Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCD8_LEIBR

TriTrypDb:

LbrM.22.0770 , LBRM2903_220013200

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.529
CLV_C14_Caspase3-7	209	213	PF00656	0.547
CLV_NRD_NRD_1	113	115	PF00675	0.601
CLV_NRD_NRD_1	183	185	PF00675	0.433
CLV_NRD_NRD_1	332	334	PF00675	0.506
CLV_NRD_NRD_1	4	6	PF00675	0.629
CLV_NRD_NRD_1	524	526	PF00675	0.543
CLV_NRD_NRD_1	588	590	PF00675	0.707
CLV_NRD_NRD_1	610	612	PF00675	0.637
CLV_NRD_NRD_1	629	631	PF00675	0.612
CLV_NRD_NRD_1	690	692	PF00675	0.583
CLV_PCSK_FUR_1	608	612	PF00082	0.653
CLV_PCSK_KEX2_1	113	115	PF00082	0.586
CLV_PCSK_KEX2_1	183	185	PF00082	0.433
CLV_PCSK_KEX2_1	332	334	PF00082	0.506
CLV_PCSK_KEX2_1	523	525	PF00082	0.560
CLV_PCSK_KEX2_1	588	590	PF00082	0.707
CLV_PCSK_KEX2_1	6	8	PF00082	0.632
CLV_PCSK_KEX2_1	610	612	PF00082	0.641
CLV_PCSK_KEX2_1	690	692	PF00082	0.583
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.632
CLV_PCSK_SKI1_1	104	108	PF00082	0.606
CLV_PCSK_SKI1_1	114	118	PF00082	0.632
CLV_PCSK_SKI1_1	17	21	PF00082	0.637
CLV_PCSK_SKI1_1	414	418	PF00082	0.524
CLV_PCSK_SKI1_1	631	635	PF00082	0.685
CLV_PCSK_SKI1_1	656	660	PF00082	0.596
DEG_APCC_DBOX_1	23	31	PF00400	0.570
DEG_SCF_FBW7_1	289	295	PF00400	0.542
DEG_SPOP_SBC_1	119	123	PF00917	0.567
DEG_SPOP_SBC_1	292	296	PF00917	0.549
DEG_SPOP_SBC_1	409	413	PF00917	0.684
DEG_SPOP_SBC_1	491	495	PF00917	0.606
DOC_CKS1_1	289	294	PF01111	0.542
DOC_CYCLIN_RxL_1	356	364	PF00134	0.493
DOC_CYCLIN_RxL_1	653	662	PF00134	0.601
DOC_MAPK_DCC_7	135	144	PF00069	0.493
DOC_MAPK_gen_1	113	119	PF00069	0.692
DOC_MAPK_MEF2A_6	135	144	PF00069	0.602
DOC_PP2B_LxvP_1	238	241	PF13499	0.623
DOC_PP4_FxxP_1	38	41	PF00568	0.564
DOC_PP4_FxxP_1	441	444	PF00568	0.483
DOC_USP7_MATH_1	219	223	PF00917	0.649
DOC_USP7_MATH_1	247	251	PF00917	0.502
DOC_USP7_MATH_1	405	409	PF00917	0.675
DOC_USP7_MATH_1	41	45	PF00917	0.514
DOC_USP7_MATH_1	432	436	PF00917	0.553
DOC_USP7_MATH_1	458	462	PF00917	0.569
DOC_USP7_MATH_1	519	523	PF00917	0.580
DOC_USP7_MATH_1	54	58	PF00917	0.543
DOC_USP7_UBL2_3	100	104	PF12436	0.611
DOC_WW_Pin1_4	212	217	PF00397	0.778
DOC_WW_Pin1_4	231	236	PF00397	0.501
DOC_WW_Pin1_4	288	293	PF00397	0.565
DOC_WW_Pin1_4	440	445	PF00397	0.594
DOC_WW_Pin1_4	636	641	PF00397	0.532
LIG_14-3-3_CanoR_1	17	22	PF00244	0.642
LIG_14-3-3_CanoR_1	359	364	PF00244	0.521
LIG_14-3-3_CanoR_1	414	419	PF00244	0.626
LIG_14-3-3_CanoR_1	525	531	PF00244	0.536
LIG_14-3-3_CanoR_1	630	640	PF00244	0.567
