Putative adaptor complex AP-1 medium subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adaptor complex AP-1 medium subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HCF3_LEIBR

TriTrypDb:

LbrM.22.1040 , LBRM2903_220016100

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030119	AP-type membrane coat adaptor complex	3	11
GO:0030131	clathrin adaptor complex	4	11
GO:0032991	protein-containing complex	1	11
GO:0098796	membrane protein complex	2	11
GO:0005737	cytoplasm	2	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCF3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.298
CLV_PCSK_SKI1_1	226	230	PF00082	0.276
CLV_PCSK_SKI1_1	288	292	PF00082	0.223
CLV_PCSK_SKI1_1	403	407	PF00082	0.257
CLV_PCSK_SKI1_1	420	424	PF00082	0.264
CLV_PCSK_SKI1_1	94	98	PF00082	0.391
DEG_COP1_1	23	31	PF00400	0.387
DEG_SCF_FBW7_2	44	49	PF00400	0.356
DOC_CKS1_1	163	168	PF01111	0.302
DOC_CKS1_1	414	419	PF01111	0.389
DOC_MAPK_FxFP_2	118	121	PF00069	0.414
DOC_MAPK_MEF2A_6	383	390	PF00069	0.270
DOC_MAPK_MEF2A_6	59	67	PF00069	0.423
DOC_PP1_RVXF_1	224	230	PF00149	0.389
DOC_PP1_RVXF_1	257	264	PF00149	0.257
DOC_PP1_RVXF_1	385	391	PF00149	0.389
DOC_PP4_FxxP_1	118	121	PF00568	0.335
DOC_PP4_FxxP_1	263	266	PF00568	0.257
DOC_PP4_FxxP_1	368	371	PF00568	0.257
DOC_PP4_FxxP_1	390	393	PF00568	0.257
DOC_SPAK_OSR1_1	389	393	PF12202	0.389
DOC_USP7_MATH_1	161	165	PF00917	0.517
DOC_USP7_MATH_1	323	327	PF00917	0.301
DOC_USP7_MATH_1	408	412	PF00917	0.179
DOC_USP7_UBL2_3	383	387	PF12436	0.347
DOC_USP7_UBL2_3	406	410	PF12436	0.336
DOC_USP7_UBL2_3	90	94	PF12436	0.411
DOC_WW_Pin1_4	10	15	PF00397	0.392
DOC_WW_Pin1_4	162	167	PF00397	0.431
DOC_WW_Pin1_4	413	418	PF00397	0.389
DOC_WW_Pin1_4	42	47	PF00397	0.375
LIG_14-3-3_CanoR_1	234	240	PF00244	0.389
LIG_14-3-3_CanoR_1	259	264	PF00244	0.257
LIG_14-3-3_CanoR_1	310	320	PF00244	0.283
LIG_14-3-3_CanoR_1	360	368	PF00244	0.355
LIG_14-3-3_CanoR_1	374	381	PF00244	0.216
LIG_14-3-3_CanoR_1	420	428	PF00244	0.257
LIG_14-3-3_CanoR_1	84	89	PF00244	0.326
LIG_Actin_WH2_2	274	290	PF00022	0.179
LIG_BIR_II_1	1	5	PF00653	0.286
LIG_FHA_1	216	222	PF00498	0.315
LIG_FHA_1	294	300	PF00498	0.376
LIG_FHA_1	335	341	PF00498	0.389
LIG_FHA_1	414	420	PF00498	0.389
LIG_FHA_2	312	318	PF00498	0.338
LIG_FHA_2	98	104	PF00498	0.325
LIG_Integrin_RGD_1	21	23	PF01839	0.338
LIG_LIR_Apic_2	117	121	PF02991	0.340
LIG_LIR_Apic_2	164	170	PF02991	0.261
LIG_LIR_Apic_2	262	266	PF02991	0.260
LIG_LIR_Apic_2	367	371	PF02991	0.352
LIG_LIR_Gen_1	103	112	PF02991	0.339
LIG_LIR_Gen_1	267	277	PF02991	0.257
LIG_LIR_Gen_1	54	63	PF02991	0.349
LIG_LIR_Nem_3	103	108	PF02991	0.357
LIG_LIR_Nem_3	117	123	PF02991	0.386
LIG_LIR_Nem_3	267	273	PF02991	0.389
LIG_LIR_Nem_3	415	421	PF02991	0.271
LIG_LIR_Nem_3	54	58	PF02991	0.328
LIG_LIR_Nem_3	87	92	PF02991	0.336
LIG_Pex14_2	89	93	PF04695	0.323
LIG_SH2_CRK	55	59	PF00017	0.287
LIG_SH2_CRK	83	87	PF00017	0.230
LIG_SH2_GRB2like	175	178	PF00017	0.334
