Protein kinase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HCE6_LEIBR

TriTrypDb:

LbrM.22.0850 , LBRM2903_220014000

Length:

358

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCE6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	25
GO:0006793	phosphorus metabolic process	3	25
GO:0006796	phosphate-containing compound metabolic process	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0009987	cellular process	1	25
GO:0016310	phosphorylation	5	25
GO:0019538	protein metabolic process	3	25
GO:0036211	protein modification process	4	25
GO:0043170	macromolecule metabolic process	3	25
GO:0043412	macromolecule modification	4	25
GO:0044237	cellular metabolic process	2	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	25
GO:0003824	catalytic activity	1	25
GO:0004672	protein kinase activity	3	25
GO:0004674	protein serine/threonine kinase activity	4	22
GO:0005488	binding	1	25
GO:0005524	ATP binding	5	25
GO:0016301	kinase activity	4	25
GO:0016740	transferase activity	2	25
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	25
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	25
GO:0017076	purine nucleotide binding	4	25
GO:0030554	adenyl nucleotide binding	5	25
GO:0032553	ribonucleotide binding	3	25
GO:0032555	purine ribonucleotide binding	4	25
GO:0032559	adenyl ribonucleotide binding	5	25
GO:0035639	purine ribonucleoside triphosphate binding	4	25
GO:0036094	small molecule binding	2	25
GO:0043167	ion binding	2	25
GO:0043168	anion binding	3	25
GO:0097159	organic cyclic compound binding	2	25
GO:0097367	carbohydrate derivative binding	2	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:1901265	nucleoside phosphate binding	3	25
GO:1901363	heterocyclic compound binding	2	25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.544
CLV_NRD_NRD_1	251	253	PF00675	0.294
CLV_NRD_NRD_1	325	327	PF00675	0.390
CLV_NRD_NRD_1	47	49	PF00675	0.344
CLV_PCSK_FUR_1	45	49	PF00082	0.355
CLV_PCSK_KEX2_1	325	327	PF00082	0.400
CLV_PCSK_KEX2_1	47	49	PF00082	0.324
CLV_PCSK_SKI1_1	177	181	PF00082	0.251
CLV_PCSK_SKI1_1	290	294	PF00082	0.326
CLV_PCSK_SKI1_1	318	322	PF00082	0.438
CLV_PCSK_SKI1_1	325	329	PF00082	0.413
CLV_PCSK_SKI1_1	52	56	PF00082	0.353
DEG_APCC_DBOX_1	187	195	PF00400	0.397
DEG_MDM2_SWIB_1	55	62	PF02201	0.397
DEG_Nend_UBRbox_3	1	3	PF02207	0.508
DOC_CYCLIN_yCln2_LP_2	251	257	PF00134	0.279
DOC_MAPK_gen_1	177	186	PF00069	0.257
DOC_MAPK_gen_1	315	324	PF00069	0.179
DOC_MAPK_gen_1	335	344	PF00069	0.458
DOC_MAPK_HePTP_8	334	346	PF00069	0.207
DOC_MAPK_MEF2A_6	151	159	PF00069	0.215
DOC_MAPK_MEF2A_6	315	324	PF00069	0.425
DOC_MAPK_MEF2A_6	337	346	PF00069	0.204
DOC_PP2B_LxvP_1	307	310	PF13499	0.299
DOC_USP7_MATH_1	27	31	PF00917	0.470
DOC_USP7_MATH_1	354	358	PF00917	0.578
DOC_USP7_MATH_1	77	81	PF00917	0.377
DOC_USP7_MATH_2	277	283	PF00917	0.294
DOC_USP7_MATH_2	297	303	PF00917	0.213
DOC_USP7_UBL2_3	290	294	PF12436	0.132
DOC_USP7_UBL2_3	39	43	PF12436	0.424
DOC_WW_Pin1_4	143	148	PF00397	0.232
DOC_WW_Pin1_4	215	220	PF00397	0.259
LIG_14-3-3_CanoR_1	11	19	PF00244	0.571
LIG_14-3-3_CanoR_1	229	235	PF00244	0.397
LIG_14-3-3_CanoR_1	52	62	PF00244	0.313
