Galactose oxidase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Galactose oxidase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCC7_LEIBR

TriTrypDb:

LbrM.22.0930 , LBRM2903_220015000

Length:

1187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HCC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.652
CLV_C14_Caspase3-7	771	775	PF00656	0.778
CLV_C14_Caspase3-7	864	868	PF00656	0.664
CLV_NRD_NRD_1	1107	1109	PF00675	0.475
CLV_NRD_NRD_1	41	43	PF00675	0.636
CLV_NRD_NRD_1	418	420	PF00675	0.439
CLV_NRD_NRD_1	932	934	PF00675	0.444
CLV_PCSK_FUR_1	415	419	PF00082	0.449
CLV_PCSK_KEX2_1	1033	1035	PF00082	0.553
CLV_PCSK_KEX2_1	41	43	PF00082	0.582
CLV_PCSK_KEX2_1	417	419	PF00082	0.418
CLV_PCSK_KEX2_1	931	933	PF00082	0.515
CLV_PCSK_PC1ET2_1	1033	1035	PF00082	0.670
CLV_PCSK_SKI1_1	1034	1038	PF00082	0.572
CLV_PCSK_SKI1_1	421	425	PF00082	0.582
CLV_PCSK_SKI1_1	518	522	PF00082	0.350
CLV_PCSK_SKI1_1	855	859	PF00082	0.523
DEG_APCC_DBOX_1	640	648	PF00400	0.578
DEG_Nend_UBRbox_2	1	3	PF02207	0.565
DEG_ODPH_VHL_1	909	921	PF01847	0.321
DEG_SPOP_SBC_1	391	395	PF00917	0.490
DEG_SPOP_SBC_1	878	882	PF00917	0.493
DOC_CDC14_PxL_1	140	148	PF14671	0.722
DOC_CDC14_PxL_1	718	726	PF14671	0.441
DOC_CKS1_1	248	253	PF01111	0.463
DOC_CYCLIN_RxL_1	851	860	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	1037	1043	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	829	835	PF00134	0.597
DOC_MAPK_DCC_7	1033	1043	PF00069	0.524
DOC_MAPK_gen_1	516	523	PF00069	0.470
DOC_MAPK_gen_1	851	858	PF00069	0.523
DOC_MAPK_gen_1	890	899	PF00069	0.506
DOC_PP1_RVXF_1	216	223	PF00149	0.618
DOC_PP2B_LxvP_1	1043	1046	PF13499	0.451
DOC_PP2B_LxvP_1	1060	1063	PF13499	0.425
DOC_PP2B_LxvP_1	946	949	PF13499	0.614
DOC_PP4_FxxP_1	178	181	PF00568	0.490
DOC_USP7_MATH_1	142	146	PF00917	0.609
DOC_USP7_MATH_1	148	152	PF00917	0.548
DOC_USP7_MATH_1	181	185	PF00917	0.632
DOC_USP7_MATH_1	209	213	PF00917	0.715
DOC_USP7_MATH_1	292	296	PF00917	0.369
DOC_USP7_MATH_1	401	405	PF00917	0.518
DOC_USP7_MATH_1	483	487	PF00917	0.316
DOC_USP7_MATH_1	74	78	PF00917	0.753
DOC_USP7_MATH_1	742	746	PF00917	0.587
DOC_USP7_MATH_1	757	761	PF00917	0.514
DOC_USP7_MATH_1	792	796	PF00917	0.693
DOC_USP7_MATH_1	805	809	PF00917	0.685
DOC_USP7_MATH_1	876	880	PF00917	0.638
DOC_WW_Pin1_4	1020	1025	PF00397	0.625
DOC_WW_Pin1_4	105	110	PF00397	0.655
DOC_WW_Pin1_4	112	117	PF00397	0.600
DOC_WW_Pin1_4	126	131	PF00397	0.558
DOC_WW_Pin1_4	168	173	PF00397	0.620
DOC_WW_Pin1_4	190	195	PF00397	0.573
DOC_WW_Pin1_4	196	201	PF00397	0.533
DOC_WW_Pin1_4	207	212	PF00397	0.470
DOC_WW_Pin1_4	244	249	PF00397	0.379
DOC_WW_Pin1_4	511	516	PF00397	0.354
DOC_WW_Pin1_4	651	656	PF00397	0.647
