Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCC0_LEIBR

TriTrypDb:

LbrM.22.0940 , LBRM2903_220015100

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCC0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.436
CLV_C14_Caspase3-7	135	139	PF00656	0.557
CLV_C14_Caspase3-7	420	424	PF00656	0.619
CLV_NRD_NRD_1	153	155	PF00675	0.501
CLV_NRD_NRD_1	251	253	PF00675	0.500
CLV_NRD_NRD_1	293	295	PF00675	0.552
CLV_NRD_NRD_1	313	315	PF00675	0.361
CLV_NRD_NRD_1	336	338	PF00675	0.553
CLV_NRD_NRD_1	444	446	PF00675	0.658
CLV_NRD_NRD_1	452	454	PF00675	0.608
CLV_NRD_NRD_1	609	611	PF00675	0.727
CLV_NRD_NRD_1	644	646	PF00675	0.781
CLV_NRD_NRD_1	80	82	PF00675	0.499
CLV_PCSK_KEX2_1	155	157	PF00082	0.434
CLV_PCSK_KEX2_1	251	253	PF00082	0.480
CLV_PCSK_KEX2_1	3	5	PF00082	0.654
CLV_PCSK_KEX2_1	313	315	PF00082	0.589
CLV_PCSK_KEX2_1	336	338	PF00082	0.525
CLV_PCSK_KEX2_1	444	446	PF00082	0.639
CLV_PCSK_KEX2_1	452	454	PF00082	0.516
CLV_PCSK_KEX2_1	47	49	PF00082	0.446
CLV_PCSK_KEX2_1	609	611	PF00082	0.767
CLV_PCSK_KEX2_1	644	646	PF00082	0.782
CLV_PCSK_KEX2_1	68	70	PF00082	0.469
CLV_PCSK_KEX2_1	80	82	PF00082	0.453
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.434
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.654
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.460
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.469
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.453
CLV_PCSK_SKI1_1	252	256	PF00082	0.535
CLV_PCSK_SKI1_1	453	457	PF00082	0.654
CLV_PCSK_SKI1_1	517	521	PF00082	0.561
CLV_PCSK_SKI1_1	624	628	PF00082	0.782
CLV_PCSK_SKI1_1	65	69	PF00082	0.441
CLV_PCSK_SKI1_1	81	85	PF00082	0.470
DEG_APCC_DBOX_1	452	460	PF00400	0.430
DEG_Nend_Nbox_1	1	3	PF02207	0.698
DEG_SPOP_SBC_1	615	619	PF00917	0.757
DOC_MAPK_gen_1	154	160	PF00069	0.490
DOC_MAPK_gen_1	352	359	PF00069	0.637
DOC_MAPK_MEF2A_6	188	196	PF00069	0.499
DOC_MAPK_MEF2A_6	90	99	PF00069	0.548
DOC_PP1_RVXF_1	104	110	PF00149	0.408
DOC_PP1_RVXF_1	154	161	PF00149	0.358
DOC_PP4_FxxP_1	160	163	PF00568	0.481
DOC_PP4_FxxP_1	579	582	PF00568	0.591
DOC_USP7_MATH_1	385	389	PF00917	0.753
DOC_USP7_MATH_1	414	418	PF00917	0.708
DOC_USP7_MATH_1	424	428	PF00917	0.659
DOC_USP7_MATH_1	432	436	PF00917	0.570
DOC_USP7_MATH_1	439	443	PF00917	0.637
DOC_USP7_MATH_1	448	452	PF00917	0.642
DOC_USP7_MATH_1	593	597	PF00917	0.651
DOC_USP7_MATH_1	615	619	PF00917	0.731
DOC_USP7_MATH_1	667	671	PF00917	0.530
DOC_USP7_UBL2_3	235	239	PF12436	0.610
DOC_USP7_UBL2_3	278	282	PF12436	0.516
DOC_USP7_UBL2_3	295	299	PF12436	0.582
DOC_USP7_UBL2_3	620	624	PF12436	0.574
DOC_USP7_UBL2_3	68	72	PF12436	0.459
DOC_USP7_UBL2_3	80	84	PF12436	0.450
DOC_WW_Pin1_4	315	320	PF00397	0.419
DOC_WW_Pin1_4	609	614	PF00397	0.685