LIG_14-3-3_CanoR_1	96	101	PF00244	0.360
LIG_Actin_RPEL_3	166	185	PF02755	0.213
LIG_BIR_III_2	353	357	PF00653	0.404
LIG_BRCT_BRCA1_1	2	6	PF00533	0.618
LIG_BRCT_BRCA1_1	83	87	PF00533	0.398
LIG_FHA_1	179	185	PF00498	0.265
LIG_FHA_1	319	325	PF00498	0.426
LIG_FHA_1	55	61	PF00498	0.255
LIG_FHA_1	87	93	PF00498	0.293
LIG_FHA_2	128	134	PF00498	0.185
LIG_LIR_Apic_2	218	224	PF02991	0.257
LIG_LIR_Gen_1	56	63	PF02991	0.221
LIG_LIR_Nem_3	272	276	PF02991	0.315
LIG_LIR_Nem_3	30	35	PF02991	0.419
LIG_LIR_Nem_3	56	62	PF02991	0.334
LIG_Pex14_2	55	59	PF04695	0.279
LIG_SH2_GRB2like	122	125	PF00017	0.279
LIG_SH2_GRB2like	24	27	PF00017	0.569
LIG_SH2_NCK_1	122	126	PF00017	0.230
LIG_SH2_PTP2	24	27	PF00017	0.569
LIG_SH2_SRC	122	125	PF00017	0.208
LIG_SH2_SRC	203	206	PF00017	0.279
LIG_SH2_SRC	24	27	PF00017	0.569
LIG_SH2_STAP1	232	236	PF00017	0.278
LIG_SH2_STAP1	246	250	PF00017	0.213
LIG_SH2_STAP1	281	285	PF00017	0.352
LIG_SH2_STAT5	118	121	PF00017	0.404
LIG_SH2_STAT5	168	171	PF00017	0.313
LIG_SH2_STAT5	221	224	PF00017	0.275
LIG_SH2_STAT5	24	27	PF00017	0.569
LIG_SH3_2	38	43	PF14604	0.432
LIG_SH3_3	32	38	PF00018	0.371
LIG_SUMO_SIM_anti_2	152	159	PF11976	0.268
LIG_SUMO_SIM_anti_2	282	290	PF11976	0.350
LIG_SUMO_SIM_par_1	102	108	PF11976	0.364
LIG_TRFH_1	220	224	PF08558	0.290
LIG_TYR_ITIM	244	249	PF00017	0.221
LIG_UBA3_1	244	253	PF00899	0.257
LIG_UBA3_1	285	290	PF00899	0.278
MOD_CK1_1	14	20	PF00069	0.733
MOD_CK1_1	31	37	PF00069	0.490
MOD_CK1_1	75	81	PF00069	0.373
MOD_CK2_1	102	108	PF00069	0.390
MOD_CK2_1	299	305	PF00069	0.234
MOD_GlcNHglycan	16	19	PF01048	0.617
MOD_GlcNHglycan	188	191	PF01048	0.379
MOD_GlcNHglycan	207	210	PF01048	0.272
MOD_GlcNHglycan	81	84	PF01048	0.342
MOD_GSK3_1	127	134	PF00069	0.324
MOD_GSK3_1	139	146	PF00069	0.357
MOD_GSK3_1	211	218	PF00069	0.294
MOD_GSK3_1	265	272	PF00069	0.408
MOD_GSK3_1	27	34	PF00069	0.490
MOD_GSK3_1	280	287	PF00069	0.269
MOD_GSK3_1	295	302	PF00069	0.274
MOD_GSK3_1	75	82	PF00069	0.325
MOD_N-GLC_1	258	263	PF02516	0.397
MOD_N-GLC_1	63	68	PF02516	0.284
MOD_NEK2_1	1	6	PF00069	0.503
MOD_NEK2_1	179	184	PF00069	0.273
MOD_NEK2_1	186	191	PF00069	0.263
MOD_NEK2_1	197	202	PF00069	0.133
MOD_NEK2_1	255	260	PF00069	0.294
MOD_NEK2_1	28	33	PF00069	0.460
MOD_NEK2_2	113	118	PF00069	0.217
MOD_PIKK_1	127	133	PF00454	0.185
MOD_PKA_2	299	305	PF00069	0.297
MOD_Plk_1	113	119	PF00069	0.213
MOD_Plk_2-3	299	305	PF00069	0.213
MOD_Plk_4	113	119	PF00069	0.213
MOD_Plk_4	2	8	PF00069	0.421
MOD_Plk_4	31	37	PF00069	0.411
MOD_Plk_4	54	60	PF00069	0.220
MOD_Plk_4	66	72	PF00069	0.176
MOD_ProDKin_1	143	149	PF00069	0.232
MOD_ProDKin_1	215	221	PF00069	0.259
TRG_DiLeu_BaEn_1	152	157	PF01217	0.299
TRG_ENDOCYTIC_2	246	249	PF00928	0.224
TRG_ER_diArg_1	324	326	PF00400	0.351
TRG_ER_diArg_1	334	337	PF00400	0.352
TRG_ER_diArg_1	44	47	PF00400	0.366
TRG_NES_CRM1_1	284	299	PF08389	0.302
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D3	Leptomonas seymouri	31%	68%
A0A0N0P3N5	Leptomonas seymouri	39%	83%
A0A0N0P787	Leptomonas seymouri	25%	93%
A0A0N0P7D2	Leptomonas seymouri	28%	100%
A0A0N0P8H5	Leptomonas seymouri	29%	100%
A0A0N0P953	Leptomonas seymouri	40%	75%
A0A0N1HY86	Leptomonas seymouri	38%	69%
