CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCF0_LEIBR

TriTrypDb:

LbrM.22.0990 , LBRM2903_220015600

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.526
CLV_NRD_NRD_1	182	184	PF00675	0.408
CLV_NRD_NRD_1	23	25	PF00675	0.343
CLV_NRD_NRD_1	378	380	PF00675	0.557
CLV_NRD_NRD_1	456	458	PF00675	0.539
CLV_NRD_NRD_1	605	607	PF00675	0.537
CLV_NRD_NRD_1	97	99	PF00675	0.430
CLV_PCSK_FUR_1	603	607	PF00082	0.524
CLV_PCSK_FUR_1	95	99	PF00082	0.409
CLV_PCSK_KEX2_1	181	183	PF00082	0.380
CLV_PCSK_KEX2_1	22	24	PF00082	0.383
CLV_PCSK_KEX2_1	456	458	PF00082	0.539
CLV_PCSK_KEX2_1	603	605	PF00082	0.529
CLV_PCSK_KEX2_1	95	97	PF00082	0.449
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.383
CLV_PCSK_PC7_1	600	606	PF00082	0.514
CLV_PCSK_SKI1_1	132	136	PF00082	0.312
CLV_PCSK_SKI1_1	666	670	PF00082	0.451
CLV_PCSK_SKI1_1	97	101	PF00082	0.374
DEG_Nend_UBRbox_3	1	3	PF02207	0.455
DEG_SCF_FBW7_1	360	365	PF00400	0.564
DEG_SCF_FBW7_1	467	474	PF00400	0.690
DEG_SPOP_SBC_1	539	543	PF00917	0.509
DOC_CKS1_1	468	473	PF01111	0.699
DOC_CKS1_1	524	529	PF01111	0.548
DOC_CYCLIN_RxL_1	20	31	PF00134	0.351
DOC_CYCLIN_RxL_1	663	672	PF00134	0.439
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	572	578	PF00134	0.527
DOC_MAPK_gen_1	22	29	PF00069	0.432
DOC_MAPK_gen_1	456	463	PF00069	0.535
DOC_MAPK_gen_1	603	615	PF00069	0.601
DOC_MAPK_gen_1	78	87	PF00069	0.372
DOC_MAPK_MEF2A_6	132	139	PF00069	0.312
DOC_MAPK_MEF2A_6	22	29	PF00069	0.423
DOC_MAPK_MEF2A_6	616	624	PF00069	0.534
DOC_MAPK_MEF2A_6	666	673	PF00069	0.444
DOC_MAPK_NFAT4_5	22	30	PF00069	0.432
DOC_MAPK_NFAT4_5	666	674	PF00069	0.444
DOC_PP2B_LxvP_1	396	399	PF13499	0.494
DOC_PP2B_LxvP_1	505	508	PF13499	0.512
DOC_PP2B_PxIxI_1	104	110	PF00149	0.396
DOC_PP4_FxxP_1	142	145	PF00568	0.388
DOC_USP7_MATH_1	116	120	PF00917	0.302
DOC_USP7_MATH_1	191	195	PF00917	0.374
DOC_USP7_MATH_1	375	379	PF00917	0.634
DOC_USP7_MATH_1	39	43	PF00917	0.518
DOC_USP7_MATH_1	539	543	PF00917	0.666
DOC_USP7_MATH_1	578	582	PF00917	0.504
DOC_USP7_MATH_1	699	703	PF00917	0.555
DOC_WW_Pin1_4	107	112	PF00397	0.385
DOC_WW_Pin1_4	358	363	PF00397	0.602
DOC_WW_Pin1_4	467	472	PF00397	0.635
DOC_WW_Pin1_4	523	528	PF00397	0.545
DOC_WW_Pin1_4	679	684	PF00397	0.546
LIG_14-3-3_CanoR_1	24	30	PF00244	0.378
LIG_14-3-3_CanoR_1	408	413	PF00244	0.486
LIG_14-3-3_CanoR_1	681	687	PF00244	0.524
LIG_Actin_WH2_2	102	120	PF00022	0.339
LIG_BRCT_BRCA1_1	118	122	PF00533	0.364
