AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone, putative

Species:

Leishmania braziliensis

UniProt:

A4HCE5_LEIBR

TriTrypDb:

LbrM.22.0840 , LBRM2903_220013800

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HCE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCE5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	19
GO:0003824	catalytic activity	1	19
GO:0005488	binding	1	19
GO:0005524	ATP binding	5	19
GO:0016462	pyrophosphatase activity	5	19
GO:0016787	hydrolase activity	2	19
GO:0016817	hydrolase activity, acting on acid anhydrides	3	19
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	19
GO:0016887	ATP hydrolysis activity	7	19
GO:0017076	purine nucleotide binding	4	19
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	19
GO:0030554	adenyl nucleotide binding	5	19
GO:0032553	ribonucleotide binding	3	19
GO:0032555	purine ribonucleotide binding	4	19
GO:0032559	adenyl ribonucleotide binding	5	19
GO:0035639	purine ribonucleoside triphosphate binding	4	19
GO:0036094	small molecule binding	2	19
GO:0043167	ion binding	2	19
GO:0043168	anion binding	3	19
GO:0097159	organic cyclic compound binding	2	19
GO:0097367	carbohydrate derivative binding	2	19
GO:1901265	nucleoside phosphate binding	3	19
GO:1901363	heterocyclic compound binding	2	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.393
CLV_C14_Caspase3-7	499	503	PF00656	0.717
CLV_NRD_NRD_1	218	220	PF00675	0.399
CLV_NRD_NRD_1	317	319	PF00675	0.399
CLV_NRD_NRD_1	421	423	PF00675	0.314
CLV_NRD_NRD_1	490	492	PF00675	0.532
CLV_NRD_NRD_1	670	672	PF00675	0.361
CLV_NRD_NRD_1	93	95	PF00675	0.307
CLV_PCSK_KEX2_1	317	319	PF00082	0.413
CLV_PCSK_KEX2_1	421	423	PF00082	0.333
CLV_PCSK_KEX2_1	489	491	PF00082	0.590
CLV_PCSK_KEX2_1	494	496	PF00082	0.553
CLV_PCSK_KEX2_1	93	95	PF00082	0.335
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.449
CLV_PCSK_PC7_1	417	423	PF00082	0.322
CLV_PCSK_PC7_1	490	496	PF00082	0.417
CLV_PCSK_SKI1_1	148	152	PF00082	0.376
CLV_PCSK_SKI1_1	191	195	PF00082	0.363
CLV_PCSK_SKI1_1	270	274	PF00082	0.308
CLV_PCSK_SKI1_1	304	308	PF00082	0.378
CLV_PCSK_SKI1_1	342	346	PF00082	0.281
CLV_PCSK_SKI1_1	510	514	PF00082	0.459
CLV_PCSK_SKI1_1	94	98	PF00082	0.275
DEG_APCC_DBOX_1	525	533	PF00400	0.518
DEG_APCC_DBOX_1	569	577	PF00400	0.577
DOC_ANK_TNKS_1	319	326	PF00023	0.562
DOC_CKS1_1	676	681	PF01111	0.627
DOC_CYCLIN_RxL_1	507	514	PF00134	0.554
DOC_CYCLIN_yClb1_LxF_4	327	332	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.275
DOC_MAPK_gen_1	189	197	PF00069	0.579
DOC_MAPK_gen_1	291	301	PF00069	0.552
DOC_MAPK_gen_1	390	399	PF00069	0.503
DOC_MAPK_gen_1	563	573	PF00069	0.552
DOC_MAPK_gen_1	93	101	PF00069	0.525
DOC_MAPK_MEF2A_6	355	362	PF00069	0.474
DOC_MAPK_MEF2A_6	566	573	PF00069	0.591
DOC_PIKK_1	110	118	PF02985	0.525
DOC_PP1_RVXF_1	280	286	PF00149	0.588
DOC_PP1_RVXF_1	327	333	PF00149	0.527
DOC_PP2B_LxvP_1	540	543	PF13499	0.481
DOC_PP2B_LxvP_1	64	67	PF13499	0.335
DOC_SPAK_OSR1_1	320	324	PF12202	0.570
DOC_SPAK_OSR1_1	566	570	PF12202	0.618
DOC_USP7_MATH_1	213	217	PF00917	0.516
DOC_USP7_MATH_1	456	460	PF00917	0.652