A0A0N1HZW6	Leptomonas seymouri	28%	81%
A0A0N1I6T8	Leptomonas seymouri	32%	100%
A0A0N1IHY4	Leptomonas seymouri	27%	88%
A0A0N1IIF9	Leptomonas seymouri	30%	100%
A0A0N1IM47	Leptomonas seymouri	79%	98%
A0A0N1PC31	Leptomonas seymouri	28%	92%
A0A0N1PD05	Leptomonas seymouri	40%	80%
A0A0N1PDW7	Leptomonas seymouri	32%	91%
A0A0N1PEV2	Leptomonas seymouri	30%	66%
A0A0S4IHW4	Bodo saltans	26%	80%
A0A0S4IKH2	Bodo saltans	38%	72%
A0A0S4IMB7	Bodo saltans	44%	81%
A0A0S4IQ75	Bodo saltans	34%	71%
A0A0S4IRG0	Bodo saltans	29%	100%
A0A0S4IRZ7	Bodo saltans	36%	73%
A0A0S4ISS4	Bodo saltans	26%	100%
A0A0S4IX86	Bodo saltans	42%	83%
A0A0S4IZY3	Bodo saltans	27%	100%
A0A0S4J3Y5	Bodo saltans	29%	83%
A0A0S4J4B3	Bodo saltans	29%	80%
A0A0S4J4X4	Bodo saltans	30%	100%
A0A0S4J7K4	Bodo saltans	28%	74%
A0A0S4J804	Bodo saltans	38%	68%
A0A0S4J842	Bodo saltans	27%	67%
A0A0S4JCG2	Bodo saltans	29%	80%
A0A0S4JER5	Bodo saltans	28%	79%
A0A0S4JF22	Bodo saltans	30%	100%
A0A0S4JK24	Bodo saltans	36%	82%
A0A0S4JNA1	Bodo saltans	35%	72%
A0A0S4JPZ1	Bodo saltans	39%	80%
A0A0S4JU73	Bodo saltans	30%	75%
A0A0S4JUJ2	Bodo saltans	33%	100%
A0A0S4JVD7	Bodo saltans	29%	82%
A0A0S4JWD5	Bodo saltans	28%	92%
A0A0S4KMV7	Bodo saltans	33%	100%
A0A1X0NFW4	Trypanosomatidae	28%	76%
A0A1X0NIA0	Trypanosomatidae	43%	83%
A0A1X0NIX2	Trypanosomatidae	41%	82%
A0A1X0NJV4	Trypanosomatidae	28%	70%
A0A1X0NKA1	Trypanosomatidae	32%	81%
A0A1X0NNE5	Trypanosomatidae	27%	71%
A0A1X0NQ63	Trypanosomatidae	31%	100%
A0A1X0NRZ9	Trypanosomatidae	34%	97%
A0A1X0NTL6	Trypanosomatidae	51%	77%
A0A1X0NTR6	Trypanosomatidae	30%	100%
A0A1X0NUQ4	Trypanosomatidae	27%	94%
A0A1X0NW24	Trypanosomatidae	25%	100%
A0A1X0NWR7	Trypanosomatidae	30%	70%
A0A1X0NY93	Trypanosomatidae	26%	91%
A0A1X0P1A2	Trypanosomatidae	29%	77%
A0A1X0P527	Trypanosomatidae	38%	81%
A0A1X0P549	Trypanosomatidae	40%	75%
A0A1X0P5B1	Trypanosomatidae	28%	100%
A0A1X0P6V1	Trypanosomatidae	31%	100%
A0A1X0P735	Trypanosomatidae	31%	100%
A0A1X0P7V0	Trypanosomatidae	29%	100%
A0A1X0P863	Trypanosomatidae	41%	72%
A0A1X0P8A0	Trypanosomatidae	28%	100%
A0A1X0P963	Trypanosomatidae	31%	74%
A0A1X0P994	Trypanosomatidae	42%	72%
A0A1X0P9C4	Trypanosomatidae	37%	71%
A0A3Q8IAQ1	Leishmania donovani	88%	100%
A0A3Q8IB30	Leishmania donovani	29%	100%
A0A3Q8IB74	Leishmania donovani	28%	88%
A0A3Q8IC87	Leishmania donovani	31%	96%
A0A3Q8IEH3	Leishmania donovani	27%	99%
A0A3Q8IFK8	Leishmania donovani	39%	81%
A0A3Q8IFW0	Leishmania donovani	40%	83%
A0A3Q8IHH8	Leishmania donovani	36%	71%
A0A3Q8IIG1	Leishmania donovani	31%	93%
A0A3Q8IPJ5	Leishmania donovani	26%	100%
A0A3Q8IRT6	Leishmania donovani	28%	70%
A0A3R7K5P9	Trypanosoma rangeli	31%	96%
A0A3R7KCZ4	Trypanosoma rangeli	41%	89%
A0A3R7KRP1	Trypanosoma rangeli	30%	75%
A0A3R7M5C7	Trypanosoma rangeli	31%	100%
A0A3R7M848	Trypanosoma rangeli	30%	76%
A0A3R7MHW5	Trypanosoma rangeli	30%	90%
A0A3R7MJP3	Trypanosoma rangeli	29%	100%
A0A3R7MKG5	Trypanosoma rangeli	41%	81%
A0A3R7MKJ1	Trypanosoma rangeli	29%	66%
A0A3R7N4D8	Trypanosoma rangeli	24%	89%
A0A3R7N5S4	Trypanosoma rangeli	25%	94%
A0A3R7NKI8	Trypanosoma rangeli	31%	100%
A0A3R7NLI6	Trypanosoma rangeli	31%	97%