LIG_BRCT_BRCA1_1	324	328	PF00533	0.376
LIG_CtBP_PxDLS_1	312	316	PF00389	0.312
LIG_FHA_1	144	150	PF00498	0.340
LIG_FHA_1	226	232	PF00498	0.363
LIG_FHA_1	28	34	PF00498	0.437
LIG_FHA_1	338	344	PF00498	0.468
LIG_FHA_1	44	50	PF00498	0.503
LIG_FHA_1	462	468	PF00498	0.559
LIG_FHA_1	491	497	PF00498	0.604
LIG_FHA_1	531	537	PF00498	0.686
LIG_FHA_1	567	573	PF00498	0.545
LIG_FHA_2	339	345	PF00498	0.332
LIG_FHA_2	363	369	PF00498	0.562
LIG_FHA_2	672	678	PF00498	0.541
LIG_LIR_Nem_3	119	125	PF02991	0.472
LIG_LIR_Nem_3	418	422	PF02991	0.479
LIG_LIR_Nem_3	485	491	PF02991	0.535
LIG_LIR_Nem_3	533	537	PF02991	0.688
LIG_LYPXL_yS_3	259	262	PF13949	0.312
LIG_MYND_1	391	395	PF01753	0.470
LIG_MYND_3	144	148	PF01753	0.312
LIG_NRBOX	247	253	PF00104	0.291
LIG_NRBOX	664	670	PF00104	0.479
LIG_PCNA_PIPBox_1	69	78	PF02747	0.360
LIG_Pex3_1	665	676	PF04882	0.466
LIG_SH2_GRB2like	136	139	PF00017	0.312
LIG_SH2_NCK_1	537	541	PF00017	0.674
LIG_SH2_PTP2	136	139	PF00017	0.388
LIG_SH2_PTP2	397	400	PF00017	0.479
LIG_SH2_SRC	136	139	PF00017	0.388
LIG_SH2_SRC	397	400	PF00017	0.479
LIG_SH2_STAT5	123	126	PF00017	0.380
LIG_SH2_STAT5	136	139	PF00017	0.299
LIG_SH2_STAT5	397	400	PF00017	0.479
LIG_SH2_STAT5	537	540	PF00017	0.669
LIG_SH2_STAT5	75	78	PF00017	0.346
LIG_SH2_STAT5	79	82	PF00017	0.359
LIG_SH3_1	357	363	PF00018	0.559
LIG_SH3_3	357	363	PF00018	0.559
LIG_SH3_3	395	401	PF00018	0.485
LIG_SH3_3	586	592	PF00018	0.434
LIG_SUMO_SIM_par_1	105	110	PF11976	0.411
LIG_SUMO_SIM_par_1	145	151	PF11976	0.350
LIG_SUMO_SIM_par_1	154	161	PF11976	0.355
LIG_SUMO_SIM_par_1	227	234	PF11976	0.285
LIG_SUMO_SIM_par_1	667	672	PF11976	0.533
LIG_TRAF2_1	52	55	PF00917	0.609
LIG_TRAF2_1	581	584	PF00917	0.527
LIG_TYR_ITIM	134	139	PF00017	0.388
LIG_UBA3_1	17	22	PF00899	0.324
LIG_UBA3_1	250	257	PF00899	0.380
LIG_UBA3_1	76	83	PF00899	0.357
MOD_CAAXbox	705	708	PF01239	0.546
MOD_CK1_1	28	34	PF00069	0.619
MOD_CK1_1	284	290	PF00069	0.231
MOD_CK1_1	42	48	PF00069	0.529
MOD_CK1_1	450	456	PF00069	0.589
MOD_CK1_1	503	509	PF00069	0.664
MOD_CK1_1	562	568	PF00069	0.801
MOD_CK1_1	68	74	PF00069	0.292
MOD_CK2_1	338	344	PF00069	0.404
MOD_CK2_1	375	381	PF00069	0.577
MOD_CK2_1	49	55	PF00069	0.599
MOD_CK2_1	578	584	PF00069	0.543
MOD_CK2_1	625	631	PF00069	0.502
MOD_CK2_1	671	677	PF00069	0.533
MOD_GlcNHglycan	118	121	PF01048	0.345
MOD_GlcNHglycan	286	289	PF01048	0.231
MOD_GlcNHglycan	35	38	PF01048	0.727
