Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-lactamase superfamily domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCF4_LEIBR

TriTrypDb:

LbrM.22.1020 , LBRM2903_220015900

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.685
CLV_C14_Caspase3-7	151	155	PF00656	0.310
CLV_NRD_NRD_1	276	278	PF00675	0.356
CLV_PCSK_KEX2_1	276	278	PF00082	0.357
CLV_PCSK_SKI1_1	416	420	PF00082	0.436
DEG_APCC_DBOX_1	212	220	PF00400	0.183
DEG_APCC_DBOX_1	73	81	PF00400	0.554
DEG_SPOP_SBC_1	129	133	PF00917	0.395
DEG_SPOP_SBC_1	297	301	PF00917	0.299
DOC_MAPK_gen_1	266	275	PF00069	0.399
DOC_MAPK_gen_1	276	283	PF00069	0.333
DOC_MAPK_gen_1	290	298	PF00069	0.434
DOC_MAPK_MEF2A_6	290	298	PF00069	0.530
DOC_MAPK_MEF2A_6	63	72	PF00069	0.376
DOC_MAPK_NFAT4_5	63	71	PF00069	0.346
DOC_USP7_MATH_1	120	124	PF00917	0.750
DOC_USP7_MATH_1	128	132	PF00917	0.688
DOC_USP7_MATH_1	310	314	PF00917	0.620
DOC_USP7_MATH_1	340	344	PF00917	0.453
DOC_USP7_MATH_1	354	358	PF00917	0.374
DOC_USP7_MATH_1	369	373	PF00917	0.468
DOC_USP7_MATH_1	439	443	PF00917	0.374
DOC_USP7_MATH_1	55	59	PF00917	0.511
DOC_USP7_UBL2_3	217	221	PF12436	0.283
DOC_WW_Pin1_4	116	121	PF00397	0.509
DOC_WW_Pin1_4	236	241	PF00397	0.539
DOC_WW_Pin1_4	388	393	PF00397	0.452
DOC_WW_Pin1_4	394	399	PF00397	0.489
DOC_WW_Pin1_4	89	94	PF00397	0.691
LIG_14-3-3_CanoR_1	116	120	PF00244	0.680
LIG_14-3-3_CanoR_1	121	129	PF00244	0.641
LIG_14-3-3_CanoR_1	213	217	PF00244	0.383
LIG_14-3-3_CanoR_1	276	284	PF00244	0.349
LIG_14-3-3_CanoR_1	63	69	PF00244	0.405
LIG_14-3-3_CanoR_1	8	16	PF00244	0.504
LIG_14-3-3_CanoR_1	84	94	PF00244	0.486
LIG_Actin_WH2_2	437	452	PF00022	0.474
LIG_BIR_II_1	1	5	PF00653	0.673
LIG_BRCT_BRCA1_1	1	5	PF00533	0.511
LIG_BRCT_BRCA1_1	371	375	PF00533	0.461
LIG_Clathr_ClatBox_1	283	287	PF01394	0.468
LIG_Clathr_ClatBox_1	379	383	PF01394	0.338
LIG_deltaCOP1_diTrp_1	200	206	PF00928	0.420
LIG_FHA_1	168	174	PF00498	0.420
LIG_FHA_1	391	397	PF00498	0.366
LIG_FHA_1	89	95	PF00498	0.615
LIG_FHA_2	149	155	PF00498	0.280
LIG_FHA_2	237	243	PF00498	0.428
LIG_FHA_2	277	283	PF00498	0.343
LIG_FHA_2	98	104	PF00498	0.532
LIG_Integrin_RGD_1	74	76	PF01839	0.432
LIG_LIR_Nem_3	154	159	PF02991	0.329
LIG_LIR_Nem_3	314	320	PF02991	0.356
LIG_LRP6_Inhibitor_1	226	232	PF00058	0.253
LIG_SH2_CRK	24	28	PF00017	0.353
LIG_SH2_CRK	318	322	PF00017	0.341
LIG_SH2_STAT5	135	138	PF00017	0.498
LIG_SH2_STAT5	156	159	PF00017	0.337
LIG_SH2_STAT5	210	213	PF00017	0.279
LIG_SH2_STAT5	225	228	PF00017	0.382
LIG_SH2_STAT5	328	331	PF00017	0.401
LIG_SH2_STAT5	361	364	PF00017	0.319
LIG_SH2_STAT5	401	404	PF00017	0.351
LIG_SH2_STAT5	417	420	PF00017	0.159
LIG_SH3_3	14	20	PF00018	0.432
LIG_SH3_3	409	415	PF00018	0.464
LIG_SH3_3	463	469	PF00018	0.307
LIG_SH3_3	51	57	PF00018	0.506
LIG_SH3_3	75	81	PF00018	0.545
LIG_SUMO_SIM_anti_2	26	32	PF11976	0.266
LIG_SUMO_SIM_par_1	169	174	PF11976	0.420
LIG_UBA3_1	406	414	PF00899	0.308
