Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCG3_LEIBR

TriTrypDb:

LbrM.22.1110 , LBRM2903_220016900

Length:

789

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.650
CLV_C14_Caspase3-7	738	742	PF00656	0.282
CLV_NRD_NRD_1	170	172	PF00675	0.657
CLV_NRD_NRD_1	21	23	PF00675	0.539
CLV_NRD_NRD_1	375	377	PF00675	0.363
CLV_NRD_NRD_1	393	395	PF00675	0.363
CLV_NRD_NRD_1	484	486	PF00675	0.477
CLV_NRD_NRD_1	505	507	PF00675	0.388
CLV_NRD_NRD_1	682	684	PF00675	0.401
CLV_NRD_NRD_1	689	691	PF00675	0.549
CLV_NRD_NRD_1	787	789	PF00675	0.587
CLV_PCSK_KEX2_1	170	172	PF00082	0.567
CLV_PCSK_KEX2_1	20	22	PF00082	0.561
CLV_PCSK_KEX2_1	237	239	PF00082	0.575
CLV_PCSK_KEX2_1	375	377	PF00082	0.355
CLV_PCSK_KEX2_1	393	395	PF00082	0.363
CLV_PCSK_KEX2_1	484	486	PF00082	0.485
CLV_PCSK_KEX2_1	504	506	PF00082	0.244
CLV_PCSK_KEX2_1	784	786	PF00082	0.287
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.575
CLV_PCSK_PC1ET2_1	784	786	PF00082	0.287
CLV_PCSK_PC7_1	233	239	PF00082	0.573
CLV_PCSK_SKI1_1	153	157	PF00082	0.631
CLV_PCSK_SKI1_1	233	237	PF00082	0.575
CLV_PCSK_SKI1_1	445	449	PF00082	0.441
CLV_PCSK_SKI1_1	468	472	PF00082	0.549
CLV_PCSK_SKI1_1	513	517	PF00082	0.389
CLV_PCSK_SKI1_1	530	534	PF00082	0.503
CLV_PCSK_SKI1_1	652	656	PF00082	0.415
CLV_PCSK_SKI1_1	658	662	PF00082	0.389
CLV_PCSK_SKI1_1	67	71	PF00082	0.664
CLV_PCSK_SKI1_1	683	687	PF00082	0.439
CLV_PCSK_SKI1_1	776	780	PF00082	0.444
DEG_APCC_DBOX_1	232	240	PF00400	0.567
DEG_SCF_FBW7_1	126	133	PF00400	0.590
DEG_SCF_FBW7_2	609	614	PF00400	0.412
DEG_SPOP_SBC_1	110	114	PF00917	0.593
DEG_SPOP_SBC_1	207	211	PF00917	0.604
DOC_CKS1_1	127	132	PF01111	0.657
DOC_CKS1_1	227	232	PF01111	0.567
DOC_CYCLIN_yCln2_LP_2	474	480	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	654	657	PF00134	0.353
DOC_MAPK_gen_1	170	180	PF00069	0.445
DOC_MAPK_gen_1	361	372	PF00069	0.339
DOC_MAPK_MEF2A_6	307	315	PF00069	0.478
DOC_MAPK_MEF2A_6	366	374	PF00069	0.310
DOC_MAPK_MEF2A_6	545	553	PF00069	0.333
DOC_PP2B_LxvP_1	354	357	PF13499	0.431
DOC_PP2B_LxvP_1	654	657	PF13499	0.353
DOC_USP7_MATH_1	111	115	PF00917	0.776
DOC_USP7_MATH_1	130	134	PF00917	0.554
DOC_USP7_MATH_1	142	146	PF00917	0.482
DOC_USP7_MATH_1	174	178	PF00917	0.620
DOC_USP7_MATH_1	182	186	PF00917	0.506
DOC_USP7_MATH_1	208	212	PF00917	0.580
DOC_USP7_MATH_1	273	277	PF00917	0.550
DOC_USP7_MATH_1	438	442	PF00917	0.394
DOC_USP7_MATH_1	56	60	PF00917	0.531
DOC_USP7_UBL2_3	4	8	PF12436	0.550
DOC_USP7_UBL2_3	780	784	PF12436	0.509
DOC_WW_Pin1_4	126	131	PF00397	0.641
DOC_WW_Pin1_4	223	228	PF00397	0.567
