| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 35 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 17 |
| NetGPI | no | yes: 0, no: 17 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 5 |
| GO:0110165 | cellular anatomical entity | 1 | 5 |
Related structures:
AlphaFold database: A4HCG7
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 18 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 18 |
| GO:0006753 | nucleoside phosphate metabolic process | 4 | 18 |
| GO:0006793 | phosphorus metabolic process | 3 | 18 |
| GO:0006796 | phosphate-containing compound metabolic process | 4 | 18 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 18 |
| GO:0008152 | metabolic process | 1 | 18 |
| GO:0009058 | biosynthetic process | 2 | 18 |
| GO:0009117 | nucleotide metabolic process | 5 | 18 |
| GO:0009165 | nucleotide biosynthetic process | 6 | 18 |
| GO:0009262 | deoxyribonucleotide metabolic process | 4 | 18 |
| GO:0009263 | deoxyribonucleotide biosynthetic process | 5 | 18 |
| GO:0009987 | cellular process | 1 | 18 |
| GO:0018130 | heterocycle biosynthetic process | 4 | 18 |
| GO:0019438 | aromatic compound biosynthetic process | 4 | 18 |
| GO:0019637 | organophosphate metabolic process | 3 | 18 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 18 |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 4 | 18 |
| GO:0044237 | cellular metabolic process | 2 | 18 |
| GO:0044238 | primary metabolic process | 2 | 18 |
| GO:0044249 | cellular biosynthetic process | 3 | 18 |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 4 | 18 |
| GO:0044281 | small molecule metabolic process | 2 | 18 |
| GO:0046483 | heterocycle metabolic process | 3 | 18 |
| GO:0055086 | nucleobase-containing small molecule metabolic process | 3 | 18 |
| GO:0071704 | organic substance metabolic process | 2 | 18 |
| GO:0090407 | organophosphate biosynthetic process | 4 | 18 |
| GO:1901135 | carbohydrate derivative metabolic process | 3 | 18 |
| GO:1901137 | carbohydrate derivative biosynthetic process | 4 | 18 |
| GO:1901293 | nucleoside phosphate biosynthetic process | 5 | 18 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 18 |
| GO:1901362 | organic cyclic compound biosynthetic process | 4 | 18 |
| GO:1901576 | organic substance biosynthetic process | 3 | 18 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 18 |
| GO:0016491 | oxidoreductase activity | 2 | 18 |
| GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | 6 | 10 |
| GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | 3 | 10 |
| GO:0016728 | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor | 4 | 10 |
| GO:0061731 | ribonucleoside-diphosphate reductase activity | 5 | 10 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 93 | 95 | PF00675 | 0.406 |