A0A3R7RIN5	Trypanosoma rangeli	37%	72%
A0A3S5H4Z4	Leishmania donovani	30%	68%
A0A3S5H528	Leishmania donovani	26%	100%
A0A3S5H5U5	Leishmania donovani	23%	100%
A0A3S5H606	Leishmania donovani	33%	100%
A0A3S5H7M0	Leishmania donovani	33%	69%
A0A3S5H7N7	Leishmania donovani	24%	100%
A0A3S7WRG1	Leishmania donovani	26%	100%
A0A3S7WTN9	Leishmania donovani	24%	100%
A0A3S7WUX5	Leishmania donovani	31%	100%
A0A3S7WWE7	Leishmania donovani	24%	100%
A0A3S7WYP4	Leishmania donovani	26%	100%
A0A3S7X123	Leishmania donovani	25%	100%
A0A3S7X6T8	Leishmania donovani	41%	80%
A0A3S7X7D5	Leishmania donovani	28%	100%
A0A3S7X8Z8	Leishmania donovani	25%	100%
A0A3S7XAL3	Leishmania donovani	40%	72%
A0A3S7XAT9	Leishmania donovani	39%	71%
A0A3S7XAX0	Leishmania donovani	37%	75%
A0A422N701	Trypanosoma rangeli	34%	80%
A0A422NCP0	Trypanosoma rangeli	42%	72%
A0A422NFN4	Trypanosoma rangeli	27%	70%
A0A422NUF0	Trypanosoma rangeli	51%	90%
A0A422P0J2	Trypanosoma rangeli	29%	100%
A0A422P0N6	Trypanosoma rangeli	32%	100%
A0A422P292	Trypanosoma rangeli	27%	100%
A0A422P2B2	Trypanosoma rangeli	26%	78%
A0A8I3S724	Canis lupus familiaris	31%	88%
A0AUV4	Mus musculus	29%	70%
A2BD05	Sus scrofa	33%	100%
A2XFF4	Oryza sativa subsp. indica	31%	70%
A3B529	Oryza sativa subsp. japonica	32%	82%
A4H3C7	Leishmania braziliensis	32%	68%
A4H3J3	Leishmania braziliensis	27%	100%
A4H4S9	Leishmania braziliensis	22%	100%
A4H539	Leishmania braziliensis	32%	100%
A4H9H4	Leishmania braziliensis	31%	100%
A4H9L8	Leishmania braziliensis	29%	100%
A4HAC8	Leishmania braziliensis	28%	100%
A4HBL4	Leishmania braziliensis	24%	100%
A4HCD7	Leishmania braziliensis	31%	84%
A4HDU3	Leishmania braziliensis	26%	100%
A4HED7	Leishmania braziliensis	27%	92%
A4HF96	Leishmania braziliensis	24%	100%
A4HFA1	Leishmania braziliensis	26%	100%
A4HFF3	Leishmania braziliensis	25%	100%
A4HG26	Leishmania braziliensis	26%	100%
A4HH03	Leishmania braziliensis	31%	93%
A4HHP8	Leishmania braziliensis	25%	100%
A4HHQ5	Leishmania braziliensis	37%	71%
A4HHR5	Leishmania braziliensis	34%	69%
A4HI35	Leishmania braziliensis	28%	70%
A4HJT5	Leishmania braziliensis	39%	81%
A4HJW2	Leishmania braziliensis	41%	83%
A4HLR0	Leishmania braziliensis	41%	80%
A4HNI1	Leishmania braziliensis	39%	75%
A4HNR5	Leishmania braziliensis	28%	100%
A4HP12	Leishmania braziliensis	40%	70%
A4HP13	Leishmania braziliensis	36%	71%
A4HRM6	Leishmania infantum	30%	68%
A4HRT2	Leishmania infantum	26%	100%
A4HTB4	Leishmania infantum	33%	100%
A4HUS3	Leishmania infantum	26%	100%
A4HWP5	Leishmania infantum	24%	100%
A4HXU0	Leishmania infantum	31%	100%
A4HXY2	Leishmania infantum	29%	100%
A4HZA2	Leishmania infantum	24%	100%
A4HZV1	Leishmania infantum	31%	96%
A4HZW8	Leishmania infantum	88%	100%
A4I140	Leishmania infantum	26%	100%
A4I2H8	Leishmania infantum	26%	100%
A4I3C6	Leishmania infantum	27%	99%
A4I435	Leishmania infantum	31%	93%
A4I4X0	Leishmania infantum	36%	71%
A4I4X5	Leishmania infantum	33%	69%
A4I5B1	Leishmania infantum	28%	70%
A4I5X0	Leishmania infantum	24%	100%
A4I7A1	Leishmania infantum	39%	81%
A4I7C4	Leishmania infantum	40%	83%
A4I960	Leishmania infantum	40%	80%
A4I9H1	Leishmania infantum	28%	100%