LIG_SH2_PTP2	404	407	PF00017	0.389
LIG_SH2_STAT3	132	135	PF00017	0.351
LIG_SH2_STAT3	342	345	PF00017	0.389
LIG_SH2_STAT3	421	424	PF00017	0.257
LIG_SH2_STAT5	132	135	PF00017	0.385
LIG_SH2_STAT5	394	397	PF00017	0.321
LIG_SH2_STAT5	404	407	PF00017	0.264
LIG_SH2_STAT5	413	416	PF00017	0.321
LIG_SH2_STAT5	421	424	PF00017	0.270
LIG_SH2_STAT5	55	58	PF00017	0.275
LIG_SH2_STAT5	6	9	PF00017	0.267
LIG_SH2_STAT5	64	67	PF00017	0.269
LIG_SH2_STAT5	92	95	PF00017	0.351
LIG_SH3_3	160	166	PF00018	0.347
LIG_SH3_3	317	323	PF00018	0.340
LIG_SH3_3	411	417	PF00018	0.389
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.197
LIG_SUMO_SIM_par_1	64	69	PF11976	0.399
LIG_TYR_ITIM	107	112	PF00017	0.305
LIG_TYR_ITIM	402	407	PF00017	0.257
LIG_WRC_WIRS_1	260	265	PF05994	0.257
MOD_CDK_SPxK_1	162	168	PF00069	0.382
MOD_CDK_SPxxK_3	413	420	PF00069	0.389
MOD_CK1_1	10	16	PF00069	0.387
MOD_CK1_1	145	151	PF00069	0.564
MOD_CK1_1	235	241	PF00069	0.334
MOD_CK1_1	372	378	PF00069	0.271
MOD_CK2_1	234	240	PF00069	0.450
MOD_CK2_1	311	317	PF00069	0.389
MOD_GlcNHglycan	213	216	PF01048	0.274
MOD_GlcNHglycan	234	237	PF01048	0.407
MOD_GlcNHglycan	397	400	PF01048	0.257
MOD_GlcNHglycan	424	427	PF01048	0.260
MOD_GSK3_1	133	140	PF00069	0.530
MOD_GSK3_1	145	152	PF00069	0.630
MOD_GSK3_1	211	218	PF00069	0.283
MOD_GSK3_1	289	296	PF00069	0.353
MOD_GSK3_1	304	311	PF00069	0.262
MOD_GSK3_1	369	376	PF00069	0.286
MOD_GSK3_1	408	415	PF00069	0.179
MOD_GSK3_1	66	73	PF00069	0.276
MOD_N-GLC_2	72	74	PF02516	0.355
MOD_NEK2_1	134	139	PF00069	0.565
MOD_NEK2_1	229	234	PF00069	0.259
MOD_NEK2_1	395	400	PF00069	0.280
MOD_NEK2_1	66	71	PF00069	0.314
MOD_PIKK_1	22	28	PF00454	0.396
MOD_PIKK_1	332	338	PF00454	0.433
MOD_PIKK_1	420	426	PF00454	0.257
MOD_PIKK_1	94	100	PF00454	0.446
MOD_PK_1	84	90	PF00069	0.348
MOD_PKA_2	211	217	PF00069	0.276
MOD_PKA_2	309	315	PF00069	0.241
MOD_PKA_2	373	379	PF00069	0.291
MOD_Plk_1	242	248	PF00069	0.389
MOD_Plk_1	268	274	PF00069	0.382
MOD_Plk_4	134	140	PF00069	0.515
MOD_Plk_4	27	33	PF00069	0.449
MOD_Plk_4	53	59	PF00069	0.452
MOD_Plk_4	84	90	PF00069	0.374
MOD_ProDKin_1	10	16	PF00069	0.387
MOD_ProDKin_1	162	168	PF00069	0.420
MOD_ProDKin_1	413	419	PF00069	0.389
MOD_ProDKin_1	42	48	PF00069	0.367
MOD_SUMO_rev_2	3	13	PF00179	0.303
TRG_DiLeu_BaEn_1	186	191	PF01217	0.197
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.306
TRG_ENDOCYTIC_2	109	112	PF00928	0.306
TRG_ENDOCYTIC_2	404	407	PF00928	0.290
TRG_ENDOCYTIC_2	55	58	PF00928	0.274
TRG_ENDOCYTIC_2	64	67	PF00928	0.266
TRG_ENDOCYTIC_2	83	86	PF00928	0.427
TRG_NES_CRM1_1	197	210	PF08389	0.389
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F2	Leptomonas seymouri	27%	91%
A0A0N1I7F0	Leptomonas seymouri	83%	100%
A0A0N1ILY9	Leptomonas seymouri	27%	99%
A0A0N1PAY6	Leptomonas seymouri	24%	96%
A0A0S4INT9	Bodo saltans	25%	95%
A0A0S4JHW9	Bodo saltans	30%	94%
A0A0S4JX54	Bodo saltans	28%	89%
A0A1X0NJW3	Trypanosomatidae	27%	96%
A0A1X0NL86	Trypanosomatidae	28%	100%
