Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCC9_LEIBR

TriTrypDb:

LbrM.22.0680 , LBRM2903_220012200

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCC9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.513
CLV_C14_Caspase3-7	83	87	PF00656	0.617
CLV_NRD_NRD_1	173	175	PF00675	0.482
CLV_NRD_NRD_1	29	31	PF00675	0.475
CLV_NRD_NRD_1	62	64	PF00675	0.586
CLV_PCSK_KEX2_1	173	175	PF00082	0.429
CLV_PCSK_SKI1_1	173	177	PF00082	0.426
CLV_PCSK_SKI1_1	180	184	PF00082	0.479
CLV_PCSK_SKI1_1	235	239	PF00082	0.482
CLV_PCSK_SKI1_1	30	34	PF00082	0.409
DEG_APCC_DBOX_1	46	54	PF00400	0.483
DEG_SCF_FBW7_1	506	512	PF00400	0.561
DEG_SPOP_SBC_1	267	271	PF00917	0.793
DEG_SPOP_SBC_1	493	497	PF00917	0.704
DOC_ANK_TNKS_1	575	582	PF00023	0.534
DOC_CKS1_1	506	511	PF01111	0.561
DOC_CYCLIN_RxL_1	27	36	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	537	540	PF00134	0.551
DOC_MAPK_gen_1	481	491	PF00069	0.693
DOC_MAPK_MEF2A_6	481	489	PF00069	0.635
DOC_PP2B_LxvP_1	148	151	PF13499	0.554
DOC_PP2B_LxvP_1	183	186	PF13499	0.463
DOC_PP2B_LxvP_1	32	35	PF13499	0.462
DOC_PP2B_LxvP_1	395	398	PF13499	0.692
DOC_PP2B_LxvP_1	489	492	PF13499	0.618
DOC_PP2B_LxvP_1	537	540	PF13499	0.551
DOC_USP7_MATH_1	137	141	PF00917	0.516
DOC_USP7_MATH_1	151	155	PF00917	0.419
DOC_USP7_MATH_1	206	210	PF00917	0.602
DOC_USP7_MATH_1	368	372	PF00917	0.772
DOC_USP7_MATH_1	389	393	PF00917	0.743
DOC_USP7_MATH_1	442	446	PF00917	0.598
DOC_USP7_MATH_1	492	496	PF00917	0.647
DOC_USP7_MATH_1	509	513	PF00917	0.718
DOC_USP7_MATH_2	565	571	PF00917	0.551
DOC_WW_Pin1_4	244	249	PF00397	0.526
DOC_WW_Pin1_4	505	510	PF00397	0.726
DOC_WW_Pin1_4	514	519	PF00397	0.773
LIG_14-3-3_CanoR_1	10	15	PF00244	0.476
LIG_14-3-3_CanoR_1	165	171	PF00244	0.462
LIG_14-3-3_CanoR_1	189	193	PF00244	0.632
LIG_14-3-3_CanoR_1	310	314	PF00244	0.686
LIG_14-3-3_CanoR_1	427	434	PF00244	0.585
LIG_14-3-3_CanoR_1	484	490	PF00244	0.684
LIG_14-3-3_CanoR_1	529	535	PF00244	0.557
LIG_14-3-3_CanoR_1	571	576	PF00244	0.547
LIG_14-3-3_CanoR_1	80	89	PF00244	0.536
LIG_Actin_WH2_2	97	112	PF00022	0.654
LIG_BRCT_BRCA1_1	195	199	PF00533	0.431
LIG_BRCT_BRCA1_1	419	423	PF00533	0.645
LIG_BRCT_BRCA1_1	473	477	PF00533	0.557
LIG_BRCT_BRCA1_1	571	575	PF00533	0.548
LIG_FHA_1	167	173	PF00498	0.464
LIG_FHA_1	185	191	PF00498	0.553
LIG_FHA_1	248	254	PF00498	0.757
LIG_FHA_1	269	275	PF00498	0.699
LIG_FHA_1	27	33	PF00498	0.446
LIG_FHA_1	34	40	PF00498	0.407
LIG_FHA_1	431	437	PF00498	0.628
