Pre-mRNA-splicing factor 18

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Prp18 domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCE1_LEIBR

TriTrypDb:

LbrM.22.0800 , LBRM2903_220013500

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:1990904	ribonucleoprotein complex	2	7
GO:0005682	U5 snRNP	5	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0071020	post-spliceosomal complex	4	1
GO:0071021	U2-type post-spliceosomal complex	5	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0120114	Sm-like protein family complex	2	1

Expansion

Sequence features

A4HCE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCE1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006396	RNA processing	6	6
GO:0006397	mRNA processing	7	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0008380	RNA splicing	7	6
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	6
GO:0016071	mRNA metabolic process	6	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0000350	generation of catalytic spliceosome for second transesterification step	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.655
CLV_NRD_NRD_1	267	269	PF00675	0.485
CLV_NRD_NRD_1	296	298	PF00675	0.477
CLV_NRD_NRD_1	443	445	PF00675	0.320
CLV_NRD_NRD_1	491	493	PF00675	0.271
CLV_PCSK_KEX2_1	109	111	PF00082	0.603
CLV_PCSK_KEX2_1	267	269	PF00082	0.494
CLV_PCSK_KEX2_1	491	493	PF00082	0.271
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.603
CLV_PCSK_SKI1_1	267	271	PF00082	0.485
CLV_PCSK_SKI1_1	53	57	PF00082	0.624
DEG_APCC_DBOX_1	443	451	PF00400	0.471
DEG_Nend_UBRbox_3	1	3	PF02207	0.493
DEG_ODPH_VHL_1	362	375	PF01847	0.486
DEG_SCF_FBW7_1	260	265	PF00400	0.415
DEG_SPOP_SBC_1	125	129	PF00917	0.528
DEG_SPOP_SBC_1	64	68	PF00917	0.553
DOC_CKS1_1	259	264	PF01111	0.388
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.249
DOC_MAPK_FxFP_2	536	539	PF00069	0.344
DOC_MAPK_gen_1	405	413	PF00069	0.362
DOC_MAPK_gen_1	444	452	PF00069	0.549
DOC_MAPK_gen_1	456	464	PF00069	0.438
DOC_MAPK_MEF2A_6	465	473	PF00069	0.520
DOC_PP2B_LxvP_1	361	364	PF13499	0.417
DOC_PP2B_LxvP_1	437	440	PF13499	0.332
DOC_PP4_FxxP_1	245	248	PF00568	0.368
DOC_PP4_FxxP_1	259	262	PF00568	0.475
DOC_PP4_FxxP_1	536	539	PF00568	0.423
DOC_USP7_MATH_1	108	112	PF00917	0.600
DOC_USP7_MATH_1	134	138	PF00917	0.654
DOC_USP7_MATH_1	146	150	PF00917	0.576
DOC_USP7_MATH_1	152	156	PF00917	0.506
DOC_USP7_MATH_1	213	217	PF00917	0.599
DOC_USP7_MATH_1	234	238	PF00917	0.563
DOC_USP7_MATH_1	425	429	PF00917	0.553
