Protein kinase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein kinase sos2, putative

Species:

Leishmania braziliensis

UniProt:

A4HCD7_LEIBR

TriTrypDb:

LbrM.22.0750 , LBRM2903_220012900

Length:

426

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

A4HCD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCD7

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0035556	intracellular signal transduction	3	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	11
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.756
CLV_MEL_PAP_1	60	66	PF00089	0.260
CLV_NRD_NRD_1	117	119	PF00675	0.302
CLV_NRD_NRD_1	339	341	PF00675	0.612
CLV_NRD_NRD_1	54	56	PF00675	0.604
CLV_NRD_NRD_1	62	64	PF00675	0.495
CLV_PCSK_KEX2_1	117	119	PF00082	0.317
CLV_PCSK_KEX2_1	62	64	PF00082	0.498
CLV_PCSK_KEX2_1	82	84	PF00082	0.336
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.336

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T0	Leptomonas seymouri	27%	78%
A0A0N0P787	Leptomonas seymouri	28%	100%
A0A0N1I1M7	Leptomonas seymouri	31%	66%
A0A0N1PC32	Leptomonas seymouri	32%	100%
A0A0N1PDW7	Leptomonas seymouri	78%	100%
A0A0N1PE80	Leptomonas seymouri	33%	76%
A0A0S4IHW4	Bodo saltans	28%	95%
A0A0S4IMB7	Bodo saltans	26%	96%
A0A0S4IQX7	Bodo saltans	27%	100%
A0A0S4IV16	Bodo saltans	30%	100%

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