LIG_FHA_1	495	501	PF00498	0.761
LIG_FHA_2	21	27	PF00498	0.424
LIG_FHA_2	236	242	PF00498	0.498
LIG_FHA_2	281	287	PF00498	0.671
LIG_FHA_2	92	98	PF00498	0.601
LIG_IBAR_NPY_1	553	555	PF08397	0.684
LIG_LIR_Apic_2	580	586	PF02991	0.721
LIG_LIR_Gen_1	227	237	PF02991	0.458
LIG_LIR_Gen_1	312	319	PF02991	0.648
LIG_LIR_Gen_1	533	541	PF02991	0.557
LIG_LIR_Gen_1	74	81	PF02991	0.478
LIG_LIR_Nem_3	157	163	PF02991	0.446
LIG_LIR_Nem_3	227	233	PF02991	0.456
LIG_LIR_Nem_3	292	297	PF02991	0.544
LIG_LIR_Nem_3	312	317	PF02991	0.650
LIG_LIR_Nem_3	533	537	PF02991	0.562
LIG_LIR_Nem_3	74	78	PF02991	0.475
LIG_NRBOX	171	177	PF00104	0.476
LIG_SH2_CRK	583	587	PF00017	0.656
LIG_SH2_SRC	149	152	PF00017	0.476
LIG_SH2_STAT5	149	152	PF00017	0.416
LIG_SH2_STAT5	168	171	PF00017	0.410
LIG_SH2_STAT5	38	41	PF00017	0.500
LIG_SH2_STAT5	382	385	PF00017	0.694
LIG_SH2_STAT5	418	421	PF00017	0.765
LIG_SH2_STAT5	555	558	PF00017	0.725
LIG_SH3_3	179	185	PF00018	0.523
LIG_SH3_3	21	27	PF00018	0.424
LIG_SH3_3	454	460	PF00018	0.553
LIG_SUMO_SIM_par_1	363	371	PF11976	0.577
LIG_SUMO_SIM_par_1	432	437	PF11976	0.543
LIG_TRAF2_1	518	521	PF00917	0.581
MOD_CK1_1	209	215	PF00069	0.539
MOD_CK1_1	247	253	PF00069	0.702
MOD_CK1_1	268	274	PF00069	0.702
MOD_CK1_1	280	286	PF00069	0.737
MOD_CK1_1	298	304	PF00069	0.753
MOD_CK1_1	346	352	PF00069	0.655
MOD_CK1_1	371	377	PF00069	0.706
MOD_CK1_1	414	420	PF00069	0.600
MOD_CK1_1	468	474	PF00069	0.664
MOD_CK1_1	495	501	PF00069	0.665
MOD_CK1_1	512	518	PF00069	0.688
MOD_CK1_1	527	533	PF00069	0.761
MOD_CK1_1	545	551	PF00069	0.636
MOD_CK1_1	570	576	PF00069	0.547
MOD_CK2_1	151	157	PF00069	0.500
MOD_CK2_1	273	279	PF00069	0.567
MOD_CK2_1	514	520	PF00069	0.582
MOD_GlcNHglycan	129	132	PF01048	0.750
MOD_GlcNHglycan	207	211	PF01048	0.601
MOD_GlcNHglycan	275	278	PF01048	0.662
MOD_GlcNHglycan	279	283	PF01048	0.694
MOD_GlcNHglycan	297	300	PF01048	0.791
MOD_GlcNHglycan	328	331	PF01048	0.618
MOD_GlcNHglycan	345	348	PF01048	0.643
MOD_GlcNHglycan	369	373	PF01048	0.698
MOD_GlcNHglycan	411	414	PF01048	0.749
MOD_GlcNHglycan	428	431	PF01048	0.561
MOD_GlcNHglycan	444	447	PF01048	0.623
MOD_GlcNHglycan	461	464	PF01048	0.728
MOD_GlcNHglycan	470	473	PF01048	0.642
MOD_GSK3_1	184	191	PF00069	0.514
MOD_GSK3_1	242	249	PF00069	0.487
MOD_GSK3_1	261	268	PF00069	0.772
MOD_GSK3_1	269	276	PF00069	0.773
MOD_GSK3_1	295	302	PF00069	0.776
MOD_GSK3_1	309	316	PF00069	0.603
MOD_GSK3_1	346	353	PF00069	0.691