A4IB02	Leishmania infantum	25%	100%
A4ICT0	Leishmania infantum	28%	100%
A4IDC1	Leishmania infantum	40%	70%
A4IDC2	Leishmania infantum	39%	71%
A4IDK3	Leishmania infantum	37%	75%
A5GFW1	Sus scrofa	31%	89%
A8WXF6	Caenorhabditis briggsae	29%	67%
B0LT89	Rattus norvegicus	29%	83%
B8BBT7	Oryza sativa subsp. indica	31%	70%
C0HKC8	Mus musculus	29%	71%
C0HKC9	Mus musculus	29%	71%
C9ZIN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	72%
C9ZIZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	79%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	88%
C9ZKX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	72%
C9ZMH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	81%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	78%
C9ZSI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZW68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	83%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	81%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	91%
C9ZZX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZZX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A2M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A2P2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	81%
D0A2Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	73%
D0A2Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	72%
D0A5C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A8X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	97%
D3ZBE5	Rattus norvegicus	32%	100%
D3ZHP7	Rattus norvegicus	32%	76%
E9ACA4	Leishmania major	32%	68%
E9ACG8	Leishmania major	26%	100%
E9AEB9	Leishmania major	37%	71%
E9AEC9	Leishmania major	33%	69%
E9AET0	Leishmania major	25%	100%
E9AG71	Leishmania infantum	23%	100%
E9AGS0	Leishmania infantum	28%	88%
E9AJJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	66%
E9AJQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9ALF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ALF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	69%
E9ALG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	71%
E9ALH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ANF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ARK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ARW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	88%
E9ASH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ASK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	68%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	74%
E9ASS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	70%
E9ASS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	71%
E9AT06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	74%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	96%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AX78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AYN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AYN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AZF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	93%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	70%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	81%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	83%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	80%
