MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HCC5_LEIBR

TriTrypDb:

LbrM.22.0950 , LBRM2903_220015200

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HCC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCC5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0022857	transmembrane transporter activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	527	531	PF00656	0.423
CLV_NRD_NRD_1	218	220	PF00675	0.258
CLV_NRD_NRD_1	717	719	PF00675	0.641
CLV_NRD_NRD_1	817	819	PF00675	0.422
CLV_PCSK_KEX2_1	375	377	PF00082	0.260
CLV_PCSK_KEX2_1	717	719	PF00082	0.641
CLV_PCSK_KEX2_1	817	819	PF00082	0.422
CLV_PCSK_KEX2_1	90	92	PF00082	0.300
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.278
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.300
CLV_PCSK_PC7_1	86	92	PF00082	0.300
CLV_PCSK_SKI1_1	188	192	PF00082	0.292
CLV_PCSK_SKI1_1	269	273	PF00082	0.207
CLV_PCSK_SKI1_1	406	410	PF00082	0.504
CLV_PCSK_SKI1_1	689	693	PF00082	0.693
CLV_PCSK_SKI1_1	701	705	PF00082	0.630
CLV_PCSK_SKI1_1	734	738	PF00082	0.673
CLV_PCSK_SKI1_1	90	94	PF00082	0.257
DEG_APCC_DBOX_1	405	413	PF00400	0.304
DEG_ODPH_VHL_1	355	368	PF01847	0.357
DEG_SCF_FBW7_1	299	304	PF00400	0.402
DEG_SCF_TRCP1_1	37	42	PF00400	0.292
DEG_SCF_TRCP1_1	620	625	PF00400	0.490
DEG_SPOP_SBC_1	174	178	PF00917	0.304
DEG_SPOP_SBC_1	769	773	PF00917	0.469
DOC_CKS1_1	11	16	PF01111	0.533
DOC_CKS1_1	132	137	PF01111	0.351
DOC_MAPK_gen_1	375	383	PF00069	0.444
DOC_MAPK_gen_1	90	97	PF00069	0.402
DOC_MAPK_HePTP_8	117	129	PF00069	0.357
DOC_MAPK_MEF2A_6	120	129	PF00069	0.351
DOC_MAPK_MEF2A_6	473	481	PF00069	0.500
DOC_MAPK_MEF2A_6	90	99	PF00069	0.402
DOC_PP1_RVXF_1	378	384	PF00149	0.498
DOC_PP2B_LxvP_1	191	194	PF13499	0.292
DOC_PP2B_LxvP_1	45	48	PF13499	0.304
DOC_PP2B_LxvP_1	536	539	PF13499	0.401
DOC_PP2B_PxIxI_1	488	494	PF00149	0.291
DOC_PP4_FxxP_1	230	233	PF00568	0.402
DOC_PP4_FxxP_1	250	253	PF00568	0.439
DOC_PP4_FxxP_1	456	459	PF00568	0.474
DOC_PP4_FxxP_1	579	582	PF00568	0.405
DOC_PP4_MxPP_1	789	792	PF00568	0.408
DOC_SPAK_OSR1_1	120	124	PF12202	0.292
DOC_USP7_MATH_1	174	178	PF00917	0.304
DOC_USP7_MATH_1	212	216	PF00917	0.424
DOC_USP7_MATH_1	259	263	PF00917	0.481
DOC_USP7_MATH_1	618	622	PF00917	0.477
DOC_USP7_MATH_1	662	666	PF00917	0.606
DOC_USP7_MATH_1	767	771	PF00917	0.537
DOC_USP7_MATH_1	797	801	PF00917	0.350
DOC_WW_Pin1_4	10	15	PF00397	0.548
DOC_WW_Pin1_4	131	136	PF00397	0.351
DOC_WW_Pin1_4	248	253	PF00397	0.457
DOC_WW_Pin1_4	297	302	PF00397	0.402
DOC_WW_Pin1_4	600	605	PF00397	0.529
DOC_WW_Pin1_4	643	648	PF00397	0.476