DOC_USP7_MATH_1	46	50	PF00917	0.397
DOC_USP7_MATH_1	78	82	PF00917	0.496
DOC_WW_Pin1_4	162	167	PF00397	0.603
DOC_WW_Pin1_4	26	31	PF00397	0.558
DOC_WW_Pin1_4	52	57	PF00397	0.444
DOC_WW_Pin1_4	592	597	PF00397	0.571
DOC_WW_Pin1_4	675	680	PF00397	0.544
LIG_14-3-3_CanoR_1	228	234	PF00244	0.579
LIG_14-3-3_CanoR_1	355	361	PF00244	0.458
LIG_14-3-3_CanoR_1	426	433	PF00244	0.647
LIG_14-3-3_CanoR_1	489	498	PF00244	0.735
LIG_14-3-3_CanoR_1	566	570	PF00244	0.554
LIG_14-3-3_CanoR_1	6	12	PF00244	0.443
LIG_AP2alpha_2	224	226	PF02296	0.462
LIG_APCC_ABBA_1	106	111	PF00400	0.559
LIG_APCC_ABBA_1	253	258	PF00400	0.572
LIG_APCC_ABBA_1	397	402	PF00400	0.481
LIG_BIR_III_4	541	545	PF00653	0.458
LIG_deltaCOP1_diTrp_1	52	61	PF00928	0.470
LIG_EH1_1	512	520	PF00400	0.543
LIG_eIF4E_1	95	101	PF01652	0.489
LIG_FHA_1	305	311	PF00498	0.536
LIG_FHA_1	437	443	PF00498	0.674
LIG_FHA_2	307	313	PF00498	0.431
LIG_FHA_2	497	503	PF00498	0.593
LIG_FHA_2	676	682	PF00498	0.604
LIG_LIR_Apic_2	160	166	PF02991	0.617
LIG_LIR_Apic_2	52	56	PF02991	0.467
LIG_LIR_Apic_2	555	559	PF02991	0.570
LIG_LIR_Gen_1	19	30	PF02991	0.503
LIG_LIR_Gen_1	574	582	PF02991	0.529
LIG_LIR_Gen_1	60	69	PF02991	0.317
LIG_LIR_Nem_3	153	158	PF02991	0.557
LIG_LIR_Nem_3	19	25	PF02991	0.506
LIG_LIR_Nem_3	198	203	PF02991	0.539
LIG_LIR_Nem_3	52	57	PF02991	0.482
LIG_LIR_Nem_3	60	64	PF02991	0.324
LIG_NRBOX	528	534	PF00104	0.531
LIG_PCNA_PIPBox_1	689	698	PF02747	0.548
LIG_PCNA_TLS_4	194	201	PF02747	0.471
LIG_PCNA_yPIPBox_3	689	701	PF02747	0.449
LIG_PDZ_Class_3	704	709	PF00595	0.505
LIG_Pex14_1	271	275	PF04695	0.538
LIG_Pex14_2	296	300	PF04695	0.527
LIG_Pex14_2	376	380	PF04695	0.529
LIG_Pex14_2	57	61	PF04695	0.447
LIG_Rb_pABgroove_1	394	402	PF01858	0.481
LIG_REV1ctd_RIR_1	373	382	PF16727	0.460
LIG_SH2_CRK	163	167	PF00017	0.596
LIG_SH2_CRK	335	339	PF00017	0.468
LIG_SH2_GRB2like	284	287	PF00017	0.440
LIG_SH2_NCK_1	109	113	PF00017	0.558
LIG_SH2_NCK_1	163	167	PF00017	0.586
LIG_SH2_SRC	109	112	PF00017	0.613
LIG_SH2_SRC	171	174	PF00017	0.700
LIG_SH2_SRC	200	203	PF00017	0.469
LIG_SH2_STAP1	372	376	PF00017	0.468
LIG_SH2_STAP1	95	99	PF00017	0.648
LIG_SH2_STAT3	284	287	PF00017	0.440
LIG_SH2_STAT3	673	676	PF00017	0.592
LIG_SH2_STAT5	126	129	PF00017	0.504
LIG_SH2_STAT5	171	174	PF00017	0.590
LIG_SH2_STAT5	200	203	PF00017	0.558
LIG_SH2_STAT5	284	287	PF00017	0.534
LIG_SH2_STAT5	288	291	PF00017	0.562
LIG_SH2_STAT5	352	355	PF00017	0.383
LIG_SH2_STAT5	673	676	PF00017	0.493
LIG_SH3_1	53	59	PF00018	0.356
LIG_SH3_3	331	337	PF00018	0.481
LIG_SH3_3	355	361	PF00018	0.544
LIG_SH3_3	53	59	PF00018	0.356
LIG_SH3_3	72	78	PF00018	0.283
LIG_SUMO_SIM_anti_2	307	312	PF11976	0.527
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.280
LIG_SUMO_SIM_par_1	305	312	PF11976	0.437
LIG_SUMO_SIM_par_1	546	552	PF11976	0.533
LIG_TRAF2_1	650	653	PF00917	0.548
LIG_TYR_ITIM	587	592	PF00017	0.445
MOD_CDC14_SPxK_1	165	168	PF00782	0.438
MOD_CDK_SPK_2	592	597	PF00069	0.430
MOD_CDK_SPxK_1	162	168	PF00069	0.450
MOD_CK1_1	10	16	PF00069	0.573
MOD_CK2_1	46	52	PF00069	0.382
MOD_CK2_1	479	485	PF00069	0.602
MOD_CK2_1	675	681	PF00069	0.404