LIG_14-3-3_CanoR_1	80	87	PF00244	0.591
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_BRCT_BRCA1_1	34	38	PF00533	0.604
LIG_BRCT_BRCA1_1	418	422	PF00533	0.517
LIG_BRCT_BRCA1_1	434	438	PF00533	0.479
LIG_Clathr_ClatBox_1	27	31	PF01394	0.565
LIG_Clathr_ClatBox_1	360	364	PF01394	0.433
LIG_deltaCOP1_diTrp_1	343	347	PF00928	0.503
LIG_deltaCOP1_diTrp_1	694	699	PF00928	0.485
LIG_DLG_GKlike_1	359	367	PF00625	0.526
LIG_EVH1_1	396	400	PF00568	0.624
LIG_FHA_1	197	203	PF00498	0.608
LIG_FHA_1	228	234	PF00498	0.639
LIG_FHA_1	255	261	PF00498	0.519
LIG_FHA_1	310	316	PF00498	0.571
LIG_FHA_1	44	50	PF00498	0.523
LIG_FHA_1	446	452	PF00498	0.500
LIG_FHA_1	632	638	PF00498	0.781
LIG_FHA_1	659	665	PF00498	0.597
LIG_FHA_2	165	171	PF00498	0.530
LIG_FHA_2	18	24	PF00498	0.644
LIG_FHA_2	293	299	PF00498	0.770
LIG_FHA_2	480	486	PF00498	0.704
LIG_FHA_2	667	673	PF00498	0.677
LIG_FHA_2	677	683	PF00498	0.537
LIG_LIR_Apic_2	35	41	PF02991	0.564
LIG_LIR_Gen_1	435	446	PF02991	0.486
LIG_LIR_Gen_1	485	492	PF02991	0.581
LIG_LIR_Gen_1	52	63	PF02991	0.550
LIG_LIR_Gen_1	527	535	PF02991	0.581
LIG_LIR_Nem_3	126	131	PF02991	0.537
LIG_LIR_Nem_3	435	441	PF02991	0.491
LIG_LIR_Nem_3	485	490	PF02991	0.576
LIG_LIR_Nem_3	52	58	PF02991	0.605
LIG_LIR_Nem_3	527	531	PF02991	0.598
LIG_NRBOX	177	183	PF00104	0.438
LIG_NRBOX	356	362	PF00104	0.429
LIG_PAM2_1	427	439	PF00658	0.486
LIG_PDZ_Class_1	698	703	PF00595	0.502
LIG_SH2_CRK	528	532	PF00017	0.518
LIG_SH2_CRK	55	59	PF00017	0.514
LIG_SH2_GRB2like	62	65	PF00017	0.605
LIG_SH2_NCK_1	271	275	PF00017	0.469
LIG_SH2_NCK_1	62	66	PF00017	0.452
LIG_SH2_SRC	285	288	PF00017	0.553
LIG_SH2_SRC	478	481	PF00017	0.466
LIG_SH2_SRC	62	65	PF00017	0.447
LIG_SH2_STAP1	271	275	PF00017	0.469
LIG_SH2_STAP1	538	542	PF00017	0.501
LIG_SH2_STAP1	55	59	PF00017	0.514
LIG_SH2_STAT3	538	541	PF00017	0.494
LIG_SH2_STAT5	285	288	PF00017	0.553
LIG_SH2_STAT5	314	317	PF00017	0.520
LIG_SH2_STAT5	36	39	PF00017	0.570
LIG_SH2_STAT5	478	481	PF00017	0.703
LIG_SH2_STAT5	486	489	PF00017	0.583
LIG_SH3_1	462	468	PF00018	0.521
LIG_SH3_1	7	13	PF00018	0.494
LIG_SH3_2	237	242	PF14604	0.625
LIG_SH3_2	397	402	PF14604	0.669
LIG_SH3_3	134	140	PF00018	0.561
LIG_SH3_3	213	219	PF00018	0.799
LIG_SH3_3	234	240	PF00018	0.552
LIG_SH3_3	286	292	PF00018	0.542
LIG_SH3_3	394	400	PF00018	0.633
LIG_SH3_3	426	432	PF00018	0.558
LIG_SH3_3	462	468	PF00018	0.739
LIG_SH3_3	634	640	PF00018	0.535
LIG_SH3_3	7	13	PF00018	0.494
LIG_SH3_CIN85_PxpxPR_1	237	242	PF14604	0.625
