Ribosomal_L22p domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L22p/L17e, putative

Species:

Leishmania braziliensis

UniProt:

A4HCD5_LEIBR

TriTrypDb:

LbrM.22.0760 , LBRM2903_220013100

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	12
GO:0032991	protein-containing complex	1	12
GO:0044391	ribosomal subunit	3	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

A4HCD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCD5

PDB structure(s): 7aih_M , 7am2_M , 7ane_M

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0042255	ribosome assembly	7	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.280
CLV_PCSK_KEX2_1	17	19	PF00082	0.458
CLV_PCSK_KEX2_1	258	260	PF00082	0.402
CLV_PCSK_KEX2_1	39	41	PF00082	0.472
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.563
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.437
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.472
CLV_PCSK_PC7_1	13	19	PF00082	0.562
CLV_PCSK_SKI1_1	3	7	PF00082	0.355
CLV_PCSK_SKI1_1	59	63	PF00082	0.360
CLV_PCSK_SKI1_1	96	100	PF00082	0.369
DOC_CYCLIN_RxL_1	53	65	PF00134	0.365
DOC_MAPK_gen_1	144	152	PF00069	0.280
DOC_MAPK_gen_1	170	176	PF00069	0.295
DOC_MAPK_gen_1	224	233	PF00069	0.280
DOC_MAPK_MEF2A_6	144	152	PF00069	0.280
DOC_MAPK_MEF2A_6	226	235	PF00069	0.280
DOC_MAPK_MEF2A_6	263	271	PF00069	0.324
DOC_MAPK_NFAT4_5	145	153	PF00069	0.374
DOC_PP2B_LxvP_1	269	272	PF13499	0.460
DOC_USP7_MATH_1	138	142	PF00917	0.303
DOC_USP7_MATH_1	250	254	PF00917	0.388
DOC_USP7_UBL2_3	190	194	PF12436	0.280
DOC_WW_Pin1_4	165	170	PF00397	0.365
DOC_WW_Pin1_4	54	59	PF00397	0.410
LIG_14-3-3_CanoR_1	154	159	PF00244	0.280
LIG_14-3-3_CanoR_1	40	50	PF00244	0.430
LIG_FHA_1	262	268	PF00498	0.319
LIG_FHA_1	55	61	PF00498	0.400
LIG_FHA_2	232	238	PF00498	0.323
LIG_LIR_Gen_1	94	105	PF02991	0.375
LIG_LIR_Nem_3	141	146	PF02991	0.295
LIG_LIR_Nem_3	65	70	PF02991	0.333
LIG_LIR_Nem_3	94	100	PF02991	0.370
LIG_PDZ_Class_3	274	279	PF00595	0.414
LIG_SH2_CRK	251	255	PF00017	0.399
LIG_SH2_STAP1	132	136	PF00017	0.390
LIG_SH2_STAP1	251	255	PF00017	0.399
LIG_SH2_STAP1	32	36	PF00017	0.519
LIG_SH2_STAT3	38	41	PF00017	0.386
LIG_SH2_STAT5	114	117	PF00017	0.360
LIG_SH2_STAT5	201	204	PF00017	0.365
LIG_SUMO_SIM_anti_2	149	154	PF11976	0.295
LIG_SUMO_SIM_par_1	231	238	PF11976	0.280
LIG_SUMO_SIM_par_1	264	270	PF11976	0.348
LIG_SxIP_EBH_1	246	255	PF03271	0.407
LIG_TYR_ITIM	249	254	PF00017	0.404
LIG_UBA3_1	254	258	PF00899	0.414
MOD_CDC14_SPxK_1	168	171	PF00782	0.365
MOD_CDK_SPK_2	165	170	PF00069	0.365
MOD_CDK_SPK_2	54	59	PF00069	0.410
MOD_CDK_SPxK_1	165	171	PF00069	0.365
MOD_CK1_1	253	259	PF00069	0.407
MOD_CK2_1	154	160	PF00069	0.313
MOD_CK2_1	231	237	PF00069	0.317
MOD_GlcNHglycan	140	143	PF01048	0.420
MOD_GlcNHglycan	43	46	PF01048	0.404
MOD_GSK3_1	222	229	PF00069	0.291
MOD_GSK3_1	62	69	PF00069	0.338
MOD_NEK2_1	231	236	PF00069	0.315
MOD_NEK2_1	25	30	PF00069	0.403
MOD_NEK2_1	62	67	PF00069	0.332
MOD_NEK2_1	70	75	PF00069	0.375
MOD_PIKK_1	20	26	PF00454	0.407
MOD_PIKK_1	86	92	PF00454	0.426
MOD_PK_1	154	160	PF00069	0.374
MOD_PKA_1	226	232	PF00069	0.280
MOD_Plk_1	148	154	PF00069	0.295
MOD_Plk_1	244	250	PF00069	0.400
MOD_Plk_1	62	68	PF00069	0.332
MOD_Plk_4	130	136	PF00069	0.376
MOD_Plk_4	148	154	PF00069	0.215
MOD_Plk_4	250	256	PF00069	0.387
MOD_ProDKin_1	165	171	PF00069	0.365
MOD_ProDKin_1	54	60	PF00069	0.405
TRG_ENDOCYTIC_2	132	135	PF00928	0.395
TRG_ENDOCYTIC_2	251	254	PF00928	0.407
TRG_ER_diArg_1	196	199	PF00400	0.438
TRG_ER_diArg_1	215	218	PF00400	0.293
TRG_NES_CRM1_1	147	160	PF08389	0.280
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYB3	Leptomonas seymouri	90%	100%
A0A0S4KGN2	Bodo saltans	66%	100%
A0A1X0NUR3	Trypanosomatidae	74%	100%
A0A3Q8IE90	Leishmania donovani	94%	100%
A0A422N4F8	Trypanosoma rangeli	75%	100%
A4HZW1	Leishmania infantum	94%	100%
C9ZSI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AVR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QBR0	Leishmania major	93%	100%
V5BR61	Trypanosoma cruzi	75%	100%