| CLV_PCSK_KEX2_1 | 16 | 18 | PF00082 | 0.596 |
| CLV_PCSK_KEX2_1 | 249 | 251 | PF00082 | 0.515 |
| CLV_PCSK_PC1ET2_1 | 16 | 18 | PF00082 | 0.620 |
| CLV_PCSK_PC1ET2_1 | 249 | 251 | PF00082 | 0.515 |
| CLV_PCSK_SKI1_1 | 130 | 134 | PF00082 | 0.315 |
| CLV_PCSK_SKI1_1 | 81 | 85 | PF00082 | 0.383 |
| DEG_APCC_DBOX_1 | 80 | 88 | PF00400 | 0.583 |
| DEG_COP1_1 | 153 | 160 | PF00400 | 0.549 |
| DOC_MAPK_gen_1 | 285 | 294 | PF00069 | 0.328 |
| DOC_MAPK_MEF2A_6 | 249 | 258 | PF00069 | 0.314 |
| DOC_MAPK_MEF2A_6 | 288 | 296 | PF00069 | 0.406 |
| DOC_PP1_RVXF_1 | 223 | 230 | PF00149 | 0.515 |
| DOC_PP1_RVXF_1 | 79 | 86 | PF00149 | 0.515 |
| DOC_USP7_MATH_1 | 2 | 6 | PF00917 | 0.618 |
| DOC_USP7_MATH_1 | 35 | 39 | PF00917 | 0.809 |
| DOC_WW_Pin1_4 | 36 | 41 | PF00397 | 0.637 |
| LIG_14-3-3_CanoR_1 | 150 | 158 | PF00244 | 0.549 |
| LIG_14-3-3_CanoR_1 | 332 | 338 | PF00244 | 0.349 |
| LIG_14-3-3_CanoR_1 | 36 | 40 | PF00244 | 0.634 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.806 |
| LIG_BIR_III_2 | 308 | 312 | PF00653 | 0.315 |
| LIG_BRCT_BRCA1_1 | 218 | 222 | PF00533 | 0.599 |
| LIG_BRCT_BRCA1_1 | 237 | 241 | PF00533 | 0.207 |
| LIG_BRCT_BRCA1_1 | 382 | 386 | PF00533 | 0.549 |
| LIG_BRCT_BRCA1_1 | 388 | 392 | PF00533 | 0.546 |
| LIG_deltaCOP1_diTrp_1 | 210 | 215 | PF00928 | 0.531 |
| LIG_EH_1 | 77 | 81 | PF12763 | 0.702 |
| LIG_FHA_1 | 175 | 181 | PF00498 | 0.508 |
| LIG_FHA_1 | 18 | 24 | PF00498 | 0.745 |
| LIG_FHA_2 | 103 | 109 | PF00498 | 0.520 |
| LIG_FHA_2 | 185 | 191 | PF00498 | 0.564 |
| LIG_FHA_2 | 23 | 29 | PF00498 | 0.720 |
| LIG_FHA_2 | 40 | 46 | PF00498 | 0.690 |
| LIG_FHA_2 | 51 | 57 | PF00498 | 0.634 |
| LIG_FHA_2 | 65 | 71 | PF00498 | 0.783 |
| LIG_GBD_Chelix_1 | 329 | 337 | PF00786 | 0.515 |
| LIG_LIR_Gen_1 | 117 | 125 | PF02991 | 0.511 |
| LIG_LIR_Gen_1 | 175 | 186 | PF02991 | 0.514 |
| LIG_LIR_Gen_1 | 238 | 247 | PF02991 | 0.367 |
| LIG_LIR_Gen_1 | 271 | 278 | PF02991 | 0.315 |
| LIG_LIR_Gen_1 | 346 | 357 | PF02991 | 0.400 |
| LIG_LIR_Nem_3 | 117 | 121 | PF02991 | 0.531 |
| LIG_LIR_Nem_3 | 175 | 181 | PF02991 | 0.514 |
| LIG_LIR_Nem_3 | 238 | 244 | PF02991 | 0.367 |
| LIG_LIR_Nem_3 | 271 | 276 | PF02991 | 0.315 |
| LIG_LIR_Nem_3 | 77 | 83 | PF02991 | 0.614 |
| LIG_LIR_Nem_3 | 91 | 96 | PF02991 | 0.507 |
| LIG_PDZ_Class_3 | 387 | 392 | PF00595 | 0.587 |
| LIG_Pex14_2 | 237 | 241 | PF04695 | 0.367 |
| LIG_REV1ctd_RIR_1 | 361 | 371 | PF16727 | 0.454 |
| LIG_SH2_CRK | 178 | 182 | PF00017 | 0.515 |
| LIG_SH2_STAP1 | 178 | 182 | PF00017 | 0.515 |
| LIG_SH2_STAT3 | 164 | 167 | PF00017 | 0.515 |
| LIG_SH2_STAT3 | 96 | 99 | PF00017 | 0.606 |
| LIG_SH2_STAT5 | 185 | 188 | PF00017 | 0.509 |
| LIG_SH2_STAT5 | 325 | 328 | PF00017 | 0.315 |
| LIG_SH2_STAT5 | 82 | 85 | PF00017 | 0.514 |
