Small nuclear ribonucleoprotein Sm D1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small nuclear ribonucleoprotein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCC3_LEIBR

TriTrypDb:

LbrM.22.0960 , LBRM2903_220015300

Length:

103

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	8
GO:1990904	ribonucleoprotein complex	2	9
GO:0000243	commitment complex	5	1
GO:0005681	spliceosomal complex	3	1
GO:0005682	U5 snRNP	5	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005685	U1 snRNP	5	1
GO:0005686	U2 snRNP	5	1
GO:0005687	U4 snRNP	5	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0005737	cytoplasm	2	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0034715	pICln-Sm protein complex	3	1
GO:0034719	SMN-Sm protein complex	3	1
GO:0071011	precatalytic spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HCC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCC3

Function

Biological processes
Term	Name	Level	Count
GO:0000387	spliceosomal snRNP assembly	7	3
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	3
GO:0022607	cellular component assembly	4	3
GO:0022618	ribonucleoprotein complex assembly	6	3
GO:0043933	protein-containing complex organization	4	3
GO:0065003	protein-containing complex assembly	5	3
GO:0071826	ribonucleoprotein complex subunit organization	5	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	20	28	PF00400	0.547
DOC_MAPK_gen_1	58	65	PF00069	0.582
DOC_MAPK_MEF2A_6	21	29	PF00069	0.523
DOC_USP7_MATH_2	6	12	PF00917	0.434
DOC_USP7_UBL2_3	54	58	PF12436	0.514
DOC_WW_Pin1_4	2	7	PF00397	0.677
LIG_Actin_WH2_2	17	32	PF00022	0.582
LIG_Actin_WH2_2	77	93	PF00022	0.614
LIG_BIR_II_1	1	5	PF00653	0.698
LIG_Clathr_ClatBox_1	24	28	PF01394	0.547
LIG_FHA_1	84	90	PF00498	0.453
LIG_FHA_2	21	27	PF00498	0.523
LIG_LIR_Gen_1	74	84	PF02991	0.524
LIG_LIR_Gen_1	86	95	PF02991	0.485
LIG_LIR_Nem_3	74	80	PF02991	0.500
LIG_LIR_Nem_3	86	90	PF02991	0.499
LIG_SH2_CRK	87	91	PF00017	0.562
LIG_SH2_PTP2	77	80	PF00017	0.502
LIG_SH2_SRC	41	44	PF00017	0.582
LIG_SH2_STAT5	41	44	PF00017	0.582
LIG_SH2_STAT5	77	80	PF00017	0.523
LIG_SUMO_SIM_par_1	23	28	PF11976	0.547
LIG_SUMO_SIM_par_1	61	67	PF11976	0.574
LIG_TYR_ITIM	75	80	PF00017	0.502
LIG_WRC_WIRS_1	13	18	PF05994	0.597
MOD_CK1_1	33	39	PF00069	0.547
MOD_CK1_1	83	89	PF00069	0.551
MOD_CK2_1	2	8	PF00069	0.678
MOD_CK2_1	20	26	PF00069	0.509
MOD_GlcNHglycan	35	38	PF01048	0.347
MOD_GlcNHglycan	93	96	PF01048	0.404
MOD_GSK3_1	2	9	PF00069	0.667
MOD_LATS_1	52	58	PF00433	0.582
MOD_N-GLC_1	30	35	PF02516	0.323
MOD_NEK2_1	20	25	PF00069	0.523
MOD_PK_1	30	36	PF00069	0.582
MOD_PKA_2	20	26	PF00069	0.523
MOD_PKA_2	70	76	PF00069	0.620
MOD_Plk_1	30	36	PF00069	0.511
MOD_Plk_4	20	26	PF00069	0.523
MOD_Plk_4	30	36	PF00069	0.505
MOD_Plk_4	45	51	PF00069	0.523
MOD_Plk_4	9	15	PF00069	0.508
MOD_ProDKin_1	2	8	PF00069	0.674
MOD_SUMO_rev_2	26	32	PF00179	0.582
TRG_ENDOCYTIC_2	77	80	PF00928	0.523
TRG_ENDOCYTIC_2	87	90	PF00928	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P814	Leptomonas seymouri	87%	98%
A0A1X0PAE8	Trypanosomatidae	35%	90%
A0A3Q8ICE0	Leishmania donovani	93%	100%
A0A422NSZ6	Trypanosoma rangeli	33%	90%
A4HZX8	Leishmania infantum	93%	100%
C9ZSL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	97%
E9AVT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O42661	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	88%
P62314	Homo sapiens	43%	87%
P62315	Mus musculus	43%	87%
P62318	Homo sapiens	30%	82%
P62320	Mus musculus	30%	82%
P62323	Xenopus laevis	30%	82%
Q10013	Caenorhabditis elegans	49%	82%
Q3ZC10	Bos taurus	43%	87%
Q4QBP1	Leishmania major	93%	100%
Q4R5F6	Macaca fascicularis	43%	87%
Q8QZX5	Mus musculus	30%	84%
Q969L4	Homo sapiens	30%	84%
Q9SSF1	Arabidopsis thaliana	45%	90%
Q9SY09	Arabidopsis thaliana	49%	89%
Q9UUC6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q9VU02	Drosophila melanogaster	46%	83%
V5BVX9	Trypanosoma cruzi	63%	100%