E9B4G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
F4I1N8	Arabidopsis thaliana	29%	88%
G5EFM9	Caenorhabditis elegans	30%	100%
O00506	Homo sapiens	29%	84%
O01775	Caenorhabditis elegans	33%	100%
O08875	Rattus norvegicus	32%	83%
O13945	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	67%
O14965	Homo sapiens	30%	89%
O15865	Plasmodium falciparum (isolate K1 / Thailand)	33%	70%
O22932	Arabidopsis thaliana	30%	82%
O22971	Arabidopsis thaliana	32%	71%
O35942	Mus musculus	36%	81%
O54863	Mus musculus	30%	100%
O55099	Rattus norvegicus	29%	100%
O59697	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	85%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O61122	Dictyostelium discoideum	29%	75%
O61267	Drosophila melanogaster	32%	75%
O64629	Arabidopsis thaliana	30%	100%
O65554	Arabidopsis thaliana	33%	81%
O77708	Oryctolagus cuniculus	28%	67%
O80902	Arabidopsis thaliana	31%	83%
O88445	Mus musculus	30%	100%
O96526	Leishmania major	28%	100%
P05986	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	90%
P06245	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	94%
P07934	Mus musculus	34%	92%
P08413	Rattus norvegicus	28%	66%
P08458	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	73%
P11275	Rattus norvegicus	28%	75%
P11730	Rattus norvegicus	29%	68%
P11798	Mus musculus	28%	75%
P11801	Homo sapiens	29%	84%
P13286	Rattus norvegicus	33%	92%
P15791	Rattus norvegicus	28%	67%
P16911	Drosophila melanogaster	30%	100%
P22209	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	82%
P23443	Homo sapiens	29%	68%
P25323	Dictyostelium discoideum	29%	100%
P28652	Mus musculus	28%	66%
P31751	Homo sapiens	29%	74%
P34208	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	72%
P39009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	70%
P42818	Arabidopsis thaliana	28%	77%
P47197	Rattus norvegicus	30%	74%
P49136	Cricetulus longicaudatus	35%	100%
P49137	Homo sapiens	35%	90%
P49138	Mus musculus	33%	93%
P49139	Oryctolagus cuniculus	35%	98%
P51955	Homo sapiens	35%	80%
P51956	Homo sapiens	39%	71%
P54644	Dictyostelium discoideum	30%	81%
P59895	Rattus norvegicus	33%	100%
P67998	Oryctolagus cuniculus	29%	68%
P67999	Rattus norvegicus	29%	68%
P92937	Arabidopsis thaliana	32%	85%
P92958	Arabidopsis thaliana	29%	70%
P97477	Mus musculus	28%	91%
Q00168	Drosophila melanogaster	28%	68%
Q03428	Trypanosoma brucei brucei	39%	83%
Q08942	Trypanosoma brucei brucei	39%	83%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	78%
Q0D4B2	Oryza sativa subsp. japonica	30%	68%
Q0JI49	Oryza sativa subsp. japonica	32%	71%
Q0V7M1	Bos taurus	29%	84%
Q0VD22	Bos taurus	31%	74%
Q10292	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	80%
Q10LQ2	Oryza sativa subsp. japonica	32%	79%
Q10SC8	Oryza sativa subsp. japonica	31%	79%
Q12706	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	82%
Q13177	Homo sapiens	27%	68%
Q13557	Homo sapiens	28%	72%
Q14012	Homo sapiens	30%	97%
Q16644	Homo sapiens	30%	94%
Q16816	Homo sapiens	34%	93%
Q17941	Caenorhabditis elegans	30%	66%
Q27687	Leishmania major	29%	100%