MOD_Cter_Amidation	91	94	PF01082	0.375
MOD_GlcNHglycan	12	15	PF01048	0.617
MOD_GlcNHglycan	44	47	PF01048	0.409
MOD_GlcNHglycan	457	461	PF01048	0.582
MOD_GlcNHglycan	48	51	PF01048	0.391
MOD_GlcNHglycan	611	614	PF01048	0.687
MOD_GlcNHglycan	666	670	PF01048	0.696
MOD_GlcNHglycan	80	83	PF01048	0.514
MOD_GlcNHglycan	88	91	PF01048	0.541
MOD_GSK3_1	10	17	PF00069	0.732
MOD_GSK3_1	2	9	PF00069	0.676
MOD_GSK3_1	356	363	PF00069	0.433
MOD_GSK3_1	42	49	PF00069	0.559
MOD_GSK3_1	481	488	PF00069	0.734
MOD_GSK3_1	78	85	PF00069	0.611
MOD_N-GLC_1	14	19	PF02516	0.472
MOD_NEK2_1	39	44	PF00069	0.585
MOD_NEK2_1	445	450	PF00069	0.713
MOD_NEK2_2	213	218	PF00069	0.537
MOD_NEK2_2	295	300	PF00069	0.438
MOD_NEK2_2	565	570	PF00069	0.445
MOD_PIKK_1	137	143	PF00454	0.495
MOD_PIKK_1	694	700	PF00454	0.406
MOD_PKA_1	219	225	PF00069	0.429
MOD_PKA_1	489	495	PF00069	0.693
MOD_PKA_2	425	431	PF00069	0.537
MOD_PKA_2	489	495	PF00069	0.633
MOD_PKA_2	5	11	PF00069	0.552
MOD_PKA_2	565	571	PF00069	0.470
MOD_PKA_2	703	709	PF00069	0.559
MOD_Plk_1	183	189	PF00069	0.421
MOD_Plk_1	20	26	PF00069	0.476
MOD_Plk_1	213	219	PF00069	0.425
MOD_Plk_1	304	310	PF00069	0.511
MOD_Plk_1	456	462	PF00069	0.520
MOD_Plk_2-3	379	385	PF00069	0.268
MOD_Plk_4	127	133	PF00069	0.420
MOD_Plk_4	295	301	PF00069	0.389
MOD_Plk_4	306	312	PF00069	0.386
MOD_Plk_4	7	13	PF00069	0.519
MOD_Plk_4	82	88	PF00069	0.625
MOD_ProDKin_1	162	168	PF00069	0.498
MOD_ProDKin_1	26	32	PF00069	0.709
MOD_ProDKin_1	52	58	PF00069	0.548
MOD_ProDKin_1	592	598	PF00069	0.455
MOD_ProDKin_1	675	681	PF00069	0.415
MOD_SUMO_for_1	182	185	PF00179	0.464
MOD_SUMO_rev_2	278	283	PF00179	0.514
TRG_DiLeu_BaEn_1	577	582	PF01217	0.510
TRG_DiLeu_BaEn_1	60	65	PF01217	0.341
TRG_DiLeu_BaEn_2	393	399	PF01217	0.333
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.440
TRG_ENDOCYTIC_2	109	112	PF00928	0.557
TRG_ENDOCYTIC_2	200	203	PF00928	0.407
TRG_ENDOCYTIC_2	372	375	PF00928	0.290
TRG_ENDOCYTIC_2	575	578	PF00928	0.399
TRG_ENDOCYTIC_2	589	592	PF00928	0.457
TRG_ER_diArg_1	189	192	PF00400	0.487
TRG_ER_diArg_1	317	320	PF00400	0.538
TRG_ER_diArg_1	489	491	PF00400	0.546
TRG_ER_diArg_1	569	572	PF00400	0.411
TRG_ER_diArg_1	93	95	PF00400	0.363
TRG_NES_CRM1_1	577	591	PF08389	0.402
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	634	638	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	98	103	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P906	Leptomonas seymouri	28%	96%
A0A0S4JAD3	Bodo saltans	32%	100%
A0A1X0NTT2	Trypanosomatidae	37%	100%
A0A3Q8IC80	Leishmania donovani	75%	96%
A0A3Q8IC95	Leishmania donovani	64%	98%
A0A3Q8IHZ0	Leishmania donovani	28%	99%
A0A422NUH1	Trypanosoma rangeli	34%	100%
A4HZW7	Leishmania infantum	65%	99%
A4IDZ9	Leishmania infantum	27%	99%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AU21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
E9AVS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	98%
E9AVS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	97%
Q4Q0H4	Leishmania major	27%	97%
Q4QBQ3	Leishmania major	75%	100%
Q4QBQ4	Leishmania major	65%	100%
V5DMJ8	Trypanosoma cruzi	35%	98%