DOC_WW_Pin1_4	299	304	PF00397	0.543
DOC_WW_Pin1_4	607	612	PF00397	0.588
DOC_WW_Pin1_4	617	622	PF00397	0.562
DOC_WW_Pin1_4	645	650	PF00397	0.362
DOC_WW_Pin1_4	673	678	PF00397	0.451
DOC_WW_Pin1_4	8	13	PF00397	0.541
LIG_14-3-3_CanoR_1	191	199	PF00244	0.532
LIG_14-3-3_CanoR_1	287	293	PF00244	0.517
LIG_14-3-3_CanoR_1	296	304	PF00244	0.436
LIG_14-3-3_CanoR_1	312	316	PF00244	0.414
LIG_14-3-3_CanoR_1	366	371	PF00244	0.381
LIG_14-3-3_CanoR_1	496	503	PF00244	0.466
LIG_14-3-3_CanoR_1	552	561	PF00244	0.356
LIG_14-3-3_CanoR_1	78	82	PF00244	0.516
LIG_Actin_WH2_2	424	439	PF00022	0.514
LIG_APCC_ABBA_1	396	401	PF00400	0.394
LIG_BIR_II_1	1	5	PF00653	0.410
LIG_CtBP_PxDLS_1	461	465	PF00389	0.380
LIG_EH1_1	728	736	PF00400	0.317
LIG_eIF4E_1	497	503	PF01652	0.400
LIG_FHA_1	365	371	PF00498	0.298
LIG_FHA_1	387	393	PF00498	0.372
LIG_FHA_1	446	452	PF00498	0.411
LIG_FHA_1	514	520	PF00498	0.457
LIG_FHA_2	12	18	PF00498	0.527
LIG_FHA_2	120	126	PF00498	0.744
LIG_FHA_2	127	133	PF00498	0.716
LIG_FHA_2	212	218	PF00498	0.566
LIG_FHA_2	331	337	PF00498	0.370
LIG_FHA_2	404	410	PF00498	0.516
LIG_FHA_2	554	560	PF00498	0.477
LIG_FHA_2	721	727	PF00498	0.546
LIG_IBAR_NPY_1	616	618	PF08397	0.391
LIG_LIR_Apic_2	457	461	PF02991	0.410
LIG_LIR_Apic_2	615	621	PF02991	0.496
LIG_LIR_Gen_1	196	207	PF02991	0.574
LIG_LIR_Gen_1	336	346	PF02991	0.349
LIG_LIR_Gen_1	408	419	PF02991	0.481
LIG_LIR_Gen_1	489	497	PF02991	0.360
LIG_LIR_Gen_1	547	557	PF02991	0.441
LIG_LIR_LC3C_4	367	372	PF02991	0.304
LIG_LIR_Nem_3	196	202	PF02991	0.502
LIG_LIR_Nem_3	291	295	PF02991	0.653
LIG_LIR_Nem_3	336	341	PF02991	0.340
LIG_LIR_Nem_3	408	414	PF02991	0.481
LIG_LIR_Nem_3	457	462	PF02991	0.412
LIG_LIR_Nem_3	489	493	PF02991	0.343
LIG_LIR_Nem_3	494	500	PF02991	0.387
LIG_LIR_Nem_3	547	553	PF02991	0.426
LIG_LIR_Nem_3	759	764	PF02991	0.420
LIG_LYPXL_yS_3	271	274	PF13949	0.643
LIG_Pex14_1	514	518	PF04695	0.368
LIG_Pex14_2	482	486	PF04695	0.428
LIG_Pex14_2	666	670	PF04695	0.387
LIG_SH2_CRK	199	203	PF00017	0.533
LIG_SH2_CRK	618	622	PF00017	0.461
LIG_SH2_CRK	71	75	PF00017	0.605
LIG_SH2_NCK_1	497	501	PF00017	0.475
LIG_SH2_PTP2	308	311	PF00017	0.508
LIG_SH2_PTP2	343	346	PF00017	0.385
LIG_SH2_PTP2	548	551	PF00017	0.333
LIG_SH2_PTP2	630	633	PF00017	0.396
LIG_SH2_SRC	343	346	PF00017	0.385
LIG_SH2_SRC	548	551	PF00017	0.364
LIG_SH2_STAT5	192	195	PF00017	0.557
LIG_SH2_STAT5	234	237	PF00017	0.642
LIG_SH2_STAT5	308	311	PF00017	0.639
LIG_SH2_STAT5	343	346	PF00017	0.352
LIG_SH2_STAT5	380	383	PF00017	0.354
LIG_SH2_STAT5	458	461	PF00017	0.312
LIG_SH2_STAT5	469	472	PF00017	0.458