Q29502	Oryctolagus cuniculus	27%	68%
Q2HJF7	Bos taurus	28%	73%
Q2QMI0	Oryza sativa subsp. japonica	30%	79%
Q2QY53	Oryza sativa subsp. japonica	33%	82%
Q2QYM3	Oryza sativa subsp. japonica	31%	82%
Q2RAX3	Oryza sativa subsp. japonica	33%	79%
Q2RBF0	Oryza sativa subsp. japonica	31%	82%
Q2TA06	Bos taurus	31%	89%
Q2V452	Arabidopsis thaliana	34%	81%
Q38997	Arabidopsis thaliana	30%	70%
Q3MHJ9	Bos taurus	28%	66%
Q3SWY6	Bos taurus	29%	84%
Q3SYZ2	Bos taurus	30%	93%
Q3SZW1	Bos taurus	32%	98%
Q3U3Q1	Mus musculus	32%	76%
Q3UMW7	Mus musculus	31%	93%
Q4Q1J2	Leishmania major	37%	75%
Q4Q1S3	Leishmania major	38%	71%
Q4Q1S4	Leishmania major	40%	70%
Q4Q3K6	Leishmania major	28%	100%
Q4Q3Y9	Leishmania major	40%	80%
Q4Q5T9	Leishmania major	40%	100%
Q4Q5W2	Leishmania major	40%	100%
Q4Q701	Leishmania major	24%	100%
Q4Q7M5	Leishmania major	28%	70%
Q4Q7W2	Leishmania major	31%	93%
Q4Q8T4	Leishmania major	26%	100%
Q4Q8U0	Leishmania major	25%	100%
Q4QA98	Leishmania major	27%	100%
Q4QBQ2	Leishmania major	88%	100%
Q4QBR6	Leishmania major	31%	100%
Q4QCK0	Leishmania major	24%	100%
Q4QDK3	Leishmania major	27%	100%
Q4QDX7	Leishmania major	29%	100%
Q4QH69	Leishmania major	26%	100%
Q4QIJ7	Leishmania major	33%	100%
Q4QIV8	Leishmania major	22%	100%
Q4V7Q6	Xenopus laevis	31%	76%
Q501V0	Danio rerio	30%	85%
Q54CY9	Dictyostelium discoideum	33%	100%
Q54L81	Dictyostelium discoideum	28%	77%
Q54PB4	Dictyostelium discoideum	32%	74%
Q54PX0	Dictyostelium discoideum	31%	72%
Q54QD5	Dictyostelium discoideum	28%	74%
Q54SJ5	Dictyostelium discoideum	31%	100%
Q556S2	Dictyostelium discoideum	26%	70%
Q55BN8	Dictyostelium discoideum	28%	86%
Q5JLD8	Oryza sativa subsp. japonica	31%	80%
Q5JLQ9	Oryza sativa subsp. japonica	33%	75%
Q5JLS2	Oryza sativa subsp. japonica	31%	66%
Q5KQF5	Oryza sativa subsp. japonica	31%	79%
Q5QNM6	Oryza sativa subsp. japonica	29%	70%
Q5RCC4	Pongo abelii	28%	75%
Q5UQ78	Acanthamoeba polyphaga mimivirus	29%	80%
Q5W736	Oryza sativa subsp. japonica	31%	78%
Q5Z6X0	Oryza sativa subsp. japonica	31%	70%
Q5ZJH6	Gallus gallus	31%	76%
Q5ZKI0	Gallus gallus	28%	75%
Q60823	Mus musculus	29%	74%
Q60EY8	Oryza sativa subsp. japonica	31%	77%
Q61241	Mus musculus	32%	98%
Q63450	Rattus norvegicus	30%	96%
Q63484	Rattus norvegicus	30%	75%
Q64303	Rattus norvegicus	27%	68%
Q66H84	Rattus norvegicus	31%	93%
Q68Y49	Oryza sativa subsp. japonica	30%	70%
Q69Q47	Oryza sativa subsp. japonica	34%	79%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	96%
Q6DEH3	Danio rerio	28%	73%
Q6ERS0	Oryza sativa subsp. japonica	32%	89%
Q6ERS4	Oryza sativa subsp. japonica	29%	79%
Q6H7U5	Oryza sativa subsp. japonica	32%	73%
Q6IP76	Xenopus laevis	28%	74%
Q6PHR2	Homo sapiens	32%	76%
Q6PHZ2	Mus musculus	28%	72%
Q6SA08	Homo sapiens	28%	100%
Q6TJY3	Bos taurus	29%	68%
Q6X4A2	Oryza sativa subsp. japonica	31%	80%
Q6YY75	Oryza sativa subsp. japonica	34%	67%
Q6Z9F4	Oryza sativa subsp. japonica	31%	79%
Q6ZLP5	Oryza sativa subsp. japonica	31%	80%
Q75GK4	Oryza sativa subsp. japonica	31%	80%
Q7X996	Oryza sativa subsp. japonica	31%	81%
Q7XIW5	Oryza sativa subsp. japonica	29%	81%
Q7YRC6	Bos taurus	29%	100%
Q7ZX15	Xenopus laevis	28%	74%
