MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HCC5_LEIBR

TriTrypDb:

LbrM.22.0950 , LBRM2903_220015200

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

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Expansion

Sequence features

A4HCC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCC5

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0022857	transmembrane transporter activity	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	527	531	PF00656	0.423
CLV_NRD_NRD_1	218	220	PF00675	0.258
CLV_NRD_NRD_1	717	719	PF00675	0.641
CLV_NRD_NRD_1	817	819	PF00675	0.422
CLV_PCSK_KEX2_1	375	377	PF00082	0.260
CLV_PCSK_KEX2_1	717	719	PF00082	0.641
CLV_PCSK_KEX2_1	817	819	PF00082	0.422
CLV_PCSK_KEX2_1	90	92	PF00082	0.300
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.278
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.300

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAL7	Leptomonas seymouri	50%	100%
A0A3R7R683	Trypanosoma rangeli	41%	100%
A0A3S5H7B0	Leishmania donovani	71%	88%
A4HZX7	Leishmania infantum	71%	88%
E9AVT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	89%
Q4QBP2	Leishmania major	69%	100%

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