| LIG_SH3_3 | 152 | 158 | PF00018 | 0.510 |
| LIG_SH3_3 | 34 | 40 | PF00018 | 0.752 |
| LIG_SH3_3 | 44 | 50 | PF00018 | 0.765 |
| LIG_SH3_3 | 80 | 86 | PF00018 | 0.515 |
| LIG_SUMO_SIM_par_1 | 333 | 340 | PF11976 | 0.419 |
| LIG_TRAF2_1 | 105 | 108 | PF00917 | 0.525 |
| LIG_TRAF2_1 | 221 | 224 | PF00917 | 0.606 |
| LIG_TRAF2_1 | 69 | 72 | PF00917 | 0.749 |
| LIG_TRAF2_2 | 86 | 91 | PF00917 | 0.619 |
| LIG_TRFH_1 | 82 | 86 | PF08558 | 0.583 |
| LIG_TYR_ITIM | 87 | 92 | PF00017 | 0.515 |
| LIG_UBA3_1 | 244 | 249 | PF00899 | 0.367 |
| LIG_UBA3_1 | 333 | 341 | PF00899 | 0.406 |
| LIG_UBA3_1 | 354 | 360 | PF00899 | 0.428 |
| MOD_CK1_1 | 218 | 224 | PF00069 | 0.515 |
| MOD_CK1_1 | 38 | 44 | PF00069 | 0.693 |
| MOD_CK2_1 | 102 | 108 | PF00069 | 0.516 |
| MOD_CK2_1 | 184 | 190 | PF00069 | 0.564 |
| MOD_CK2_1 | 218 | 224 | PF00069 | 0.552 |
| MOD_CK2_1 | 22 | 28 | PF00069 | 0.632 |
| MOD_CK2_1 | 261 | 267 | PF00069 | 0.315 |
| MOD_CK2_1 | 333 | 339 | PF00069 | 0.401 |
| MOD_CK2_1 | 38 | 44 | PF00069 | 0.708 |
| MOD_CK2_1 | 384 | 390 | PF00069 | 0.576 |
| MOD_CK2_1 | 50 | 56 | PF00069 | 0.637 |
| MOD_CK2_1 | 64 | 70 | PF00069 | 0.745 |
| MOD_DYRK1A_RPxSP_1 | 36 | 40 | PF00069 | 0.623 |
| MOD_GlcNHglycan | 218 | 221 | PF01048 | 0.400 |
| MOD_GlcNHglycan | 237 | 240 | PF01048 | 0.207 |
| MOD_GlcNHglycan | 30 | 33 | PF01048 | 0.513 |
| MOD_GlcNHglycan | 377 | 380 | PF01048 | 0.733 |
| MOD_GSK3_1 | 172 | 179 | PF00069 | 0.515 |
| MOD_GSK3_1 | 35 | 42 | PF00069 | 0.658 |
| MOD_GSK3_1 | 375 | 382 | PF00069 | 0.495 |
| MOD_GSK3_1 | 98 | 105 | PF00069 | 0.509 |
| MOD_N-GLC_1 | 343 | 348 | PF02516 | 0.572 |
| MOD_NEK2_1 | 181 | 186 | PF00069 | 0.515 |
| MOD_NEK2_1 | 237 | 242 | PF00069 | 0.364 |
| MOD_NEK2_1 | 277 | 282 | PF00069 | 0.406 |
| MOD_NEK2_1 | 333 | 338 | PF00069 | 0.329 |
| MOD_PIKK_1 | 343 | 349 | PF00454 | 0.406 |
| MOD_PKA_1 | 384 | 390 | PF00069 | 0.589 |
| MOD_PKA_2 | 28 | 34 | PF00069 | 0.818 |
| MOD_PKA_2 | 35 | 41 | PF00069 | 0.623 |
| MOD_Plk_4 | 176 | 182 | PF00069 | 0.513 |
| MOD_ProDKin_1 | 36 | 42 | PF00069 | 0.634 |
| MOD_SUMO_rev_2 | 153 | 158 | PF00179 | 0.619 |
| MOD_SUMO_rev_2 | 188 | 193 | PF00179 | 0.606 |
| TRG_DiLeu_BaEn_1 | 191 | 196 | PF01217 | 0.536 |
| TRG_DiLeu_BaLyEn_6 | 222 | 227 | PF01217 | 0.606 |
| TRG_DiLeu_BaLyEn_6 | 310 | 315 | PF01217 | 0.325 |
| TRG_DiLeu_BaLyEn_6 | 329 | 334 | PF01217 | 0.315 |
| TRG_DiLeu_LyEn_5 | 191 | 196 | PF01217 | 0.536 |
| TRG_ENDOCYTIC_2 | 178 | 181 | PF00928 | 0.515 |
| TRG_ENDOCYTIC_2 | 325 | 328 | PF00928 | 0.315 |
| TRG_ENDOCYTIC_2 | 82 | 85 | PF00928 | 0.515 |
| TRG_ENDOCYTIC_2 | 89 | 92 | PF00928 | 0.515 |
| TRG_NES_CRM1_1 | 110 | 125 | PF08389 | 0.575 |
| TRG_NES_CRM1_1 | 145 | 159 | PF08389 | 0.515 |
| TRG_NES_CRM1_1 | 324 | 339 | PF08389 | 0.419 |