LIG_WRC_WIRS_1	203	208	PF05994	0.413
LIG_WW_1	21	24	PF00397	0.418
MOD_CDK_SPK_2	116	121	PF00069	0.477
MOD_CDK_SPxxK_3	388	395	PF00069	0.325
MOD_CK1_1	108	114	PF00069	0.785
MOD_CK1_1	212	218	PF00069	0.279
MOD_CK1_1	230	236	PF00069	0.438
MOD_CK1_1	238	244	PF00069	0.494
MOD_CK1_1	32	38	PF00069	0.363
MOD_CK1_1	343	349	PF00069	0.627
MOD_CK1_1	363	369	PF00069	0.334
MOD_CK2_1	236	242	PF00069	0.407
MOD_CK2_1	276	282	PF00069	0.384
MOD_GlcNHglycan	107	110	PF01048	0.725
MOD_GlcNHglycan	2	5	PF01048	0.588
MOD_GlcNHglycan	232	235	PF01048	0.504
MOD_GlcNHglycan	31	34	PF01048	0.371
MOD_GlcNHglycan	56	60	PF01048	0.522
MOD_GSK3_1	116	123	PF00069	0.724
MOD_GSK3_1	167	174	PF00069	0.414
MOD_GSK3_1	202	209	PF00069	0.357
MOD_GSK3_1	211	218	PF00069	0.345
MOD_GSK3_1	25	32	PF00069	0.326
MOD_GSK3_1	336	343	PF00069	0.394
MOD_GSK3_1	390	397	PF00069	0.491
MOD_GSK3_1	55	62	PF00069	0.427
MOD_GSK3_1	64	71	PF00069	0.377
MOD_GSK3_1	7	14	PF00069	0.537
MOD_GSK3_1	82	89	PF00069	0.570
MOD_N-GLC_1	105	110	PF02516	0.673
MOD_N-GLC_1	116	121	PF02516	0.641
MOD_N-GLC_1	260	265	PF02516	0.564
MOD_N-GLC_1	64	69	PF02516	0.390
MOD_NEK2_1	171	176	PF00069	0.407
MOD_NEK2_1	211	216	PF00069	0.444
MOD_NEK2_1	25	30	PF00069	0.417
MOD_NEK2_1	68	73	PF00069	0.388
MOD_NEK2_2	122	127	PF00069	0.548
MOD_NEK2_2	148	153	PF00069	0.290
MOD_PIKK_1	11	17	PF00454	0.434
MOD_PIKK_1	340	346	PF00454	0.580
MOD_PKA_1	276	282	PF00069	0.376
MOD_PKA_2	115	121	PF00069	0.545
MOD_PKA_2	212	218	PF00069	0.311
MOD_PKA_2	227	233	PF00069	0.323
MOD_PKA_2	275	281	PF00069	0.342
MOD_PKA_2	336	342	PF00069	0.458
MOD_PKA_2	7	13	PF00069	0.455
MOD_Plk_1	219	225	PF00069	0.354
MOD_Plk_1	457	463	PF00069	0.462
MOD_Plk_1	64	70	PF00069	0.384
MOD_Plk_4	167	173	PF00069	0.388
MOD_Plk_4	202	208	PF00069	0.384
MOD_Plk_4	25	31	PF00069	0.410
MOD_ProDKin_1	116	122	PF00069	0.505
MOD_ProDKin_1	236	242	PF00069	0.543
MOD_ProDKin_1	388	394	PF00069	0.462
MOD_ProDKin_1	89	95	PF00069	0.692
MOD_SUMO_for_1	98	101	PF00179	0.510
TRG_ENDOCYTIC_2	156	159	PF00928	0.329
TRG_ENDOCYTIC_2	24	27	PF00928	0.357
TRG_ENDOCYTIC_2	328	331	PF00928	0.342
TRG_ENDOCYTIC_2	461	464	PF00928	0.386
TRG_ER_diArg_1	275	277	PF00400	0.446
TRG_NES_CRM1_1	377	388	PF08389	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M2	Leptomonas seymouri	65%	100%
A0A0N1PFX0	Leptomonas seymouri	35%	100%
A0A0S4J8Q0	Bodo saltans	39%	100%
A0A1X0NTE2	Trypanosomatidae	39%	100%
A0A1X0NX03	Trypanosomatidae	24%	100%
A0A3Q8IFK3	Leishmania donovani	86%	100%
A0A3S7WXD8	Leishmania donovani	46%	100%
A0A422NHR8	Trypanosoma rangeli	39%	100%
A4HZY3	Leishmania infantum	86%	100%
A4HZY4	Leishmania infantum	46%	100%
C9ZSM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AVU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AVU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
Q4QBN4	Leishmania major	45%	100%
Q4QBN5	Leishmania major	85%	98%
V5BVW3	Trypanosoma cruzi	41%	100%