LIG_SUMO_SIM_par_1	359	364	PF11976	0.494
LIG_TRAF2_1	13	16	PF00917	0.544
LIG_TRAF2_1	548	551	PF00917	0.548
LIG_TYR_ITIM	53	58	PF00017	0.506
LIG_WRC_WIRS_1	105	110	PF05994	0.518
LIG_WRC_WIRS_1	125	130	PF05994	0.542
LIG_WW_3	239	243	PF00397	0.621
MOD_CK1_1	118	124	PF00069	0.605
MOD_CK1_1	196	202	PF00069	0.593
MOD_CK1_1	227	233	PF00069	0.597
MOD_CK1_1	250	256	PF00069	0.543
MOD_CK1_1	302	308	PF00069	0.633
MOD_CK1_1	309	315	PF00069	0.590
MOD_CK1_1	350	356	PF00069	0.496
MOD_CK1_1	408	414	PF00069	0.676
MOD_CK1_1	420	426	PF00069	0.734
MOD_CK1_1	445	451	PF00069	0.560
MOD_CK1_1	493	499	PF00069	0.645
MOD_CK1_1	506	512	PF00069	0.738
MOD_CK1_1	603	609	PF00069	0.559
MOD_CK1_1	75	81	PF00069	0.656
MOD_CK2_1	159	165	PF00069	0.689
MOD_CK2_1	17	23	PF00069	0.609
MOD_CK2_1	242	248	PF00069	0.651
MOD_CK2_1	292	298	PF00069	0.766
MOD_CK2_1	36	42	PF00069	0.642
MOD_CK2_1	666	672	PF00069	0.675
MOD_CK2_1	676	682	PF00069	0.533
MOD_CMANNOS	344	347	PF00535	0.501
MOD_CMANNOS	388	391	PF00535	0.477
MOD_CMANNOS	696	699	PF00535	0.484
MOD_Cter_Amidation	111	114	PF01082	0.587
MOD_Cter_Amidation	628	631	PF01082	0.682
MOD_GlcNHglycan	110	113	PF01048	0.602
MOD_GlcNHglycan	128	131	PF01048	0.586
MOD_GlcNHglycan	161	164	PF01048	0.658
MOD_GlcNHglycan	254	257	PF01048	0.586
MOD_GlcNHglycan	272	275	PF01048	0.546
MOD_GlcNHglycan	295	298	PF01048	0.697
MOD_GlcNHglycan	301	304	PF01048	0.773
MOD_GlcNHglycan	329	332	PF01048	0.496
MOD_GlcNHglycan	370	374	PF01048	0.685
MOD_GlcNHglycan	407	410	PF01048	0.676
MOD_GlcNHglycan	419	422	PF01048	0.739
MOD_GlcNHglycan	495	498	PF01048	0.663
MOD_GlcNHglycan	580	583	PF01048	0.700
MOD_GlcNHglycan	601	605	PF01048	0.552
MOD_GlcNHglycan	619	622	PF01048	0.496
MOD_GlcNHglycan	70	73	PF01048	0.564
MOD_GlcNHglycan	83	86	PF01048	0.770
MOD_GSK3_1	104	111	PF00069	0.661
MOD_GSK3_1	115	122	PF00069	0.533
MOD_GSK3_1	194	201	PF00069	0.576
MOD_GSK3_1	224	231	PF00069	0.646
MOD_GSK3_1	250	257	PF00069	0.524
MOD_GSK3_1	288	295	PF00069	0.618
MOD_GSK3_1	299	306	PF00069	0.567
MOD_GSK3_1	32	39	PF00069	0.588
MOD_GSK3_1	343	350	PF00069	0.498
MOD_GSK3_1	405	412	PF00069	0.604
MOD_GSK3_1	416	423	PF00069	0.618
MOD_GSK3_1	427	434	PF00069	0.590
MOD_GSK3_1	486	493	PF00069	0.619
MOD_GSK3_1	499	506	PF00069	0.689
MOD_GSK3_1	578	585	PF00069	0.544
MOD_GSK3_1	599	606	PF00069	0.639
MOD_GSK3_1	629	636	PF00069	0.634
MOD_GSK3_1	658	665	PF00069	0.630
MOD_GSK3_1	68	75	PF00069	0.532
MOD_N-GLC_1	578	583	PF02516	0.700
MOD_NEK2_1	1	6	PF00069	0.606
MOD_NEK2_1	108	113	PF00069	0.742
