Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytoskeleton associated protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCB9_LEIBR

TriTrypDb:

LbrM.22.0660 , LBRM2903_220012100

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005856	cytoskeleton	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.526
CLV_C14_Caspase3-7	175	179	PF00656	0.615
CLV_C14_Caspase3-7	197	201	PF00656	0.398
CLV_C14_Caspase3-7	296	300	PF00656	0.449
CLV_NRD_NRD_1	151	153	PF00675	0.483
CLV_NRD_NRD_1	217	219	PF00675	0.439
CLV_NRD_NRD_1	70	72	PF00675	0.473
CLV_PCSK_KEX2_1	212	214	PF00082	0.433
CLV_PCSK_KEX2_1	216	218	PF00082	0.436
CLV_PCSK_KEX2_1	269	271	PF00082	0.485
CLV_PCSK_KEX2_1	59	61	PF00082	0.529
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.512
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.516
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.363
CLV_PCSK_PC7_1	213	219	PF00082	0.495
CLV_PCSK_SKI1_1	104	108	PF00082	0.379
CLV_PCSK_SKI1_1	266	270	PF00082	0.492
CLV_PCSK_SKI1_1	276	280	PF00082	0.481
CLV_PCSK_SKI1_1	301	305	PF00082	0.527
CLV_PCSK_SKI1_1	306	310	PF00082	0.486
CLV_PCSK_SKI1_1	49	53	PF00082	0.377
DEG_APCC_DBOX_1	317	325	PF00400	0.363
DEG_APCC_DBOX_1	70	78	PF00400	0.493
DOC_CKS1_1	30	35	PF01111	0.629
DOC_CYCLIN_RxL_1	56	66	PF00134	0.566
DOC_MAPK_MEF2A_6	222	229	PF00069	0.461
DOC_MAPK_RevD_3	139	154	PF00069	0.391
DOC_PP4_FxxP_1	19	22	PF00568	0.553
DOC_WW_Pin1_4	221	226	PF00397	0.555
DOC_WW_Pin1_4	29	34	PF00397	0.642
LIG_14-3-3_CanoR_1	206	214	PF00244	0.554
LIG_14-3-3_CanoR_1	246	254	PF00244	0.580
LIG_APCC_ABBA_1	106	111	PF00400	0.503
LIG_APCC_ABBA_1	61	66	PF00400	0.466
LIG_APCC_ABBAyCdc20_2	60	66	PF00400	0.502
LIG_FHA_1	224	230	PF00498	0.544
LIG_FHA_1	246	252	PF00498	0.524
LIG_FHA_1	88	94	PF00498	0.589
LIG_FHA_2	105	111	PF00498	0.375
LIG_FHA_2	184	190	PF00498	0.631
LIG_FHA_2	30	36	PF00498	0.625
LIG_LIR_Apic_2	16	22	PF02991	0.547
LIG_LIR_Gen_1	133	144	PF02991	0.559
LIG_LIR_Nem_3	133	139	PF02991	0.550
LIG_NBox_RRM_1	155	165	PF00076	0.369
LIG_PCNA_yPIPBox_3	114	122	PF02747	0.393
LIG_RPA_C_Fungi	197	209	PF08784	0.393
LIG_SH2_STAP1	191	195	PF00017	0.395
LIG_SH2_STAP1	286	290	PF00017	0.595
LIG_SH2_STAP1	36	40	PF00017	0.610
LIG_SH2_STAP1	64	68	PF00017	0.483
LIG_SH2_STAT3	166	169	PF00017	0.526
LIG_SH2_STAT5	166	169	PF00017	0.512
LIG_SH2_STAT5	327	330	PF00017	0.476
LIG_SH3_1	222	228	PF00018	0.463
LIG_SH3_3	222	228	PF00018	0.463
LIG_SH3_3	27	33	PF00018	0.676
LIG_SUMO_SIM_anti_2	73	82	PF11976	0.556
LIG_SUMO_SIM_par_1	103	112	PF11976	0.459
LIG_TRAF2_1	32	35	PF00917	0.622
MOD_CK1_1	8	14	PF00069	0.807
MOD_CK1_1	98	104	PF00069	0.612
MOD_CK2_1	104	110	PF00069	0.504
MOD_CK2_1	183	189	PF00069	0.619
MOD_CK2_1	29	35	PF00069	0.656
MOD_GlcNHglycan	7	10	PF01048	0.720
MOD_GSK3_1	217	224	PF00069	0.527
MOD_GSK3_1	272	279	PF00069	0.590
MOD_LATS_1	215	221	PF00433	0.428
MOD_N-GLC_1	14	19	PF02516	0.710
MOD_N-GLC_1	173	178	PF02516	0.518
MOD_NEK2_1	245	250	PF00069	0.621
MOD_NEK2_1	272	277	PF00069	0.588
MOD_NEK2_2	286	291	PF00069	0.594
MOD_PKA_1	217	223	PF00069	0.450
MOD_PKA_2	217	223	PF00069	0.522
MOD_PKA_2	245	251	PF00069	0.450
MOD_Plk_1	14	20	PF00069	0.609
MOD_Plk_1	286	292	PF00069	0.591
MOD_Plk_1	53	59	PF00069	0.497
MOD_Plk_1	98	104	PF00069	0.527
MOD_Plk_2-3	183	189	PF00069	0.509
MOD_Plk_4	104	110	PF00069	0.611
MOD_ProDKin_1	221	227	PF00069	0.551
MOD_ProDKin_1	29	35	PF00069	0.637
MOD_SUMO_for_1	254	257	PF00179	0.648
MOD_SUMO_for_1	308	311	PF00179	0.568
MOD_SUMO_rev_2	124	128	PF00179	0.420
MOD_SUMO_rev_2	274	283	PF00179	0.448
MOD_SUMO_rev_2	310	317	PF00179	0.558
TRG_DiLeu_BaEn_1	194	199	PF01217	0.467
TRG_DiLeu_BaEn_1	257	262	PF01217	0.534
TRG_DiLeu_BaEn_4	312	318	PF01217	0.528
TRG_DiLeu_BaLyEn_6	303	308	PF01217	0.388
TRG_ENDOCYTIC_2	64	67	PF00928	0.471
TRG_ER_diArg_1	144	147	PF00400	0.518
TRG_ER_diArg_1	216	218	PF00400	0.487
TRG_NES_CRM1_1	256	271	PF08389	0.452
TRG_NLS_MonoExtC_3	151	157	PF00514	0.379
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I875	Leptomonas seymouri	66%	75%
A0A1X0NT91	Trypanosomatidae	37%	73%
A0A3Q8IFG4	Leishmania donovani	72%	77%
C9ZSG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	75%
E9AVQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	81%
Q4QBS4	Leishmania major	69%	100%
V5BLI8	Trypanosoma cruzi	34%	100%