Gamma-glutamylcyclotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ChaC-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCF7_LEIBR

TriTrypDb:

LbrM.22.1080 , LBRM2903_220016500

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HCF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCF7

Function

Biological processes
Term	Name	Level	Count
GO:0006518	peptide metabolic process	4	14
GO:0006575	cellular modified amino acid metabolic process	3	14
GO:0006749	glutathione metabolic process	4	14
GO:0006751	glutathione catabolic process	5	14
GO:0006790	sulfur compound metabolic process	3	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009056	catabolic process	2	14
GO:0009987	cellular process	1	14
GO:0042219	cellular modified amino acid catabolic process	4	14
GO:0043171	peptide catabolic process	4	14
GO:0043603	amide metabolic process	3	14
GO:0044237	cellular metabolic process	2	14
GO:0044248	cellular catabolic process	3	14
GO:0044273	sulfur compound catabolic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901565	organonitrogen compound catabolic process	4	14
GO:1901575	organic substance catabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0003839	gamma-glutamylcyclotransferase activity	5	14
GO:0016829	lyase activity	2	14
GO:0016840	carbon-nitrogen lyase activity	3	14
GO:0016842	amidine-lyase activity	4	14
GO:0061928	glutathione specific gamma-glutamylcyclotransferase activity	5	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.436
CLV_PCSK_KEX2_1	56	58	PF00082	0.284
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.316
CLV_PCSK_SKI1_1	259	263	PF00082	0.435
CLV_PCSK_SKI1_1	56	60	PF00082	0.269
CLV_PCSK_SKI1_1	75	79	PF00082	0.273
DEG_APCC_DBOX_1	230	238	PF00400	0.547
DOC_CDC14_PxL_1	134	142	PF14671	0.375
DOC_CYCLIN_RxL_1	256	266	PF00134	0.510
DOC_PP4_FxxP_1	18	21	PF00568	0.540
DOC_PP4_FxxP_1	94	97	PF00568	0.443
DOC_USP7_MATH_1	224	228	PF00917	0.473
DOC_WW_Pin1_4	141	146	PF00397	0.534
LIG_14-3-3_CanoR_1	119	125	PF00244	0.505
LIG_14-3-3_CanoR_1	75	80	PF00244	0.473
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_FHA_1	129	135	PF00498	0.535
LIG_FHA_1	211	217	PF00498	0.547
LIG_FHA_2	106	112	PF00498	0.431
LIG_LIR_Apic_2	154	159	PF02991	0.457
LIG_LIR_Apic_2	16	21	PF02991	0.560
LIG_LIR_Gen_1	105	114	PF02991	0.548
LIG_LIR_Gen_1	232	241	PF02991	0.518
LIG_LIR_Gen_1	25	36	PF02991	0.476
LIG_LIR_Nem_3	105	110	PF02991	0.548
LIG_LIR_Nem_3	114	120	PF02991	0.535
LIG_LIR_Nem_3	232	236	PF02991	0.518
LIG_LIR_Nem_3	25	31	PF02991	0.518
LIG_LIR_Nem_3	45	51	PF02991	0.341
LIG_PDZ_Class_1	275	280	PF00595	0.616
LIG_Pex14_1	38	42	PF04695	0.475
LIG_SH2_CRK	117	121	PF00017	0.518
LIG_SH2_CRK	156	160	PF00017	0.375
LIG_SH2_CRK	33	37	PF00017	0.474
LIG_SH2_CRK	55	59	PF00017	0.464
LIG_SH2_NCK_1	117	121	PF00017	0.461
LIG_SH2_STAP1	48	52	PF00017	0.521
LIG_SH2_STAT3	14	17	PF00017	0.600
LIG_SH2_STAT5	198	201	PF00017	0.489
LIG_SH2_STAT5	207	210	PF00017	0.463
LIG_SH2_STAT5	233	236	PF00017	0.475
LIG_SH2_STAT5	51	54	PF00017	0.494
LIG_SH3_1	179	185	PF00018	0.375
LIG_SH3_1	67	73	PF00018	0.493
LIG_SH3_2	70	75	PF14604	0.493
LIG_SH3_2	97	102	PF14604	0.547
LIG_SH3_3	179	185	PF00018	0.524
LIG_SH3_3	223	229	PF00018	0.375
LIG_SH3_3	67	73	PF00018	0.467
LIG_SH3_3	94	100	PF00018	0.516
LIG_WRC_WIRS_1	20	25	PF05994	0.465
MOD_CDK_SPK_2	141	146	PF00069	0.392
MOD_CK1_1	105	111	PF00069	0.524
MOD_CK1_1	147	153	PF00069	0.559
MOD_CK1_1	240	246	PF00069	0.449
MOD_CK2_1	162	168	PF00069	0.518
MOD_GlcNHglycan	151	154	PF01048	0.274
MOD_GlcNHglycan	226	229	PF01048	0.274
MOD_GlcNHglycan	268	272	PF01048	0.479
MOD_GlcNHglycan	3	6	PF01048	0.588
MOD_GSK3_1	1	8	PF00069	0.674
MOD_GSK3_1	105	112	PF00069	0.375
MOD_GSK3_1	128	135	PF00069	0.492
MOD_GSK3_1	140	147	PF00069	0.472
MOD_GSK3_1	215	222	PF00069	0.487
MOD_GSK3_1	240	247	PF00069	0.499
MOD_GSK3_1	75	82	PF00069	0.491
MOD_N-GLC_1	132	137	PF02516	0.324
MOD_N-GLC_1	162	167	PF02516	0.318
MOD_NEK2_1	140	145	PF00069	0.410
MOD_NEK2_1	237	242	PF00069	0.574
MOD_PK_1	102	108	PF00069	0.375
MOD_PKA_2	127	133	PF00069	0.446
MOD_PKA_2	9	15	PF00069	0.591
MOD_Plk_4	102	108	PF00069	0.410
MOD_Plk_4	120	126	PF00069	0.516
MOD_Plk_4	32	38	PF00069	0.481
MOD_Plk_4	47	53	PF00069	0.475
MOD_Plk_4	75	81	PF00069	0.466
MOD_ProDKin_1	141	147	PF00069	0.534
TRG_DiLeu_BaEn_2	231	237	PF01217	0.495
TRG_ENDOCYTIC_2	117	120	PF00928	0.493
TRG_ENDOCYTIC_2	233	236	PF00928	0.518
TRG_ENDOCYTIC_2	33	36	PF00928	0.474
TRG_ENDOCYTIC_2	55	58	PF00928	0.464
TRG_ER_diArg_1	262	265	PF00400	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P815	Leptomonas seymouri	64%	100%
A0A1X0NTG7	Trypanosomatidae	44%	100%
A0A3Q8ILN3	Leishmania donovani	61%	100%
A0A3R7NMW8	Trypanosoma rangeli	44%	100%
A0A3S5H7B1	Leishmania donovani	85%	100%
A4HZZ0	Leishmania infantum	61%	100%
A4HZZ1	Leishmania infantum	84%	87%
B3STU3	Rattus norvegicus	33%	100%
C9ZSN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AVV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9AVV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	87%
P32656	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P87305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q4QBM7	Leishmania major	81%	100%
Q4QBM8	Leishmania major	61%	90%
Q84QC1	Arabidopsis thaliana	33%	100%
Q8R3J5	Mus musculus	33%	100%
Q9BUX1	Homo sapiens	32%	100%