Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCG2_LEIBR

TriTrypDb:

LbrM.22.1130 , LBRM2903_220017100

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	8
GO:0032991	protein-containing complex	1	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:1990904	ribonucleoprotein complex	2	8

Expansion

Sequence features

A4HCG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	323	325	PF00675	0.824
CLV_NRD_NRD_1	94	96	PF00675	0.553
CLV_PCSK_KEX2_1	323	325	PF00082	0.824
CLV_PCSK_KEX2_1	94	96	PF00082	0.531
CLV_PCSK_SKI1_1	382	386	PF00082	0.555
CLV_PCSK_SKI1_1	404	408	PF00082	0.464
CLV_PCSK_SKI1_1	422	426	PF00082	0.445
DEG_Nend_Nbox_1	1	3	PF02207	0.466
DEG_SPOP_SBC_1	180	184	PF00917	0.446
DEG_SPOP_SBC_1	192	196	PF00917	0.496
DOC_CYCLIN_RxL_1	109	120	PF00134	0.503
DOC_CYCLIN_RxL_1	368	380	PF00134	0.452
DOC_CYCLIN_RxL_1	419	429	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.471
DOC_MAPK_MEF2A_6	431	438	PF00069	0.303
DOC_PP1_RVXF_1	371	378	PF00149	0.435
DOC_PP2B_LxvP_1	114	117	PF13499	0.482
DOC_PP2B_LxvP_1	150	153	PF13499	0.539
DOC_PP2B_LxvP_1	251	254	PF13499	0.656
DOC_PP4_FxxP_1	237	240	PF00568	0.468
DOC_USP7_MATH_1	117	121	PF00917	0.629
DOC_USP7_MATH_1	206	210	PF00917	0.452
DOC_USP7_MATH_1	254	258	PF00917	0.751
DOC_USP7_MATH_1	286	290	PF00917	0.750
DOC_USP7_MATH_1	314	318	PF00917	0.712
DOC_USP7_MATH_1	340	344	PF00917	0.401
DOC_USP7_MATH_1	352	356	PF00917	0.464
DOC_USP7_MATH_1	49	53	PF00917	0.654
DOC_WW_Pin1_4	16	21	PF00397	0.410
DOC_WW_Pin1_4	268	273	PF00397	0.724
DOC_WW_Pin1_4	416	421	PF00397	0.505
LIG_14-3-3_CanoR_1	179	189	PF00244	0.443
LIG_14-3-3_CanoR_1	208	213	PF00244	0.492
LIG_14-3-3_CanoR_1	229	235	PF00244	0.546
LIG_BRCT_BRCA1_1	14	18	PF00533	0.432
LIG_BRCT_BRCA1_1	288	292	PF00533	0.682
LIG_BRCT_BRCA1_1	354	358	PF00533	0.400
LIG_CSL_BTD_1	114	117	PF09270	0.488
LIG_FHA_1	180	186	PF00498	0.474
LIG_FHA_1	193	199	PF00498	0.462
LIG_FHA_1	37	43	PF00498	0.437
LIG_FHA_1	398	404	PF00498	0.546
LIG_FHA_1	441	447	PF00498	0.645
LIG_FHA_1	8	14	PF00498	0.415
LIG_FHA_2	171	177	PF00498	0.473
LIG_FHA_2	182	188	PF00498	0.450
LIG_FHA_2	198	204	PF00498	0.420
LIG_FHA_2	231	237	PF00498	0.557
LIG_FHA_2	32	38	PF00498	0.378
LIG_FHA_2	383	389	PF00498	0.430
LIG_FHA_2	425	431	PF00498	0.427
LIG_FHA_2	79	85	PF00498	0.517
LIG_IBAR_NPY_1	75	77	PF08397	0.426
LIG_LIR_Apic_2	235	240	PF02991	0.482
LIG_LIR_Gen_1	133	139	PF02991	0.416
LIG_LIR_Nem_3	133	137	PF02991	0.431
LIG_PCNA_yPIPBox_3	102	114	PF02747	0.370
LIG_Pex14_1	437	441	PF04695	0.451
LIG_Pex14_2	347	351	PF04695	0.466
LIG_SH2_CRK	77	81	PF00017	0.537
LIG_SH2_SRC	146	149	PF00017	0.434
