Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HCE2_LEIBR

TriTrypDb:

LbrM.22.0810 , LBRM2903_220013600

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.343
CLV_NRD_NRD_1	350	352	PF00675	0.425
CLV_NRD_NRD_1	87	89	PF00675	0.338
CLV_PCSK_KEX2_1	141	143	PF00082	0.314
CLV_PCSK_KEX2_1	350	352	PF00082	0.516
CLV_PCSK_KEX2_1	87	89	PF00082	0.191
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.327
CLV_PCSK_PC7_1	137	143	PF00082	0.191
CLV_PCSK_SKI1_1	337	341	PF00082	0.271
DEG_APCC_DBOX_1	303	311	PF00400	0.435
DEG_APCC_DBOX_1	6	14	PF00400	0.244
DEG_Nend_Nbox_1	1	3	PF02207	0.397
DEG_ODPH_VHL_1	93	106	PF01847	0.191
DEG_SCF_FBW7_1	235	241	PF00400	0.292
DOC_CKS1_1	235	240	PF01111	0.293
DOC_CKS1_1	310	315	PF01111	0.257
DOC_CYCLIN_RxL_1	5	17	PF00134	0.256
DOC_MAPK_gen_1	141	149	PF00069	0.191
DOC_MAPK_gen_1	186	194	PF00069	0.464
DOC_MAPK_gen_1	5	13	PF00069	0.243
DOC_MAPK_MEF2A_6	141	149	PF00069	0.323
DOC_MAPK_MEF2A_6	280	289	PF00069	0.370
DOC_MAPK_MEF2A_6	5	12	PF00069	0.230
DOC_MAPK_NFAT4_5	142	150	PF00069	0.191
DOC_MAPK_NFAT4_5	5	13	PF00069	0.246
DOC_PP1_SILK_1	26	31	PF00149	0.172
DOC_PP2B_LxvP_1	289	292	PF13499	0.398
DOC_PP4_FxxP_1	104	107	PF00568	0.225
DOC_SPAK_OSR1_1	60	64	PF12202	0.191
DOC_USP7_MATH_1	188	192	PF00917	0.301
DOC_USP7_MATH_1	205	209	PF00917	0.304
DOC_USP7_MATH_1	264	268	PF00917	0.500
DOC_USP7_MATH_1	279	283	PF00917	0.290
DOC_WW_Pin1_4	210	215	PF00397	0.616
DOC_WW_Pin1_4	234	239	PF00397	0.368
DOC_WW_Pin1_4	268	273	PF00397	0.281
DOC_WW_Pin1_4	309	314	PF00397	0.264
LIG_14-3-3_CanoR_1	243	253	PF00244	0.349
LIG_14-3-3_CanoR_1	280	287	PF00244	0.404
LIG_14-3-3_CanoR_1	290	296	PF00244	0.450
LIG_14-3-3_CanoR_1	65	70	PF00244	0.298
LIG_14-3-3_CanoR_1	88	94	PF00244	0.191
LIG_Actin_WH2_2	21	37	PF00022	0.263
LIG_FHA_1	15	21	PF00498	0.342
LIG_FHA_1	168	174	PF00498	0.342
LIG_FHA_1	219	225	PF00498	0.422
LIG_FHA_1	239	245	PF00498	0.194
LIG_FHA_1	24	30	PF00498	0.190
LIG_FHA_1	310	316	PF00498	0.270
LIG_LIR_Apic_2	103	107	PF02991	0.265
LIG_LIR_Gen_1	155	165	PF02991	0.524
LIG_LIR_Gen_1	221	231	PF02991	0.349
LIG_LIR_Gen_1	257	266	PF02991	0.287
LIG_LIR_Gen_1	68	76	PF02991	0.314
LIG_LIR_Nem_3	155	161	PF02991	0.447
LIG_LIR_Nem_3	221	226	PF02991	0.362
LIG_LIR_Nem_3	257	262	PF02991	0.494
LIG_LIR_Nem_3	322	328	PF02991	0.265
LIG_LIR_Nem_3	68	72	PF02991	0.258
LIG_LIR_Nem_3	77	81	PF02991	0.262
LIG_REV1ctd_RIR_1	51	62	PF16727	0.191
LIG_SH2_CRK	259	263	PF00017	0.491
LIG_SH2_GRB2like	223	226	PF00017	0.275
LIG_SH2_NCK_1	259	263	PF00017	0.283
LIG_SH2_PTP2	148	151	PF00017	0.418
LIG_SH2_SRC	223	226	PF00017	0.275
LIG_SH2_SRC	98	101	PF00017	0.207
LIG_SH2_STAP1	348	352	PF00017	0.297
LIG_SH2_STAT5	127	130	PF00017	0.185
