NADH-cytochrome b5 reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-cytochrome b5 reductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HCD3_LEIBR

TriTrypDb:

LbrM.22.0720 , LBRM2903_220012600

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 54

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 24
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HCD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCD3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	26
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	5	23
GO:0016491	oxidoreductase activity	2	26
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	23
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	4	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.298
CLV_PCSK_SKI1_1	121	125	PF00082	0.271
CLV_PCSK_SKI1_1	14	18	PF00082	0.320
CLV_PCSK_SKI1_1	217	221	PF00082	0.405
DEG_Nend_UBRbox_2	1	3	PF02207	0.245
DOC_CKS1_1	47	52	PF01111	0.316
DOC_MAPK_gen_1	141	147	PF00069	0.334
DOC_MAPK_gen_1	80	87	PF00069	0.289
DOC_MAPK_MEF2A_6	88	96	PF00069	0.258
DOC_PP2B_LxvP_1	124	127	PF13499	0.341
DOC_PP4_FxxP_1	15	18	PF00568	0.270
DOC_USP7_UBL2_3	230	234	PF12436	0.357
DOC_USP7_UBL2_3	241	245	PF12436	0.291
DOC_USP7_UBL2_3	93	97	PF12436	0.394
DOC_WW_Pin1_4	111	116	PF00397	0.311
DOC_WW_Pin1_4	159	164	PF00397	0.290
DOC_WW_Pin1_4	46	51	PF00397	0.316
LIG_APCC_ABBA_1	1	6	PF00400	0.494
LIG_BRCT_BRCA1_1	161	165	PF00533	0.292
LIG_BRCT_BRCA1_1	32	36	PF00533	0.352
LIG_deltaCOP1_diTrp_1	173	180	PF00928	0.395
LIG_FHA_1	198	204	PF00498	0.402
LIG_FHA_1	82	88	PF00498	0.345
LIG_LIR_Nem_3	156	161	PF02991	0.280
LIG_LIR_Nem_3	162	167	PF02991	0.286
LIG_MLH1_MIPbox_1	161	165	PF16413	0.292
LIG_PCNA_PIPBox_1	226	235	PF02747	0.377
LIG_PCNA_yPIPBox_3	220	233	PF02747	0.395
LIG_PDZ_Class_2	241	246	PF00595	0.328
LIG_Pex14_2	161	165	PF04695	0.277
LIG_REV1ctd_RIR_1	34	43	PF16727	0.249
LIG_SH2_CRK	48	52	PF00017	0.316
LIG_SH2_GRB2like	137	140	PF00017	0.330
LIG_SH2_SRC	4	7	PF00017	0.258
LIG_SH2_STAT5	164	167	PF00017	0.287
LIG_SH2_STAT5	232	235	PF00017	0.381
LIG_SH2_STAT5	48	51	PF00017	0.301
LIG_SH2_STAT5	59	62	PF00017	0.296
LIG_SH3_3	200	206	PF00018	0.323
LIG_SH3_3	41	47	PF00018	0.308
LIG_SH3_3	89	95	PF00018	0.310
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.329
LIG_TYR_ITIM	57	62	PF00017	0.403
LIG_UBA3_1	76	81	PF00899	0.317
MOD_CDK_SPxxK_3	46	53	PF00069	0.273
MOD_CK1_1	30	36	PF00069	0.265
MOD_CK1_1	7	13	PF00069	0.388
MOD_CK2_1	222	228	PF00069	0.428
MOD_DYRK1A_RPxSP_1	46	50	PF00069	0.306
MOD_GlcNHglycan	213	216	PF01048	0.422
MOD_GSK3_1	165	172	PF00069	0.283
MOD_GSK3_1	218	225	PF00069	0.489
MOD_GSK3_1	67	74	PF00069	0.347
MOD_N-GLC_1	128	133	PF02516	0.301
MOD_N-GLC_1	51	56	PF02516	0.328
MOD_NEK2_1	154	159	PF00069	0.269
MOD_NEK2_1	165	170	PF00069	0.324
MOD_NEK2_1	185	190	PF00069	0.339
MOD_PIKK_1	222	228	PF00454	0.397
MOD_Plk_1	131	137	PF00069	0.334
MOD_Plk_1	197	203	PF00069	0.356
MOD_Plk_4	185	191	PF00069	0.319
MOD_Plk_4	197	203	PF00069	0.318
MOD_ProDKin_1	111	117	PF00069	0.311
MOD_ProDKin_1	159	165	PF00069	0.290
MOD_ProDKin_1	46	52	PF00069	0.316
MOD_SUMO_rev_2	214	221	PF00179	0.405
MOD_SUMO_rev_2	38	44	PF00179	0.373
MOD_SUMO_rev_2	83	90	PF00179	0.317
TRG_DiLeu_BaEn_1	150	155	PF01217	0.314
TRG_ENDOCYTIC_2	158	161	PF00928	0.335
TRG_ENDOCYTIC_2	164	167	PF00928	0.340
TRG_ENDOCYTIC_2	48	51	PF00928	0.311
TRG_ENDOCYTIC_2	59	62	PF00928	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L4	Leptomonas seymouri	51%	85%
A0A0N0P705	Leptomonas seymouri	86%	85%
A0A0N1I279	Leptomonas seymouri	28%	73%
A0A0N1IAZ4	Leptomonas seymouri	31%	80%
A0A0N1ILC4	Leptomonas seymouri	30%	75%
A0A0N1PBS9	Leptomonas seymouri	50%	83%
A0A0S4IMP5	Bodo saltans	30%	68%
A0A0S4INB8	Bodo saltans	73%	100%
A0A0S4JK74	Bodo saltans	30%	93%
A0A0S4JV75	Bodo saltans	33%	69%
A0A0S4KHI4	Bodo saltans	48%	83%
A0A1X0NN09	Trypanosomatidae	26%	74%