| TRG_NLS_MonoExtC_3 | 15 | 21 | PF00514 | 0.798 |
| TRG_NLS_MonoExtN_4 | 14 | 20 | PF00514 | 0.709 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P8G9 | Leptomonas seymouri | 85% | 100% |
| A0A0S4JI02 | Bodo saltans | 67% | 97% |
| A0A1X0NN82 | Trypanosomatidae | 80% | 100% |
| A0A3Q8IAS1 | Leishmania donovani | 93% | 100% |
| A0A3R7N6N4 | Trypanosoma rangeli | 77% | 100% |
| A0A3S7X0X6 | Leishmania donovani | 91% | 100% |
| A4HFY2 | Leishmania braziliensis | 94% | 100% |
| A4I2X5 | Leishmania infantum | 92% | 100% |
| D0A9F7 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 80% | 100% |
| D0A9F8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 80% | 100% |
| D0A9F9 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 79% | 100% |
| E9ADI5 | Leishmania major | 92% | 100% |
| E9AGZ9 | Leishmania infantum | 93% | 100% |
| E9AVW1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 94% | 100% |
| E9AZB1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 92% | 100% |
| F5HAW0 | Human herpesvirus 8 type P (isolate GK18) | 30% | 100% |
| O15910 | Trypanosoma brucei brucei | 80% | 100% |
| O30601 | Bacillus subtilis (strain 168) | 25% | 100% |
| O36410 | Alcelaphine herpesvirus 1 (strain C500) | 29% | 100% |
| O46310 | Leishmania amazonensis | 96% | 100% |
| O57175 | Vaccinia virus (strain Ankara) | 65% | 100% |
| O64174 | Bacillus phage SPbeta | 25% | 100% |
| O83092 | Treponema pallidum (strain Nichols) | 24% | 100% |
| O84835 | Chlamydia trachomatis (strain D/UW-3/Cx) | 29% | 100% |
| P06474 | Human herpesvirus 1 (strain KOS) | 30% | 100% |
| P07201 | Spisula solidissima | 64% | 100% |
| P09247 | Varicella-zoster virus (strain Dumas) | 31% | 100% |
| P09938 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 61% | 98% |
| P0C701 | Epstein-Barr virus (strain GD1) | 32% | 100% |
| P0C8I0 | African swine fever virus (isolate Pig/Kenya/KEN-50/1950) | 39% | 100% |
| P0C8I1 | African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) | 39% | 100% |
| P0C8I2 | African swine fever virus (isolate Warthog/Namibia/Wart80/1980) | 39% | 100% |
| P0CAP6 | Epstein-Barr virus (strain B95-8) | 32% | 100% |
| P0CAP7 | Epstein-Barr virus (strain AG876) | 32% | 100% |
| P0DKH3 | Arabidopsis thaliana | 65% | 100% |
| P0DSS7 | Variola virus (isolate Human/India/Ind3/1967) | 64% | 100% |
| P0DSS8 | Variola virus | 65% | 100% |
| P10224 | Human herpesvirus 1 (strain 17) | 29% | 100% |
| P11157 | Mus musculus | 63% | 100% |
| P11158 | Vaccinia virus (strain Western Reserve) | 65% | 100% |
| P20493 | Vaccinia virus (strain Copenhagen) | 65% | 100% |
| P26713 | African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) | 41% | 100% |
| P28847 | Equine herpesvirus 1 (strain Ab4p) | 29% | 100% |