DOC_WW_Pin1_4	820	825	PF00397	0.638
LIG_14-3-3_CanoR_1	104	112	PF00244	0.704
LIG_14-3-3_CanoR_1	1053	1063	PF00244	0.477
LIG_14-3-3_CanoR_1	1131	1139	PF00244	0.531
LIG_14-3-3_CanoR_1	1178	1184	PF00244	0.552
LIG_14-3-3_CanoR_1	241	247	PF00244	0.368
LIG_14-3-3_CanoR_1	293	301	PF00244	0.398
LIG_14-3-3_CanoR_1	354	360	PF00244	0.282
LIG_14-3-3_CanoR_1	507	515	PF00244	0.384
LIG_14-3-3_CanoR_1	59	66	PF00244	0.653
LIG_14-3-3_CanoR_1	785	794	PF00244	0.614
LIG_14-3-3_CanoR_1	892	898	PF00244	0.471
LIG_14-3-3_CanoR_1	931	938	PF00244	0.716
LIG_Actin_WH2_2	216	234	PF00022	0.594
LIG_APCC_ABBA_1	260	265	PF00400	0.485
LIG_BIR_III_2	512	516	PF00653	0.411
LIG_BRCT_BRCA1_1	81	85	PF00533	0.501
LIG_BRCT_BRCA1_1	980	984	PF00533	0.502
LIG_CSK_EPIYA_1	281	285	PF00017	0.474
LIG_eIF4E_1	301	307	PF01652	0.398
LIG_eIF4E_1	718	724	PF01652	0.441
LIG_EVH1_1	140	144	PF00568	0.708
LIG_FHA_1	1033	1039	PF00498	0.667
LIG_FHA_1	1055	1061	PF00498	0.487
LIG_FHA_1	237	243	PF00498	0.593
LIG_FHA_1	251	257	PF00498	0.342
LIG_FHA_1	265	271	PF00498	0.383
LIG_FHA_1	273	279	PF00498	0.419
LIG_FHA_1	286	292	PF00498	0.521
LIG_FHA_1	356	362	PF00498	0.470
LIG_FHA_1	392	398	PF00498	0.463
LIG_FHA_1	490	496	PF00498	0.247
LIG_FHA_1	543	549	PF00498	0.429
LIG_FHA_1	550	556	PF00498	0.321
LIG_FHA_1	573	579	PF00498	0.364
LIG_FHA_1	669	675	PF00498	0.475
LIG_FHA_1	810	816	PF00498	0.608
LIG_FHA_1	821	827	PF00498	0.630
LIG_FHA_1	894	900	PF00498	0.498
LIG_FHA_1	953	959	PF00498	0.468
LIG_FHA_1	983	989	PF00498	0.657
LIG_FHA_2	1064	1070	PF00498	0.470
LIG_FHA_2	1138	1144	PF00498	0.309
LIG_FHA_2	180	186	PF00498	0.631
LIG_FHA_2	371	377	PF00498	0.342
LIG_FHA_2	496	502	PF00498	0.282
LIG_FHA_2	512	518	PF00498	0.320
LIG_FHA_2	652	658	PF00498	0.625
LIG_FHA_2	977	983	PF00498	0.428
LIG_LIR_Apic_2	1156	1162	PF02991	0.518
LIG_LIR_Apic_2	175	181	PF02991	0.495
LIG_LIR_Gen_1	1065	1074	PF02991	0.384
LIG_LIR_Gen_1	1125	1135	PF02991	0.492
LIG_LIR_Gen_1	302	313	PF02991	0.398
LIG_LIR_Gen_1	549	558	PF02991	0.459
LIG_LIR_Gen_1	590	600	PF02991	0.329
LIG_LIR_Gen_1	981	992	PF02991	0.520
LIG_LIR_LC3C_4	955	960	PF02991	0.655
LIG_LIR_Nem_3	1125	1130	PF02991	0.428
LIG_LIR_Nem_3	1133	1139	PF02991	0.370
LIG_LIR_Nem_3	219	225	PF02991	0.521
LIG_LIR_Nem_3	277	283	PF02991	0.406
LIG_LIR_Nem_3	302	308	PF02991	0.306
LIG_LIR_Nem_3	330	336	PF02991	0.371
LIG_LIR_Nem_3	499	505	PF02991	0.306
LIG_LIR_Nem_3	549	554	PF02991	0.440
LIG_LIR_Nem_3	590	596	PF02991	0.336
LIG_LIR_Nem_3	654	659	PF02991	0.557
LIG_LIR_Nem_3	82	88	PF02991	0.601
LIG_LIR_Nem_3	981	987	PF02991	0.489
LIG_MYND_1	138	142	PF01753	0.508
LIG_MYND_1	144	148	PF01753	0.501
LIG_PDZ_Class_1	1182	1187	PF00595	0.663
LIG_Pex14_1	280	284	PF04695	0.409