A0A1X0NTD3	Trypanosomatidae	60%	100%
A0A1X0P9U6	Trypanosomatidae	27%	99%
A0A3Q8IB94	Leishmania donovani	92%	100%
A0A3Q8IKF7	Leishmania donovani	28%	99%
A0A3R7KIH0	Trypanosoma rangeli	28%	93%
A0A3R7NKK1	Trypanosoma rangeli	25%	96%
A0A3S7X806	Leishmania donovani	24%	93%
A0A422NHS3	Trypanosoma rangeli	59%	100%
A0A422NLU9	Trypanosoma rangeli	30%	89%
A4HAX6	Leishmania braziliensis	24%	96%
A4HPG9	Leishmania braziliensis	27%	99%
A4HZY5	Leishmania infantum	92%	100%
A4IA35	Leishmania infantum	24%	93%
A4ID91	Leishmania infantum	28%	99%
C9ZM64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZSM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
C9ZWJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	95%
D3ZRP6	Rattus norvegicus	43%	100%
E2RED8	Canis lupus familiaris	26%	96%
E9AT81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
E9AVU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B550	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	93%
F4I562	Arabidopsis thaliana	28%	100%
O00189	Homo sapiens	26%	96%
O22715	Arabidopsis thaliana	41%	100%
O23140	Arabidopsis thaliana	35%	99%
P35585	Mus musculus	44%	100%
P35602	Caenorhabditis elegans	45%	100%
P35603	Caenorhabditis elegans	35%	98%
P38700	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	72%
P47795	Diplobatis ommata	28%	100%
P53676	Rattus norvegicus	29%	100%
P53677	Homo sapiens	29%	100%
P53678	Rattus norvegicus	29%	100%
P54672	Dictyostelium discoideum	37%	99%
P84091	Mus musculus	36%	100%
P84092	Rattus norvegicus	36%	100%
Q00776	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	91%
Q09718	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	97%
Q24K11	Bos taurus	29%	100%
Q29RY8	Bos taurus	26%	96%
Q2KJ81	Bos taurus	44%	100%
Q2PWT8	Rattus norvegicus	25%	96%
Q32Q06	Rattus norvegicus	44%	100%
Q3SYW1	Bos taurus	42%	100%
Q3ZC13	Bos taurus	36%	100%
Q4Q1B6	Leishmania major	28%	99%
Q4Q2T6	Leishmania major	24%	96%
Q4QBN3	Leishmania major	91%	100%
Q4R706	Macaca fascicularis	36%	100%
Q54HS9	Dictyostelium discoideum	44%	100%
Q5NVF7	Pongo abelii	36%	100%
Q5R478	Pongo abelii	29%	100%
Q5ZMP6	Gallus gallus	37%	100%
Q5ZMP7	Gallus gallus	29%	100%
Q6NWK2	Danio rerio	36%	99%
Q6P856	Xenopus tropicalis	36%	100%
Q7ZW98	Danio rerio	36%	99%
Q801Q8	Xenopus laevis	36%	100%
Q8R2R9	Mus musculus	28%	100%
Q96CW1	Homo sapiens	36%	100%
Q99186	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	88%
Q9BXS5	Homo sapiens	44%	100%
Q9GPF0	Dictyostelium discoideum	22%	82%
Q9GPF1	Dictyostelium discoideum	30%	100%
Q9HFE5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
Q9JKC7	Mus musculus	25%	96%
Q9JKC8	Mus musculus	29%	100%
Q9SAC9	Arabidopsis thaliana	41%	100%
Q9SB50	Arabidopsis thaliana	29%	96%
Q9WVP1	Mus musculus	42%	100%
Q9Y2T2	Homo sapiens	29%	100%
Q9Y6Q5	Homo sapiens	42%	100%
V5BKQ8	Trypanosoma cruzi	27%	100%
V5BLL2	Trypanosoma cruzi	58%	100%
V5D569	Trypanosoma cruzi	26%	87%
V5DGM7	Trypanosoma cruzi	31%	100%