DOC_USP7_MATH_1	63	67	PF00917	0.584
DOC_USP7_MATH_1	83	87	PF00917	0.545
DOC_USP7_UBL2_3	11	15	PF12436	0.523
DOC_WW_Pin1_4	222	227	PF00397	0.534
DOC_WW_Pin1_4	240	245	PF00397	0.438
DOC_WW_Pin1_4	258	263	PF00397	0.372
DOC_WW_Pin1_4	367	372	PF00397	0.455
DOC_WW_Pin1_4	38	43	PF00397	0.567
DOC_WW_Pin1_4	426	431	PF00397	0.541
DOC_WW_Pin1_4	526	531	PF00397	0.528
LIG_14-3-3_CanoR_1	143	149	PF00244	0.695
LIG_14-3-3_CanoR_1	491	495	PF00244	0.471
LIG_APCC_ABBA_1	521	526	PF00400	0.520
LIG_BRCT_BRCA1_1	241	245	PF00533	0.449
LIG_BRCT_BRCA1_1	533	537	PF00533	0.496
LIG_CtBP_PxDLS_1	440	444	PF00389	0.415
LIG_FHA_1	209	215	PF00498	0.656
LIG_FHA_1	39	45	PF00498	0.639
LIG_FHA_1	447	453	PF00498	0.562
LIG_FHA_1	510	516	PF00498	0.520
LIG_FHA_2	184	190	PF00498	0.458
LIG_FHA_2	21	27	PF00498	0.568
LIG_FHA_2	274	280	PF00498	0.490
LIG_Integrin_isoDGR_2	346	348	PF01839	0.618
LIG_LIR_Apic_2	242	248	PF02991	0.380
LIG_LIR_Apic_2	534	539	PF02991	0.421
LIG_LIR_Gen_1	279	290	PF02991	0.397
LIG_LIR_Gen_1	458	469	PF02991	0.471
LIG_LIR_Nem_3	279	285	PF02991	0.388
LIG_LIR_Nem_3	398	403	PF02991	0.481
LIG_LIR_Nem_3	458	464	PF02991	0.471
LIG_LIR_Nem_3	467	471	PF02991	0.471
LIG_MLH1_MIPbox_1	533	537	PF16413	0.496
LIG_NRBOX	330	336	PF00104	0.312
LIG_NRBOX	5	11	PF00104	0.578
LIG_SH2_PTP2	468	471	PF00017	0.528
LIG_SH2_SRC	468	471	PF00017	0.520
LIG_SH2_STAT5	254	257	PF00017	0.383
LIG_SH2_STAT5	330	333	PF00017	0.372
LIG_SH2_STAT5	374	377	PF00017	0.386
LIG_SH2_STAT5	416	419	PF00017	0.363
LIG_SH2_STAT5	468	471	PF00017	0.516
LIG_SH2_STAT5	80	83	PF00017	0.406
LIG_SH3_3	145	151	PF00018	0.599
LIG_SH3_3	215	221	PF00018	0.723
LIG_SH3_CIN85_PxpxPR_1	244	249	PF14604	0.344
LIG_SUMO_SIM_par_1	80	86	PF11976	0.403
LIG_UBA3_1	284	289	PF00899	0.453
MOD_CDC14_SPxK_1	529	532	PF00782	0.530
MOD_CDK_SPxK_1	526	532	PF00069	0.415
MOD_CK1_1	102	108	PF00069	0.586
MOD_CK1_1	128	134	PF00069	0.675
MOD_CK1_1	144	150	PF00069	0.545
MOD_CK1_1	155	161	PF00069	0.568
MOD_CK1_1	198	204	PF00069	0.443
MOD_CK1_1	208	214	PF00069	0.539
MOD_CK1_1	216	222	PF00069	0.549
MOD_CK1_1	428	434	PF00069	0.583
MOD_CK1_1	54	60	PF00069	0.580
MOD_CK1_1	74	80	PF00069	0.579
MOD_CK1_1	86	92	PF00069	0.423
MOD_CK2_1	183	189	PF00069	0.384
MOD_CK2_1	20	26	PF00069	0.578
MOD_CK2_1	300	306	PF00069	0.522
MOD_CK2_1	416	422	PF00069	0.411
MOD_CK2_1	481	487	PF00069	0.471
MOD_GlcNHglycan	143	146	PF01048	0.606
MOD_GlcNHglycan	148	151	PF01048	0.538
MOD_GlcNHglycan	152	155	PF01048	0.586