LIG_Pex14_2	593	597	PF04695	0.352
LIG_SH2_CRK	1136	1140	PF00017	0.391
LIG_SH2_CRK	854	858	PF00017	0.557
LIG_SH2_GRB2like	478	481	PF00017	0.342
LIG_SH2_NCK_1	88	92	PF00017	0.711
LIG_SH2_NCK_1	907	911	PF00017	0.574
LIG_SH2_SRC	305	308	PF00017	0.230
LIG_SH2_SRC	367	370	PF00017	0.355
LIG_SH2_SRC	478	481	PF00017	0.342
LIG_SH2_SRC	659	662	PF00017	0.660
LIG_SH2_STAP1	1056	1060	PF00017	0.459
LIG_SH2_STAT3	1056	1059	PF00017	0.531
LIG_SH2_STAT5	1054	1057	PF00017	0.524
LIG_SH2_STAT5	230	233	PF00017	0.465
LIG_SH2_STAT5	284	287	PF00017	0.495
LIG_SH2_STAT5	305	308	PF00017	0.314
LIG_SH2_STAT5	367	370	PF00017	0.306
LIG_SH2_STAT5	407	410	PF00017	0.323
LIG_SH2_STAT5	478	481	PF00017	0.342
LIG_SH2_STAT5	595	598	PF00017	0.427
LIG_SH2_STAT5	619	622	PF00017	0.511
LIG_SH2_STAT5	818	821	PF00017	0.573
LIG_SH2_STAT5	844	847	PF00017	0.467
LIG_SH3_3	1038	1044	PF00018	0.533
LIG_SH3_3	1157	1163	PF00018	0.601
LIG_SH3_3	135	141	PF00018	0.682
LIG_SH3_3	208	214	PF00018	0.712
LIG_SH3_3	245	251	PF00018	0.505
LIG_SH3_3	550	556	PF00018	0.532
LIG_SH3_3	559	565	PF00018	0.593
LIG_SH3_3	810	816	PF00018	0.563
LIG_SH3_3	821	827	PF00018	0.617
LIG_SH3_3	956	962	PF00018	0.680
LIG_SUMO_SIM_anti_2	1023	1032	PF11976	0.546
LIG_SUMO_SIM_anti_2	1116	1122	PF11976	0.420
LIG_SUMO_SIM_anti_2	526	532	PF11976	0.369
LIG_SUMO_SIM_anti_2	896	901	PF11976	0.494
LIG_SUMO_SIM_par_1	1023	1032	PF11976	0.546
LIG_SUMO_SIM_par_1	955	961	PF11976	0.641
LIG_TRAF2_1	1091	1094	PF00917	0.318
LIG_TRAF2_1	1140	1143	PF00917	0.506
LIG_TRAF2_1	702	705	PF00917	0.659
LIG_TRFH_1	907	911	PF08558	0.482
LIG_WW_2	141	144	PF00397	0.702
MOD_CDK_SPK_2	511	516	PF00069	0.354
MOD_CDK_SPK_2	820	825	PF00069	0.638
MOD_CDK_SPxxK_3	190	197	PF00069	0.524
MOD_CDK_SPxxK_3	511	518	PF00069	0.340
MOD_CK1_1	1032	1038	PF00069	0.690
MOD_CK1_1	156	162	PF00069	0.631
MOD_CK1_1	184	190	PF00069	0.648
MOD_CK1_1	193	199	PF00069	0.613
MOD_CK1_1	385	391	PF00069	0.509
MOD_CK1_1	410	416	PF00069	0.391
MOD_CK1_1	51	57	PF00069	0.725
MOD_CK1_1	536	542	PF00069	0.526
MOD_CK1_1	737	743	PF00069	0.701
MOD_CK1_1	745	751	PF00069	0.704
MOD_CK1_1	77	83	PF00069	0.702
MOD_CK1_1	879	885	PF00069	0.661
MOD_CK1_1	90	96	PF00069	0.721
MOD_CK1_1	996	1002	PF00069	0.714
MOD_CK2_1	1063	1069	PF00069	0.482
MOD_CK2_1	1110	1116	PF00069	0.463
MOD_CK2_1	1137	1143	PF00069	0.392
MOD_CK2_1	154	160	PF00069	0.619
MOD_CK2_1	209	215	PF00069	0.663
MOD_CK2_1	21	27	PF00069	0.566
MOD_CK2_1	370	376	PF00069	0.342
MOD_CK2_1	41	47	PF00069	0.784
MOD_CK2_1	495	501	PF00069	0.205
MOD_CK2_1	511	517	PF00069	0.305
MOD_CK2_1	536	542	PF00069	0.582
MOD_GlcNHglycan	1000	1003	PF01048	0.684
MOD_GlcNHglycan	105	108	PF01048	0.763
MOD_GlcNHglycan	1124	1127	PF01048	0.484