DOC_WW_Pin1_4	695	700	PF00397	0.493
DOC_WW_Pin1_4	783	788	PF00397	0.448
LIG_14-3-3_CanoR_1	146	150	PF00244	0.451
LIG_14-3-3_CanoR_1	260	270	PF00244	0.506
LIG_14-3-3_CanoR_1	380	384	PF00244	0.399
LIG_14-3-3_CanoR_1	776	783	PF00244	0.518
LIG_14-3-3_CanoR_1	817	823	PF00244	0.625
LIG_14-3-3_CanoR_1	825	831	PF00244	0.622
LIG_Actin_WH2_2	17	33	PF00022	0.451
LIG_Actin_WH2_2	458	475	PF00022	0.492
LIG_BRCT_BRCA1_1	125	129	PF00533	0.357
LIG_BRCT_BRCA1_1	316	320	PF00533	0.292
LIG_BRCT_BRCA1_1	37	41	PF00533	0.292
LIG_BRCT_BRCA1_1	633	637	PF00533	0.419
LIG_BRCT_BRCA1_1	66	70	PF00533	0.292
LIG_Clathr_ClatBox_1	728	732	PF01394	0.460
LIG_EH1_1	473	481	PF00400	0.500
LIG_eIF4E_1	186	192	PF01652	0.357
LIG_eIF4E_1	21	27	PF01652	0.504
LIG_eIF4E_1	297	303	PF01652	0.402
LIG_eIF4E_1	474	480	PF01652	0.500
LIG_FHA_1	174	180	PF00498	0.304
LIG_FHA_1	3	9	PF00498	0.613
LIG_FHA_1	328	334	PF00498	0.257
LIG_FHA_1	467	473	PF00498	0.508
LIG_FHA_1	476	482	PF00498	0.292
LIG_FHA_1	52	58	PF00498	0.309
LIG_FHA_1	583	589	PF00498	0.503
LIG_FHA_1	673	679	PF00498	0.438
LIG_FHA_1	707	713	PF00498	0.421
LIG_FHA_2	11	17	PF00498	0.634
LIG_FHA_2	431	437	PF00498	0.463
LIG_FHA_2	610	616	PF00498	0.440
LIG_LIR_Apic_2	227	233	PF02991	0.402
LIG_LIR_Apic_2	247	253	PF02991	0.439
LIG_LIR_Apic_2	576	582	PF02991	0.411
LIG_LIR_Gen_1	101	111	PF02991	0.292
LIG_LIR_Gen_1	126	136	PF02991	0.322
LIG_LIR_Gen_1	19	28	PF02991	0.532
LIG_LIR_Gen_1	300	309	PF02991	0.475
LIG_LIR_Gen_1	405	416	PF02991	0.257
LIG_LIR_Gen_1	634	644	PF02991	0.418
LIG_LIR_Gen_1	675	682	PF02991	0.417
LIG_LIR_Nem_3	101	106	PF02991	0.292
LIG_LIR_Nem_3	126	132	PF02991	0.322
LIG_LIR_Nem_3	180	186	PF02991	0.267
LIG_LIR_Nem_3	19	24	PF02991	0.535
LIG_LIR_Nem_3	300	306	PF02991	0.430
LIG_LIR_Nem_3	382	386	PF02991	0.215
LIG_LIR_Nem_3	405	411	PF02991	0.294
LIG_LIR_Nem_3	471	477	PF02991	0.535
LIG_LIR_Nem_3	634	640	PF02991	0.419
LIG_LIR_Nem_3	675	679	PF02991	0.419
LIG_MLH1_MIPbox_1	316	320	PF16413	0.292
LIG_NRBOX	163	169	PF00104	0.357
LIG_Pex14_1	137	141	PF04695	0.457
LIG_Pex14_1	181	185	PF04695	0.257
LIG_Pex14_2	384	388	PF04695	0.292
LIG_PTAP_UEV_1	646	651	PF05743	0.433
LIG_PTB_Apo_2	116	123	PF02174	0.308
LIG_PTB_Apo_2	291	298	PF02174	0.490
LIG_PTB_Apo_2	302	309	PF02174	0.277
LIG_PTB_Phospho_1	291	297	PF10480	0.490
LIG_PTB_Phospho_1	302	308	PF10480	0.277
LIG_SH2_CRK	107	111	PF00017	0.215
LIG_SH2_CRK	474	478	PF00017	0.462
LIG_SH2_STAT5	133	136	PF00017	0.351
LIG_SH2_STAT5	166	169	PF00017	0.292
LIG_SH2_STAT5	186	189	PF00017	0.171
