Endosome-associated-trafficking regulator 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCD0_LEIBR

TriTrypDb:

LbrM.22.0690 , LBRM2903_220012300

Length:

1146

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HCD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCD0

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.534
CLV_C14_Caspase3-7	903	907	PF00656	0.486
CLV_NRD_NRD_1	162	164	PF00675	0.645
CLV_NRD_NRD_1	23	25	PF00675	0.538
CLV_NRD_NRD_1	33	35	PF00675	0.541
CLV_NRD_NRD_1	553	555	PF00675	0.699
CLV_NRD_NRD_1	687	689	PF00675	0.460
CLV_PCSK_FUR_1	21	25	PF00082	0.611
CLV_PCSK_KEX2_1	162	164	PF00082	0.645
CLV_PCSK_KEX2_1	23	25	PF00082	0.538

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZX6	Leptomonas seymouri	37%	100%
A0A3Q8IB61	Leishmania donovani	67%	100%
A4HZV7	Leishmania infantum	68%	100%
E9AVQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QBS2	Leishmania major	66%	99%

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