LIG_SH2_STAT5	146	149	PF00017	0.434
LIG_SH2_STAT5	371	374	PF00017	0.439
LIG_SH2_STAT5	77	80	PF00017	0.537
LIG_SH3_3	163	169	PF00018	0.509
LIG_SH3_3	186	192	PF00018	0.438
LIG_SH3_3	242	248	PF00018	0.503
LIG_SH3_3	70	76	PF00018	0.426
LIG_SUMO_SIM_par_1	382	391	PF11976	0.436
LIG_WW_3	320	324	PF00397	0.571
MOD_CDC14_SPxK_1	419	422	PF00782	0.607
MOD_CDK_SPxK_1	416	422	PF00069	0.582
MOD_CK1_1	135	141	PF00069	0.429
MOD_CK1_1	181	187	PF00069	0.439
MOD_CK1_1	266	272	PF00069	0.824
MOD_CK1_1	387	393	PF00069	0.464
MOD_CK1_1	416	422	PF00069	0.510
MOD_CK2_1	152	158	PF00069	0.719
MOD_CK2_1	197	203	PF00069	0.418
MOD_CK2_1	230	236	PF00069	0.532
MOD_CK2_1	388	394	PF00069	0.445
MOD_GlcNHglycan	119	122	PF01048	0.666
MOD_GlcNHglycan	137	140	PF01048	0.381
MOD_GlcNHglycan	154	157	PF01048	0.609
MOD_GlcNHglycan	158	161	PF01048	0.700
MOD_GlcNHglycan	316	319	PF01048	0.793
MOD_GlcNHglycan	34	37	PF01048	0.445
MOD_GlcNHglycan	354	357	PF01048	0.408
MOD_GlcNHglycan	415	418	PF01048	0.421
MOD_GSK3_1	12	19	PF00069	0.372
MOD_GSK3_1	123	130	PF00069	0.681
MOD_GSK3_1	148	155	PF00069	0.581
MOD_GSK3_1	193	200	PF00069	0.466
MOD_GSK3_1	208	215	PF00069	0.541
MOD_GSK3_1	264	271	PF00069	0.667
MOD_GSK3_1	3	10	PF00069	0.435
MOD_GSK3_1	32	39	PF00069	0.462
MOD_GSK3_1	384	391	PF00069	0.457
MOD_GSK3_1	412	419	PF00069	0.458
MOD_GSK3_1	80	87	PF00069	0.491
MOD_N-GLC_1	302	307	PF02516	0.560
MOD_NEK2_1	178	183	PF00069	0.453
MOD_NEK2_1	212	217	PF00069	0.603
MOD_NEK2_1	264	269	PF00069	0.569
MOD_NEK2_1	30	35	PF00069	0.425
MOD_NEK2_1	412	417	PF00069	0.482
MOD_NEK2_1	424	429	PF00069	0.470
MOD_NEK2_2	287	292	PF00069	0.506
MOD_PIKK_1	254	260	PF00454	0.510
MOD_PIKK_1	49	55	PF00454	0.581
MOD_PKA_2	178	184	PF00069	0.503
MOD_PKA_2	212	218	PF00069	0.568
MOD_Plk_1	132	138	PF00069	0.343
MOD_Plk_1	388	394	PF00069	0.445
MOD_Plk_1	84	90	PF00069	0.517
MOD_Plk_4	12	18	PF00069	0.414
MOD_Plk_4	170	176	PF00069	0.402
MOD_Plk_4	193	199	PF00069	0.413
MOD_Plk_4	287	293	PF00069	0.503
MOD_Plk_4	75	81	PF00069	0.607
MOD_ProDKin_1	16	22	PF00069	0.419
MOD_ProDKin_1	268	274	PF00069	0.724
MOD_ProDKin_1	416	422	PF00069	0.510
MOD_SUMO_rev_2	376	384	PF00179	0.577
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.571
TRG_ENDOCYTIC_2	77	80	PF00928	0.584
TRG_ER_diArg_1	322	324	PF00400	0.829
TRG_ER_diArg_1	93	95	PF00400	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM43	Leptomonas seymouri	67%	100%
A0A3S7WX82	Leishmania donovani	83%	100%
A0A422N3N4	Trypanosoma rangeli	33%	100%
E9AGZ5	Leishmania infantum	83%	100%
E9AVV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QBM2	Leishmania major	85%	100%