A0A1X0NRH2	Trypanosomatidae	31%	79%
A0A1X0NT99	Trypanosomatidae	82%	86%
A0A1X0NTX4	Trypanosomatidae	48%	86%
A0A1X0NV22	Trypanosomatidae	42%	83%
A0A1X0P541	Trypanosomatidae	34%	76%
A0A3Q8I8J2	Leishmania donovani	27%	80%
A0A3Q8I905	Leishmania donovani	25%	71%
A0A3Q8IBE7	Leishmania donovani	52%	85%
A0A3Q8ILI9	Leishmania donovani	96%	85%
A0A3R7JSY9	Trypanosoma rangeli	42%	81%
A0A3R7JUA9	Trypanosoma rangeli	31%	81%
A0A3R7JZZ7	Trypanosoma rangeli	31%	80%
A0A3R7MD20	Trypanosoma rangeli	77%	85%
A0A3S5H6T5	Leishmania donovani	50%	88%
A0A3S5H7H5	Leishmania donovani	30%	75%
A0A3S7X5Q8	Leishmania donovani	27%	73%
A0A422NMZ5	Trypanosoma rangeli	33%	76%
A0QTU9	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	26%	71%
A1C7E9	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	43%	80%
A1CRK9	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	46%	76%
A1D4H0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	45%	76%
A1DHW1	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	44%	80%
A2Q898	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	46%	76%
A2QCV4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	42%	81%
A3GF86	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	43%	87%
A3LT66	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	41%	83%
A4H794	Leishmania braziliensis	30%	100%
A4H7X5	Leishmania braziliensis	50%	100%
A4HCD2	Leishmania braziliensis	53%	100%
A4HFJ6	Leishmania braziliensis	30%	100%
A4HKM5	Leishmania braziliensis	27%	73%
A4HUT9	Leishmania infantum	25%	71%
A4HVN4	Leishmania infantum	27%	80%
A4HWA2	Leishmania infantum	50%	88%
A4HZV4	Leishmania infantum	96%	85%
A4HZV5	Leishmania infantum	52%	85%
A4I862	Leishmania infantum	27%	73%
A4QR21	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	46%	74%
A4R935	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	38%	80%
A5DQ25	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	43%	87%
A5DQE4	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	41%	84%
A5E5C5	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	41%	82%
A5E7U2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	39%	82%
A6R1T7	Ajellomyces capsulatus (strain NAm1 / WU24)	42%	76%
A6R2K7	Ajellomyces capsulatus (strain NAm1 / WU24)	40%	79%
A6SI59	Botryotinia fuckeliana (strain B05.10)	47%	71%
A6ZVM6	Saccharomyces cerevisiae (strain YJM789)	35%	87%
A6ZZH2	Saccharomyces cerevisiae (strain YJM789)	42%	81%
A7EKT5	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	46%	71%
A7THS1	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	43%	83%
A7TM72	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	35%	80%
A7TNL7	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	37%	86%
B0CQN7	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	43%	80%
B1AS42	Mus musculus	28%	78%
C9ZNT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	84%
C9ZSH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	86%
C9ZSH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	86%
D0A5S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	76%
D0A6L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	80%
D0AAC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	80%
E9AD50	Leishmania major	30%	100%
E9AHE4	Leishmania infantum	30%	75%
E9ANH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	71%
E9APD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	80%
E9AQ02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	88%
E9AVR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	85%
E9AVR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	85%
E9AYX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	75%
E9B313	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	73%
E9RFT0	Mycobacterium goodii	26%	71%
O13809	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	92%
O74557	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	82%
O85675	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	24%	72%
