Mitochondrial DNA-directed RNA polymerase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

mitochondrial DNA-directed RNA polymerase

Species:

Leishmania braziliensis

UniProt:

A4HCC6_LEIBR

TriTrypDb:

LbrM.22.0670 , LBRM2903_240017800

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	2
GO:0030880	RNA polymerase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

A4HCC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.754
CLV_NRD_NRD_1	160	162	PF00675	0.871
CLV_NRD_NRD_1	185	187	PF00675	0.798
CLV_NRD_NRD_1	188	190	PF00675	0.771
CLV_PCSK_FUR_1	186	190	PF00082	0.815
CLV_PCSK_KEX2_1	119	121	PF00082	0.754
CLV_PCSK_KEX2_1	160	162	PF00082	0.871
CLV_PCSK_KEX2_1	185	187	PF00082	0.798
CLV_PCSK_KEX2_1	188	190	PF00082	0.771
CLV_PCSK_SKI1_1	72	76	PF00082	0.758
DEG_Nend_UBRbox_2	1	3	PF02207	0.823
DOC_CYCLIN_yCln2_LP_2	109	115	PF00134	0.725
DOC_MAPK_gen_1	165	173	PF00069	0.810
DOC_MAPK_MEF2A_6	167	175	PF00069	0.801
DOC_MIT_MIM_1	99	109	PF04212	0.739
DOC_PP2B_LxvP_1	47	50	PF13499	0.727
DOC_USP7_MATH_1	127	131	PF00917	0.785
DOC_USP7_MATH_1	57	61	PF00917	0.712
DOC_WW_Pin1_4	53	58	PF00397	0.716
LIG_14-3-3_CanoR_1	13	23	PF00244	0.824
LIG_14-3-3_CanoR_1	39	47	PF00244	0.722
LIG_deltaCOP1_diTrp_1	8	14	PF00928	0.812
LIG_FHA_2	91	97	PF00498	0.778
LIG_LIR_Nem_3	56	61	PF02991	0.713
LIG_LIR_Nem_3	64	68	PF02991	0.574
LIG_NRBOX	105	111	PF00104	0.732
LIG_SH2_CRK	38	42	PF00017	0.728
LIG_SH2_STAT5	61	64	PF00017	0.706
LIG_SH2_STAT5	65	68	PF00017	0.641
LIG_SH3_3	3	9	PF00018	0.808
LIG_SH3_3	51	57	PF00018	0.720
LIG_SH3_3	86	92	PF00018	0.757
LIG_TRAF2_1	93	96	PF00917	0.784
MOD_CK1_1	151	157	PF00069	0.878
MOD_CK2_1	90	96	PF00069	0.778
MOD_CMANNOS	11	14	PF00535	0.826
MOD_GlcNHglycan	153	156	PF01048	0.881
MOD_GlcNHglycan	98	102	PF01048	0.747
MOD_GSK3_1	151	158	PF00069	0.876
MOD_GSK3_1	53	60	PF00069	0.715
MOD_N-GLC_1	155	160	PF02516	0.877
MOD_PIKK_1	155	161	PF00454	0.876
MOD_PKA_2	14	20	PF00069	0.825
MOD_PKA_2	159	165	PF00069	0.867
MOD_PKB_1	146	154	PF00069	0.868
MOD_Plk_1	127	133	PF00069	0.789
MOD_Plk_1	97	103	PF00069	0.746
MOD_Plk_4	57	63	PF00069	0.708
MOD_ProDKin_1	53	59	PF00069	0.715
TRG_ENDOCYTIC_2	38	41	PF00928	0.735
TRG_ENDOCYTIC_2	68	71	PF00928	0.730
TRG_ER_diArg_1	184	186	PF00400	0.793
TRG_ER_diArg_1	188	190	PF00400	0.753