MOD_GlcNHglycan	1133	1136	PF01048	0.526
MOD_GlcNHglycan	1181	1184	PF01048	0.642
MOD_GlcNHglycan	150	153	PF01048	0.772
MOD_GlcNHglycan	156	159	PF01048	0.791
MOD_GlcNHglycan	185	189	PF01048	0.708
MOD_GlcNHglycan	308	311	PF01048	0.294
MOD_GlcNHglycan	31	34	PF01048	0.632
MOD_GlcNHglycan	37	40	PF01048	0.602
MOD_GlcNHglycan	388	391	PF01048	0.675
MOD_GlcNHglycan	401	404	PF01048	0.495
MOD_GlcNHglycan	429	432	PF01048	0.510
MOD_GlcNHglycan	43	46	PF01048	0.561
MOD_GlcNHglycan	535	538	PF01048	0.497
MOD_GlcNHglycan	562	565	PF01048	0.421
MOD_GlcNHglycan	60	63	PF01048	0.716
MOD_GlcNHglycan	620	623	PF01048	0.615
MOD_GlcNHglycan	666	669	PF01048	0.670
MOD_GlcNHglycan	671	674	PF01048	0.525
MOD_GlcNHglycan	739	742	PF01048	0.629
MOD_GlcNHglycan	744	747	PF01048	0.611
MOD_GlcNHglycan	757	760	PF01048	0.580
MOD_GlcNHglycan	76	79	PF01048	0.596
MOD_GlcNHglycan	795	798	PF01048	0.648
MOD_GlcNHglycan	807	810	PF01048	0.558
MOD_GlcNHglycan	863	867	PF01048	0.690
MOD_GlcNHglycan	872	875	PF01048	0.668
MOD_GlcNHglycan	89	92	PF01048	0.691
MOD_GlcNHglycan	995	998	PF01048	0.687
MOD_GSK3_1	1028	1035	PF00069	0.686
MOD_GSK3_1	1164	1171	PF00069	0.598
MOD_GSK3_1	1179	1186	PF00069	0.701
MOD_GSK3_1	168	175	PF00069	0.641
MOD_GSK3_1	180	187	PF00069	0.670
MOD_GSK3_1	192	199	PF00069	0.646
MOD_GSK3_1	205	212	PF00069	0.644
MOD_GSK3_1	272	279	PF00069	0.480
MOD_GSK3_1	370	377	PF00069	0.477
MOD_GSK3_1	378	385	PF00069	0.398
MOD_GSK3_1	386	393	PF00069	0.634
MOD_GSK3_1	395	402	PF00069	0.440
MOD_GSK3_1	447	454	PF00069	0.655
MOD_GSK3_1	48	55	PF00069	0.704
MOD_GSK3_1	483	490	PF00069	0.315
MOD_GSK3_1	507	514	PF00069	0.597
MOD_GSK3_1	542	549	PF00069	0.506
MOD_GSK3_1	664	671	PF00069	0.492
MOD_GSK3_1	70	77	PF00069	0.783
MOD_GSK3_1	730	737	PF00069	0.594
MOD_GSK3_1	741	748	PF00069	0.601
MOD_GSK3_1	79	86	PF00069	0.650
MOD_GSK3_1	800	807	PF00069	0.676
MOD_GSK3_1	870	877	PF00069	0.691
MOD_GSK3_1	879	886	PF00069	0.581
MOD_GSK3_1	948	955	PF00069	0.518
MOD_GSK3_1	961	968	PF00069	0.601
MOD_GSK3_1	978	985	PF00069	0.467
MOD_GSK3_1	99	106	PF00069	0.798
MOD_GSK3_1	998	1005	PF00069	0.569
MOD_N-GLC_1	1179	1184	PF02516	0.524
MOD_N-GLC_1	273	278	PF02516	0.529
MOD_N-GLC_1	52	57	PF02516	0.595
MOD_N-GLC_1	573	578	PF02516	0.469
MOD_N-GLC_1	800	805	PF02516	0.582
MOD_N-GLC_1	820	825	PF02516	0.742
MOD_N-GLC_1	953	958	PF02516	0.661
MOD_NEK2_1	1027	1032	PF00069	0.653
MOD_NEK2_1	1154	1159	PF00069	0.509
MOD_NEK2_1	242	247	PF00069	0.466
MOD_NEK2_1	273	278	PF00069	0.548
MOD_NEK2_1	306	311	PF00069	0.282
MOD_NEK2_1	355	360	PF00069	0.282
MOD_NEK2_1	409	414	PF00069	0.424
MOD_NEK2_1	489	494	PF00069	0.302
MOD_NEK2_1	495	500	PF00069	0.282
MOD_NEK2_1	560	565	PF00069	0.492
MOD_NEK2_1	572	577	PF00069	0.494