MOD_GlcNHglycan	158	161	PF01048	0.566
MOD_GlcNHglycan	165	168	PF01048	0.385
MOD_GlcNHglycan	215	218	PF01048	0.608
MOD_GlcNHglycan	226	229	PF01048	0.650
MOD_GlcNHglycan	25	30	PF01048	0.655
MOD_GlcNHglycan	422	426	PF01048	0.446
MOD_GlcNHglycan	483	486	PF01048	0.271
MOD_GlcNHglycan	53	56	PF01048	0.587
MOD_GlcNHglycan	73	76	PF01048	0.557
MOD_GSK3_1	124	131	PF00069	0.675
MOD_GSK3_1	146	153	PF00069	0.618
MOD_GSK3_1	198	205	PF00069	0.561
MOD_GSK3_1	209	216	PF00069	0.592
MOD_GSK3_1	21	28	PF00069	0.649
MOD_GSK3_1	232	239	PF00069	0.629
MOD_GSK3_1	258	265	PF00069	0.396
MOD_GSK3_1	412	419	PF00069	0.447
MOD_GSK3_1	421	428	PF00069	0.419
MOD_GSK3_1	65	72	PF00069	0.603
MOD_N-GLC_1	125	130	PF02516	0.651
MOD_N-GLC_1	198	203	PF02516	0.428
MOD_NEK2_1	101	106	PF00069	0.627
MOD_NEK2_1	124	129	PF00069	0.531
MOD_NEK2_1	156	161	PF00069	0.529
MOD_NEK2_1	202	207	PF00069	0.475
MOD_NEK2_1	238	243	PF00069	0.500
MOD_NEK2_1	351	356	PF00069	0.497
MOD_NEK2_1	403	408	PF00069	0.446
MOD_NEK2_1	44	49	PF00069	0.714
MOD_NEK2_2	83	88	PF00069	0.401
MOD_PIKK_1	183	189	PF00454	0.305
MOD_PIKK_1	216	222	PF00454	0.611
MOD_PIKK_1	362	368	PF00454	0.385
MOD_PKA_1	267	273	PF00069	0.478
MOD_PKA_2	102	108	PF00069	0.537
MOD_PKA_2	267	273	PF00069	0.578
MOD_PKA_2	490	496	PF00069	0.471
MOD_Plk_1	198	204	PF00069	0.432
MOD_Plk_1	273	279	PF00069	0.501
MOD_Plk_1	469	475	PF00069	0.467
MOD_Plk_4	273	279	PF00069	0.501
MOD_Plk_4	412	418	PF00069	0.423
MOD_Plk_4	446	452	PF00069	0.520
MOD_Plk_4	541	547	PF00069	0.446
MOD_ProDKin_1	222	228	PF00069	0.534
MOD_ProDKin_1	240	246	PF00069	0.420
MOD_ProDKin_1	258	264	PF00069	0.387
MOD_ProDKin_1	367	373	PF00069	0.452
MOD_ProDKin_1	38	44	PF00069	0.572
MOD_ProDKin_1	426	432	PF00069	0.544
MOD_ProDKin_1	526	532	PF00069	0.528
MOD_SUMO_for_1	288	291	PF00179	0.471
MOD_SUMO_rev_2	113	122	PF00179	0.543
MOD_SUMO_rev_2	302	311	PF00179	0.587
TRG_DiLeu_BaEn_2	519	525	PF01217	0.471
TRG_ENDOCYTIC_2	374	377	PF00928	0.386
TRG_ENDOCYTIC_2	468	471	PF00928	0.497
TRG_ER_diArg_1	266	268	PF00400	0.474
TRG_ER_diArg_1	490	492	PF00400	0.471
TRG_ER_diArg_1	499	502	PF00400	0.473
TRG_NES_CRM1_1	274	287	PF08389	0.471
TRG_NES_CRM1_1	323	337	PF08389	0.402
TRG_NLS_MonoExtC_3	10	15	PF00514	0.612
TRG_NLS_MonoExtN_4	11	16	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I883	Leptomonas seymouri	44%	100%
A0A3Q8ICC8	Leishmania donovani	74%	99%
A4HZW5	Leishmania infantum	73%	99%
E9AVS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4QBQ6	Leishmania major	73%	99%