Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCC4_LEIBR

TriTrypDb:

LbrM.22.0900 , LBRM2903_220014700

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.704
CLV_C14_Caspase3-7	39	43	PF00656	0.616
CLV_NRD_NRD_1	227	229	PF00675	0.607
CLV_NRD_NRD_1	362	364	PF00675	0.715
CLV_PCSK_KEX2_1	227	229	PF00082	0.642
CLV_PCSK_KEX2_1	362	364	PF00082	0.715
CLV_PCSK_SKI1_1	110	114	PF00082	0.738
CLV_PCSK_SKI1_1	348	352	PF00082	0.448
DEG_Nend_UBRbox_1	1	4	PF02207	0.526
DEG_SPOP_SBC_1	10	14	PF00917	0.741
DEG_SPOP_SBC_1	37	41	PF00917	0.768
DEG_SPOP_SBC_1	83	87	PF00917	0.558
DOC_CYCLIN_RxL_1	345	354	PF00134	0.447
DOC_MAPK_MEF2A_6	484	491	PF00069	0.590
DOC_PP1_RVXF_1	346	352	PF00149	0.348
DOC_PP4_FxxP_1	108	111	PF00568	0.695
DOC_PP4_FxxP_1	294	297	PF00568	0.534
DOC_USP7_MATH_1	119	123	PF00917	0.584
DOC_USP7_MATH_1	173	177	PF00917	0.669
DOC_USP7_MATH_1	320	324	PF00917	0.538
DOC_USP7_MATH_1	37	41	PF00917	0.729
DOC_USP7_MATH_1	59	63	PF00917	0.803
DOC_WW_Pin1_4	287	292	PF00397	0.564
DOC_WW_Pin1_4	293	298	PF00397	0.620
DOC_WW_Pin1_4	434	439	PF00397	0.447
DOC_WW_Pin1_4	54	59	PF00397	0.760
LIG_14-3-3_CanoR_1	104	112	PF00244	0.570
LIG_14-3-3_CanoR_1	161	167	PF00244	0.519
LIG_14-3-3_CanoR_1	227	231	PF00244	0.416
LIG_14-3-3_CanoR_1	268	273	PF00244	0.550
LIG_14-3-3_CanoR_1	30	35	PF00244	0.678
LIG_14-3-3_CanoR_1	412	421	PF00244	0.444
LIG_Actin_WH2_2	399	416	PF00022	0.443
LIG_BIR_III_4	42	46	PF00653	0.585
LIG_BRCT_BRCA1_1	7	11	PF00533	0.705
LIG_CSL_BTD_1	438	441	PF09270	0.480
LIG_FHA_1	107	113	PF00498	0.540
LIG_FHA_1	342	348	PF00498	0.555
LIG_FHA_1	468	474	PF00498	0.436
LIG_FHA_1	58	64	PF00498	0.565
LIG_FHA_1	85	91	PF00498	0.628
LIG_FHA_2	193	199	PF00498	0.523
LIG_FHA_2	31	37	PF00498	0.715
LIG_FHA_2	39	45	PF00498	0.785
LIG_LIR_Apic_2	106	111	PF02991	0.688
LIG_LIR_Apic_2	292	297	PF02991	0.579
LIG_LIR_Gen_1	463	473	PF02991	0.573
LIG_LIR_Nem_3	199	205	PF02991	0.476
LIG_LIR_Nem_3	392	398	PF02991	0.511
LIG_LIR_Nem_3	463	469	PF02991	0.445
LIG_PDZ_Class_2	486	491	PF00595	0.455
LIG_Pex14_2	140	144	PF04695	0.474
LIG_RPA_C_Fungi	159	171	PF08784	0.587
LIG_SH2_NCK_1	451	455	PF00017	0.576
LIG_SH2_NCK_1	466	470	PF00017	0.371
LIG_SH2_PTP2	339	342	PF00017	0.439
LIG_SH2_STAP1	205	209	PF00017	0.637
LIG_SH2_STAT5	205	208	PF00017	0.650
LIG_SH2_STAT5	310	313	PF00017	0.393
LIG_SH2_STAT5	339	342	PF00017	0.439
LIG_SH3_3	208	214	PF00018	0.609
LIG_SH3_3	22	28	PF00018	0.646
LIG_SH3_3	236	242	PF00018	0.607
LIG_SH3_3	280	286	PF00018	0.535
LIG_SH3_3	294	300	PF00018	0.691
LIG_SH3_3	337	343	PF00018	0.442
LIG_SH3_3	435	441	PF00018	0.458
LIG_SUMO_SIM_par_1	251	258	PF11976	0.468
LIG_SUMO_SIM_par_1	432	437	PF11976	0.601
LIG_TRAF2_1	33	36	PF00917	0.581
LIG_TYR_ITIM	464	469	PF00017	0.591