LIG_SH2_STAT5	548	551	PF00017	0.333
LIG_SH2_STAT5	630	633	PF00017	0.380
LIG_SH2_STAT5	642	645	PF00017	0.399
LIG_SH2_STAT5	760	763	PF00017	0.481
LIG_SH3_1	587	593	PF00018	0.472
LIG_SH3_3	124	130	PF00018	0.772
LIG_SH3_3	184	190	PF00018	0.637
LIG_SH3_3	224	230	PF00018	0.448
LIG_SH3_3	298	304	PF00018	0.502
LIG_SH3_3	394	400	PF00018	0.472
LIG_SH3_3	432	438	PF00018	0.542
LIG_SH3_3	587	593	PF00018	0.472
LIG_SH3_3	682	688	PF00018	0.505
LIG_SH3_3	737	743	PF00018	0.517
LIG_SUMO_SIM_anti_2	623	628	PF11976	0.379
LIG_SUMO_SIM_par_1	460	465	PF11976	0.376
LIG_SxIP_EBH_1	493	506	PF03271	0.459
LIG_TRAF2_1	406	409	PF00917	0.470
LIG_TRAF2_1	556	559	PF00917	0.415
LIG_TRAF2_1	702	705	PF00917	0.605
LIG_TRAF2_1	723	726	PF00917	0.449
LIG_TYR_ITIM	341	346	PF00017	0.388
LIG_WRC_WIRS_1	479	484	PF05994	0.353
LIG_WW_3	302	306	PF00397	0.465
LIG_WW_3	655	659	PF00397	0.467
MOD_CDC14_SPxK_1	302	305	PF00782	0.534
MOD_CDK_SPK_2	617	622	PF00069	0.490
MOD_CDK_SPxK_1	299	305	PF00069	0.542
MOD_CDK_SPxxK_3	226	233	PF00069	0.572
MOD_CDK_SPxxK_3	645	652	PF00069	0.362
MOD_CDK_SPxxK_3	8	15	PF00069	0.543
MOD_CK1_1	104	110	PF00069	0.686
MOD_CK1_1	11	17	PF00069	0.412
MOD_CK1_1	121	127	PF00069	0.637
MOD_CK1_1	211	217	PF00069	0.548
MOD_CK1_1	495	501	PF00069	0.492
MOD_CK1_1	97	103	PF00069	0.611
MOD_CK2_1	119	125	PF00069	0.800
MOD_CK2_1	126	132	PF00069	0.623
MOD_CK2_1	141	147	PF00069	0.541
MOD_CK2_1	211	217	PF00069	0.554
MOD_CK2_1	243	249	PF00069	0.662
MOD_CK2_1	403	409	PF00069	0.471
MOD_CK2_1	551	557	PF00069	0.359
MOD_CK2_1	58	64	PF00069	0.563
MOD_CK2_1	617	623	PF00069	0.454
MOD_CK2_1	699	705	PF00069	0.497
MOD_CK2_1	720	726	PF00069	0.497
MOD_CK2_1	92	98	PF00069	0.679
MOD_GlcNHglycan	108	111	PF01048	0.708
MOD_GlcNHglycan	144	147	PF01048	0.428
MOD_GlcNHglycan	184	187	PF01048	0.617
MOD_GlcNHglycan	210	213	PF01048	0.650
MOD_GlcNHglycan	261	264	PF01048	0.771
MOD_GlcNHglycan	510	513	PF01048	0.451
MOD_GlcNHglycan	737	740	PF01048	0.484
MOD_GSK3_1	106	113	PF00069	0.619
MOD_GSK3_1	126	133	PF00069	0.666
MOD_GSK3_1	206	213	PF00069	0.491
MOD_GSK3_1	249	256	PF00069	0.597
MOD_GSK3_1	295	302	PF00069	0.678
MOD_GSK3_1	326	333	PF00069	0.427
MOD_GSK3_1	439	446	PF00069	0.420
MOD_GSK3_1	491	498	PF00069	0.474
MOD_GSK3_1	52	59	PF00069	0.545
MOD_GSK3_1	92	99	PF00069	0.673
MOD_LATS_1	364	370	PF00433	0.383
MOD_N-GLC_1	249	254	PF02516	0.465
MOD_N-GLC_1	386	391	PF02516	0.454
MOD_N-GLC_1	472	477	PF02516	0.414
MOD_NEK2_1	106	111	PF00069	0.737
MOD_NEK2_1	443	448	PF00069	0.490
MOD_NEK2_1	46	51	PF00069	0.476
MOD_NEK2_1	462	467	PF00069	0.554
MOD_NEK2_1	478	483	PF00069	0.440
