LeishMANIAdb
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Polyhomeotic-like protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Polyhomeotic-like protein 1
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HCE0_LEIBR
TriTrypDb:
LbrM.22.0780 , LBRM2903_220013300
Length:
122

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCE0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCE0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 75 79 PF00656 0.465
DEG_SPOP_SBC_1 87 91 PF00917 0.584
DOC_USP7_MATH_1 87 91 PF00917 0.499
DOC_USP7_UBL2_3 97 101 PF12436 0.571
DOC_WW_Pin1_4 11 16 PF00397 0.578
DOC_WW_Pin1_4 55 60 PF00397 0.583
LIG_BIR_II_1 1 5 PF00653 0.606
LIG_BRCT_BRCA1_1 67 71 PF00533 0.503
LIG_FHA_1 75 81 PF00498 0.496
LIG_FHA_1 89 95 PF00498 0.595
LIG_FHA_2 103 109 PF00498 0.464
LIG_LIR_Gen_1 106 117 PF02991 0.588
LIG_LIR_Nem_3 106 112 PF02991 0.554
LIG_LIR_Nem_3 67 73 PF02991 0.496
LIG_MLH1_MIPbox_1 67 71 PF16413 0.503
LIG_SH2_STAT3 20 23 PF00017 0.606
LIG_SH3_3 96 102 PF00018 0.574
LIG_SH3_4 97 104 PF00018 0.564
LIG_TRAF2_1 105 108 PF00917 0.545
MOD_CDK_SPK_2 11 16 PF00069 0.578
MOD_CK1_1 55 61 PF00069 0.635
MOD_CK2_1 102 108 PF00069 0.548
MOD_CK2_1 87 93 PF00069 0.513
MOD_GlcNHglycan 2 5 PF01048 0.629
MOD_GlcNHglycan 31 34 PF01048 0.808
MOD_GlcNHglycan 7 10 PF01048 0.587
MOD_GSK3_1 25 32 PF00069 0.629
MOD_GSK3_1 74 81 PF00069 0.504
MOD_N-GLC_1 4 9 PF02516 0.538
MOD_PIKK_1 52 58 PF00454 0.643
MOD_Plk_1 87 93 PF00069 0.697
MOD_Plk_2-3 88 94 PF00069 0.594
MOD_ProDKin_1 11 17 PF00069 0.570
MOD_ProDKin_1 55 61 PF00069 0.581
MOD_SUMO_rev_2 39 47 PF00179 0.561
MOD_SUMO_rev_2 62 71 PF00179 0.525
TRG_DiLeu_BaEn_3 107 113 PF01217 0.537

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCN5 Leptomonas seymouri 73% 100%
A0A3Q8ILK3 Leishmania donovani 92% 100%
A4HZW3 Leishmania infantum 93% 100%
E9AVS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QBQ8 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS