SUI1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor SUI1, putative

Species:

Leishmania braziliensis

UniProt:

A4HCD6_LEIBR

TriTrypDb:

LbrM.22.0730 , LBRM2903_220012700

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HCD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCD6

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	475	479	PF00656	0.437
CLV_NRD_NRD_1	152	154	PF00675	0.515
CLV_NRD_NRD_1	385	387	PF00675	0.427
CLV_NRD_NRD_1	42	44	PF00675	0.303
CLV_NRD_NRD_1	50	52	PF00675	0.332
CLV_PCSK_KEX2_1	50	52	PF00082	0.339
CLV_PCSK_KEX2_1	560	562	PF00082	0.441
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.239
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.462
CLV_PCSK_SKI1_1	136	140	PF00082	0.399
CLV_PCSK_SKI1_1	211	215	PF00082	0.492
CLV_PCSK_SKI1_1	280	284	PF00082	0.311
CLV_PCSK_SKI1_1	331	335	PF00082	0.361
CLV_PCSK_SKI1_1	427	431	PF00082	0.430
CLV_PCSK_SKI1_1	561	565	PF00082	0.508
CLV_PCSK_SKI1_1	582	586	PF00082	0.232
CLV_PCSK_SKI1_1	622	626	PF00082	0.257
DEG_APCC_DBOX_1	234	242	PF00400	0.588
DEG_Nend_Nbox_1	1	3	PF02207	0.300
DOC_CYCLIN_RxL_1	424	434	PF00134	0.477
DOC_MAPK_DCC_7	497	505	PF00069	0.461
DOC_MAPK_DCC_7	564	573	PF00069	0.281
DOC_MAPK_gen_1	20	29	PF00069	0.474
DOC_MAPK_gen_1	235	243	PF00069	0.481
DOC_MAPK_gen_1	326	336	PF00069	0.420
DOC_MAPK_gen_1	497	505	PF00069	0.441
DOC_MAPK_gen_1	533	543	PF00069	0.385
DOC_MAPK_gen_1	622	632	PF00069	0.503
DOC_MAPK_MEF2A_6	187	196	PF00069	0.399
DOC_MAPK_MEF2A_6	497	505	PF00069	0.437
DOC_MAPK_MEF2A_6	564	573	PF00069	0.281
DOC_MAPK_RevD_3	38	52	PF00069	0.439
DOC_PP1_RVXF_1	278	285	PF00149	0.237
DOC_PP1_RVXF_1	330	337	PF00149	0.516
DOC_PP2B_LxvP_1	144	147	PF13499	0.346
DOC_PP2B_LxvP_1	298	301	PF13499	0.361
DOC_PP2B_LxvP_1	435	438	PF13499	0.526
DOC_PP2B_LxvP_1	95	98	PF13499	0.362
DOC_PP4_FxxP_1	223	226	PF00568	0.328
DOC_USP7_MATH_1	318	322	PF00917	0.478
DOC_USP7_MATH_1	438	442	PF00917	0.370
DOC_USP7_MATH_1	517	521	PF00917	0.444
DOC_USP7_UBL2_3	16	20	PF12436	0.427
DOC_USP7_UBL2_3	481	485	PF12436	0.503
DOC_USP7_UBL2_3	5	9	PF12436	0.440
DOC_USP7_UBL2_3	560	564	PF12436	0.490
DOC_USP7_UBL2_3	625	629	PF12436	0.458
DOC_WW_Pin1_4	153	158	PF00397	0.442
DOC_WW_Pin1_4	347	352	PF00397	0.523
LIG_14-3-3_CanoR_1	90	95	PF00244	0.410
LIG_Actin_WH2_2	637	652	PF00022	0.484
LIG_BRCT_BRCA1_1	219	223	PF00533	0.329
LIG_BRCT_BRCA1_1	509	513	PF00533	0.323
LIG_BRCT_BRCA1_1	58	62	PF00533	0.537
LIG_BRCT_BRCA1_1	591	595	PF00533	0.535
LIG_deltaCOP1_diTrp_1	202	212	PF00928	0.343
LIG_deltaCOP1_diTrp_1	602	608	PF00928	0.521
LIG_eIF4E_1	471	477	PF01652	0.487
