Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein kinase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCF9_LEIBR

TriTrypDb:

LbrM.22.1070 , LBRM2903_220016400

Length:

947

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCF9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0000278	mitotic cell cycle	3	1
GO:0007049	cell cycle	2	1
GO:0010564	regulation of cell cycle process	5	1
GO:0032465	regulation of cytokinesis	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051302	regulation of cell division	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.506
CLV_C14_Caspase3-7	261	265	PF00656	0.393
CLV_C14_Caspase3-7	517	521	PF00656	0.644
CLV_C14_Caspase3-7	533	537	PF00656	0.516
CLV_C14_Caspase3-7	805	809	PF00656	0.662
CLV_C14_Caspase3-7	904	908	PF00656	0.534
CLV_NRD_NRD_1	121	123	PF00675	0.355
CLV_NRD_NRD_1	533	535	PF00675	0.619
CLV_NRD_NRD_1	539	541	PF00675	0.649
CLV_NRD_NRD_1	698	700	PF00675	0.534
CLV_NRD_NRD_1	711	713	PF00675	0.607
CLV_NRD_NRD_1	735	737	PF00675	0.682
CLV_NRD_NRD_1	851	853	PF00675	0.663
CLV_PCSK_KEX2_1	121	123	PF00082	0.469
CLV_PCSK_KEX2_1	191	193	PF00082	0.552
CLV_PCSK_KEX2_1	52	54	PF00082	0.489
CLV_PCSK_KEX2_1	539	541	PF00082	0.684
CLV_PCSK_KEX2_1	698	700	PF00082	0.564
CLV_PCSK_KEX2_1	734	736	PF00082	0.684
CLV_PCSK_KEX2_1	851	853	PF00082	0.663
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.536
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.453
CLV_PCSK_PC7_1	48	54	PF00082	0.439
CLV_PCSK_PC7_1	847	853	PF00082	0.530
CLV_PCSK_SKI1_1	108	112	PF00082	0.462
CLV_PCSK_SKI1_1	278	282	PF00082	0.385
CLV_PCSK_SKI1_1	286	290	PF00082	0.311
CLV_PCSK_SKI1_1	37	41	PF00082	0.477
CLV_PCSK_SKI1_1	383	387	PF00082	0.456
CLV_PCSK_SKI1_1	456	460	PF00082	0.657
CLV_PCSK_SKI1_1	493	497	PF00082	0.549
CLV_PCSK_SKI1_1	52	56	PF00082	0.315
CLV_PCSK_SKI1_1	79	83	PF00082	0.446
CLV_PCSK_SKI1_1	943	947	PF00082	0.487
CLV_Separin_Metazoa	344	348	PF03568	0.385
CLV_Separin_Metazoa	695	699	PF03568	0.503
DEG_APCC_DBOX_1	393	401	PF00400	0.385
DEG_SPOP_SBC_1	202	206	PF00917	0.545
DOC_CKS1_1	673	678	PF01111	0.525
DOC_CYCLIN_RxL_1	275	282	PF00134	0.243
DOC_CYCLIN_yCln2_LP_2	840	846	PF00134	0.681
DOC_MAPK_DCC_7	394	402	PF00069	0.385
DOC_MAPK_gen_1	896	905	PF00069	0.635
DOC_MAPK_MEF2A_6	394	402	PF00069	0.385
DOC_MAPK_MEF2A_6	837	846	PF00069	0.654
DOC_MAPK_NFAT4_5	837	845	PF00069	0.540
DOC_PP2B_LxvP_1	840	843	PF13499	0.683
DOC_PP2B_LxvP_1	880	883	PF13499	0.531
DOC_PP4_FxxP_1	173	176	PF00568	0.507
DOC_PP4_FxxP_1	324	327	PF00568	0.243
DOC_USP7_MATH_1	131	135	PF00917	0.561
DOC_USP7_MATH_1	219	223	PF00917	0.650
