LeishMANIAdb
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Zf-LSD1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Zf-LSD1 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HCD4_LEIBR
TriTrypDb:
LbrM.22.0740 , LBRM2903_220012800
Length:
215

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCD4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCD4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 49 53 PF00656 0.439
DEG_Nend_UBRbox_2 1 3 PF02207 0.584
DOC_PP1_RVXF_1 195 202 PF00149 0.485
DOC_USP7_MATH_1 38 42 PF00917 0.541
DOC_USP7_MATH_1 43 47 PF00917 0.528
DOC_USP7_UBL2_3 140 144 PF12436 0.579
DOC_WW_Pin1_4 71 76 PF00397 0.584
DOC_WW_Pin1_4 97 102 PF00397 0.480
LIG_FHA_1 162 168 PF00498 0.487
LIG_FHA_1 174 180 PF00498 0.373
LIG_FHA_1 189 195 PF00498 0.379
LIG_FHA_1 209 215 PF00498 0.359
LIG_FHA_2 123 129 PF00498 0.570
LIG_FHA_2 4 10 PF00498 0.515
LIG_LIR_Gen_1 137 142 PF02991 0.327
LIG_LIR_Nem_3 137 141 PF02991 0.327
LIG_LIR_Nem_3 91 95 PF02991 0.451
LIG_SH2_PTP2 95 98 PF00017 0.309
LIG_SH2_STAT5 95 98 PF00017 0.479
LIG_SH3_1 95 101 PF00018 0.330
LIG_SH3_2 98 103 PF14604 0.362
LIG_SH3_3 82 88 PF00018 0.404
LIG_SH3_3 95 101 PF00018 0.490
LIG_SUMO_SIM_par_1 43 49 PF11976 0.406
LIG_TRAF2_1 46 49 PF00917 0.591
MOD_CDC14_SPxK_1 100 103 PF00782 0.371
MOD_CDK_SPxK_1 97 103 PF00069 0.356
MOD_CK1_1 121 127 PF00069 0.617
MOD_CK1_1 143 149 PF00069 0.616
MOD_CK2_1 3 9 PF00069 0.527
MOD_CK2_1 43 49 PF00069 0.532
MOD_GlcNHglycan 40 43 PF01048 0.673
MOD_GSK3_1 1 8 PF00069 0.438
MOD_GSK3_1 118 125 PF00069 0.639
MOD_GSK3_1 157 164 PF00069 0.486
MOD_LATS_1 3 9 PF00433 0.508
MOD_N-GLC_1 121 126 PF02516 0.542
MOD_NEK2_1 1 6 PF00069 0.459
MOD_NEK2_1 158 163 PF00069 0.547
MOD_Plk_4 208 214 PF00069 0.438
MOD_Plk_4 88 94 PF00069 0.436
MOD_ProDKin_1 71 77 PF00069 0.588
MOD_ProDKin_1 97 103 PF00069 0.483
MOD_SUMO_rev_2 128 134 PF00179 0.410
TRG_ENDOCYTIC_2 155 158 PF00928 0.430
TRG_Pf-PMV_PEXEL_1 127 131 PF00026 0.397
TRG_Pf-PMV_PEXEL_1 21 26 PF00026 0.573
TRG_Pf-PMV_PEXEL_1 57 61 PF00026 0.426

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6M2 Leptomonas seymouri 59% 100%
A0A0S4IY29 Bodo saltans 32% 100%
A0A1X0NT95 Trypanosomatidae 40% 100%
A0A3Q8ICB8 Leishmania donovani 73% 100%
A0A3R7RDF2 Trypanosoma rangeli 37% 100%
A4HZV2 Leishmania infantum 72% 80%
C9ZSI6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AVR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS