Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCF8_LEIBR

TriTrypDb:

LbrM.22.1060 , LBRM2903_220016300

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.563
CLV_NRD_NRD_1	102	104	PF00675	0.747
CLV_NRD_NRD_1	19	21	PF00675	0.569
CLV_NRD_NRD_1	436	438	PF00675	0.566
CLV_PCSK_KEX2_1	102	104	PF00082	0.747
CLV_PCSK_KEX2_1	19	21	PF00082	0.569
CLV_PCSK_KEX2_1	436	438	PF00082	0.566
CLV_PCSK_KEX2_1	65	67	PF00082	0.547
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.603
CLV_PCSK_PC7_1	432	438	PF00082	0.551
CLV_PCSK_SKI1_1	302	306	PF00082	0.498
CLV_PCSK_SKI1_1	324	328	PF00082	0.579
CLV_PCSK_SKI1_1	342	346	PF00082	0.504
CLV_PCSK_SKI1_1	356	360	PF00082	0.377
CLV_PCSK_SKI1_1	414	418	PF00082	0.581
CLV_PCSK_SKI1_1	87	91	PF00082	0.733
DEG_APCC_DBOX_1	21	29	PF00400	0.632
DEG_SCF_FBW7_2	88	94	PF00400	0.506
DOC_CKS1_1	88	93	PF01111	0.718
DOC_CYCLIN_RxL_1	296	309	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.681
DOC_MAPK_gen_1	265	273	PF00069	0.648
DOC_PP1_RVXF_1	205	211	PF00149	0.572
DOC_USP7_MATH_1	117	121	PF00917	0.747
DOC_USP7_MATH_1	133	137	PF00917	0.748
DOC_USP7_MATH_1	145	149	PF00917	0.631
DOC_USP7_MATH_1	181	185	PF00917	0.626
DOC_USP7_MATH_1	256	260	PF00917	0.722
DOC_USP7_MATH_1	261	265	PF00917	0.730
DOC_USP7_MATH_1	55	59	PF00917	0.346
DOC_WW_Pin1_4	129	134	PF00397	0.755
DOC_WW_Pin1_4	140	145	PF00397	0.671
DOC_WW_Pin1_4	279	284	PF00397	0.523
DOC_WW_Pin1_4	345	350	PF00397	0.546
DOC_WW_Pin1_4	370	375	PF00397	0.556
DOC_WW_Pin1_4	87	92	PF00397	0.666
LIG_14-3-3_CanoR_1	113	117	PF00244	0.742
LIG_14-3-3_CanoR_1	140	144	PF00244	0.772
LIG_14-3-3_CanoR_1	212	216	PF00244	0.632
LIG_14-3-3_CanoR_1	279	283	PF00244	0.469
LIG_14-3-3_CanoR_1	43	50	PF00244	0.406
LIG_14-3-3_CanoR_1	436	441	PF00244	0.610
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_FHA_1	16	22	PF00498	0.576
LIG_FHA_1	170	176	PF00498	0.477
LIG_FHA_1	211	217	PF00498	0.657
LIG_FHA_1	37	43	PF00498	0.635
LIG_FHA_1	379	385	PF00498	0.510
LIG_FHA_1	415	421	PF00498	0.599
LIG_FHA_1	49	55	PF00498	0.535
LIG_FHA_2	301	307	PF00498	0.509
LIG_FHA_2	31	37	PF00498	0.715
LIG_FHA_2	408	414	PF00498	0.608
LIG_FHA_2	437	443	PF00498	0.638
LIG_FHA_2	88	94	PF00498	0.718
LIG_GBD_Chelix_1	216	224	PF00786	0.586
LIG_LIR_Apic_2	239	243	PF02991	0.641
LIG_LIR_Apic_2	51	55	PF02991	0.452
LIG_LIR_Gen_1	439	448	PF02991	0.647
LIG_LIR_Nem_3	223	229	PF02991	0.522
LIG_LIR_Nem_3	361	365	PF02991	0.483
LIG_LIR_Nem_3	439	443	PF02991	0.641
LIG_LIR_Nem_3	51	56	PF02991	0.452
LIG_PALB2_WD40_1	48	56	PF16756	0.592
LIG_Pex14_2	362	366	PF04695	0.429
LIG_PTB_Apo_2	239	246	PF02174	0.620
LIG_PTB_Phospho_1	239	245	PF10480	0.627
LIG_SH2_CRK	240	244	PF00017	0.608
LIG_SH2_CRK	280	284	PF00017	0.427
LIG_SH2_GRB2like	157	160	PF00017	0.680
LIG_SH2_NCK_1	280	284	PF00017	0.440
LIG_SH2_STAP1	440	444	PF00017	0.726
LIG_SH2_STAT5	157	160	PF00017	0.721
LIG_SH2_STAT5	245	248	PF00017	0.573
LIG_SH2_STAT5	27	30	PF00017	0.728
LIG_SH2_STAT5	280	283	PF00017	0.422
LIG_SH2_STAT5	369	372	PF00017	0.480
LIG_SH2_STAT5	61	64	PF00017	0.627
LIG_SH3_3	141	147	PF00018	0.597