DOC_USP7_MATH_1	267	271	PF00917	0.448
DOC_USP7_MATH_1	495	499	PF00917	0.520
DOC_USP7_MATH_1	574	578	PF00917	0.619
DOC_USP7_MATH_1	584	588	PF00917	0.549
DOC_USP7_MATH_1	724	728	PF00917	0.708
DOC_USP7_MATH_1	738	742	PF00917	0.568
DOC_USP7_MATH_1	836	840	PF00917	0.637
DOC_USP7_MATH_1	853	857	PF00917	0.503
DOC_WW_Pin1_4	186	191	PF00397	0.553
DOC_WW_Pin1_4	409	414	PF00397	0.385
DOC_WW_Pin1_4	518	523	PF00397	0.580
DOC_WW_Pin1_4	545	550	PF00397	0.567
DOC_WW_Pin1_4	580	585	PF00397	0.671
DOC_WW_Pin1_4	664	669	PF00397	0.553
DOC_WW_Pin1_4	672	677	PF00397	0.550
DOC_WW_Pin1_4	687	692	PF00397	0.628
DOC_WW_Pin1_4	890	895	PF00397	0.536
DOC_WW_Pin1_4	929	934	PF00397	0.493
LIG_14-3-3_CanoR_1	121	127	PF00244	0.358
LIG_14-3-3_CanoR_1	132	139	PF00244	0.423
LIG_14-3-3_CanoR_1	192	197	PF00244	0.640
LIG_14-3-3_CanoR_1	338	342	PF00244	0.428
LIG_14-3-3_CanoR_1	37	46	PF00244	0.465
LIG_14-3-3_CanoR_1	466	471	PF00244	0.563
LIG_14-3-3_CanoR_1	493	501	PF00244	0.688
LIG_14-3-3_CanoR_1	555	563	PF00244	0.567
LIG_14-3-3_CanoR_1	70	76	PF00244	0.504
LIG_14-3-3_CanoR_1	887	891	PF00244	0.541
LIG_BRCT_BRCA1_1	320	324	PF00533	0.385
LIG_BRCT_BRCA1_1	680	684	PF00533	0.546
LIG_CaM_IQ_9	616	632	PF13499	0.443
LIG_deltaCOP1_diTrp_1	57	62	PF00928	0.470
LIG_eIF4E_1	95	101	PF01652	0.435
LIG_FHA_1	238	244	PF00498	0.576
LIG_FHA_1	38	44	PF00498	0.554
LIG_FHA_1	444	450	PF00498	0.422
LIG_FHA_1	494	500	PF00498	0.521
LIG_FHA_1	634	640	PF00498	0.672
LIG_FHA_1	672	678	PF00498	0.537
LIG_FHA_1	817	823	PF00498	0.698
LIG_FHA_1	877	883	PF00498	0.530
LIG_FHA_1	930	936	PF00498	0.540
LIG_FHA_1	940	946	PF00498	0.509
LIG_FHA_2	136	142	PF00498	0.674
LIG_FHA_2	432	438	PF00498	0.533
LIG_FHA_2	512	518	PF00498	0.680
LIG_FHA_2	825	831	PF00498	0.638
LIG_FHA_2	902	908	PF00498	0.538
LIG_GBD_Chelix_1	400	408	PF00786	0.385
LIG_IRF3_LxIS_1	310	317	PF10401	0.243
LIG_LIR_Apic_2	172	176	PF02991	0.505
LIG_LIR_Apic_2	321	327	PF02991	0.272
LIG_LIR_Gen_1	498	507	PF02991	0.667
LIG_LIR_Gen_1	768	775	PF02991	0.553
LIG_LIR_Gen_1	92	101	PF02991	0.434
LIG_LIR_Gen_1	938	947	PF02991	0.556
LIG_LIR_Nem_3	349	354	PF02991	0.385
LIG_LIR_Nem_3	498	504	PF02991	0.667
LIG_MYND_1	602	606	PF01753	0.640
LIG_PCNA_yPIPBox_3	12	24	PF02747	0.478
LIG_PDZ_Class_2	942	947	PF00595	0.487
LIG_SH2_CRK	156	160	PF00017	0.529
LIG_SH2_CRK	623	627	PF00017	0.444
LIG_SH2_SRC	934	937	PF00017	0.600
LIG_SH2_STAP1	50	54	PF00017	0.441
LIG_SH2_STAT5	354	357	PF00017	0.499
LIG_SH2_STAT5	366	369	PF00017	0.302
LIG_SH2_STAT5	45	48	PF00017	0.574
LIG_SH2_STAT5	934	937	PF00017	0.600
LIG_SH2_STAT5	95	98	PF00017	0.308
LIG_SH3_3	389	395	PF00018	0.385