MOD_CK1_1	117	123	PF00069	0.707
MOD_CK1_1	174	180	PF00069	0.603
MOD_CK1_1	321	327	PF00069	0.589
MOD_CK1_1	366	372	PF00069	0.613
MOD_CK1_1	416	422	PF00069	0.437
MOD_CK1_1	48	54	PF00069	0.621
MOD_CK1_1	57	63	PF00069	0.649
MOD_CK2_1	179	185	PF00069	0.731
MOD_CK2_1	30	36	PF00069	0.711
MOD_CK2_1	38	44	PF00069	0.785
MOD_GlcNHglycan	144	147	PF01048	0.704
MOD_GlcNHglycan	166	169	PF01048	0.566
MOD_GlcNHglycan	179	182	PF01048	0.636
MOD_GlcNHglycan	217	220	PF01048	0.576
MOD_GlcNHglycan	302	305	PF01048	0.685
MOD_GlcNHglycan	368	371	PF01048	0.696
MOD_GlcNHglycan	375	378	PF01048	0.629
MOD_GlcNHglycan	415	418	PF01048	0.437
MOD_GlcNHglycan	46	50	PF01048	0.666
MOD_GlcNHglycan	53	56	PF01048	0.578
MOD_GSK3_1	106	113	PF00069	0.708
MOD_GSK3_1	160	167	PF00069	0.485
MOD_GSK3_1	173	180	PF00069	0.681
MOD_GSK3_1	192	199	PF00069	0.629
MOD_GSK3_1	281	288	PF00069	0.494
MOD_GSK3_1	289	296	PF00069	0.634
MOD_GSK3_1	318	325	PF00069	0.571
MOD_GSK3_1	368	375	PF00069	0.592
MOD_GSK3_1	45	52	PF00069	0.765
MOD_GSK3_1	465	472	PF00069	0.444
MOD_GSK3_1	5	12	PF00069	0.706
MOD_N-GLC_1	122	127	PF02516	0.564
MOD_N-GLC_1	142	147	PF02516	0.716
MOD_N-GLC_1	366	371	PF02516	0.562
MOD_NEK2_1	160	165	PF00069	0.496
MOD_NEK2_1	166	171	PF00069	0.637
MOD_NEK2_1	215	220	PF00069	0.693
MOD_NEK2_1	255	260	PF00069	0.493
MOD_NEK2_1	351	356	PF00069	0.451
MOD_NEK2_1	368	373	PF00069	0.601
MOD_NEK2_1	413	418	PF00069	0.440
MOD_NEK2_1	465	470	PF00069	0.454
MOD_NEK2_1	9	14	PF00069	0.742
MOD_NEK2_2	343	348	PF00069	0.441
MOD_NEK2_2	460	465	PF00069	0.414
MOD_PIKK_1	368	374	PF00454	0.738
MOD_PK_1	268	274	PF00069	0.557
MOD_PKA_2	103	109	PF00069	0.571
MOD_PKA_2	147	153	PF00069	0.524
MOD_PKA_2	160	166	PF00069	0.529
MOD_PKA_2	226	232	PF00069	0.424
MOD_PKA_2	267	273	PF00069	0.537
MOD_PKA_2	29	35	PF00069	0.684
MOD_PKA_2	413	419	PF00069	0.439
MOD_Plk_2-3	73	79	PF00069	0.567
MOD_Plk_4	255	261	PF00069	0.486
MOD_Plk_4	313	319	PF00069	0.631
MOD_Plk_4	356	362	PF00069	0.519
MOD_Plk_4	397	403	PF00069	0.442
MOD_Plk_4	416	422	PF00069	0.437
MOD_Plk_4	442	448	PF00069	0.445
MOD_Plk_4	460	466	PF00069	0.425
MOD_ProDKin_1	287	293	PF00069	0.567
MOD_ProDKin_1	434	440	PF00069	0.450
MOD_ProDKin_1	54	60	PF00069	0.760
TRG_DiLeu_BaEn_2	135	141	PF01217	0.479
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.525
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.576
TRG_ENDOCYTIC_2	339	342	PF00928	0.439
TRG_ENDOCYTIC_2	466	469	PF00928	0.577
TRG_ER_diArg_1	361	363	PF00400	0.708
TRG_ER_diArg_1	412	415	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA8	Leptomonas seymouri	46%	85%
A0A3Q8IEA0	Leishmania donovani	74%	84%
A4HZX3	Leishmania infantum	74%	84%
E9AVT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	84%
Q4QBP7	Leishmania major	75%	100%