MOD_GlcNHglycan	41	44	PF01048	0.518
MOD_GlcNHglycan	435	438	PF01048	0.637
MOD_GlcNHglycan	502	505	PF01048	0.646
MOD_GlcNHglycan	516	522	PF01048	0.558
MOD_GlcNHglycan	528	531	PF01048	0.628
MOD_GlcNHglycan	576	579	PF01048	0.529
MOD_GSK3_1	105	112	PF00069	0.420
MOD_GSK3_1	28	35	PF00069	0.556
MOD_GSK3_1	322	329	PF00069	0.482
MOD_GSK3_1	349	356	PF00069	0.637
MOD_GSK3_1	358	365	PF00069	0.662
MOD_GSK3_1	39	46	PF00069	0.454
MOD_GSK3_1	421	428	PF00069	0.674
MOD_GSK3_1	462	469	PF00069	0.653
MOD_GSK3_1	490	497	PF00069	0.536
MOD_GSK3_1	526	533	PF00069	0.779
MOD_GSK3_1	535	542	PF00069	0.566
MOD_GSK3_1	555	562	PF00069	0.497
MOD_GSK3_1	574	581	PF00069	0.561
MOD_GSK3_1	677	684	PF00069	0.520
MOD_N-GLC_1	186	191	PF02516	0.340
MOD_N-GLC_1	196	201	PF02516	0.238
MOD_N-GLC_1	246	251	PF02516	0.388
MOD_N-GLC_1	625	630	PF02516	0.502
MOD_N-GLC_1	677	682	PF02516	0.504
MOD_NEK2_1	100	105	PF00069	0.419
MOD_NEK2_1	240	245	PF00069	0.343
MOD_NEK2_1	25	30	PF00069	0.464
MOD_NEK2_1	283	288	PF00069	0.231
MOD_NEK2_1	321	326	PF00069	0.544
MOD_NEK2_1	337	342	PF00069	0.370
MOD_NEK2_1	403	408	PF00069	0.554
MOD_NEK2_1	544	549	PF00069	0.657
MOD_NEK2_1	559	564	PF00069	0.562
MOD_NEK2_1	568	573	PF00069	0.676
MOD_NEK2_1	669	674	PF00069	0.462
MOD_PIKK_1	403	409	PF00454	0.555
MOD_PKA_2	290	296	PF00069	0.388
MOD_Plk_1	100	106	PF00069	0.404
MOD_Plk_1	246	252	PF00069	0.388
MOD_Plk_1	625	631	PF00069	0.502
MOD_Plk_1	669	675	PF00069	0.455
MOD_Plk_2-3	494	500	PF00069	0.586
MOD_Plk_4	191	197	PF00069	0.231
MOD_Plk_4	240	246	PF00069	0.352
MOD_Plk_4	45	51	PF00069	0.503
MOD_ProDKin_1	107	113	PF00069	0.377
MOD_ProDKin_1	358	364	PF00069	0.602
MOD_ProDKin_1	467	473	PF00069	0.635
MOD_ProDKin_1	523	529	PF00069	0.544
MOD_ProDKin_1	679	685	PF00069	0.554
MOD_SUMO_for_1	650	653	PF00179	0.532
MOD_SUMO_rev_2	352	359	PF00179	0.668
TRG_DiLeu_BaEn_3	583	589	PF01217	0.450
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.514
TRG_ENDOCYTIC_2	136	139	PF00928	0.312
TRG_ENDOCYTIC_2	258	261	PF00928	0.479
TRG_ER_diArg_1	181	183	PF00400	0.380
TRG_ER_diArg_1	23	25	PF00400	0.343
TRG_ER_diArg_1	603	606	PF00400	0.536
TRG_ER_diArg_1	94	97	PF00400	0.400
TRG_NES_CRM1_1	633	647	PF08389	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P818	Leptomonas seymouri	49%	100%
A0A3Q8IAR1	Leishmania donovani	69%	99%
A4HZY1	Leishmania infantum	69%	99%
E9AVU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
Q4QBN8	Leishmania major	67%	98%