MOD_NEK2_1	535	540	PF00069	0.327
MOD_NEK2_1	747	752	PF00069	0.450
MOD_NEK2_1	767	772	PF00069	0.252
MOD_NEK2_2	678	683	PF00069	0.484
MOD_PIKK_1	101	107	PF00454	0.650
MOD_PIKK_1	58	64	PF00454	0.620
MOD_PKA_2	182	188	PF00069	0.572
MOD_PKA_2	190	196	PF00069	0.590
MOD_PKA_2	282	288	PF00069	0.594
MOD_PKA_2	295	301	PF00069	0.574
MOD_PKA_2	311	317	PF00069	0.488
MOD_PKA_2	365	371	PF00069	0.445
MOD_PKA_2	392	398	PF00069	0.367
MOD_PKA_2	436	442	PF00069	0.539
MOD_PKA_2	495	501	PF00069	0.473
MOD_PKA_2	551	557	PF00069	0.270
MOD_PKA_2	720	726	PF00069	0.380
MOD_PKA_2	77	83	PF00069	0.524
MOD_PKB_1	238	246	PF00069	0.554
MOD_Plk_1	174	180	PF00069	0.638
MOD_Plk_1	248	254	PF00069	0.425
MOD_Plk_1	439	445	PF00069	0.546
MOD_Plk_2-3	700	706	PF00069	0.462
MOD_Plk_4	243	249	PF00069	0.549
MOD_Plk_4	288	294	PF00069	0.661
MOD_Plk_4	326	332	PF00069	0.598
MOD_Plk_4	366	372	PF00069	0.445
MOD_Plk_4	422	428	PF00069	0.502
MOD_Plk_4	454	460	PF00069	0.458
MOD_Plk_4	478	484	PF00069	0.563
MOD_Plk_4	566	572	PF00069	0.332
MOD_Plk_4	658	664	PF00069	0.417
MOD_ProDKin_1	126	132	PF00069	0.641
MOD_ProDKin_1	223	229	PF00069	0.563
MOD_ProDKin_1	299	305	PF00069	0.545
MOD_ProDKin_1	607	613	PF00069	0.576
MOD_ProDKin_1	617	623	PF00069	0.557
MOD_ProDKin_1	645	651	PF00069	0.358
MOD_ProDKin_1	673	679	PF00069	0.450
MOD_ProDKin_1	8	14	PF00069	0.540
MOD_SUMO_rev_2	27	35	PF00179	0.428
TRG_DiLeu_BaEn_1	422	427	PF01217	0.571
TRG_DiLeu_BaEn_4	175	181	PF01217	0.465
TRG_ENDOCYTIC_2	192	195	PF00928	0.464
TRG_ENDOCYTIC_2	199	202	PF00928	0.455
TRG_ENDOCYTIC_2	271	274	PF00928	0.643
TRG_ENDOCYTIC_2	338	341	PF00928	0.346
TRG_ENDOCYTIC_2	343	346	PF00928	0.352
TRG_ENDOCYTIC_2	380	383	PF00928	0.331
TRG_ENDOCYTIC_2	497	500	PF00928	0.483
TRG_ENDOCYTIC_2	548	551	PF00928	0.333
TRG_ENDOCYTIC_2	564	567	PF00928	0.352
TRG_ENDOCYTIC_2	71	74	PF00928	0.619
TRG_ER_diArg_1	169	171	PF00400	0.467
TRG_ER_diArg_1	19	22	PF00400	0.560
TRG_ER_diArg_1	238	241	PF00400	0.565
TRG_ER_diArg_1	374	376	PF00400	0.364
TRG_ER_diArg_1	392	394	PF00400	0.354
TRG_ER_diArg_1	483	485	PF00400	0.416
TRG_ER_diArg_1	503	506	PF00400	0.234
TRG_NLS_MonoExtC_3	236	242	PF00514	0.420
TRG_NLS_MonoExtN_4	358	365	PF00514	0.463
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	732	737	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB4	Leptomonas seymouri	49%	82%
A0A1X0NTF9	Trypanosomatidae	48%	92%
A0A3S7WXE8	Leishmania donovani	81%	81%
A4HZZ4	Leishmania infantum	81%	81%
E9AVV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	86%
Q4QBM4	Leishmania major	80%	100%
V5DMM4	Trypanosoma cruzi	50%	98%