LIG_SH2_STAT5	148	151	PF00017	0.284
LIG_SH2_STAT5	223	226	PF00017	0.275
LIG_SH2_STAT5	359	362	PF00017	0.417
LIG_SH3_1	350	356	PF00018	0.292
LIG_SH3_3	266	272	PF00018	0.298
LIG_SH3_3	302	308	PF00018	0.522
LIG_SH3_3	350	356	PF00018	0.336
LIG_SUMO_SIM_par_1	172	178	PF11976	0.318
LIG_SUMO_SIM_par_1	317	324	PF11976	0.303
LIG_SUMO_SIM_par_1	9	15	PF11976	0.382
LIG_SxIP_EBH_1	141	151	PF03271	0.191
LIG_TYR_ITSM	219	226	PF00017	0.316
LIG_WRC_WIRS_1	75	80	PF05994	0.221
LIG_WW_1	111	114	PF00397	0.253
MOD_CDK_SPxK_1	234	240	PF00069	0.285
MOD_CK1_1	213	219	PF00069	0.513
MOD_CK1_1	234	240	PF00069	0.399
MOD_CK1_1	258	264	PF00069	0.392
MOD_Cter_Amidation	85	88	PF01082	0.191
MOD_GlcNHglycan	108	111	PF01048	0.314
MOD_GlcNHglycan	118	121	PF01048	0.294
MOD_GlcNHglycan	194	197	PF01048	0.243
MOD_GlcNHglycan	281	284	PF01048	0.422
MOD_GSK3_1	106	113	PF00069	0.229
MOD_GSK3_1	11	18	PF00069	0.337
MOD_GSK3_1	188	195	PF00069	0.356
MOD_GSK3_1	205	212	PF00069	0.550
MOD_GSK3_1	214	221	PF00069	0.533
MOD_GSK3_1	226	233	PF00069	0.255
MOD_GSK3_1	234	241	PF00069	0.208
MOD_GSK3_1	264	271	PF00069	0.436
MOD_GSK3_1	315	322	PF00069	0.311
MOD_GSK3_1	61	68	PF00069	0.361
MOD_N-GLC_1	210	215	PF02516	0.562
MOD_N-GLC_1	231	236	PF02516	0.305
MOD_NEK2_1	194	199	PF00069	0.261
MOD_NEK2_1	230	235	PF00069	0.292
MOD_NEK2_1	321	326	PF00069	0.287
MOD_NEK2_1	61	66	PF00069	0.191
MOD_NEK2_2	238	243	PF00069	0.280
MOD_PIKK_1	152	158	PF00454	0.284
MOD_PIKK_1	244	250	PF00454	0.504
MOD_PK_1	35	41	PF00069	0.191
MOD_PKA_2	242	248	PF00069	0.369
MOD_PKA_2	279	285	PF00069	0.284
MOD_PKA_2	59	65	PF00069	0.298
MOD_Plk_1	164	170	PF00069	0.496
MOD_Plk_1	231	237	PF00069	0.380
MOD_Plk_1	337	343	PF00069	0.421
MOD_Plk_1	35	41	PF00069	0.246
MOD_Plk_4	164	170	PF00069	0.296
MOD_Plk_4	226	232	PF00069	0.356
MOD_Plk_4	264	270	PF00069	0.413
MOD_Plk_4	337	343	PF00069	0.427
MOD_Plk_4	65	71	PF00069	0.250
MOD_ProDKin_1	210	216	PF00069	0.616
MOD_ProDKin_1	234	240	PF00069	0.374
MOD_ProDKin_1	268	274	PF00069	0.290
MOD_ProDKin_1	309	315	PF00069	0.260
MOD_SUMO_rev_2	185	191	PF00179	0.336
MOD_SUMO_rev_2	282	289	PF00179	0.276
MOD_SUMO_rev_2	362	370	PF00179	0.422
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.243
TRG_ENDOCYTIC_2	158	161	PF00928	0.385
TRG_ENDOCYTIC_2	223	226	PF00928	0.275
TRG_ENDOCYTIC_2	259	262	PF00928	0.495
TRG_ER_diArg_1	350	352	PF00400	0.382
TRG_ER_diArg_1	7	10	PF00400	0.234
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.191

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P340	Leptomonas seymouri	27%	92%
A0A0N0P6L7	Leptomonas seymouri	47%	97%
A0A0N1HTK3	Leptomonas seymouri	25%	94%
A0A0S4J9R2	Bodo saltans	25%	76%
A0A1X0P8T4	Trypanosomatidae	28%	80%
V5BCA5	Trypanosoma cruzi	22%	80%