HIG1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCE9_LEIBR

TriTrypDb:

LbrM.22.0980 , LBRM2903_220015500

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	3

Expansion

Sequence features

A4HCE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.585
CLV_NRD_NRD_1	38	40	PF00675	0.592
CLV_NRD_NRD_1	85	87	PF00675	0.491
CLV_PCSK_KEX2_1	186	188	PF00082	0.501
CLV_PCSK_KEX2_1	38	40	PF00082	0.624
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.526
CLV_PCSK_SKI1_1	161	165	PF00082	0.470
CLV_PCSK_SKI1_1	186	190	PF00082	0.481
CLV_PCSK_SKI1_1	98	102	PF00082	0.570
DEG_Nend_UBRbox_3	1	3	PF02207	0.523
DOC_PP1_RVXF_1	184	191	PF00149	0.591
DOC_USP7_MATH_1	168	172	PF00917	0.534
LIG_APCC_ABBAyCdc20_2	38	44	PF00400	0.489
LIG_FHA_1	120	126	PF00498	0.644
LIG_FHA_1	164	170	PF00498	0.552
LIG_FHA_1	205	211	PF00498	0.586
LIG_FHA_1	29	35	PF00498	0.529
LIG_FHA_1	75	81	PF00498	0.455
LIG_FHA_1	94	100	PF00498	0.498
LIG_FHA_2	6	12	PF00498	0.634
LIG_LIR_Gen_1	171	179	PF02991	0.415
LIG_LIR_Nem_3	178	182	PF02991	0.538
LIG_LIR_Nem_3	194	199	PF02991	0.446
LIG_LIR_Nem_3	53	57	PF02991	0.454
LIG_NRBOX	209	215	PF00104	0.568
LIG_SH2_CRK	211	215	PF00017	0.519
LIG_SH2_SRC	42	45	PF00017	0.582
LIG_SH2_STAP1	193	197	PF00017	0.522
LIG_SH2_STAT5	205	208	PF00017	0.452
LIG_SH2_STAT5	52	55	PF00017	0.455
LIG_SUMO_SIM_anti_2	11	17	PF11976	0.605
LIG_SUMO_SIM_par_1	77	85	PF11976	0.549
LIG_ULM_U2AF65_1	186	191	PF00076	0.597
LIG_WRC_WIRS_1	176	181	PF05994	0.531
LIG_WRC_WIRS_1	51	56	PF05994	0.452
MOD_CK1_1	135	141	PF00069	0.670
MOD_CK1_1	92	98	PF00069	0.512
MOD_CK2_1	101	107	PF00069	0.573
MOD_CK2_1	5	11	PF00069	0.593
MOD_GlcNHglycan	137	140	PF01048	0.607
MOD_GlcNHglycan	54	57	PF01048	0.459
MOD_GSK3_1	116	123	PF00069	0.748
MOD_GSK3_1	133	140	PF00069	0.616
MOD_GSK3_1	199	206	PF00069	0.454
MOD_GSK3_1	61	68	PF00069	0.462
MOD_GSK3_1	71	78	PF00069	0.428
MOD_GSK3_1	89	96	PF00069	0.637
MOD_NEK2_1	175	180	PF00069	0.440
MOD_NEK2_1	199	204	PF00069	0.398
MOD_NEK2_1	33	38	PF00069	0.529
MOD_NEK2_1	89	94	PF00069	0.562
MOD_PIKK_1	163	169	PF00454	0.549
MOD_Plk_1	28	34	PF00069	0.530
MOD_Plk_4	140	146	PF00069	0.453
MOD_Plk_4	168	174	PF00069	0.410
MOD_Plk_4	192	198	PF00069	0.484
MOD_Plk_4	65	71	PF00069	0.461
MOD_Plk_4	75	81	PF00069	0.424
MOD_SUMO_rev_2	82	89	PF00179	0.559
TRG_DiLeu_BaEn_1	11	16	PF01217	0.607
TRG_ENDOCYTIC_2	211	214	PF00928	0.532
TRG_NLS_MonoExtN_4	183	190	PF00514	0.512
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E4	Leptomonas seymouri	63%	86%
A0A1X0NTC5	Trypanosomatidae	38%	100%
A0A3Q8IC90	Leishmania donovani	81%	86%
A0A3R7NDY8	Trypanosoma rangeli	37%	100%
A4HZY0	Leishmania infantum	81%	86%
C9ZSL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AVU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	85%
Q4QBN9	Leishmania major	81%	100%
V5BVV8	Trypanosoma cruzi	36%	100%