| P29883 | Vaccinia virus (strain L-IVP) | 64% | 100% |
| P31350 | Homo sapiens | 59% | 100% |
| P32209 | Swinepox virus (strain Kasza) | 63% | 100% |
| P36603 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 63% | 100% |
| P42170 | Caenorhabditis elegans | 60% | 100% |
| P42492 | African swine fever virus (strain Badajoz 1971 Vero-adapted) | 39% | 100% |
| P42521 | Dictyostelium discoideum | 64% | 100% |
| P48592 | Drosophila melanogaster | 58% | 100% |
| P49723 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 45% | 100% |
| P49730 | Nicotiana tabacum | 67% | 100% |
| P50644 | Equine herpesvirus 4 (strain 1942) | 29% | 100% |
| P50645 | Suid herpesvirus 1 (strain Kaplan) | 31% | 100% |
| P50649 | Plasmodium falciparum (isolate FCR-3 / Gambia) | 58% | 100% |
| P50650 | Plasmodium falciparum (isolate Dd2) | 55% | 100% |
| P50651 | Arabidopsis thaliana | 66% | 100% |
| P55983 | Helicobacter pylori (strain ATCC 700392 / 26695) | 24% | 100% |
| P69520 | Human herpesvirus 2 (strain 333) | 29% | 100% |
| P69521 | Human herpesvirus 2 (strain HG52) | 29% | 100% |
| P69924 | Escherichia coli (strain K12) | 24% | 100% |
| P69925 | Escherichia coli O157:H7 | 24% | 100% |
| P79733 | Danio rerio | 60% | 100% |
| Q01038 | Saimiriine herpesvirus 2 (strain 11) | 28% | 100% |
| Q01319 | Bovine herpesvirus 1.1 (strain Cooper) | 27% | 100% |
| Q4JQV7 | Varicella-zoster virus (strain Oka vaccine) | 31% | 100% |
| Q4KLN6 | Rattus norvegicus | 59% | 100% |
| Q4QBL8 | Leishmania major | 93% | 100% |
| Q4R741 | Macaca fascicularis | 62% | 100% |
| Q4R7Q7 | Macaca fascicularis | 59% | 100% |
| Q5R9G0 | Pongo abelii | 62% | 100% |
| Q60561 | Mesocricetus auratus | 64% | 100% |
| Q66662 | Equine herpesvirus 2 (strain 86/87) | 29% | 100% |
| Q6PEE3 | Mus musculus | 60% | 100% |
| Q6R7K3 | Ostreid herpesvirus 1 (isolate France) | 29% | 68% |
| Q6UDJ1 | Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) | 31% | 100% |
| Q77MS0 | Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) | 30% | 100% |
| Q7LG56 | Homo sapiens | 62% | 100% |
| Q7T6Y9 | Acanthamoeba polyphaga mimivirus | 41% | 94% |
| Q8SRR2 | Encephalitozoon cuniculi (strain GB-M1) | 61% | 100% |
| Q91FE8 | Invertebrate iridescent virus 6 | 23% | 100% |
| Q9C167 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 67% | 96% |
| Q9DHU2 | Yaba-like disease virus | 60% | 100% |
| Q9KFH7 | Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) | 22% | 100% |
| Q9LSD0 | Arabidopsis thaliana | 67% | 100% |
| Q9PL92 | Chlamydia muridarum (strain MoPn / Nigg) | 28% | 100% |
| Q9QTF2 | Red sea bream iridovirus | 51% | 100% |
| Q9Z6S4 | Chlamydia pneumoniae | 28% | 100% |
| Q9ZKC3 | Helicobacter pylori (strain J99 / ATCC 700824) | 25% | 100% |
| V5ASN2 | Trypanosoma cruzi | 78% | 100% |