LIG_FHA_1	116	122	PF00498	0.453
LIG_FHA_1	304	310	PF00498	0.454
LIG_FHA_1	318	324	PF00498	0.464
LIG_FHA_1	449	455	PF00498	0.512
LIG_FHA_2	244	250	PF00498	0.661
LIG_FHA_2	343	349	PF00498	0.356
LIG_FHA_2	473	479	PF00498	0.465
LIG_FHA_2	5	11	PF00498	0.529
LIG_FHA_2	543	549	PF00498	0.510
LIG_LIR_Apic_2	220	226	PF02991	0.335
LIG_LIR_Apic_2	412	418	PF02991	0.544
LIG_LIR_Gen_1	115	124	PF02991	0.502
LIG_LIR_Gen_1	202	213	PF02991	0.408
LIG_LIR_Gen_1	270	278	PF02991	0.490
LIG_LIR_Gen_1	36	42	PF02991	0.478
LIG_LIR_Gen_1	93	102	PF02991	0.377
LIG_LIR_LC3C_4	39	42	PF02991	0.478
LIG_LIR_Nem_3	115	120	PF02991	0.462
LIG_LIR_Nem_3	202	208	PF02991	0.367
LIG_LIR_Nem_3	270	274	PF02991	0.520
LIG_LIR_Nem_3	335	340	PF02991	0.272
LIG_LIR_Nem_3	36	41	PF02991	0.478
LIG_LIR_Nem_3	440	446	PF02991	0.597
LIG_LIR_Nem_3	514	518	PF02991	0.526
LIG_LIR_Nem_3	93	97	PF02991	0.353
LIG_LIR_Nem_3	99	104	PF02991	0.256
LIG_NRBOX	105	111	PF00104	0.485
LIG_OCRL_FandH_1	102	114	PF00620	0.476
LIG_Pex14_1	604	608	PF04695	0.431
LIG_Pex14_2	208	212	PF04695	0.489
LIG_Pex14_2	336	340	PF04695	0.468
LIG_REV1ctd_RIR_1	99	109	PF16727	0.441
LIG_SH2_CRK	415	419	PF00017	0.475
LIG_SH2_NCK_1	271	275	PF00017	0.454
LIG_SH2_SRC	175	178	PF00017	0.317
LIG_SH2_STAP1	271	275	PF00017	0.535
LIG_SH2_STAP1	373	377	PF00017	0.359
LIG_SH2_STAP1	518	522	PF00017	0.441
LIG_SH2_STAT5	271	274	PF00017	0.331
LIG_SH2_STAT5	354	357	PF00017	0.249
LIG_SH2_STAT5	471	474	PF00017	0.431
LIG_SH2_STAT5	483	486	PF00017	0.329
LIG_SH2_STAT5	518	521	PF00017	0.314
LIG_SH3_3	168	174	PF00018	0.479
LIG_SH3_3	611	617	PF00018	0.474
LIG_SH3_4	625	632	PF00018	0.513
LIG_SH3_5	267	271	PF00018	0.540
LIG_Sin3_3	645	652	PF02671	0.439
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.363
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.529
LIG_SUMO_SIM_anti_2	342	350	PF11976	0.264
LIG_SUMO_SIM_anti_2	596	602	PF11976	0.519
LIG_SUMO_SIM_par_1	342	350	PF11976	0.377
LIG_SUMO_SIM_par_1	427	434	PF11976	0.486
LIG_SUMO_SIM_par_1	488	496	PF11976	0.474
LIG_TYR_ITIM	269	274	PF00017	0.495
LIG_UBA3_1	145	154	PF00899	0.384
LIG_UBA3_1	531	538	PF00899	0.483
LIG_WRC_WIRS_1	512	517	PF05994	0.318
LIG_WRC_WIRS_1	590	595	PF05994	0.526
MOD_CK1_1	217	223	PF00069	0.460
MOD_CK1_1	551	557	PF00069	0.479
MOD_CK1_1	57	63	PF00069	0.579
MOD_CK1_1	575	581	PF00069	0.467
MOD_CK2_1	224	230	PF00069	0.560
MOD_CK2_1	243	249	PF00069	0.630
MOD_CK2_1	342	348	PF00069	0.367
MOD_CK2_1	4	10	PF00069	0.475
MOD_CK2_1	490	496	PF00069	0.609
MOD_CK2_1	542	548	PF00069	0.490
MOD_CK2_1	62	68	PF00069	0.549
MOD_GlcNHglycan	139	142	PF01048	0.333