MOD_NEK2_1	804	809	PF00069	0.693
MOD_NEK2_1	991	996	PF00069	0.663
MOD_OFUCOSY	731	738	PF10250	0.566
MOD_PIKK_1	1054	1060	PF00454	0.476
MOD_PIKK_1	378	384	PF00454	0.282
MOD_PIKK_1	437	443	PF00454	0.510
MOD_PIKK_1	451	457	PF00454	0.507
MOD_PIKK_1	961	967	PF00454	0.579
MOD_PKA_1	41	47	PF00069	0.587
MOD_PKA_1	931	937	PF00069	0.421
MOD_PKA_2	103	109	PF00069	0.699
MOD_PKA_2	1130	1136	PF00069	0.467
MOD_PKA_2	292	298	PF00069	0.398
MOD_PKA_2	382	388	PF00069	0.744
MOD_PKA_2	41	47	PF00069	0.653
MOD_PKA_2	426	432	PF00069	0.631
MOD_PKA_2	48	54	PF00069	0.685
MOD_PKA_2	542	548	PF00069	0.497
MOD_PKA_2	58	64	PF00069	0.768
MOD_PKA_2	68	74	PF00069	0.738
MOD_PKA_2	931	937	PF00069	0.616
MOD_Plk_1	265	271	PF00069	0.448
MOD_Plk_1	273	279	PF00069	0.373
MOD_Plk_1	573	579	PF00069	0.465
MOD_Plk_1	799	805	PF00069	0.645
MOD_Plk_1	953	959	PF00069	0.660
MOD_Plk_4	1099	1105	PF00069	0.420
MOD_Plk_4	1110	1116	PF00069	0.530
MOD_Plk_4	1155	1161	PF00069	0.535
MOD_Plk_4	21	27	PF00069	0.553
MOD_Plk_4	250	256	PF00069	0.500
MOD_Plk_4	266	272	PF00069	0.325
MOD_Plk_4	315	321	PF00069	0.286
MOD_Plk_4	355	361	PF00069	0.282
MOD_Plk_4	573	579	PF00069	0.452
MOD_Plk_4	953	959	PF00069	0.574
MOD_ProDKin_1	1020	1026	PF00069	0.626
MOD_ProDKin_1	105	111	PF00069	0.655
MOD_ProDKin_1	112	118	PF00069	0.600
MOD_ProDKin_1	126	132	PF00069	0.558
MOD_ProDKin_1	168	174	PF00069	0.623
MOD_ProDKin_1	190	196	PF00069	0.572
MOD_ProDKin_1	207	213	PF00069	0.469
MOD_ProDKin_1	244	250	PF00069	0.383
MOD_ProDKin_1	511	517	PF00069	0.345
MOD_ProDKin_1	651	657	PF00069	0.643
MOD_ProDKin_1	820	826	PF00069	0.639
TRG_DiLeu_BaEn_1	1116	1121	PF01217	0.476
TRG_DiLeu_BaEn_1	266	271	PF01217	0.484
TRG_DiLeu_BaEn_1	302	307	PF01217	0.205
TRG_DiLeu_BaEn_1	526	531	PF01217	0.463
TRG_DiLeu_BaEn_1	772	777	PF01217	0.705
TRG_DiLeu_BaEn_4	1116	1122	PF01217	0.474
TRG_DiLeu_BaLyEn_6	719	724	PF01217	0.588
TRG_ENDOCYTIC_2	1136	1139	PF00928	0.414
TRG_ENDOCYTIC_2	305	308	PF00928	0.355
TRG_ENDOCYTIC_2	854	857	PF00928	0.556
TRG_ER_diArg_1	416	419	PF00400	0.422
TRG_ER_diArg_1	889	892	PF00400	0.581
TRG_ER_diArg_1	931	933	PF00400	0.434
TRG_NES_CRM1_1	252	266	PF08389	0.450
TRG_Pf-PMV_PEXEL_1	1053	1058	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	612	617	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	855	859	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I275	Leptomonas seymouri	53%	92%
A0A1X0NTE6	Trypanosomatidae	38%	100%
A0A3S7WXC7	Leishmania donovani	73%	90%
A0A422N3K6	Trypanosoma rangeli	37%	100%
A4HZX5	Leishmania infantum	73%	90%
C9ZSL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AVT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	97%
Q4QBP4	Leishmania major	73%	99%