LIG_SH2_STAT5	198	201	PF00017	0.252
LIG_SH2_STAT5	21	24	PF00017	0.538
LIG_SH2_STAT5	319	322	PF00017	0.319
LIG_SH2_STAT5	332	335	PF00017	0.257
LIG_SH2_STAT5	795	798	PF00017	0.215
LIG_SH3_3	129	135	PF00018	0.292
LIG_SH3_3	351	357	PF00018	0.260
LIG_SH3_3	644	650	PF00018	0.472
LIG_SH3_3	651	657	PF00018	0.437
LIG_SH3_3	675	681	PF00018	0.438
LIG_SH3_3	8	14	PF00018	0.578
LIG_SUMO_SIM_anti_2	725	730	PF11976	0.465
LIG_SUMO_SIM_par_1	189	195	PF11976	0.351
LIG_SUMO_SIM_par_1	311	317	PF11976	0.351
LIG_SUMO_SIM_par_1	477	483	PF11976	0.351
LIG_SUMO_SIM_par_1	533	541	PF11976	0.411
LIG_TRAF2_1	573	576	PF00917	0.412
LIG_TYR_ITIM	131	136	PF00017	0.292
LIG_TYR_ITIM	472	477	PF00017	0.393
LIG_UBA3_1	26	31	PF00899	0.292
LIG_UBA3_1	367	375	PF00899	0.355
LIG_UBA3_1	728	734	PF00899	0.443
LIG_WRC_WIRS_1	102	107	PF05994	0.292
LIG_WRC_WIRS_1	33	38	PF05994	0.292
LIG_WRC_WIRS_1	673	678	PF05994	0.518
MOD_CDC14_SPxK_1	698	701	PF00782	0.531
MOD_CDK_SPxK_1	695	701	PF00069	0.580
MOD_CDK_SPxxK_3	600	607	PF00069	0.564
MOD_CK1_1	177	183	PF00069	0.357
MOD_CK1_1	206	212	PF00069	0.302
MOD_CK1_1	234	240	PF00069	0.215
MOD_CK1_1	311	317	PF00069	0.326
MOD_CK1_1	35	41	PF00069	0.292
MOD_CK1_1	507	513	PF00069	0.460
MOD_CK1_1	587	593	PF00069	0.636
MOD_CK1_1	643	649	PF00069	0.600
MOD_CK1_1	697	703	PF00069	0.675
MOD_CK1_1	770	776	PF00069	0.795
MOD_CK1_1	800	806	PF00069	0.370
MOD_GlcNHglycan	214	217	PF01048	0.332
MOD_GlcNHglycan	233	236	PF01048	0.329
MOD_GlcNHglycan	257	260	PF01048	0.273
MOD_GlcNHglycan	261	264	PF01048	0.247
MOD_GlcNHglycan	350	353	PF01048	0.241
MOD_GlcNHglycan	37	40	PF01048	0.292
MOD_GlcNHglycan	41	44	PF01048	0.292
MOD_GlcNHglycan	456	459	PF01048	0.316
MOD_GlcNHglycan	502	505	PF01048	0.494
MOD_GlcNHglycan	506	509	PF01048	0.518
MOD_GlcNHglycan	514	517	PF01048	0.507
MOD_GlcNHglycan	540	543	PF01048	0.731
MOD_GlcNHglycan	589	592	PF01048	0.673
MOD_GlcNHglycan	620	623	PF01048	0.672
MOD_GlcNHglycan	642	645	PF01048	0.581
MOD_GlcNHglycan	647	650	PF01048	0.546
MOD_GlcNHglycan	807	810	PF01048	0.375
MOD_GSK3_1	173	180	PF00069	0.357
MOD_GSK3_1	234	241	PF00069	0.404
MOD_GSK3_1	244	251	PF00069	0.257
MOD_GSK3_1	255	262	PF00069	0.265
MOD_GSK3_1	273	280	PF00069	0.417
MOD_GSK3_1	297	304	PF00069	0.242
MOD_GSK3_1	35	42	PF00069	0.316
MOD_GSK3_1	475	482	PF00069	0.351
MOD_GSK3_1	500	507	PF00069	0.543
MOD_GSK3_1	51	58	PF00069	0.292
MOD_GSK3_1	571	578	PF00069	0.558
MOD_GSK3_1	605	612	PF00069	0.639
MOD_GSK3_1	61	68	PF00069	0.254
MOD_GSK3_1	616	623	PF00069	0.743
MOD_GSK3_1	631	638	PF00069	0.577
MOD_GSK3_1	660	667	PF00069	0.597