DOC_WW_Pin1_4	626	631	PF00397	0.581
DOC_WW_Pin1_4	654	659	PF00397	0.553
LIG_14-3-3_CanoR_1	269	275	PF00244	0.595
LIG_14-3-3_CanoR_1	384	392	PF00244	0.741
LIG_14-3-3_CanoR_1	426	432	PF00244	0.527
LIG_14-3-3_CanoR_1	438	444	PF00244	0.469
LIG_14-3-3_CterR_2	672	674	PF00244	0.779
LIG_Actin_WH2_2	299	315	PF00022	0.625
LIG_Actin_WH2_2	8	23	PF00022	0.497
LIG_Actin_WH2_2	96	113	PF00022	0.403
LIG_AP2alpha_2	467	469	PF02296	0.549
LIG_BIR_III_2	382	386	PF00653	0.535
LIG_BRCT_BRCA1_1	243	247	PF00533	0.614
LIG_FHA_1	251	257	PF00498	0.562
LIG_FHA_1	3	9	PF00498	0.533
LIG_FHA_1	561	567	PF00498	0.556
LIG_FHA_1	603	609	PF00498	0.768
LIG_FHA_1	90	96	PF00498	0.541
LIG_FHA_2	180	186	PF00498	0.520
LIG_FHA_2	316	322	PF00498	0.538
LIG_FHA_2	418	424	PF00498	0.722
LIG_FHA_2	428	434	PF00498	0.696
LIG_Integrin_RGD_1	645	647	PF01839	0.532
LIG_LIR_Apic_2	157	163	PF02991	0.468
LIG_LIR_Apic_2	463	468	PF02991	0.555
LIG_LIR_Gen_1	112	121	PF02991	0.413
LIG_LIR_Gen_1	25	30	PF02991	0.491
LIG_LIR_Gen_1	466	477	PF02991	0.577
LIG_LIR_Nem_3	112	117	PF02991	0.410
LIG_LIR_Nem_3	30	35	PF02991	0.496
LIG_LIR_Nem_3	37	43	PF02991	0.409
LIG_LIR_Nem_3	466	472	PF02991	0.602
LIG_LIR_Nem_3	482	486	PF02991	0.552
LIG_LIR_Nem_3	549	554	PF02991	0.713
LIG_RPA_C_Fungi	129	141	PF08784	0.599
LIG_SH2_CRK	189	193	PF00017	0.525
LIG_SH2_CRK	483	487	PF00017	0.699
LIG_SH2_GRB2like	189	192	PF00017	0.500
LIG_SH2_NCK_1	465	469	PF00017	0.553
LIG_SH2_SRC	465	468	PF00017	0.550
LIG_SH2_STAP1	226	230	PF00017	0.478
LIG_SH2_STAP1	237	241	PF00017	0.553
LIG_SH2_STAP1	487	491	PF00017	0.566
LIG_SH2_STAP1	570	574	PF00017	0.721
LIG_SH2_STAT3	341	344	PF00017	0.623
LIG_SH2_STAT3	501	504	PF00017	0.618
LIG_SH2_STAT5	356	359	PF00017	0.592
LIG_SH2_STAT5	43	46	PF00017	0.458
LIG_SH2_STAT5	501	504	PF00017	0.710
LIG_SH2_STAT5	52	55	PF00017	0.485
LIG_SH2_STAT5	550	553	PF00017	0.547
LIG_SH3_3	555	561	PF00018	0.679
LIG_SH3_3	633	639	PF00018	0.721
LIG_SUMO_SIM_anti_2	301	308	PF11976	0.556
LIG_TRAF2_1	102	105	PF00917	0.348
LIG_TRAF2_1	167	170	PF00917	0.486
LIG_TRAF2_1	318	321	PF00917	0.672
MOD_CDC14_SPxK_1	629	632	PF00782	0.776
MOD_CDK_SPxK_1	626	632	PF00069	0.767
MOD_CK1_1	13	19	PF00069	0.596
MOD_CK1_1	250	256	PF00069	0.478
MOD_CK1_1	315	321	PF00069	0.600
MOD_CK1_1	417	423	PF00069	0.662
MOD_CK1_1	427	433	PF00069	0.683
MOD_CK1_1	523	529	PF00069	0.462
MOD_CK1_1	596	602	PF00069	0.713
MOD_CK1_1	604	610	PF00069	0.702
MOD_CK2_1	171	177	PF00069	0.566
MOD_CK2_1	179	185	PF00069	0.445
MOD_CK2_1	24	30	PF00069	0.564
MOD_CK2_1	255	261	PF00069	0.514
MOD_CK2_1	315	321	PF00069	0.546
MOD_CK2_1	427	433	PF00069	0.727
MOD_Cter_Amidation	497	500	PF01082	0.593
MOD_GlcNHglycan	12	15	PF01048	0.461
MOD_GlcNHglycan	122	125	PF01048	0.391
