD_NEK2_1	102	107	PF00069	0.543
MOD_NEK2_1	124	129	PF00069	0.732
MOD_NEK2_1	326	331	PF00069	0.645
MOD_NEK2_1	386	391	PF00069	0.578
MOD_PIKK_1	1	7	PF00454	0.446
MOD_PKA_1	172	178	PF00069	0.731
MOD_PKA_1	305	311	PF00069	0.819
MOD_PKA_2	172	178	PF00069	0.731
MOD_PKA_2	23	29	PF00069	0.405
MOD_PKA_2	301	307	PF00069	0.811
MOD_PKA_2	79	85	PF00069	0.806
MOD_Plk_1	163	169	PF00069	0.613
MOD_Plk_1	327	333	PF00069	0.529
MOD_Plk_1	368	374	PF00069	0.791
MOD_Plk_1	386	392	PF00069	0.447
MOD_Plk_4	4	10	PF00069	0.449
MOD_ProDKin_1	111	117	PF00069	0.680
MOD_ProDKin_1	296	302	PF00069	0.736
MOD_ProDKin_1	49	55	PF00069	0.704
MOD_ProDKin_1	61	67	PF00069	0.675
MOD_ProDKin_1	69	75	PF00069	0.515
MOD_ProDKin_1	96	102	PF00069	0.539
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.668
TRG_ENDOCYTIC_2	135	138	PF00928	0.362
TRG_ER_diArg_1	17	19	PF00400	0.529
TRG_ER_diArg_1	185	187	PF00400	0.571
TRG_ER_diArg_1	305	307	PF00400	0.780
TRG_NLS_MonoCore_2	170	175	PF00514	0.491
TRG_NLS_MonoExtN_4	171	176	PF00514	0.488
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.724
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P808	Leptomonas seymouri	47%	100%
A0A3Q8ICB1	Leishmania donovani	76%	100%
C9ZSP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AGZ7	Leishmania infantum	76%	100%
E9AVV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	75%
Q4QBM0	Leishmania major	76%	100%