MOD_NEK2_1	117	122	PF00069	0.690
MOD_NEK2_1	159	164	PF00069	0.656
MOD_NEK2_1	252	257	PF00069	0.533
MOD_NEK2_1	270	275	PF00069	0.604
MOD_NEK2_1	327	332	PF00069	0.613
MOD_NEK2_1	479	484	PF00069	0.657
MOD_NEK2_1	650	655	PF00069	0.563
MOD_NEK2_1	658	663	PF00069	0.573
MOD_NEK2_2	247	252	PF00069	0.498
MOD_NEK2_2	314	319	PF00069	0.512
MOD_NEK2_2	54	59	PF00069	0.510
MOD_PIKK_1	254	260	PF00454	0.488
MOD_PIKK_1	280	286	PF00454	0.686
MOD_PIKK_1	345	351	PF00454	0.493
MOD_PIKK_1	43	49	PF00454	0.535
MOD_PIKK_1	662	668	PF00454	0.591
MOD_PK_1	242	248	PF00069	0.684
MOD_PKA_1	524	530	PF00069	0.608
MOD_PKA_1	588	594	PF00069	0.704
MOD_PKA_1	690	696	PF00069	0.572
MOD_PKA_2	280	286	PF00069	0.550
MOD_PKA_2	309	315	PF00069	0.525
MOD_PKA_2	524	530	PF00069	0.608
MOD_PKA_2	588	594	PF00069	0.696
MOD_PKA_2	629	635	PF00069	0.555
MOD_PKA_2	690	696	PF00069	0.572
MOD_Plk_1	123	129	PF00069	0.515
MOD_Plk_1	247	253	PF00069	0.574
MOD_Plk_1	32	38	PF00069	0.567
MOD_Plk_1	41	47	PF00069	0.534
MOD_Plk_2-3	676	682	PF00069	0.635
MOD_Plk_4	198	204	PF00069	0.650
MOD_Plk_4	219	225	PF00069	0.655
MOD_Plk_4	247	253	PF00069	0.594
MOD_Plk_4	423	429	PF00069	0.541
MOD_Plk_4	513	519	PF00069	0.604
MOD_Plk_4	526	532	PF00069	0.519
MOD_Plk_4	54	60	PF00069	0.530
MOD_Plk_4	659	665	PF00069	0.667
MOD_Plk_4	676	682	PF00069	0.597
MOD_Plk_4	91	97	PF00069	0.510
MOD_ProDKin_1	212	218	PF00069	0.780
MOD_ProDKin_1	231	237	PF00069	0.501
MOD_ProDKin_1	288	294	PF00069	0.567
MOD_ProDKin_1	440	446	PF00069	0.593
MOD_ProDKin_1	636	642	PF00069	0.531
MOD_SUMO_for_1	203	206	PF00179	0.658
TRG_DiLeu_BaEn_1	23	28	PF01217	0.650
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.557
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.429
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.563
TRG_ENDOCYTIC_2	528	531	PF00928	0.522
TRG_ENDOCYTIC_2	55	58	PF00928	0.508
TRG_ENDOCYTIC_2	8	11	PF00928	0.579
TRG_ER_diArg_1	182	184	PF00400	0.434
TRG_ER_diArg_1	5	8	PF00400	0.607
TRG_ER_diArg_1	523	525	PF00400	0.557
TRG_ER_diArg_1	587	589	PF00400	0.695
TRG_ER_diArg_1	607	610	PF00400	0.516
TRG_ER_diArg_1	689	691	PF00400	0.593
TRG_NLS_MonoExtC_3	4	9	PF00514	0.619
TRG_NLS_MonoExtN_4	5	10	PF00514	0.616
TRG_Pf-PMV_PEXEL_1	359	364	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL70	Leptomonas seymouri	43%	94%
A0A3Q8IBF7	Leishmania donovani	75%	100%
A4HZW2	Leishmania infantum	75%	100%
E9AVS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QBQ9	Leishmania major	74%	99%