LIG_SH3_3	283	289	PF00018	0.348
LIG_SH3_3	29	35	PF00018	0.667
LIG_SH3_3	346	352	PF00018	0.523
LIG_SH3_3	372	378	PF00018	0.500
LIG_SH3_3	85	91	PF00018	0.743
LIG_TRAF2_1	255	258	PF00917	0.684
LIG_TRAF2_1	91	94	PF00917	0.495
LIG_UBA3_1	233	241	PF00899	0.546
MOD_CK1_1	136	142	PF00069	0.710
MOD_CK1_1	143	149	PF00069	0.645
MOD_CK1_1	2	8	PF00069	0.772
MOD_CK1_1	219	225	PF00069	0.598
MOD_CK1_1	247	253	PF00069	0.546
MOD_CK1_1	347	353	PF00069	0.512
MOD_CK1_1	407	413	PF00069	0.603
MOD_CK1_1	41	47	PF00069	0.567
MOD_CK2_1	143	149	PF00069	0.809
MOD_CK2_1	181	187	PF00069	0.538
MOD_CK2_1	361	367	PF00069	0.570
MOD_CK2_1	412	418	PF00069	0.589
MOD_CK2_1	436	442	PF00069	0.676
MOD_CK2_1	87	93	PF00069	0.708
MOD_GlcNHglycan	119	122	PF01048	0.730
MOD_GlcNHglycan	133	136	PF01048	0.644
MOD_GlcNHglycan	246	249	PF01048	0.494
MOD_GlcNHglycan	257	261	PF01048	0.636
MOD_GlcNHglycan	319	322	PF01048	0.480
MOD_GlcNHglycan	4	7	PF01048	0.754
MOD_GlcNHglycan	406	409	PF01048	0.602
MOD_GSK3_1	112	119	PF00069	0.789
MOD_GSK3_1	129	136	PF00069	0.652
MOD_GSK3_1	139	146	PF00069	0.621
MOD_GSK3_1	216	223	PF00069	0.533
MOD_GSK3_1	256	263	PF00069	0.648
MOD_GSK3_1	300	307	PF00069	0.537
MOD_GSK3_1	37	44	PF00069	0.550
MOD_N-GLC_1	317	322	PF02516	0.501
MOD_NEK2_1	112	117	PF00069	0.751
MOD_NEK2_1	216	221	PF00069	0.541
MOD_NEK2_1	304	309	PF00069	0.547
MOD_NEK2_1	336	341	PF00069	0.579
MOD_NEK2_2	196	201	PF00069	0.498
MOD_PK_1	103	109	PF00069	0.762
MOD_PK_1	232	238	PF00069	0.529
MOD_PKA_1	436	442	PF00069	0.572
MOD_PKA_2	112	118	PF00069	0.749
MOD_PKA_2	139	145	PF00069	0.770
MOD_PKA_2	15	21	PF00069	0.628
MOD_PKA_2	211	217	PF00069	0.608
MOD_PKA_2	278	284	PF00069	0.486
MOD_PKA_2	42	48	PF00069	0.419
MOD_PKA_2	436	442	PF00069	0.572
MOD_Plk_1	317	323	PF00069	0.486
MOD_Plk_1	387	393	PF00069	0.552
MOD_Plk_1	412	418	PF00069	0.576
MOD_Plk_2-3	361	367	PF00069	0.570
MOD_Plk_4	103	109	PF00069	0.720
MOD_Plk_4	161	167	PF00069	0.566
MOD_Plk_4	169	175	PF00069	0.427
MOD_Plk_4	181	187	PF00069	0.348
MOD_Plk_4	211	217	PF00069	0.595
MOD_Plk_4	300	306	PF00069	0.469
MOD_Plk_4	336	342	PF00069	0.577
MOD_Plk_4	361	367	PF00069	0.430
MOD_Plk_4	378	384	PF00069	0.485
MOD_Plk_4	387	393	PF00069	0.463
MOD_Plk_4	48	54	PF00069	0.450
MOD_ProDKin_1	129	135	PF00069	0.756
MOD_ProDKin_1	140	146	PF00069	0.670
MOD_ProDKin_1	279	285	PF00069	0.518
MOD_ProDKin_1	345	351	PF00069	0.542
MOD_ProDKin_1	370	376	PF00069	0.562
MOD_ProDKin_1	87	93	PF00069	0.664
MOD_SUMO_for_1	295	298	PF00179	0.505
MOD_SUMO_for_1	358	361	PF00179	0.324
MOD_SUMO_rev_2	235	243	PF00179	0.548
TRG_ENDOCYTIC_2	27	30	PF00928	0.728
TRG_ENDOCYTIC_2	428	431	PF00928	0.560
TRG_ENDOCYTIC_2	440	443	PF00928	0.586
TRG_ER_diArg_1	19	22	PF00400	0.580
TRG_ER_diArg_1	435	437	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P811	Leptomonas seymouri	79%	100%
A0A0S4JBD1	Bodo saltans	47%	100%
A0A3R7MFR3	Trypanosoma rangeli	55%	100%
A0A3S7WX76	Leishmania donovani	88%	100%
A4HZY7	Leishmania infantum	87%	93%
E9AVU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBN1	Leishmania major	90%	100%
V5BVW6	Trypanosoma cruzi	53%	100%