LIG_SH3_3	516	522	PF00018	0.598
LIG_SH3_3	543	549	PF00018	0.670
LIG_SH3_3	670	676	PF00018	0.579
LIG_SH3_3	715	721	PF00018	0.538
LIG_SH3_3	859	865	PF00018	0.652
LIG_SUMO_SIM_par_1	669	675	PF11976	0.658
LIG_TRAF2_1	412	415	PF00917	0.385
LIG_TRAF2_1	651	654	PF00917	0.508
LIG_UBA3_1	100	108	PF00899	0.450
LIG_WRC_WIRS_1	170	175	PF05994	0.506
LIG_WRC_WIRS_1	504	509	PF05994	0.671
MOD_CDC14_SPxK_1	893	896	PF00782	0.530
MOD_CDK_SPK_2	186	191	PF00069	0.525
MOD_CDK_SPK_2	687	692	PF00069	0.661
MOD_CDK_SPxK_1	186	192	PF00069	0.526
MOD_CDK_SPxK_1	890	896	PF00069	0.538
MOD_CDK_SPxxK_3	409	416	PF00069	0.385
MOD_CK1_1	134	140	PF00069	0.553
MOD_CK1_1	201	207	PF00069	0.615
MOD_CK1_1	238	244	PF00069	0.785
MOD_CK1_1	249	255	PF00069	0.525
MOD_CK1_1	431	437	PF00069	0.395
MOD_CK1_1	457	463	PF00069	0.564
MOD_CK1_1	503	509	PF00069	0.752
MOD_CK1_1	564	570	PF00069	0.581
MOD_CK1_1	578	584	PF00069	0.519
MOD_CK1_1	727	733	PF00069	0.690
MOD_CK1_1	788	794	PF00069	0.672
MOD_CK1_1	802	808	PF00069	0.535
MOD_CK1_1	825	831	PF00069	0.690
MOD_CK1_1	871	877	PF00069	0.680
MOD_CK2_1	409	415	PF00069	0.385
MOD_CK2_1	431	437	PF00069	0.537
MOD_CK2_1	824	830	PF00069	0.634
MOD_GlcNHglycan	133	136	PF01048	0.574
MOD_GlcNHglycan	184	187	PF01048	0.599
MOD_GlcNHglycan	205	208	PF01048	0.729
MOD_GlcNHglycan	220	224	PF01048	0.645
MOD_GlcNHglycan	248	251	PF01048	0.464
MOD_GlcNHglycan	260	263	PF01048	0.364
MOD_GlcNHglycan	508	511	PF01048	0.673
MOD_GlcNHglycan	540	543	PF01048	0.623
MOD_GlcNHglycan	558	561	PF01048	0.633
MOD_GlcNHglycan	653	658	PF01048	0.538
MOD_GlcNHglycan	680	683	PF01048	0.658
MOD_GlcNHglycan	7	10	PF01048	0.494
MOD_GlcNHglycan	731	734	PF01048	0.653
MOD_GlcNHglycan	740	743	PF01048	0.582
MOD_GlcNHglycan	824	827	PF01048	0.544
MOD_GSK3_1	1	8	PF00069	0.642
MOD_GSK3_1	100	107	PF00069	0.447
MOD_GSK3_1	122	129	PF00069	0.447
MOD_GSK3_1	130	137	PF00069	0.531
MOD_GSK3_1	182	189	PF00069	0.583
MOD_GSK3_1	198	205	PF00069	0.592
MOD_GSK3_1	235	242	PF00069	0.790
MOD_GSK3_1	248	255	PF00069	0.517
MOD_GSK3_1	314	321	PF00069	0.527
MOD_GSK3_1	538	545	PF00069	0.698
MOD_GSK3_1	561	568	PF00069	0.608
MOD_GSK3_1	574	581	PF00069	0.568
MOD_GSK3_1	584	591	PF00069	0.604
MOD_GSK3_1	640	647	PF00069	0.452
MOD_GSK3_1	671	678	PF00069	0.666
MOD_GSK3_1	738	745	PF00069	0.597
MOD_GSK3_1	759	766	PF00069	0.664
MOD_GSK3_1	781	788	PF00069	0.544
MOD_GSK3_1	868	875	PF00069	0.565
MOD_GSK3_1	882	889	PF00069	0.550
MOD_N-GLC_1	104	109	PF02516	0.332
MOD_N-GLC_1	831	836	PF02516	0.552
MOD_N-GLC_1	872	877	PF02516	0.659
MOD_N-GLC_1	939	944	PF02516	0.454
MOD_NEK2_1	100	105	PF00069	0.383
