Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HCC2_LEIBR

TriTrypDb:

LbrM.22.0920 , LBRM2903_220014900

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	222	224	PF00675	0.586
CLV_PCSK_KEX2_1	222	224	PF00082	0.586
CLV_PCSK_SKI1_1	362	366	PF00082	0.497
CLV_PCSK_SKI1_1	374	378	PF00082	0.540
DEG_APCC_DBOX_1	361	369	PF00400	0.454
DEG_SCF_FBW7_2	32	38	PF00400	0.507
DEG_SCF_FBW7_2	88	95	PF00400	0.531
DEG_SPOP_SBC_1	233	237	PF00917	0.539
DEG_SPOP_SBC_1	264	268	PF00917	0.599
DOC_ANK_TNKS_1	350	357	PF00023	0.501
DOC_CDC14_PxL_1	197	205	PF14671	0.521
DOC_CDC14_PxL_1	82	90	PF14671	0.535
DOC_CKS1_1	32	37	PF01111	0.507
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	204	207	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.508
DOC_MAPK_gen_1	222	228	PF00069	0.525
DOC_MAPK_gen_1	75	83	PF00069	0.614
DOC_PP2B_LxvP_1	203	206	PF13499	0.702
DOC_PP2B_LxvP_1	45	48	PF13499	0.538
DOC_PP4_FxxP_1	30	33	PF00568	0.509
DOC_USP7_MATH_1	232	236	PF00917	0.548
DOC_USP7_MATH_1	245	249	PF00917	0.610
DOC_USP7_MATH_1	264	268	PF00917	0.568
DOC_USP7_MATH_1	49	53	PF00917	0.533
DOC_WW_Pin1_4	162	167	PF00397	0.589
DOC_WW_Pin1_4	302	307	PF00397	0.523
DOC_WW_Pin1_4	31	36	PF00397	0.611
DOC_WW_Pin1_4	60	65	PF00397	0.582
DOC_WW_Pin1_4	76	81	PF00397	0.483
DOC_WW_Pin1_4	88	93	PF00397	0.507
LIG_14-3-3_CanoR_1	227	233	PF00244	0.538
LIG_14-3-3_CanoR_1	336	344	PF00244	0.463
LIG_BIR_II_1	1	5	PF00653	0.500
LIG_BIR_III_4	277	281	PF00653	0.512
LIG_BRCT_BRCA1_1	172	176	PF00533	0.562
LIG_BRCT_BRCA1_1	26	30	PF00533	0.499
LIG_deltaCOP1_diTrp_1	284	290	PF00928	0.485
LIG_eIF4E_1	40	46	PF01652	0.519
LIG_eIF4E_1	82	88	PF01652	0.538
LIG_FHA_1	191	197	PF00498	0.615
LIG_FHA_1	214	220	PF00498	0.516
LIG_FHA_1	41	47	PF00498	0.516
LIG_FHA_1	52	58	PF00498	0.541
LIG_Integrin_RGD_1	351	353	PF01839	0.502
LIG_LIR_Apic_2	110	114	PF02991	0.597
LIG_LIR_Apic_2	161	166	PF02991	0.540
LIG_LIR_Apic_2	27	33	PF02991	0.578
LIG_LIR_Gen_1	285	296	PF02991	0.405
LIG_LIR_Gen_1	6	16	PF02991	0.692
LIG_LIR_Nem_3	26	32	PF02991	0.512
LIG_LIR_Nem_3	285	291	PF02991	0.473
LIG_LIR_Nem_3	34	40	PF02991	0.649
LIG_MLH1_MIPbox_1	26	30	PF16413	0.499
LIG_NRBOX	343	349	PF00104	0.496
LIG_Pex14_1	315	319	PF04695	0.425
LIG_SH2_CRK	163	167	PF00017	0.512
LIG_SH2_GRB2like	40	43	PF00017	0.520
LIG_SH2_NCK_1	111	115	PF00017	0.603
LIG_SH2_NCK_1	157	161	PF00017	0.550
LIG_SH2_SRC	111	114	PF00017	0.602
LIG_SH2_STAP1	135	139	PF00017	0.547
LIG_SH2_STAP1	321	325	PF00017	0.476
LIG_SH2_STAP1	37	41	PF00017	0.512