P00387	Homo sapiens	39%	82%
P07514	Bos taurus	40%	82%
P0CP14	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	38%	84%
P0CP15	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	38%	84%
P19734	Pseudomonas sp. (strain CF600)	26%	70%
P20070	Rattus norvegicus	41%	82%
P36060	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	81%
P38626	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	87%
P39871	Zea mays	32%	100%
P83291	Arabidopsis thaliana	45%	75%
P83686	Sus scrofa	39%	90%
Q04516	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	79%
Q0CRD8	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	46%	77%
Q0CY37	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	43%	83%
Q0P487	Danio rerio	35%	80%
Q0SJK8	Rhodococcus jostii (strain RHA1)	24%	66%
Q0U9W5	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	46%	73%
Q0UEY4	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	40%	87%
Q0X0E5	Canis lupus familiaris	40%	82%
Q12746	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	79%
Q1DWN4	Coccidioides immitis (strain RS)	43%	80%
Q1DXN1	Coccidioides immitis (strain RS)	45%	76%
Q2HG02	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	47%	71%
Q2UFN3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	42%	84%
Q2UKB8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	43%	76%
Q3C1E0	Comamonas sp.	23%	73%
Q3KNK3	Mus musculus	40%	89%
Q3MHW9	Bos taurus	37%	81%
Q4P7Y8	Ustilago maydis (strain 521 / FGSC 9021)	45%	70%
Q4PGW7	Ustilago maydis (strain 521 / FGSC 9021)	40%	76%
Q4Q541	Leishmania major	27%	100%
Q4QBR9	Leishmania major	95%	100%
Q4QBS0	Leishmania major	52%	100%
Q4QFH9	Leishmania major	50%	100%
Q4QG48	Leishmania major	30%	100%
Q4QH53	Leishmania major	24%	100%
Q4WJW8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	45%	76%
Q4X0B5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	44%	80%
Q54NC1	Dictyostelium discoideum	45%	86%
Q59M70	Candida albicans (strain SC5314 / ATCC MYA-2876)	41%	82%
Q59P03	Candida albicans (strain SC5314 / ATCC MYA-2876)	41%	84%
Q5AZB4	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	42%	79%
Q5BG98	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	45%	76%
Q5BJ68	Xenopus tropicalis	36%	81%
Q5EB81	Rattus norvegicus	40%	81%
Q5PQA4	Xenopus laevis	37%	83%
Q5ZHX7	Gallus gallus	38%	81%
Q60HG4	Macaca fascicularis	40%	82%
Q6AY12	Rattus norvegicus	36%	89%
Q6BCY4	Homo sapiens	35%	89%
Q6BQ54	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	40%	82%
Q6BUX2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	43%	87%
Q6C9G8	Yarrowia lipolytica (strain CLIB 122 / E 150)	40%	85%
Q6CA86	Yarrowia lipolytica (strain CLIB 122 / E 150)	39%	85%
Q6CID0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	38%	88%
Q6CS27	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	41%	83%
Q6FLT3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	86%
Q6FUX5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	39%	83%
Q6IPT4	Homo sapiens	30%	78%
Q75AL4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	38%	86%
Q75C62	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	80%
Q7RXL1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	40%	79%
Q7SFY2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	48%	72%
Q7WTJ2	Acinetobacter calcoaceticus (strain PHEA-2)	23%	70%
Q9DB73	Mus musculus	40%	81%
Q9DCN2	Mus musculus	41%	82%
Q9K3E1	Colwellia maris	24%	81%
Q9LCI7	Shewanella putrefaciens	23%	82%
Q9LCI9	Moritella marina	23%	81%
Q9LCJ2	Colwellia psychrerythraea	24%	81%
Q9LCJ3	Alteromonas macleodii	24%	81%
Q9LCJ4	Pseudoalteromonas haloplanktis	23%	81%
Q9UHQ9	Homo sapiens	40%	81%
Q9UR35	Mortierella alpina	42%	83%
Q9ZNT1	Arabidopsis thaliana	41%	88%
V5AQN7	Trypanosoma cruzi	31%	81%
V5AU35	Trypanosoma cruzi	33%	76%
V5B8B1	Trypanosoma cruzi	32%	80%
V5BVT5	Trypanosoma cruzi	78%	85%
V5DCP7	Trypanosoma cruzi	42%	100%