MOD_NEK2_1	126	131	PF00069	0.395
MOD_NEK2_1	198	203	PF00069	0.614
MOD_NEK2_1	246	251	PF00069	0.484
MOD_NEK2_1	314	319	PF00069	0.495
MOD_NEK2_1	334	339	PF00069	0.199
MOD_NEK2_1	428	433	PF00069	0.361
MOD_NEK2_1	538	543	PF00069	0.584
MOD_NEK2_1	562	567	PF00069	0.579
MOD_NEK2_1	579	584	PF00069	0.600
MOD_NEK2_1	88	93	PF00069	0.333
MOD_NEK2_1	886	891	PF00069	0.685
MOD_NEK2_2	378	383	PF00069	0.385
MOD_NEK2_2	495	500	PF00069	0.520
MOD_NEK2_2	542	547	PF00069	0.551
MOD_NEK2_2	836	841	PF00069	0.686
MOD_PIKK_1	124	130	PF00454	0.373
MOD_PIKK_1	640	646	PF00454	0.592
MOD_PIKK_1	724	730	PF00454	0.706
MOD_PK_1	466	472	PF00069	0.545
MOD_PKA_1	191	197	PF00069	0.540
MOD_PKA_2	131	137	PF00069	0.430
MOD_PKA_2	191	197	PF00069	0.602
MOD_PKA_2	314	320	PF00069	0.492
MOD_PKA_2	334	340	PF00069	0.199
MOD_PKA_2	390	396	PF00069	0.385
MOD_PKA_2	538	544	PF00069	0.693
MOD_PKA_2	816	822	PF00069	0.554
MOD_PKA_2	836	842	PF00069	0.507
MOD_PKA_2	886	892	PF00069	0.559
MOD_Plk_1	198	204	PF00069	0.542
MOD_Plk_1	799	805	PF00069	0.670
MOD_Plk_1	872	878	PF00069	0.653
MOD_Plk_2-3	901	907	PF00069	0.541
MOD_Plk_4	198	204	PF00069	0.579
MOD_Plk_4	242	248	PF00069	0.508
MOD_Plk_4	249	255	PF00069	0.414
MOD_Plk_4	272	278	PF00069	0.470
MOD_Plk_4	466	472	PF00069	0.665
MOD_Plk_4	500	506	PF00069	0.746
MOD_Plk_4	575	581	PF00069	0.553
MOD_Plk_4	706	712	PF00069	0.516
MOD_Plk_4	799	805	PF00069	0.670
MOD_Plk_4	872	878	PF00069	0.569
MOD_Plk_4	90	96	PF00069	0.531
MOD_ProDKin_1	186	192	PF00069	0.555
MOD_ProDKin_1	409	415	PF00069	0.385
MOD_ProDKin_1	518	524	PF00069	0.579
MOD_ProDKin_1	545	551	PF00069	0.567
MOD_ProDKin_1	580	586	PF00069	0.673
MOD_ProDKin_1	664	670	PF00069	0.554
MOD_ProDKin_1	672	678	PF00069	0.549
MOD_ProDKin_1	687	693	PF00069	0.627
MOD_ProDKin_1	890	896	PF00069	0.538
MOD_ProDKin_1	929	935	PF00069	0.490
MOD_SUMO_for_1	651	654	PF00179	0.595
TRG_DiLeu_BaEn_1	635	640	PF01217	0.595
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.385
TRG_ENDOCYTIC_2	366	369	PF00928	0.385
TRG_ENDOCYTIC_2	623	626	PF00928	0.584
TRG_ENDOCYTIC_2	95	98	PF00928	0.415
TRG_ER_diArg_1	120	122	PF00400	0.351
TRG_ER_diArg_1	32	35	PF00400	0.561
TRG_ER_diArg_1	371	374	PF00400	0.366
TRG_ER_diArg_1	538	540	PF00400	0.561
TRG_ER_diArg_1	626	629	PF00400	0.498
TRG_ER_diArg_1	697	699	PF00400	0.505
TRG_ER_diArg_1	734	736	PF00400	0.681
TRG_ER_diArg_1	851	853	PF00400	0.641
TRG_ER_diArg_1	896	899	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBH5	Leishmania donovani	62%	100%
A4HZY8	Leishmania infantum	62%	96%
E9AVU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4QBN0	Leishmania major	61%	98%