LIG_SH2_STAT5	29	32	PF00017	0.594
LIG_SH2_STAT5	40	43	PF00017	0.648
LIG_SH2_STAT5	50	53	PF00017	0.559
LIG_SH2_STAT5	55	58	PF00017	0.679
LIG_SH2_STAT5	82	85	PF00017	0.606
LIG_SH3_3	300	306	PF00018	0.509
LIG_SH3_3	61	67	PF00018	0.622
LIG_SH3_3	80	86	PF00018	0.475
LIG_SH3_4	117	124	PF00018	0.535
LIG_SUMO_SIM_par_1	144	151	PF11976	0.556
MOD_CK1_1	10	16	PF00069	0.619
MOD_CK1_1	162	168	PF00069	0.513
MOD_CK1_1	179	185	PF00069	0.597
MOD_CK1_1	276	282	PF00069	0.544
MOD_CK2_1	125	131	PF00069	0.634
MOD_CK2_1	155	161	PF00069	0.587
MOD_GlcNHglycan	103	106	PF01048	0.652
MOD_GlcNHglycan	137	140	PF01048	0.546
MOD_GlcNHglycan	172	175	PF01048	0.571
MOD_GlcNHglycan	236	239	PF01048	0.733
MOD_GlcNHglycan	247	250	PF01048	0.636
MOD_GlcNHglycan	277	281	PF01048	0.553
MOD_GlcNHglycan	83	86	PF01048	0.621
MOD_GSK3_1	155	162	PF00069	0.546
MOD_GSK3_1	170	177	PF00069	0.574
MOD_GSK3_1	241	248	PF00069	0.548
MOD_GSK3_1	265	272	PF00069	0.582
MOD_GSK3_1	3	10	PF00069	0.569
MOD_GSK3_1	36	43	PF00069	0.735
MOD_N-GLC_1	179	184	PF02516	0.576
MOD_N-GLC_1	190	195	PF02516	0.586
MOD_NEK2_1	125	130	PF00069	0.533
MOD_NEK2_1	155	160	PF00069	0.552
MOD_NEK2_1	176	181	PF00069	0.610
MOD_NEK2_1	226	231	PF00069	0.527
MOD_NEK2_1	263	268	PF00069	0.523
MOD_NEK2_1	81	86	PF00069	0.583
MOD_NEK2_2	265	270	PF00069	0.537
MOD_OFUCOSY	225	230	PF10250	0.530
MOD_PIKK_1	179	185	PF00454	0.576
MOD_PIKK_1	213	219	PF00454	0.509
MOD_PKA_2	226	232	PF00069	0.534
MOD_PKA_2	269	275	PF00069	0.617
MOD_PKA_2	335	341	PF00069	0.480
MOD_Plk_1	3	9	PF00069	0.496
MOD_Plk_1	317	323	PF00069	0.452
MOD_Plk_4	192	198	PF00069	0.659
MOD_Plk_4	36	42	PF00069	0.544
MOD_Plk_4	4	10	PF00069	0.496
MOD_Plk_4	51	57	PF00069	0.488
MOD_ProDKin_1	162	168	PF00069	0.589
MOD_ProDKin_1	302	308	PF00069	0.530
MOD_ProDKin_1	31	37	PF00069	0.612
MOD_ProDKin_1	60	66	PF00069	0.581
MOD_ProDKin_1	76	82	PF00069	0.484
MOD_ProDKin_1	88	94	PF00069	0.505
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.540
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.489
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.546
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.538
TRG_ENDOCYTIC_2	19	22	PF00928	0.500
TRG_ENDOCYTIC_2	29	32	PF00928	0.478
TRG_ER_diArg_1	221	223	PF00400	0.556
TRG_ER_diArg_1	75	78	PF00400	0.551
TRG_NES_CRM1_1	360	371	PF08389	0.454
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AVT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	77%
Q4QBP5	Leishmania major	53%	100%