MOD_GlcNHglycan	172	176	PF01048	0.544
MOD_GlcNHglycan	242	246	PF01048	0.538
MOD_GlcNHglycan	314	317	PF01048	0.580
MOD_GlcNHglycan	393	397	PF01048	0.637
MOD_GlcNHglycan	427	430	PF01048	0.695
MOD_GlcNHglycan	433	437	PF01048	0.547
MOD_GlcNHglycan	522	525	PF01048	0.463
MOD_GlcNHglycan	595	598	PF01048	0.757
MOD_GlcNHglycan	652	655	PF01048	0.593
MOD_GSK3_1	439	446	PF00069	0.554
MOD_GSK3_1	593	600	PF00069	0.722
MOD_GSK3_1	609	616	PF00069	0.670
MOD_GSK3_1	650	657	PF00069	0.698
MOD_GSK3_1	667	674	PF00069	0.543
MOD_N-GLC_1	190	195	PF02516	0.566
MOD_NEK2_1	241	246	PF00069	0.517
MOD_NEK2_1	247	252	PF00069	0.481
MOD_NEK2_1	255	260	PF00069	0.436
MOD_NEK2_1	312	317	PF00069	0.599
MOD_NEK2_1	425	430	PF00069	0.703
MOD_NEK2_1	520	525	PF00069	0.650
MOD_NEK2_1	614	619	PF00069	0.751
MOD_NEK2_2	439	444	PF00069	0.498
MOD_NEK2_2	468	473	PF00069	0.594
MOD_PIKK_1	112	118	PF00454	0.425
MOD_PKA_1	499	505	PF00069	0.610
MOD_PKA_2	250	256	PF00069	0.503
MOD_PKA_2	312	318	PF00069	0.571
MOD_PKA_2	345	351	PF00069	0.443
MOD_PKA_2	425	431	PF00069	0.597
MOD_PKA_2	443	449	PF00069	0.681
MOD_Plk_1	190	196	PF00069	0.565
MOD_Plk_1	24	30	PF00069	0.571
MOD_Plk_2-3	25	31	PF00069	0.344
MOD_Plk_4	414	420	PF00069	0.640
MOD_ProDKin_1	315	321	PF00069	0.419
MOD_ProDKin_1	609	615	PF00069	0.685
MOD_ProDKin_1	626	632	PF00069	0.584
MOD_ProDKin_1	654	660	PF00069	0.553
MOD_SUMO_for_1	221	224	PF00179	0.579
MOD_SUMO_for_1	298	301	PF00179	0.595
MOD_SUMO_for_1	363	366	PF00179	0.646
MOD_SUMO_rev_2	223	230	PF00179	0.461
MOD_SUMO_rev_2	315	325	PF00179	0.413
MOD_SUMO_rev_2	565	574	PF00179	0.676
MOD_SUMO_rev_2	86	92	PF00179	0.589
TRG_DiLeu_BaEn_1	279	284	PF01217	0.557
TRG_DiLeu_BaEn_4	320	326	PF01217	0.624
TRG_DiLeu_BaLyEn_6	579	584	PF01217	0.687
TRG_ENDOCYTIC_2	189	192	PF00928	0.475
TRG_ENDOCYTIC_2	237	240	PF00928	0.468
TRG_ENDOCYTIC_2	356	359	PF00928	0.592
TRG_ENDOCYTIC_2	483	486	PF00928	0.633
TRG_ER_diArg_1	106	109	PF00400	0.496
TRG_ER_diArg_1	19	22	PF00400	0.474
TRG_ER_diArg_1	312	314	PF00400	0.615
TRG_ER_diArg_1	443	445	PF00400	0.490
TRG_ER_diArg_1	608	610	PF00400	0.708
TRG_ER_diArg_1	643	645	PF00400	0.784
TRG_NES_CRM1_1	198	213	PF08389	0.554
TRG_NES_CRM1_1	358	371	PF08389	0.585
TRG_NLS_Bipartite_1	68	85	PF00514	0.331
TRG_NLS_MonoExtC_3	79	84	PF00514	0.497
TRG_NLS_MonoExtN_4	80	85	PF00514	0.615
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8W6	Leptomonas seymouri	67%	100%
A0A0S4KMX4	Bodo saltans	45%	100%
A0A1X0NU00	Trypanosomatidae	52%	100%
A0A3S7WXA7	Leishmania donovani	83%	99%
A0A422MU25	Trypanosoma rangeli	54%	100%
A4HZX6	Leishmania infantum	83%	99%
C9ZSL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AVT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QBP3	Leishmania major	83%	100%