Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HCE4_LEIBR

TriTrypDb:

LbrM.22.0830

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HCE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	225	227	PF00675	0.703
CLV_NRD_NRD_1	314	316	PF00675	0.737
CLV_PCSK_KEX2_1	225	227	PF00082	0.703
CLV_PCSK_KEX2_1	314	316	PF00082	0.737
CLV_PCSK_SKI1_1	188	192	PF00082	0.700
CLV_PCSK_SKI1_1	267	271	PF00082	0.750
CLV_PCSK_SKI1_1	301	305	PF00082	0.714
DEG_APCC_DBOX_1	185	193	PF00400	0.503
DOC_ANK_TNKS_1	316	323	PF00023	0.533
DOC_CKS1_1	233	238	PF01111	0.526
DOC_CYCLIN_RxL_1	185	196	PF00134	0.502
DOC_CYCLIN_yClb1_LxF_4	324	329	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.517
DOC_MAPK_gen_1	186	194	PF00069	0.498
DOC_MAPK_gen_1	288	298	PF00069	0.551
DOC_MAPK_MEF2A_6	186	194	PF00069	0.498
DOC_PP1_RVXF_1	277	283	PF00149	0.532
DOC_PP1_RVXF_1	324	330	PF00149	0.534
DOC_PP1_RVXF_1	63	69	PF00149	0.549
DOC_PP2B_LxvP_1	190	193	PF13499	0.485
DOC_PP2B_LxvP_1	20	23	PF13499	0.808
DOC_SPAK_OSR1_1	317	321	PF12202	0.531
DOC_USP7_MATH_1	132	136	PF00917	0.534
DOC_USP7_MATH_1	193	197	PF00917	0.495
DOC_WW_Pin1_4	128	133	PF00397	0.511
DOC_WW_Pin1_4	165	170	PF00397	0.544
DOC_WW_Pin1_4	232	237	PF00397	0.527
DOC_WW_Pin1_4	98	103	PF00397	0.501
LIG_14-3-3_CanoR_1	141	146	PF00244	0.517
LIG_14-3-3_CanoR_1	171	179	PF00244	0.582
LIG_14-3-3_CanoR_1	225	231	PF00244	0.497
LIG_14-3-3_CanoR_1	88	92	PF00244	0.535
LIG_APCC_ABBA_1	250	255	PF00400	0.528
LIG_BRCT_BRCA1_1	100	104	PF00533	0.516
LIG_Clathr_ClatBox_1	103	107	PF01394	0.559
LIG_FHA_1	142	148	PF00498	0.516
LIG_FHA_1	225	231	PF00498	0.497
LIG_FHA_1	302	308	PF00498	0.516
LIG_FHA_1	54	60	PF00498	0.549
LIG_FHA_2	178	184	PF00498	0.550
LIG_FHA_2	304	310	PF00498	0.515
LIG_LIR_Gen_1	16	26	PF02991	0.810
LIG_LIR_Gen_1	48	59	PF02991	0.549
LIG_LIR_Nem_3	16	22	PF02991	0.814
LIG_LIR_Nem_3	196	200	PF02991	0.483
LIG_LIR_Nem_3	48	54	PF02991	0.549
LIG_PDZ_Class_2	326	331	PF00595	0.542
LIG_Pex14_1	268	272	PF04695	0.539
LIG_Pex14_2	15	19	PF04695	0.814
LIG_Pex14_2	293	297	PF04695	0.549
LIG_SH2_CRK	111	115	PF00017	0.498
LIG_SH2_GRB2like	281	284	PF00017	0.532
LIG_SH2_PTP2	51	54	PF00017	0.549
LIG_SH2_STAP1	219	223	PF00017	0.535
LIG_SH2_STAT3	281	284	PF00017	0.532
LIG_SH2_STAT5	122	125	PF00017	0.472
LIG_SH2_STAT5	208	211	PF00017	0.491
LIG_SH2_STAT5	281	284	PF00017	0.532
LIG_SH2_STAT5	285	288	PF00017	0.506
LIG_SH2_STAT5	33	36	PF00017	0.774
LIG_SH2_STAT5	51	54	PF00017	0.234
LIG_SH2_STAT5	91	94	PF00017	0.494
LIG_SH3_3	103	109	PF00018	0.561
LIG_SH3_3	157	163	PF00018	0.562
LIG_SH3_3	230	236	PF00018	0.517
LIG_SH3_3	63	69	PF00018	0.549
LIG_SUMO_SIM_anti_2	144	149	PF11976	0.509
LIG_SUMO_SIM_anti_2	304	309	PF11976	0.514
LIG_SUMO_SIM_par_1	143	149	PF11976	0.509
LIG_SUMO_SIM_par_1	302	309	PF11976	0.517
LIG_SUMO_SIM_par_1	51	56	PF11976	0.549
LIG_TRAF2_1	175	178	PF00917	0.594
LIG_WRC_WIRS_1	38	43	PF05994	0.786
MOD_CDK_SPxK_1	165	171	PF00069	0.549
MOD_CK1_1	221	227	PF00069	0.513
MOD_CK1_1	78	84	PF00069	0.583
MOD_CK2_1	172	178	PF00069	0.586
MOD_GlcNHglycan	2	5	PF01048	0.629
MOD_GlcNHglycan	78	81	PF01048	0.777
MOD_GSK3_1	128	135	PF00069	0.518
MOD_GSK3_1	137	144	PF00069	0.424
MOD_GSK3_1	217	224	PF00069	0.541
MOD_GSK3_1	37	44	PF00069	0.782
MOD_GSK3_1	70	77	PF00069	0.711
MOD_N-GLC_1	217	222	PF02516	0.753
MOD_N-GLC_1	5	10	PF02516	0.608
MOD_NEK2_1	137	142	PF00069	0.549
MOD_NEK2_1	15	20	PF00069	0.814
MOD_NEK2_1	41	46	PF00069	0.772
MOD_NEK2_1	53	58	PF00069	0.339
MOD_NEK2_1	70	75	PF00069	0.405
MOD_NEK2_1	76	81	PF00069	0.504
MOD_NEK2_2	292	297	PF00069	0.547
MOD_PIKK_1	172	178	PF00454	0.586
MOD_PKA_2	224	230	PF00069	0.498
MOD_PKA_2	87	93	PF00069	0.539
MOD_Plk_1	301	307	PF00069	0.514
MOD_Plk_4	15	21	PF00069	0.814
MOD_Plk_4	292	298	PF00069	0.543
MOD_Plk_4	303	309	PF00069	0.378
MOD_Plk_4	45	51	PF00069	0.650
MOD_Plk_4	87	93	PF00069	0.539
MOD_ProDKin_1	128	134	PF00069	0.513
MOD_ProDKin_1	165	171	PF00069	0.549
MOD_ProDKin_1	232	238	PF00069	0.521
MOD_ProDKin_1	98	104	PF00069	0.509
MOD_SUMO_rev_2	275	280	PF00179	0.528
TRG_DiLeu_BaEn_4	211	217	PF01217	0.525
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.509
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.549
TRG_ENDOCYTIC_2	111	114	PF00928	0.503
TRG_ENDOCYTIC_2	51	54	PF00928	0.549
TRG_ER_diArg_1	186	189	PF00400	0.511
TRG_ER_diArg_1	314	317	PF00400	0.536