Q84VQ3	Arabidopsis thaliana	31%	82%
Q852Q0	Oryza sativa subsp. japonica	31%	70%
Q852Q1	Oryza sativa subsp. japonica	31%	70%
Q86AD7	Dictyostelium discoideum	32%	91%
Q8BGW6	Mus musculus	28%	90%
Q8BHI9	Mus musculus	34%	82%
Q8BSK8	Mus musculus	29%	68%
Q8C0N0	Mus musculus	31%	72%
Q8C0V7	Mus musculus	31%	72%
Q8C1R0	Mus musculus	28%	96%
Q8CIN4	Mus musculus	27%	68%
Q8ICR0	Plasmodium falciparum (isolate 3D7)	33%	70%
Q8IY84	Homo sapiens	34%	82%
Q8LIG4	Oryza sativa subsp. japonica	31%	80%
Q8MYF1	Dictyostelium discoideum	28%	79%
Q8RWC9	Arabidopsis thaliana	31%	81%
Q8SRL5	Encephalitozoon cuniculi (strain GB-M1)	28%	100%
Q8SWM6	Encephalitozoon cuniculi (strain GB-M1)	30%	76%
Q8TDX7	Homo sapiens	32%	100%
Q8W1D5	Arabidopsis thaliana	29%	73%
Q8WQ45	Leishmania donovani	28%	100%
Q8WU08	Homo sapiens	28%	90%
Q91YA2	Mus musculus	28%	84%
Q91YS8	Mus musculus	30%	96%
Q923T9	Mus musculus	29%	68%
Q924X7	Mus musculus	33%	73%
Q925K9	Mus musculus	33%	100%
Q93VD3	Arabidopsis thaliana	31%	74%
Q94C40	Arabidopsis thaliana	31%	83%
Q94CG0	Arabidopsis thaliana	32%	86%
Q95266	Sus scrofa	28%	72%
Q96PF2	Homo sapiens	30%	100%
Q96PN8	Homo sapiens	33%	100%
Q99KH8	Mus musculus	29%	83%
Q9BXA6	Homo sapiens	33%	100%
Q9BXA7	Homo sapiens	33%	98%
Q9BYT3	Homo sapiens	31%	70%
Q9C562	Arabidopsis thaliana	30%	75%
Q9D2E1	Mus musculus	33%	100%
Q9DG02	Xenopus laevis	28%	75%
Q9ES70	Mus musculus	33%	100%
Q9ES74	Mus musculus	32%	100%
Q9FJ54	Arabidopsis thaliana	32%	82%
Q9FJ55	Arabidopsis thaliana	31%	74%
Q9FLZ3	Arabidopsis thaliana	32%	72%
Q9HC98	Homo sapiens	33%	100%
Q9LDI3	Arabidopsis thaliana	33%	80%
Q9LEU7	Arabidopsis thaliana	31%	80%
Q9LGV5	Oryza sativa subsp. japonica	31%	78%
Q9LP51	Arabidopsis thaliana	31%	69%
Q9LT35	Arabidopsis thaliana	33%	86%
Q9LWM4	Oryza sativa subsp. japonica	31%	78%
Q9LYQ8	Arabidopsis thaliana	31%	79%
Q9MAM1	Arabidopsis thaliana	31%	80%
Q9N0X0	Sus scrofa	28%	100%
Q9P7I2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q9QYZ3	Mus musculus	32%	74%
Q9R0A5	Mus musculus	41%	70%
Q9SEZ7	Arabidopsis thaliana	31%	76%
Q9SN43	Arabidopsis thaliana	31%	73%
Q9STV4	Arabidopsis thaliana	32%	80%
Q9SUL7	Arabidopsis thaliana	30%	84%
Q9UBS0	Homo sapiens	33%	74%
Q9UQB9	Homo sapiens	30%	100%
Q9UQM7	Homo sapiens	28%	75%
Q9WUA6	Mus musculus	30%	75%
Q9XIW0	Arabidopsis thaliana	31%	83%
Q9XTG7	Caenorhabditis elegans	30%	68%
Q9Y243	Homo sapiens	30%	75%
Q9Y6E0	Homo sapiens	29%	81%
Q9Y899	Emericella nidulans	29%	89%
Q9Z1M4	Mus musculus	32%	74%
Q9Z2W1	Mus musculus	29%	84%
V5AYC9	Trypanosoma cruzi	30%	100%
V5B871	Trypanosoma cruzi	29%	84%
V5B8E0	Trypanosoma cruzi	27%	100%
V5B9R6	Trypanosoma cruzi	27%	100%
V5BAZ8	Trypanosoma cruzi	27%	93%
V5BC28	Trypanosoma cruzi	41%	71%
V5BEK5	Trypanosoma cruzi	29%	100%
V5BNV8	Trypanosoma cruzi	32%	100%
V5BP88	Trypanosoma cruzi	30%	77%
V5BPJ0	Trypanosoma cruzi	42%	72%
V5BR65	Trypanosoma cruzi	53%	90%
V5BV49	Trypanosoma cruzi	27%	100%
V5BWC2	Trypanosoma cruzi	32%	100%
V5C224	Trypanosoma cruzi	38%	72%
V5D579	Trypanosoma cruzi	41%	83%
V5D9M1	Trypanosoma cruzi	33%	98%
V5DMJ4	Trypanosoma cruzi	31%	100%
V5DQT5	Trypanosoma cruzi	29%	78%
W0LYS5	Macrobrachium nipponense	29%	100%