MOD_GSK3_1	689	696	PF00069	0.710
MOD_GSK3_1	697	704	PF00069	0.605
MOD_GSK3_1	796	803	PF00069	0.365
MOD_GSK3_1	805	812	PF00069	0.330
MOD_N-GLC_1	338	343	PF02516	0.351
MOD_N-GLC_1	454	459	PF02516	0.313
MOD_NEK2_1	1	6	PF00069	0.581
MOD_NEK2_1	175	180	PF00069	0.417
MOD_NEK2_1	295	300	PF00069	0.395
MOD_NEK2_1	320	325	PF00069	0.319
MOD_NEK2_1	338	343	PF00069	0.292
MOD_NEK2_1	401	406	PF00069	0.382
MOD_NEK2_1	410	415	PF00069	0.266
MOD_NEK2_1	438	443	PF00069	0.419
MOD_NEK2_1	479	484	PF00069	0.294
MOD_NEK2_1	512	517	PF00069	0.618
MOD_NEK2_1	605	610	PF00069	0.732
MOD_NEK2_1	61	66	PF00069	0.297
MOD_NEK2_1	635	640	PF00069	0.611
MOD_NEK2_2	181	186	PF00069	0.357
MOD_NEK2_2	288	293	PF00069	0.357
MOD_NEK2_2	379	384	PF00069	0.241
MOD_PIKK_1	275	281	PF00454	0.346
MOD_PIKK_1	327	333	PF00454	0.292
MOD_PIKK_1	443	449	PF00454	0.292
MOD_PIKK_1	571	577	PF00454	0.662
MOD_PKA_2	145	151	PF00069	0.292
MOD_PKA_2	259	265	PF00069	0.360
MOD_PKA_2	379	385	PF00069	0.210
MOD_PKA_2	438	444	PF00069	0.351
MOD_PKA_2	775	781	PF00069	0.751
MOD_PKB_1	607	615	PF00069	0.549
MOD_Plk_1	273	279	PF00069	0.335
MOD_Plk_1	338	344	PF00069	0.292
MOD_Plk_2-3	831	837	PF00069	0.607
MOD_Plk_4	125	131	PF00069	0.294
MOD_Plk_4	145	151	PF00069	0.171
MOD_Plk_4	16	22	PF00069	0.443
MOD_Plk_4	308	314	PF00069	0.305
MOD_Plk_4	379	385	PF00069	0.210
MOD_Plk_4	410	416	PF00069	0.314
MOD_Plk_4	475	481	PF00069	0.299
MOD_Plk_4	61	67	PF00069	0.297
MOD_Plk_4	770	776	PF00069	0.544
MOD_Plk_4	98	104	PF00069	0.303
MOD_ProDKin_1	10	16	PF00069	0.407
MOD_ProDKin_1	131	137	PF00069	0.351
MOD_ProDKin_1	248	254	PF00069	0.291
MOD_ProDKin_1	297	303	PF00069	0.215
MOD_ProDKin_1	600	606	PF00069	0.672
MOD_ProDKin_1	643	649	PF00069	0.600
MOD_ProDKin_1	695	701	PF00069	0.622
MOD_ProDKin_1	783	789	PF00069	0.559
MOD_SUMO_for_1	271	274	PF00179	0.215
MOD_SUMO_rev_2	727	736	PF00179	0.446
MOD_SUMO_rev_2	85	92	PF00179	0.357
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.694
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.390
TRG_ENDOCYTIC_2	107	110	PF00928	0.357
TRG_ENDOCYTIC_2	133	136	PF00928	0.292
TRG_ENDOCYTIC_2	21	24	PF00928	0.405
TRG_ENDOCYTIC_2	296	299	PF00928	0.357
TRG_ENDOCYTIC_2	450	453	PF00928	0.292
TRG_ENDOCYTIC_2	474	477	PF00928	0.337
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAL7	Leptomonas seymouri	50%	100%
A0A3R7R683	Trypanosoma rangeli	41%	100%
A0A3S5H7B0	Leishmania donovani	71%	88%
A4HZX7	Leishmania infantum	71%	88%
E9AVT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	89%
Q4QBP2	Leishmania major	69%	100%