MOD_GSK3_1	371	378	PF00069	0.767
MOD_GSK3_1	426	433	PF00069	0.580
MOD_GSK3_1	455	462	PF00069	0.755
MOD_GSK3_1	471	478	PF00069	0.609
MOD_GSK3_1	505	512	PF00069	0.676
MOD_GSK3_1	516	523	PF00069	0.657
MOD_GSK3_1	541	548	PF00069	0.660
MOD_GSK3_1	555	562	PF00069	0.699
MOD_GSK3_1	567	574	PF00069	0.589
MOD_GSK3_1	80	87	PF00069	0.598
MOD_N-GLC_1	193	198	PF02516	0.492
MOD_N-GLC_1	253	258	PF02516	0.645
MOD_N-GLC_1	326	331	PF02516	0.556
MOD_N-GLC_1	465	470	PF02516	0.604
MOD_N-GLC_1	509	514	PF02516	0.802
MOD_N-GLC_2	424	426	PF02516	0.522
MOD_N-GLC_2	453	455	PF02516	0.557
MOD_NEK2_1	109	114	PF00069	0.640
MOD_NEK2_1	156	161	PF00069	0.519
MOD_NEK2_1	193	198	PF00069	0.492
MOD_NEK2_1	20	25	PF00069	0.500
MOD_NEK2_1	265	270	PF00069	0.727
MOD_NEK2_1	289	294	PF00069	0.724
MOD_NEK2_1	350	355	PF00069	0.645
MOD_NEK2_1	419	424	PF00069	0.660
MOD_NEK2_1	477	482	PF00069	0.610
MOD_NEK2_1	524	529	PF00069	0.769
MOD_NEK2_1	541	546	PF00069	0.475
MOD_NEK2_2	151	156	PF00069	0.594
MOD_PIKK_1	33	39	PF00454	0.519
MOD_PIKK_1	434	440	PF00454	0.669
MOD_PIKK_1	80	86	PF00454	0.591
MOD_PKA_2	109	115	PF00069	0.727
MOD_PKA_2	164	170	PF00069	0.464
MOD_PKA_2	188	194	PF00069	0.629
MOD_PKA_2	309	315	PF00069	0.685
MOD_PKA_2	426	432	PF00069	0.529
MOD_PKA_2	46	52	PF00069	0.482
MOD_PKA_2	485	491	PF00069	0.683
MOD_PKA_2	570	576	PF00069	0.547
MOD_Plk_1	137	143	PF00069	0.647
MOD_Plk_1	390	396	PF00069	0.666
MOD_Plk_1	465	471	PF00069	0.562
MOD_Plk_4	151	157	PF00069	0.599
MOD_Plk_4	20	26	PF00069	0.434
MOD_Plk_4	309	315	PF00069	0.630
MOD_Plk_4	360	366	PF00069	0.773
MOD_Plk_4	414	420	PF00069	0.528
MOD_Plk_4	495	501	PF00069	0.528
MOD_ProDKin_1	244	250	PF00069	0.538
MOD_ProDKin_1	505	511	PF00069	0.729
MOD_ProDKin_1	514	520	PF00069	0.773
MOD_SUMO_rev_2	196	205	PF00179	0.429
MOD_SUMO_rev_2	226	231	PF00179	0.436
TRG_DiLeu_BaEn_1	391	396	PF01217	0.785
TRG_DiLeu_BaEn_2	225	231	PF01217	0.469
TRG_DiLeu_BaEn_4	226	232	PF01217	0.464
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.469
TRG_DiLeu_LyEn_5	391	396	PF01217	0.785
TRG_ENDOCYTIC_2	160	163	PF00928	0.446
TRG_ER_diArg_1	172	174	PF00400	0.478
TRG_ER_diArg_1	221	224	PF00400	0.444
TRG_ER_diArg_1	484	487	PF00400	0.663
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.758
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6L3	Leptomonas seymouri	48%	100%
A0A3S7WX90	Leishmania donovani	80%	100%
E9AVQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QBS3	Leishmania major	80%	99%