MOD_GlcNHglycan	158	161	PF01048	0.432
MOD_GlcNHglycan	320	323	PF01048	0.487
MOD_GlcNHglycan	33	36	PF01048	0.176
MOD_GlcNHglycan	361	364	PF01048	0.507
MOD_GlcNHglycan	409	412	PF01048	0.469
MOD_GlcNHglycan	56	59	PF01048	0.237
MOD_GSK3_1	10	17	PF00069	0.471
MOD_GSK3_1	149	156	PF00069	0.462
MOD_GSK3_1	269	276	PF00069	0.525
MOD_GSK3_1	342	349	PF00069	0.392
MOD_GSK3_1	438	445	PF00069	0.462
MOD_GSK3_1	507	514	PF00069	0.460
MOD_GSK3_1	572	579	PF00069	0.522
MOD_N-GLC_1	214	219	PF02516	0.458
MOD_NEK2_1	137	142	PF00069	0.377
MOD_NEK2_1	165	170	PF00069	0.347
MOD_NEK2_1	200	205	PF00069	0.346
MOD_NEK2_1	325	330	PF00069	0.368
MOD_NEK2_1	376	381	PF00069	0.461
MOD_NEK2_1	511	516	PF00069	0.564
MOD_NEK2_1	608	613	PF00069	0.470
MOD_NEK2_1	62	67	PF00069	0.420
MOD_NEK2_2	438	443	PF00069	0.396
MOD_PIKK_1	354	360	PF00454	0.342
MOD_PIKK_1	469	475	PF00454	0.288
MOD_PIKK_1	654	660	PF00454	0.521
MOD_PKA_1	4	10	PF00069	0.437
MOD_PKA_1	44	50	PF00069	0.462
MOD_PKA_2	200	206	PF00069	0.353
MOD_PKA_2	438	444	PF00069	0.395
MOD_Plk_1	115	121	PF00069	0.302
MOD_Plk_1	214	220	PF00069	0.465
MOD_Plk_1	462	468	PF00069	0.364
MOD_Plk_2-3	273	279	PF00069	0.311
MOD_Plk_2-3	342	348	PF00069	0.356
MOD_Plk_4	116	122	PF00069	0.412
MOD_Plk_4	200	206	PF00069	0.283
MOD_Plk_4	293	299	PF00069	0.367
MOD_Plk_4	304	310	PF00069	0.368
MOD_Plk_4	332	338	PF00069	0.286
MOD_Plk_4	342	348	PF00069	0.307
MOD_Plk_4	409	415	PF00069	0.272
MOD_Plk_4	438	444	PF00069	0.638
MOD_Plk_4	462	468	PF00069	0.563
MOD_Plk_4	472	478	PF00069	0.404
MOD_Plk_4	507	513	PF00069	0.362
MOD_Plk_4	542	548	PF00069	0.348
MOD_Plk_4	57	63	PF00069	0.439
MOD_Plk_4	96	102	PF00069	0.282
MOD_ProDKin_1	153	159	PF00069	0.440
MOD_ProDKin_1	347	353	PF00069	0.521
MOD_SUMO_for_1	537	540	PF00179	0.336
MOD_SUMO_rev_2	13	22	PF00179	0.473
TRG_DiLeu_BaEn_2	67	73	PF01217	0.554
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.332
TRG_ENDOCYTIC_2	271	274	PF00928	0.553
TRG_ENDOCYTIC_2	373	376	PF00928	0.340
TRG_NES_CRM1_1	588	602	PF08389	0.439
TRG_NLS_Bipartite_1	3	24	PF00514	0.478
TRG_NLS_MonoExtC_3	152	157	PF00514	0.447
TRG_NLS_MonoExtC_3	19	25	PF00514	0.462
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I577	Leptomonas seymouri	57%	95%
A0A0S4INV2	Bodo saltans	24%	75%
A0A1X0NTA4	Trypanosomatidae	32%	100%
A0A3S5H7A8	Leishmania donovani	76%	100%
A0A422N4G3	Trypanosoma rangeli	34%	100%
A4HZV3	Leishmania infantum	76%	100%
C9ZSH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AVR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QBR8	Leishmania major	76%	100%
V5BLJ1	Trypanosoma cruzi	31%	92%